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Total Synthesis Of Amphidinolide W And Efforts Toward Total Synthesis Of Lasonolide A
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Book Synopsis Total Synthesis of (+)-amphidinolide W and Efforts Toward Total Synthesis of ( - )-lasonolide A by : Gangli Gong
Download or read book Total Synthesis of (+)-amphidinolide W and Efforts Toward Total Synthesis of ( - )-lasonolide A written by Gangli Gong and published by . This book was released on 2005 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward Synthesis of Lasonolide A, Total Synthesis and Structural Determination of Dispongin A and B by : Kailas Bhalchandra Sawant
Download or read book Studies Toward Synthesis of Lasonolide A, Total Synthesis and Structural Determination of Dispongin A and B written by Kailas Bhalchandra Sawant and published by . This book was released on 2007 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress Towards the Total Synthesis of Amphidinolide E by : Andrew Frederick Nolting
Download or read book Progress Towards the Total Synthesis of Amphidinolide E written by Andrew Frederick Nolting and published by . This book was released on 2006 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward the Synthesis of the Amphidinolides by : Brian J. Myers
Download or read book Studies Toward the Synthesis of the Amphidinolides written by Brian J. Myers and published by . This book was released on 2000 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Total Synthesis of the Assigned Structure of Amphidinolide A by : Lamont R. Terrell
Download or read book The Total Synthesis of the Assigned Structure of Amphidinolide A written by Lamont R. Terrell and published by . This book was released on 2002 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of Amphidinolides O and P by : Matthew A. Foster
Download or read book Studies Towards the Total Synthesis of Amphidinolides O and P written by Matthew A. Foster and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress Towards the Total Synthesis of the Potent Antitumor Antibiotic Amphidinolide C by : Jesse D. Carrick
Download or read book Progress Towards the Total Synthesis of the Potent Antitumor Antibiotic Amphidinolide C written by Jesse D. Carrick and published by . This book was released on 2004 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Progress Towards the Total Synthesis and Structural Assignment of Amphidinolide N and Caribenolide I by : William E. Brenzovich (Jr.)
Download or read book Progress Towards the Total Synthesis and Structural Assignment of Amphidinolide N and Caribenolide I written by William E. Brenzovich (Jr.) and published by . This book was released on 2008 with total page 916 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward the Total Synthesis of Amphidinolide B1 by : Wei Zhang
Download or read book Synthetic Studies Toward the Total Synthesis of Amphidinolide B1 written by Wei Zhang and published by . This book was released on 2006 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward the Total Synthesis of Amphidinolide C by : Robert H. Bates
Download or read book Studies Toward the Total Synthesis of Amphidinolide C written by Robert H. Bates and published by . This book was released on 2009 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: Amphidinolide C is one of the most biologically potent members of the amphidinolide family of natural products. Detailed in this thesis are studies toward the total synthesis of this complex macrolide. Three distinct syntheses of the C(1)-C(9) fragment are described. The first generation synthesis involves a diastereoselective chelate-controlled [3+2]-annulation reaction to form the C(3)-C(6) trans tetrahydrofuran. The second generation approach takes advantage of the C(4) methyl substituent to induce diastereoselectivity in an intramolecular hetero-Michael cyclization to form the same tetrahydrofuran. The third generation incorporates a non-chelate-controlled [3+2]-annulation reaction to afford the cis tetrahydrofuran product, followed by a base-promoted epimerization to the desired trans tetrahydrofuran. This route was accomplished in fewer steps than the first generation synthesis. Also described are stereoselective syntheses of the C(18)-C(34) C(10)-C(26) fragments of amphidinolide C, and the C(10)-C(29) fragment of amphidinolide F, a closely related natural product. Finally, a clear plan for the completion of the total synthesis of amphidinolide C is presented.
Book Synopsis Towards the Total Synthesis of Amphidinolide F. by : Daniel A. Mills
Download or read book Towards the Total Synthesis of Amphidinolide F. written by Daniel A. Mills and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Toward a Total Synthesis of (+)-amphidinolide P and Related Studies by : Jens-Martin Herold
Download or read book Toward a Total Synthesis of (+)-amphidinolide P and Related Studies written by Jens-Martin Herold and published by . This book was released on 2008 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Finally, novel palladium-catalyzed conjugate additions of organozinc reagents to alpha,beta-unsaturated aldehydes are discussed. This methodology can be diastereoselective and can be used for the selective preparation of (E)-silyl enol ethers. The palladium-catalyzed reaction is also compared to its copper-catalyzed counterpart.
Book Synopsis Towards the Total Synthesis of Amphidinolide C by : Guang Yang
Download or read book Towards the Total Synthesis of Amphidinolide C written by Guang Yang and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Part I written by Liang Lu and published by . This book was released on 2010 with total page 786 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structural architecture present in marine toxin azaspiracid - 20 stereocenters, 9 rings, 3 separated spirocenters - has attracted considerable synthetic attention. Our efforts toward the synthesis of azaspiracid have led to the completion of both C1-C26 northern and C27-C40 southern halves. Herein, the synthesis of southern FGHI ring system is described. The key steps included an Andrus anti-aldol coupling to furnish the C32, C33 stereocenters, an acid-catalyzed ketalization to furnish FG rings, and a Yb(OTf)3-mediated spiroaminal formation to generate I ring. The first total synthesis of cytotoxic macrolides amphidinolide B1 and the proposed structure of amphidinolide B2 have been accomplished. The key developed protocols include a metal catalyst-free sequence for the synthesis of the diene subunit, a non-chelation-controlled aldol coupling to install the C18 stereocenter, an efficient macrocyclization of the 26-membered lactone ring, and the incorporation of the labile allylic epoxide moiety. The unique structure of the highly substituted diene functionality represents significant synthetic challenges. A Wittig / HWE reaction sequence yielded the C13-C15 diene moiety in good yield in excellent diastereoselectivity. Subsequent Sharpless epoxidation and Red-Al-mediated regionselective epoxide opening gave the C16 tertiary alcohol. The protecting groups on C21 were discovered to have significant effects on the aldol reaction between C9-C18 aldehyde and C19-C25 methyl ketone. Although chelating groups such as PMB, Bn afforded 18S isomer as a single diastereomer, the removal of these groups has proven problematic. Non-chelating silyl group generated 18R isomer in 8:1 dr at -100°C, while the 18S stereomer was obtained at -40°C in 1.2:1 dr. A spontaneous intramolecular Wadsworth-Emmons olefination established the 26-membered macrocycle. The oxidation and in situ elimination of a selenide moiety proceeded smoothly in the presence of free alcohols using TMSOOTMS. The first total synthesis of amphidinolide B1 and the proposed structure of amphidinolide B2 were accomplished in 29 linear steps. Additionally, We discovered that the initially proposed structure of amphidinolide B2 was incorrect.
Book Synopsis The Total Synthesis of the Proposed Structure of Amphidinolide A by : Joseph Samuel Ward
Download or read book The Total Synthesis of the Proposed Structure of Amphidinolide A written by Joseph Samuel Ward and published by . This book was released on 2002 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Towards the Total Synthesis of Amphidinolides C and F. by : Ludovic Decultot
Download or read book Towards the Total Synthesis of Amphidinolides C and F. written by Ludovic Decultot and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of the Amphidinolide C Family of Natural Products by : Andrew P. Osnowski
Download or read book Studies Towards the Total Synthesis of the Amphidinolide C Family of Natural Products written by Andrew P. Osnowski and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
