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Author : Juliet Midgley McComas
Publisher :
ISBN 13 :
Total Pages : 264 pages
Book Rating : 4.:/5 (559 download)
Download or read book Toward the Synthesis of Phorboxazole B written by Juliet Midgley McComas and published by . This book was released on 2003 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nimesh Mistry MChem
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (16 download)
Download or read book Stusies Towards the Synthesis of (+)-Phorboxazole B written by Nimesh Mistry MChem and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 173 pages
Book Rating : 4.:/5 (931 download)
Download or read book Studies Towards the Synthesis of (+)-phorboxazole B written by and published by . This book was released on 2010 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Amber Reilly
Publisher :
ISBN 13 : 9781124420738
Total Pages : 179 pages
Book Rating : 4.4/5 (27 download)
Download or read book Progress Toward the Total Synthesis of Batrachotoxinin A and Phorboxazole B written by Amber Reilly and published by . This book was released on 2010 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part I of this dissertation presents the studies directed toward the total synthesis of batrachotoxin. The general approach towards the synthesis of batrachotoxin involves preparation of the AB rings and the DE rings independently, followed by union of these two ring systems, subsequent closure of the C ring, and elaboration to the natural product. A deconjugative alkylation approach has thus far proved to be the most reliable route to the union of the AB rings to the DE rings, however other methods should be explored. Model studies and synthesis of advanced intermediates have provided a good foundation for future work towards the synthesis of batrachotoxin. Part II of this dissertation presents the studies directed toward the total synthesis of Phorboxazole B with an emphasis on efforts for uniting the side chain and macrocyclic core of the natural product by Wittig olefination. Model studies provided detailed insight into the conditions that would be optimal for union of these two advanced intermediates. While these model studies indicated a promising outcome and were even performed on highly elaborate model compounds, these conditions did not translate well in the union of the real side chain and macrocyle of Phorboxazole.
Author : Justin Philip Vitale
Publisher :
ISBN 13 :
Total Pages : 434 pages
Book Rating : 4.:/5 (529 download)
Download or read book Segment-coupling Prins Reactions written by Justin Philip Vitale and published by . This book was released on 2003 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Brian Stuart Lucas
Publisher :
ISBN 13 :
Total Pages : 526 pages
Book Rating : 4.:/5 (89 download)
Download or read book The Total Synthesis of Phorboxazole B written by Brian Stuart Lucas and published by . This book was released on 2006 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : E. A. Arnott
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (879 download)
Download or read book Studies Towards the Total Synthesis of Phorboxazoles A and B. written by E. A. Arnott and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael Philip Clark
Publisher :
ISBN 13 :
Total Pages : 870 pages
Book Rating : 4.3/5 ( download)
Download or read book Studies Toward the Synthesis of Phorboxazole A written by Michael Philip Clark and published by . This book was released on 2001 with total page 870 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Laura Marie Wysocki
Publisher :
ISBN 13 :
Total Pages : 404 pages
Book Rating : 4.:/5 (891 download)
Download or read book The Total Synthesis of Trilobacin and Investigation of the Synthesis of Phorboxazole B written by Laura Marie Wysocki and published by . This book was released on 2008 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Punlop Kuntiyong
Publisher :
ISBN 13 :
Total Pages : 648 pages
Book Rating : 4.:/5 (573 download)
Download or read book Studies Toward the Total Synthesis of Phorboxazole A written by Punlop Kuntiyong and published by . This book was released on 2004 with total page 648 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies toward the total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, were conducted and resulted in a route to an advanced intermediate, C4-C32, for this purpose. A key feature of our approach is the stereoselective synthesis of two cis-2,6-disubstituted tetrahydropyrans present in the macrolide portion of phorboxazole A by palladium (II) mediated intramolecular alkoxy carbonylation. This provided the C20-C32 and C9-C19 tetrahydropyran subunits of phorboxazole A. An attempt at diastereoselective formation of the third C5-C9 trans-2,6-disubstituted tetrahydropyran by hydride reduction of a C9 hemiketal was complicated by reduction of the C7 exocyclic olefin. However, the C5-C9 tetrahydropyran was constructed by an intramolecular etherification sequence using a novel allylsilane as the source of C4-C8 of the macrolactone. The studies carried out in the course of this thesis have set in place a major segment of the phorboxazole A structure; they require only the addition of the C1-C3 unit and minor functional group modifications to complete the macrolide portion of the molecule.
Author : Tae Hee Lee
Publisher :
ISBN 13 :
Total Pages : 890 pages
Book Rating : 4.:/5 (712 download)
Download or read book Total Synthesis of Phorboxazole A written by Tae Hee Lee and published by . This book was released on 2006 with total page 890 pages. Available in PDF, EPUB and Kindle. Book excerpt: The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A. The synthesis used a convergent approach involving five subunits, namely to prepare C3-C8 (195), C9-C19 (149), C20-C32 (131), C33-C41 (130) and C42-C46 (129). Assembly of two subunits, 130 and 131, employed Evans coupling protocol and provided 141 in excellent yield. The coupled product 141 was converted to aldehyde 215 in a six step sequence in which Julia-Kocienski olefination using a benzothiazole sulfone 129 was used to install the triene side chain. Allylsilylation of 149 with 195 afforded 202, which was linked by Wittig olefination with 215 to furnish 216. The C5-C9 trans-2,6-disubstituted tetrahydropyran ring was constructed from 216 in a three step sequence. Further transformations from 219 led to phorboxazole A (1) as an off-white solid.
Author : Kevin Patrick Minbiole
Publisher :
ISBN 13 :
Total Pages : 348 pages
Book Rating : 4.:/5 (244 download)
Download or read book Total Synthesis of Phorboxazole A written by Kevin Patrick Minbiole and published by . This book was released on 2001 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Regina M. Meis
Publisher :
ISBN 13 :
Total Pages : 90 pages
Book Rating : 4.:/5 (244 download)
Download or read book Synthetic Studies Towards One Gram of (+)-phorboxazole A and the Total Synthesis of 13-deoxy-14-o-alkenylphorboxazole written by Regina M. Meis and published by . This book was released on 2005 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Gordon W. Gribble
Publisher : Springer
ISBN 13 : 364231791X
Total Pages : 456 pages
Book Rating : 4.6/5 (423 download)
Download or read book Metalation of Azoles and Related Five-Membered Ring Heterocycles written by Gordon W. Gribble and published by Springer. This book was released on 2012-07-09 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: T. L.S. Kishbaugh: Metalation of Pyrrole.- K.-S. Yeung: Furans and Benzofurans.- P. E. Alford: Lithiation-Based and Magnesation-Based Strategies for the Functionalization of Imidazole: 2001–2010.- L. Fu: Metalation of Oxazoles and Benzoxazoles.- S. Roy • S. Roy • G. W. Gribble: Metalation of Pyrazoles and Indazoles.- J. C. Badenock: Metalation Reactions of Isoxazoles and Benzisoxazoles.- Y.-J. Wu: Thiazoles and Benzothiazoles.- C. F. Nutaitis: Isothiazoles and Benzisothiazoles.- E. R. Biehl: Recent Advances in the Synthesis of Thiophenes and Benzothiophenes.- J. M. Lopchuk: Mesoionics.- J. M. Lopchuk: Azoles with 3-4 Heteroatoms.
Author : Christopher Andrew Luckhurst
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (894 download)
Download or read book Studies Towards the Total Synthesis of the Phorboxazoles written by Christopher Andrew Luckhurst and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Todd Matthew Hansen
Publisher :
ISBN 13 :
Total Pages : 492 pages
Book Rating : 4.:/5 (319 download)
Download or read book I. Enhanced Synthesis and Diversification of the Phorboxazole Chemotype ; II. Synthetic Studies Towards the Marine Natural Product Isoobtusadiene written by Todd Matthew Hansen and published by . This book was released on 2002 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Nga M. Do
Publisher :
ISBN 13 :
Total Pages : 110 pages
Book Rating : 4.:/5 (45 download)
Download or read book Synthetic Studies Toward Phorboxazole written by Nga M. Do and published by . This book was released on 1998 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
