Toxicity Report on Reproductive Dose Range-Finding Study of Genistein (CAS No. 446-72-0) Administered in Feed to Sprague-Dawley Rats

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Publisher : DIANE Publishing
ISBN 13 : 1428988807
Total Pages : 320 pages
Book Rating : 4.4/5 (289 download)

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Book Synopsis Toxicity Report on Reproductive Dose Range-Finding Study of Genistein (CAS No. 446-72-0) Administered in Feed to Sprague-Dawley Rats by : K. Barry Delclos

Download or read book Toxicity Report on Reproductive Dose Range-Finding Study of Genistein (CAS No. 446-72-0) Administered in Feed to Sprague-Dawley Rats written by K. Barry Delclos and published by DIANE Publishing. This book was released on 2008-04 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genistein is a naturally occurring isoflavone that interacts with estrogen receptors & multiple other molecular targets. Human exposure to Genistein is through consumption of soy products, including soy-based infant formula & dietary supplements. A series of short-term studies with Genistein was conducted with two goals: to obtain data necessary to establish dose levels for subsequent multi-generation reproductive & chronic toxicity studies; & to evaluate the effects of Genistein on endpoints outside the reproductive tract. This report focuses on the reproductive & toxicology endpoints. Data obtained in separate evaluations of behavioral, neuroanatomical, neurochemical, & immunological endpoints are also discussed. Illustrations.

Technical Report on the Toxicology and Carcinogenesis Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study)

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Publisher : DIANE Publishing
ISBN 13 : 1437900739
Total Pages : 242 pages
Book Rating : 4.4/5 (379 download)

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Book Synopsis Technical Report on the Toxicology and Carcinogenesis Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study) by : D. A. Casciano

Download or read book Technical Report on the Toxicology and Carcinogenesis Study of Genistein (CAS No. 446-72-0) in Sprague-Dawley Rats (Feed Study) written by D. A. Casciano and published by DIANE Publishing. This book was released on 2008-10 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genistein is an isoflavone that occurs in soy products incl. soy-based infant formulas. It is known as ¿environmental estrogens¿ which can affect the hormone activities and possibly reproductive function of wildlife and humans through exposure. Studies were conducted on 3 such chemicals to see if exposure to such chemicals could have any effect on animals¿ reproductive systems or development of cancers. Rats were exposed to genistein for part or all of the study period and examined at the end of 2 years. Exposure to Genistein for 2 years caused tumors of the mammary gland and pituitary gland in female rats. Exposure to Genistein for shorter durations was also assoc. with increased rates of pituitary gland and mammary gland tumors. Ill.

Technical Report Series

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Publisher :
ISBN 13 :
Total Pages : 248 pages
Book Rating : 4.:/5 (9 download)

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Book Synopsis Technical Report Series by :

Download or read book Technical Report Series written by and published by . This book was released on 2008 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Endocrine Disruption and Human Health

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Publisher : Academic Press
ISBN 13 : 0128011203
Total Pages : 390 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Endocrine Disruption and Human Health by : Philippa D. Darbre

Download or read book Endocrine Disruption and Human Health written by Philippa D. Darbre and published by Academic Press. This book was released on 2015-03-21 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Endocrine Disruption and Human Health starts with an overview of what endocrine disruptors are, the issues surrounding them, and the source of these chemicals in the ecosystem. This is followed by an overview of the mechanisms of action and assay systems. The third section includes chapters written by specialists on different aspects of concern for the effects of endocrine disruption on human health. Finally, the authors consider the risk assessment of endocrine disruptors and the pertinent regulation developed by the EU, the US FDA, as well as REACH and NGOs. The book has been written for researchers and research clinicians interested in learning about the actions of endocrine disruptors and current evidence justifying concerns for human health but is useful for those approaching the subject for the first time, graduate students, and advanced undergraduate students. - Provides readers with access to a range of information from the basic mechanisms and assays to cutting-edge research investigating concerns for human health - Presents a comprehensive, translational look at all aspects of endocrine disruption and its effects on human health - Offers guidance on the risk assessment of endocrine disruptors and current relevant regulatory considerations

Hormonally Active Agents in the Environment

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Publisher : National Academies Press
ISBN 13 : 0309064198
Total Pages : 453 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Hormonally Active Agents in the Environment by : National Research Council

Download or read book Hormonally Active Agents in the Environment written by National Research Council and published by National Academies Press. This book was released on 2000-02-03 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some investigators have hypothesized that estrogens and other hormonally active agents found in the environment might be involved in breast cancer increases and sperm count declines in humans as well as deformities and reproductive problems seen in wildlife. This book looks in detail at the science behind the ominous prospect of "estrogen mimics" threatening health and well-being, from the level of ecosystems and populations to individual people and animals. The committee identifies research needs and offers specific recommendations to decision-makers. This authoritative volume: Critically evaluates the literature on hormonally active agents in the environment and identifies known and suspected toxicologic mechanisms and effects of fish, wildlife, and humans. Examines whether and how exposure to hormonally active agents occursâ€"in diet, in pharmaceuticals, from industrial releases into the environmentâ€"and why the debate centers on estrogens. Identifies significant uncertainties, limitations of knowledge, and weaknesses in the scientific literature. The book presents a wealth of information and investigates a wide range of examples across the spectrum of life that might be related to these agents.

Phytoestrogens and Health

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Publisher : The American Oil Chemists Society
ISBN 13 : 9781893997325
Total Pages : 682 pages
Book Rating : 4.9/5 (973 download)

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Book Synopsis Phytoestrogens and Health by : G. Sarwar Gilani

Download or read book Phytoestrogens and Health written by G. Sarwar Gilani and published by The American Oil Chemists Society. This book was released on 2002-06-30 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Drug Transporters in Drug Disposition, Effects and Toxicity

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Publisher : Springer Nature
ISBN 13 : 9811376476
Total Pages : 588 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Drug Transporters in Drug Disposition, Effects and Toxicity by : Xiaodong Liu

Download or read book Drug Transporters in Drug Disposition, Effects and Toxicity written by Xiaodong Liu and published by Springer Nature. This book was released on 2019-09-30 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides with a comprehensive overview of the role of drug transporters in drug disposition and efficacy/toxicity, as well as drug-drug interactions and recent advances in the field. Transporters are known determinants of drug disposition and efficacy/toxicity. In general, they are divided into solute carrier (SLC) and ATP binding cassette (ABC) families, and are located along cell membranes, where they mediate drug uptake into cells and export out of cells. Drug transporters are essential in maintaining cell homeostasis, and their gene mutations may cause or contribute to severe human genetic disorders, such as cystic fibrosis, neurological disease, retinal degeneration, anemia, and cholesterol and bile transport defects. Conversely, some diseases may also alter transporter functions and expressions, in turn aggravating disease process. Further, since over-expression of some ABC transporters is a potential contributor to multidrug-resistance (MDR), the book presents a number of strategies to overcome MDR, including ABC transporter inhibitors and applying epigenetic methods to modulate transporter expressions and functions. This book is useful for graduate students and professionals who are looking to refresh or expand their knowledge of this exciting field.

Sprouted Grains

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Publisher : Elsevier
ISBN 13 : 0128115262
Total Pages : 347 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Sprouted Grains by : Hao Feng

Download or read book Sprouted Grains written by Hao Feng and published by Elsevier. This book was released on 2018-10-11 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sprouted Grains: Nutritional Value, Production and Applications is a complete and comprehensive overview of sprouted grains, with coverage from grain to product. Sections includes discussions on the process of grain germination from both a genetic and physiological perspective, the nutrients and bioactive compounds present in spouted grains, and the equipment and technical innovation of use to manufacturers of sprouted grains and sprouted grain products. This book is essential reading for cereal science academics and postgraduate students interested in the subject of cereal processing, but is also ideal for industrial product developers in cereal companies. This edited volume brings together the world's leading researchers on sprouted grains. - Presents the nutrient and bioactive components of these healthy grains - Provides extensive coverage of products developed from sprouted grains - Includes contributions from an International team of both academic and industrial authors - Covers the equipment and technology used in grain processing

Food Bioactives

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Publisher : Springer
ISBN 13 : 3319516396
Total Pages : 329 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Food Bioactives by : Munish Puri

Download or read book Food Bioactives written by Munish Puri and published by Springer. This book was released on 2017-04-07 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on various types of bioactive compounds, including secondary metabolites, oligosaccharides, polysaccharides, flavonoids, peptides/proteins, carotenoid pigments, quinones, terpenes, and polyunsaturated fatty acids, and presents an overview of their nutraceutical activities. It covers the current status and future potential of food compounds, as well as extraction technologies for bioactives derived from plant, fungi and marine-derived bioactive agents. Finally, health-promoting effects of plant, fungi and marine-derived bioactive agents are discussed. Chapters come from top researchers in this area from around the globe. The volume caters to the needs of undergraduate and post-graduate students in the area of food biotechnology, food bioprocessing, biotechnology, food engineering, etc., and also contains information pertinent to researchers.

Cosmeceuticals and Active Cosmetics

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Publisher : CRC Press
ISBN 13 : 1482214172
Total Pages : 460 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Cosmeceuticals and Active Cosmetics by : Raja K Sivamani

Download or read book Cosmeceuticals and Active Cosmetics written by Raja K Sivamani and published by CRC Press. This book was released on 2015-09-18 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cosmeceuticals and Active Cosmetics discusses the science of nearly two dozen cosmeceuticals used today. This third edition provides ample evidence on specific cosmeceutical substances, their classes of use, skin conditions for which they are used, and points of interest arising from other considerations, such as toxicology and manufacturing. The book discusses both cosmetic and therapeutic uses of cosmeceuticals for various conditions including rosacea, dry skin, alopecia, eczema, seborrheic dermatitis, purpura, and vitiligo. Active ingredients in the following products are discussed: caffeine, curcumin, green tea, Rhodiola rosea, milk thistle, and more. Also covered are topical peptides and proteins, amino acids and derivatives, antioxidants, vitamins E and C, niacinamide, botanical extracts, and biomarine actives. Providing ample scientific references, this book is an excellent guide to understanding the science behind the use of cosmeceuticals to treat a variety of dermatological conditions.

Chitooligosaccharides

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Publisher : Springer Nature
ISBN 13 : 3030928063
Total Pages : 352 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Chitooligosaccharides by : Se-Kwon Kim

Download or read book Chitooligosaccharides written by Se-Kwon Kim and published by Springer Nature. This book was released on 2022-02-23 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book outlines the production of chitooligossacharides and their derivatives and discusses their main biological activities, biomedical applications and their role in disease prevention. Chitooligosaccharides are products of chitosan or chitin degradation, prepared by enzymatic or chemical hydrolysis of chitosan, and they consist mainly of N-acetyl glucosamine and glucosamine bonded with a glycosidic bond. Compared to chitin and chitosan, chitooligossacharides offer advantages for large-scale and commercial applications due to their solubility in water and lower molecular weight. Written by leading experts, this book is divided into four parts. The first part provides a general introduction to chitooligossacharides. The second part focuses on the bioproduction of chitooligossacharides through enzymatic synthesis and also covers physical and chemical methods of synthesis. The third part explores the major biological activities of chitooligosaccharides, including antioxidant, antimicrobial, anti-allergic, anti-inflammatory, anti-cancer and neuroprotective activities, and discusses the disease preventing mechanisms of chitooligosaccharides. In this section, readers will also find about the latest in vivo studies which support the use of chitooligosaccharides in the prevention and control of disease. The final part highlights important biomedical applications of chitooligosaccharides, including in tissue engineering, drug delivery and wound healing applications. It also includes the volume editor’s perspective on the health and safety risks of chitooligosaccharides. Given its scope, this book is useful not only for researches in the field but also for students interested in biomaterials, pharmaceuticals, marine biotechnology, nutraceuticals and food science.

An Evidence-based Approach to Phytochemicals and Other Dietary Factors

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Publisher : Thieme
ISBN 13 : 3132579963
Total Pages : 588 pages
Book Rating : 4.1/5 (325 download)

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Book Synopsis An Evidence-based Approach to Phytochemicals and Other Dietary Factors by : Jane Higdon

Download or read book An Evidence-based Approach to Phytochemicals and Other Dietary Factors written by Jane Higdon and published by Thieme. This book was released on 2012-11-07 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in a completely updated second edition, An Evidence-based Approach to Dietary Phytochemicals and Other Dietary Factors is a trusted resource for all health professionals who need to interpret the explosion of information on the role of a plant-based diet in health and disease. It consolidates a wealth of scientifically accurate, peer-reviewed data on plant foods, dietary phytochemicals, and dietary supplements, and includes information on essential intake recommendations, dietary sources, nutrient and drug interactions, phytochemicals in disease prevention, possible adverse effects, and much more. Special features: All chapters revised and updated, with new sections on choline, coenzyme Q10, L-Carnitine, lipoic acid, and other dietary factors Logically structured for quick access to information: begins with the evidence-based benefits of fruits and vegetables, legumes, nuts, whole grains, coffee, and tea; and goes on to the scientific and clinical data on individual dietary phytochemicals and classes of phytochemicals, including carotenoids, flavonoids, fiber, and more Summaries at the end of each chapter for rapid review Peer-reviewed by experts in the field, ensuring that all material is accurate and up-to-date The well-constructed appendix includes not only a quick reference to diseases and foods and where to find them in the book, but also useful tables on phytochemical-drug interactions, phytochemical-nutrient interactions, and phytochemical-rich foods; a summary of the glycemic index of dietary carbohydrates; and a comprehensive glossary of terms

Biotechnology of Anti-diabetic Medicinal Plants

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Publisher : Springer Nature
ISBN 13 : 9811635293
Total Pages : 482 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Biotechnology of Anti-diabetic Medicinal Plants by : Saikat Gantait

Download or read book Biotechnology of Anti-diabetic Medicinal Plants written by Saikat Gantait and published by Springer Nature. This book was released on 2021-11-13 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a unique overview of insights on the genetic basis of anti-diabetic activity, chemistry, physiology, biotechnology, mode-of-action, as well as cellular mechanisms of anti-diabetic secondary metabolites from medicinal plants. The World Health Organization estimated that 80% of the populations of developing countries rely on traditional medicines, mostly plant drugs, for their primary health care needs. There is an increasing demand for medicinal plants having anti-diabetic potential in both developing and developed countries. The expanding trade in medicinal plants has serious implications on the survival of several plant species, with many under threat to become extinct. This book describes various approaches to conserve these genetic resources. It discusses the whole spectrum of biotechnological tools from micro-propagation for large-scale multiplication, cell-culture techniques to the biosynthesis and enhancement of pharmaceutical compounds in the plants. It also discusses the genetic transformation as well as short- to long-term conservation of plant genetic resources via synthetic seed production and cryopreservation, respectively. The book is enriched with expert contributions from across the globe. This reference book is useful for researchers in the pharmaceutical and biotechnological industries, medicinal chemists, biochemists, botanists, molecular biologists, academicians, students as well as diabetic patients, traditional medicine practitioners, scientists in medicinal and aromatic plants, Ayurveda, Siddha, Unani and other traditional medical practitioners.

National Toxicology Program Annual Report for Fiscal Year ...

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Author :
Publisher :
ISBN 13 :
Total Pages : 320 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis National Toxicology Program Annual Report for Fiscal Year ... by : National Toxicology Program (U.S.)

Download or read book National Toxicology Program Annual Report for Fiscal Year ... written by National Toxicology Program (U.S.) and published by . This book was released on 1994 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Handbook of Dietary Phytochemicals

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Publisher : Springer
ISBN 13 : 9789811541476
Total Pages : 1953 pages
Book Rating : 4.5/5 (414 download)

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Book Synopsis Handbook of Dietary Phytochemicals by : Jianbo Xiao

Download or read book Handbook of Dietary Phytochemicals written by Jianbo Xiao and published by Springer. This book was released on 2021-09-02 with total page 1953 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent advances in the chemistry, bioactivity, nutrition, and functional aspects of dietary phytochemicals, as well as the health and functional aspects of foods rich in phytochemicals. Consisting of forty-four chapters, it discusses the different chemical types of phytochemicals in our diets and food and presents data collected from animal or human experiments that are directly related to human health. Each chapter covers the chemistry, epidemiological study, bioavailability, bioactivity (animal experiments) function in humans and safety, as well as products on the market. Moreover, the more than 200 figures make it easy to grasp the main findings in each area.

Magnesium: Current Status and New Developments

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Publisher : Springer Science & Business Media
ISBN 13 : 9780792348214
Total Pages : 448 pages
Book Rating : 4.3/5 (482 download)

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Book Synopsis Magnesium: Current Status and New Developments by : Theophile Theophanides

Download or read book Magnesium: Current Status and New Developments written by Theophile Theophanides and published by Springer Science & Business Media. This book was released on 1997-09-30 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the Proceedings of the 8th International Symposium on Magnesium. It presents research and applications in order to interface between medical doctors, clinicians and scientists responsible for magnesium involvement in the pathogenesis of diseases, its biological significance, metabolism and many other utilizations which are associated with membranes and cells. The topics which are discussed concern mechanisms of the mode of action of free magnesium cations, hydrated cations and magnesium-linked cations.

Xenobiotics in the Soil Environment

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Publisher : Springer
ISBN 13 : 3319477447
Total Pages : 407 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Xenobiotics in the Soil Environment by : Muhammad Zaffar Hashmi

Download or read book Xenobiotics in the Soil Environment written by Muhammad Zaffar Hashmi and published by Springer. This book was released on 2017-02-15 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the vast variety of xenobiotics, such as pesticides, antibiotics, antibiotic resistance genes, agrochemicals and other pollutants, their interactions with the soil environment, and the currently available strategies and techniques for soil decontamination and bioremediation. Topics covered include: transport mechanisms of pollutants along the Himalayas; use of earthworms in biomonitoring; metagenomic strategies for assessing contaminated sites; xenobiotics in the food chain; phyto-chemical remediation; biodegradation by fungi; and the use of enzymes and potential microbes in biotransformation. Accordingly, the book offers a valuable guide for scientists in the fields of environmental ecology, soil and food sciences, agriculture, and applied microbiology.