Total Synthesis Of Thielocin B1 As A Protein Protein Interaction Inhibitor Of Pac3 Homodimer

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Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer

Author : Kosuke Ohsawa
Publisher : Springer
ISBN 13 : 4431554475
Total Pages : 119 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer by : Kosuke Ohsawa

Download or read book Total Synthesis of Thielocin B1 as a Protein-Protein Interaction Inhibitor of PAC3 Homodimer written by Kosuke Ohsawa and published by Springer. This book was released on 2015-01-13 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on thielocin B1 (TB1), which was found to be an inhibitor of protein–protein interactions (PPIs) of proteasome assembling chaperone (PAC) 3 homodimer, and elucidates the mechanism by nuclear magnetic resonance (NMR) studies. Interfaces of PPIs recently have been expected to be novel therapeutic targets, while it is difficult to apply conventional methodology based on lock and key theory. The author achieved the first total synthesis of TB1 and its spin-labeled derivative to carry out NMR experiments because the supply of TB1 from natural sources was limited. Unique 2,2’,6,6’-tetrasubstituted diphenyl ether moiety of TB1 was synthesized from a depsidone skeleton by chemoselective reduction of lactone. In the process of elongating side wings, efficient formylation utilizing dichloromethyl methyl ether–silver trifluoromethanesulfonate was developed for the sterically hindered aromatic compound. NMR titration experiments and paramagnetic relaxation enhancement observation of PAC3 homodimer were performed with synthesized TB1 and its molecular probe, respectively. The results of the above NMR studies and additional in silico docking studies suggested that TB1 promotes the dissociation to monomeric PAC3 after interaction with PAC3 homodimer. The rare mechanism shown in this book indicates a potential novel drug target in the interfaces of PPIs with no cavity or groove.

Designer Biopolymers

Author : Ayae Sugawara-Narutaki
Publisher : MDPI
ISBN 13 : 3039363700
Total Pages : 182 pages
Book Rating : 4.0/5 (393 download)

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Book Synopsis Designer Biopolymers by : Ayae Sugawara-Narutaki

Download or read book Designer Biopolymers written by Ayae Sugawara-Narutaki and published by MDPI. This book was released on 2020-12-14 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nature has evolved sequence-controlled polymers, such as DNA and proteins, over its long history. The recent progress of synthetic chemistry, DNA recombinant technology, and computational science, as well as the elucidation of molecular mechanisms in biological processes, drive us to design ingenious polymers that are inspired by naturally occurring polymers, but surpass them in specialized functions. The term “designer biopolymers” refers to polymers which consist of biological building units, such as nucleotides, amino acids, and monosaccharides, in a sequence-controlled manner. This book particularly focuses on the self-assembling aspect of designer biopolymers. Self-assembly is one common feature in biopolymers that is used to realize their dynamic biological activities and is strictly controlled by the sequence of biopolymers. In a broad sense, the self-assembly of biopolymers includes a double-helix formation of DNA, protein folding, and higher-order protein assembly (e.g., viral capsids). Designer biopolymers are now going beyond what nature evolved: researchers have generated DNA origami, protein cages, peptide nanofibers, and gels. This book illustrates the latest interdisciplinary work on self-assembling designer biopolymers. As shown by this book, the self-assembly of biopolymers has a great impact on a variety of research fields, including molecular biology, neurodegenerative diseases, drug delivery, gene therapy, regenerative medicine, and biomineralization. Designer biopolymers will help researchers to better understand biological processes, as well as to create innovative molecular systems. We believe that this book will provide readers with new ideas for their molecular design strategies for frontier research.

Protective Groups in Organic Synthesis

Author : Theodora W. Greene
Publisher :
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Protective Groups in Organic Synthesis by : Theodora W. Greene

Download or read book Protective Groups in Organic Synthesis written by Theodora W. Greene and published by . This book was released on 1981-05-14 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides comprehensive information on the most useful protective groups for the hydroxyl, amino, carboxyl, carbonyl, and sulfhydryl groups. Discusses the chemistry of the classes of protective groups, as well as that of the individual protective groups within the class using structures, equations and references. Reactivity Charts for each class of protective group serve as an aid in their appropriate choice and provide estimates of their relative reactivities toward 108 prototype reagents.

Name Reactions

Author : Jie Jack Li
Publisher : Springer Science & Business Media
ISBN 13 : 3540300317
Total Pages : 670 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Name Reactions by : Jie Jack Li

Download or read book Name Reactions written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2007-02-16 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book differs from others on name reactions in organic chemistry by focusing on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. This book contains major improvements over the previous edition and the subject index is significantly expanded.

Atlas of Soil Ascomycetes

Author : J. Guarro
Publisher :
ISBN 13 : 9789070351885
Total Pages : 486 pages
Book Rating : 4.3/5 (518 download)

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Book Synopsis Atlas of Soil Ascomycetes by : J. Guarro

Download or read book Atlas of Soil Ascomycetes written by J. Guarro and published by . This book was released on 2012 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This compendium includes almost all presently known species of ascomycetes that have been reported in soil and which sporulate in culture. They constitute a very broad spectrum of genera belonging to very diverse orders, but mainly to the Onygenales, Sordariales, Eurotiales, Thelebolales, Pezizales, Melanosporales, Pleosporales, Xylariales, Coniochaetales and Microascales. The goal of this book is to provide sufficient data for users to recognise and identify these species. It includes the description of 146 genera and 698 species. For each genus a dichotomous key to facilitate species identification is provided and for each genus and species the salient morphological features are described. These descriptions are accompanied by line drawings illustrating the most representative structures. Light micrographs, supplemented by scanning electron micrographs and Nomarski interference contrast micrographs of most of the species treated in the book are also included. In addition, numerous species not found in soil but related to those included in this book are referenced or described. This book will be of value not only to soil microbiologists and plant pathologists concerned with the soilborne fungi and diseases, but also to anyone interested in identifying fungi in general, because many of the genera included here are not confined to soil. Since most of the fungi of biotechnological or clinical interest (dermatophytes, dimorphic fungi and opportunists) are soil-borne ascomycetes, the content of this book is of interest for a wide range of scientists."--pub. desc.

Name Reactions

Author : Jie Jack Li
Publisher : Springer Science & Business Media
ISBN 13 : 3662048353
Total Pages : 435 pages
Book Rating : 4.6/5 (62 download)

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Book Synopsis Name Reactions by : Jie Jack Li

Download or read book Name Reactions written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book differs from others on name reactions in organic chemistry by focusing on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. This book contains major improvements over the previous edition and the subject index is significantly expanded.

Challenges in Synthetic Organic Chemistry

Author : Teruaki Mukaiyama
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 248 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Challenges in Synthetic Organic Chemistry by : Teruaki Mukaiyama

Download or read book Challenges in Synthetic Organic Chemistry written by Teruaki Mukaiyama and published by Oxford University Press, USA. This book was released on 1994 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the life's work of Professor Teruaki Mukaiyama, one of Japan's most important and respected synthetic organic chemists. It includes information on his early research into a wide range of reactions, including dehydration reactions, the use of organosulfur compounds, and oxidation-reduction condensations in peptide and nucleotide synthesis reagents, as well as an account of Mukaiyama's important work on the applications of titanium compounds in organic synthesis. Three final chapters review Mukaiyama's work in synthetic control, stereoselective synthesis of carbohydrates, the stereoselective aldol, and Michael reactions. This unique book makes accessible much research that has only been available in Japanese, and provides a rare account of the contributions of one of the world's leading chemists.

Bacterial Chromatin

Author : Remus T. Dame
Publisher : Springer Nature
ISBN 13 : 1071639307
Total Pages : 654 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Bacterial Chromatin by : Remus T. Dame

Download or read book Bacterial Chromatin written by Remus T. Dame and published by Springer Nature. This book was released on with total page 654 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Pharmacology Made Incredibly Easy!

Author : Lippincott Williams & Wilkins
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496350472
Total Pages : 1190 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Pharmacology Made Incredibly Easy! by : Lippincott Williams & Wilkins

Download or read book Pharmacology Made Incredibly Easy! written by Lippincott Williams & Wilkins and published by Lippincott Williams & Wilkins. This book was released on 2016-06-07 with total page 1190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Get all the basics on drug therapies—and administer drugs confidently and accurately—with the newly updated Pharmacology Made Incredibly Easy, 4th Edition. Written in the enjoyable, award-winning Incredibly Easy style, this easy-to-follow, fully illustrated guide offers step-by-step direction on the medication process, from assessing patient needs, to planning care, to implementation and positive outcomes. Strengthen your understanding of your class materials, get ready for the NCLEX® or certification exam, and administer drug therapies—safely and effectively! Build a strong platform of pharmacology knowledge and skills with. . . NEW and updated content on the newest approved medications and dosages and NEW tables listing: NEW vaccines and treatment for biological weapons exposure NEW treatment and antidotes for chemical weapons exposure NEW herbal drugs content NEW icons and images that clarify content Revised and updated content on the concepts of pharmacokinetics, pharmacodynamics, and pharmacotherapeutics Pharmacology basics – How drugs are derived, developed, classified, and administered; classes of drugs by body system; their uses and mechanisms “Nurse Joy” and “Nurse Jake” illustrated characters offering tips and insights throughout Quick-scan format with concise, bulleted content Hundreds of illustrations and diagrams explaining key concepts and providing clear direction on administering drugs; drug distribution, absorption, and metabolism; potential drug interactions; adverse reactions; how different classes of drugs work in different body systems Special chapter features: Just the facts – A quick summary of chapter content Advice from the experts – Experienced practitioners’ insights Prototype pro – Actions, indications, and nursing considerations for common prototype drugs Nursing process – Patient assessment, diagnosis, outcome goals, implementation, and evaluation for each type and class of drug Pharm function – Illustrating how drugs act in the body; recognizing and treating adverse reactions Before you give that drug – Warnings to consider before you administer a drug Education edge – Information to share with your patient Quick quiz – End-of-chapter questions with answers/explanations, to help you remember the essentials End-of-book multiple-choice Q&A; Quick Guides to Medication Safety, Ophthalmic and Dermatologic Drugs, and Abbreviations to Avoid; Glossary of essential pharmacology terms.

Pharmacology

Author : Joanne I. Moore
Publisher : Springer Science & Business Media
ISBN 13 : 1468402803
Total Pages : 255 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Pharmacology by : Joanne I. Moore

Download or read book Pharmacology written by Joanne I. Moore and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than ten years ago, the faculty members of the Department of Pharmacology at the University of Oklahoma College of Medicine developed a review book of medical pharmacology in response to requests from our second year medical students who were preparing to sit for the Part I examination of the National Board of Medical Examiners. The students expressed a need for an organized approach to cope with the volume of basic science curricular material presented during the first two years. Therefore, our review book was not designed to provide a comprehensive text on pharmacology, but rather to provide the students with a significant core of information, as a refresher, after they had successfully completed a basic course in pharmacology. This book represents a major revision of our review of medical pharmacology. The book has been reorganized, updated and expanded to provide current information on major new drugs and information on older drug groups that typically are covered on licensure examinations. The book also has been expanded to include a large number of new questions for self-examination. The faculty have endeavored to retain a reasonably concise, relevant and readable review book that will provide the students with a thorough review of pharmacology. Students are advised to refer to comprehensive textbooks, as needed, to fill in any gaps in their knowledge which may be disclosed by the self-examinations.

Nursing2022 Drug Handbook

Author : Lippincott Williams & Wilkins
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1975160150
Total Pages : 2933 pages
Book Rating : 4.9/5 (751 download)

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Book Synopsis Nursing2022 Drug Handbook by : Lippincott Williams & Wilkins

Download or read book Nursing2022 Drug Handbook written by Lippincott Williams & Wilkins and published by Lippincott Williams & Wilkins. This book was released on 2021-03-04 with total page 2933 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE #1 Drug Guide for nurses & other clinicians...always dependable, always up to date! Look for these outstanding features: Completely updated nursing-focused drug monographs featuring 3,500 generic, brand-name, and combination drugs in an easy A-to-Z format NEW 32 brand-new FDA-approved drugs in this edition, including the COVID-19 drug remdesivir—tabbed and conveniently grouped in a handy “NEW DRUGS” section for easy retrieval NEW Thousands of clinical updates—new dosages and indications, Black Box warnings, genetic-related information, adverse reactions, nursing considerations, clinical alerts, and patient teaching information Special focus on U.S. and Canadian drug safety issues and concerns Photoguide insert with images of 439 commonly prescribed tablets and capsules

Dosage Calculations Made Incredibly Easy!

Author : Springhouse
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9781582551340
Total Pages : 322 pages
Book Rating : 4.5/5 (513 download)

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Book Synopsis Dosage Calculations Made Incredibly Easy! by : Springhouse

Download or read book Dosage Calculations Made Incredibly Easy! written by Springhouse and published by Lippincott Williams & Wilkins. This book was released on 2002 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This entertaining guide is now more fun, more up-to-date, and even easier to use -- an indispensable resource for nurses who want to take the stress out of dosage calculations. New to this edition are a chapter on dimensional analysis; numerous lighthearted learning aids called "Cheat Sheets"; and "Practice Makes Perfect" -- case study questions and answers that let nurses assess their progress. Contents include math basics; measurement systems; drug orders and administration records; calculating oral, topical, and rectal drug dosages; calculating parenteral injections and I.V. infusions; and calculating pediatric, obstetric, and critical care dosages.

Medical Dosage Calculations For Dummies

Author : Richard Snyder
Publisher : John Wiley & Sons
ISBN 13 : 0470930640
Total Pages : 396 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Medical Dosage Calculations For Dummies by : Richard Snyder

Download or read book Medical Dosage Calculations For Dummies written by Richard Snyder and published by John Wiley & Sons. This book was released on 2011-05-03 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: Score your highest in a medical dosage calculations course A recent shortage of nurses in a society with an aging population has triggered the demand for students to enter the field of medical study. A dosage calculations course is required for most students earning an applied science degree in nursing, pharmacology, or paramedic programs. Medical Dosage Calculations For Dummies tracks a typical dosage calculations course and provides helpful content in an approachable and easy-to-understand format. Plus, you'll get examples of the various calculations made to determine the appropriate quantity of drug or solution that should be administered to patients. Calculating drug dosages utilizing ratio-proportion, formula, and dimensional analysis Systems of measurement, including metric and apothecary and other conversion equivalents for a global audience The ins and outs of the charting systems for MAR (Medicine Administration Records) If you're one of the hundreds of thousands of students aspiring to enter the medical field, Medical Dosage Calculations For Dummies is your ticket for scoring your highest on exams.

Pharmacy Calculation Workbook: 250 Questions to Prepare for the NAPLEX and PTCB Exam

Author : Coventry House Publishing
Publisher : Coventry House Publishing
ISBN 13 :
Total Pages : 146 pages
Book Rating : 4./5 ( download)

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Book Synopsis Pharmacy Calculation Workbook: 250 Questions to Prepare for the NAPLEX and PTCB Exam by : Coventry House Publishing

Download or read book Pharmacy Calculation Workbook: 250 Questions to Prepare for the NAPLEX and PTCB Exam written by Coventry House Publishing and published by Coventry House Publishing. This book was released on 2019-06-11 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pharmacy Calculation Workbook provides 250 calculation questions to prepare for the demanding NAPLEX and PTCB Exam. Master exam topics with intensive practice in the areas you'll find on the test. All questions are test-level difficulty and focused solely on helping you pass. Whether you’re challenging the exam for the first time or trying again after an unsuccessful attempt, you will learn the critical skills needed to master the exam. Included are practice questions for the following topics: • Calculation Fundamentals • Dilutions and Concentrations • Density and Specific Gravity • Patient Specific Dosing • Intravenous Infusions and Flow Rates • Compounding • Reducing and Enlarging Formulas • Expressions of Concentration • Electrolyte Solutions • Nutrition Support • Isotonic and Buffer Solutions • Pharmaceutical Conversions

Pharmacology Success

Author : Kathryn Cadenhead Colgrove
Publisher : F.A. Davis
ISBN 13 : 0803694210
Total Pages : 513 pages
Book Rating : 4.8/5 (36 download)

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Book Synopsis Pharmacology Success by : Kathryn Cadenhead Colgrove

Download or read book Pharmacology Success written by Kathryn Cadenhead Colgrove and published by F.A. Davis. This book was released on 2018-09-18 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology made manageable. Assure your mastery of pharmacology nursing knowledge while improving your critical-thinking and test-taking skills. Over 1,200 NCLEX®-style questions on medication administration provide the practice you need to build your confidence. Rationales for both correct and incorrect answers as well as Medication Memory Joggers for select questions.

Davis's Drug Guide for Nurses

Author : Judith Hopfer Deglin
Publisher : F. A. Davis Company
ISBN 13 : 9780803611528
Total Pages : 1416 pages
Book Rating : 4.6/5 (115 download)

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Book Synopsis Davis's Drug Guide for Nurses by : Judith Hopfer Deglin

Download or read book Davis's Drug Guide for Nurses written by Judith Hopfer Deglin and published by F. A. Davis Company. This book was released on 2005 with total page 1416 pages. Available in PDF, EPUB and Kindle. Book excerpt: New edition of the number one nursing drug guide in the educational market.

Protein-Protein Interactions

Author : Michael D. Wendt
Publisher : Springer
ISBN 13 : 9783642289644
Total Pages : 0 pages
Book Rating : 4.2/5 (896 download)

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Book Synopsis Protein-Protein Interactions by : Michael D. Wendt

Download or read book Protein-Protein Interactions written by Michael D. Wendt and published by Springer. This book was released on 2012-06-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Michael D. Wendt Protein-Protein Interactions as Drug Targets Shaomeng Wang , Yujun Zhao , Denzil Bernard , Angelo Aguilar , Sanjeev Kumar Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics Kurt Deshayes , Jeremy Murray , Domagoj Vucic The Development of Small-Molecule IAP Antagonists for the Treatment of Cancer John F. Kadow , David R. Langley , Nicholas A. Meanwell , Michael A. Walker , Kap-Sun Yeung , Richard Pracitto Protein-Protein Interaction Targets to Inhibit HIV-1 Infection Nicholas A. Meanwell , David R. Langley Inhibitors of Protein-Protein Interactions in Paramyxovirus Fusion – a Focus on Respiratory Syncytial Virus Andrew B. Mahon , Stephen E. Miller , Stephen T. Joy , Paramjit S. Arora Rational Design Strategies for Developing Synthetic Inhibitors of Helical Protein Interfaces Michael D. Wendt The Discovery of Navitoclax, a Bcl-2 Family Inhibitor