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Tight Junctions In Cancer Metastasis
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Book Synopsis Tight Junctions in Cancer Metastasis by : Tracey A. Martin
Download or read book Tight Junctions in Cancer Metastasis written by Tracey A. Martin and published by Springer Science & Business Media. This book was released on 2013-02-26 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.
Book Synopsis Tight Junctions by : Lorenza González-Mariscal
Download or read book Tight Junctions written by Lorenza González-Mariscal and published by Springer Nature. This book was released on 2022-05-31 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume explores the dynamic topic of tight junctions. The book focuses on tight junctions' role in sealing adjacent epithelial cells in a narrow band just beneath their apical surface. The book explains how tight junctions consist of a network of claudins and other proteins, and delves into how they hold cells together and form functional and protective barriers, regulating the passage of molecules and ions through the space between cells. The book opens with a discussion of the evolution of research on tight junctions, discussing a range of primary areas of growth, including the current knowledge on the particular physiological function of different claudins due to the development of an array of knock out mice. The chapters also explore in-depth studies of tight junctions in specific tissues (gut, lung and endothelia). This book offers a comprehensive understanding on post-translational modifications of occludin and its impact on tight junction function, as well as the molecular composition and function of tricellular tight junctions. This volume is particularly relevant to students and scientists in neuroscience, cell biology, physiology, cell differentiation, and cancer research.
Book Synopsis Tight Junctions in Inflammation and Cancer by : Ajaz A. Bhat
Download or read book Tight Junctions in Inflammation and Cancer written by Ajaz A. Bhat and published by Springer Nature. This book was released on 2023-10-12 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an updated account of tight junctions of different epithelia and endothelia and addresses their anatomy, biochemistry, physiology, synthesis, assembly, and modulation. It also discusses the relationship between molecular structure, function, regulation, posttranslational modifications of tight junction proteins and their role in gut microbiota maintenance, epithelial-mesenchymal transition, and intestinal barrier dysfunction-associated disorders important for the progression of human cancers. This book presents the pathological alterations of tight junctions at the blood-brain barrier that intensify or even initiate neurological dysfunction. Further, it reviews the significance of tight junctions and tight junction proteins in cancer development, infectious diseases, allergic reactions, and autoimmune disorders. Lastly, it highlights strategies for modulating tight junctions to enhance drug availability and organ deposition. This book is immensely useful for basic, translational, clinical, and interdisciplinary cancer researchers, practicing oncologists, and immunologists.
Book Synopsis Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention by : Wen G. Jiang
Download or read book Cancer Metastasis, Molecular and Cellular Mechanisms and Clinical Intervention written by Wen G. Jiang and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the molecular and cellular aspects of cancer metastasis, and discusses the clinical aspect of micro- and macro-metastases, which result in the death of the majority of patients with cancer. The current edition attempts to examine the current status of the basic scientific and clinical research in the area, and is a very useful reference for clinicians, oncologists, and biologists. It is intended for undergraduates as well as postgraduates in the area of medicine, oncology, and cancer biology.
Book Synopsis Metastasis of Breast Cancer by : R.E. Mansel
Download or read book Metastasis of Breast Cancer written by R.E. Mansel and published by Springer Science & Business Media. This book was released on 2007-06-14 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by experts in the subject area, the book covers a broad range of topics in the metastasis of breast cancer, from genetics, biology to clinical management. Main topics include genetic control, biology, growth factors, cell adhesion, cell motility and invasion, natures of bone metastasis, sentinel node therapies, hormonal links, new biomarkers and detection of micrometastasis and diagnosis. This timely book also covers the current treatment options.
Book Synopsis Tight Junction Protein Signaling and Cancer Biology by : Zeina Nehme
Download or read book Tight Junction Protein Signaling and Cancer Biology written by Zeina Nehme and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Tight junctions (TJs) are intercellular protein complexes that preserve tissue homeostasis and integrity through the control of paracellular permeability and cell polarity. Recent findings have revealed the functional role of TJ proteins outside TJs and beyond their classical cellular functions as selective gatekeepers. This is illustrated by the dysregulation in TJ protein expression levels in response to external and intracellular stimuli, notably during tumorigenesis. A large body of knowledge has uncovered the well-established functional role of TJ proteins in cancer pathogenesis. Mechanistically, TJ proteins act as bidirectional signaling hubs that connect the extracellular compartment to the intracellular compartment. By modulating key signaling pathways, TJ proteins are crucial players in the regulation of cell proliferation, migration, and differentiation, all of which being essential cancer hallmarks crucial for tumor growth and metastasis. TJ proteins also promote the acquisition of stem cell phenotypes in cancer cells. These findings highlight their contribution to carcinogenesis and therapeutic resistance. Moreover, recent preclinical and clinical studies have used TJ proteins as therapeutic targets or prognostic markers. This review summarizes the functional role of TJ proteins in cancer biology and their impact for novel strategies to prevent and treat cancer
Author :Itzhak D. Goldberg Publisher :Springer Science & Business Media ISBN 13 :9783764351175 Total Pages :320 pages Book Rating :4.3/5 (511 download)
Book Synopsis Epithelial-Mesenchymal Interactions in Cancer by : Itzhak D. Goldberg
Download or read book Epithelial-Mesenchymal Interactions in Cancer written by Itzhak D. Goldberg and published by Springer Science & Business Media. This book was released on 1995-11-29 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: gar discusses recent studies of the SF gene promoter that may be relevant to understanding the detailed molecular mechanism(s) by which soluble factors regulate SF production. Polverini and Nickoloff discuss another mechanism by which SF may enhance tumor growth, ie., stimulation of angiogenesis, the formation of new blood vessels from pre-existing microvessels. Angiogenesis is required for continued growth of most solid tumors, and provides a mechanism by which the stroma may continue to grow along with the tumor cells. Although endothelial cells are stromal cells, they express a number of epithelial characteristics including (i) epithelial-like tight junctions and junctional proteins; (ii) the ability to organize into flat tened tubular structures; (iii) the c-met receptor protein; and (iv) biologic responsiveness to SF. It is, perhaps, not surprising that vascular endothe lial cells may both produce and respond to SF in different situations. 'Epithelialness' may be defined in two ways: (i) expression of generic epithelial structures and proteins (eg., specialized junctions, junctional proteins [eg., cadherins, ZOl], cytokeratins); and (ii) production of specific differentiated products (eg., milk proteins by mammary epithelia, renin by renal tubular epithelia of the juxtaglomerular apparatus). Recent studies suggest that SF Ic-met signalling may mediate epithelia mesenchyme interconversion, in part by modifying some of the generic epithelial characteristics. Nusrat discusses the effects of SF on the epithelial junctional apparatus. Relatively little is known about whether and how SF regulates cell-specific differentiation.
Book Synopsis Cancer Metastasis by : Volker Schirrmacher
Download or read book Cancer Metastasis written by Volker Schirrmacher and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: These are the Proceedings of the 2nd International Metastasis Congress of the Metastasis Research Society which took place in the town hall (Stadthalle) of Heidelberg, FRG, in September, 1988. This first Metastasis Congress in the FRG was organized in conjunction with the German Association of Cancer Research (SEK) of the German Cancer Society. The congress topic generated tremendous interest and attracted about 400 scientists from 22 countries. Most participants came from Europe, Israel, and the United States. Why did we organize the Metastasis Congress? Only about 50% of all people who develop some form of cancer are curable. Despite improved patient care and increasingly innovative and effective techniques for diagnosing and treating primary cancers, the development of secondary cancer colonies, i. e. , metastasis, can not be prevented and is the major cause of death. In the Federal Republic of Germany there are still as many as 160 000 cancer patients per year who succumb to their disease, often after periods of terrible suffering, and this overall figure is not improving. Partly because of the complexity of the process, basic research on metastasis has lagged behind other disciplines such as carcino genesis and cancer genetics. Metastasis formation involves the ability of malig nant cells to invade adjacent tissue and to penetrate into lymphatic or blood circulatory systems, or both, and to spread to near or distant sites to form new tumor colonies. Meanwhile, research on metastasis is receiving much attention.
Book Synopsis Mechanisms of Cancer Metastasis by : Kenneth V. Honn
Download or read book Mechanisms of Cancer Metastasis written by Kenneth V. Honn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past twenty years have witnessed significant advances in the treatment of cancer by surgery and radiation therapy. Gains with cytotoxic chemotherapy have been much more modest. Of the approximately 900,000 newly diagnosed cases of cancer each year, 50010 result in death of the patient. The primary cause of these deaths is metastasis. Although the term metastasis was first coined by Recamier in 1829, only in the past ten years have there been intensive scientific investigations into the mechanisms by which tumor cells metastasize. What has emerged is a complex process of host-tumor cell interactions which has been termed the metastatic cascade. Due to the complexity of the metastatic process, the study of metastasis is multifaceted and involves elements of such areas as differentiation, en zymology, genetics, hematology, immunology, membrane biochemistry and molecular biology. The major objectives of this book were to present the most recent advances in our understanding of how tumor cells metastasize to secondary sites by the leading experts in the biology of tumor invasion and metastasis. We hope that this book will lead to new concepts for the treatment of subclinical metastatic cancer. The chapters in this book address both the basic science of metastasis and potential clinical therapies directed toward interruption of the metastatic cascade or toward eradication of subclinical metastases. Many relevant topics have been omitted due to space considerations and thus the topics included reflect the prej udices of the editors.
Book Synopsis Microcirculation in Cancer Metastasis by : F. William Orr
Download or read book Microcirculation in Cancer Metastasis written by F. William Orr and published by CRC Press. This book was released on 1991-07-25 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although mechanisms involved in the spread of cancer have been the subject of a major research endeavor over the past decade, metastatic tumors still account for significant clinical morbidity and the failure of cancer treatment. Not only are the vascular pathways the most common route for the dissemination of cancer cells, but interactions between the cells and the circulation act as important rate-regulators for the metastatic process. This authoritative, multi-authored volume addresses the importance of microcirculation in cancer metastasis. The book begins with up-to-date reviews on the biology of endothelial cells and the structure and physiology of the normal and tumor microcirculations, and then emphasizes interactions between components of the microcirculation and cancer cells. Metastasis is discussed through chapters exploring the entry of cancer cells into the circulation, the biophysics and morphology of cancer cell traffic and arrest, interactions with host cells and the basement membranes, and angiogenesis. This fascinating book will interest oncologists, pathologists, and students of metastasis or the microcirculation.
Book Synopsis Cancer Metastasis and Cancer Stem Cell/Niche by : Takanori Kawaguchi
Download or read book Cancer Metastasis and Cancer Stem Cell/Niche written by Takanori Kawaguchi and published by Bentham Science Publishers. This book was released on 2016-11-04 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt: A malignant tumor is an actively growing tissue, composed of cells derived from a single cell line that has undergone irreversible differentiation. These cells are invasive and also metastasize in the body, resulting in malignant cancer. Recent research suggests that a malignant tumor originates from cancer stem cells (CSC) accompanied with physiological niches. Cancer Metastasis and Stem Cell/Niche explains the invasiveness and metastasis of cancer cells I the light of information gained from the CSC / niche theory. Five chapters present a review on the fundamental relationships between CSCs, their niche and metastasis, the regulation of cell surface glycan expression in CSCs, tumor endothelial cells and metastasis, toll-like receptor 4 (TLR4)-mediated premetastatic microenvironment, and in surgical cancer metastasis. This monograph is intended as a primary reference on CSC research for physiologists, clinical oncologists, stem cell researchers and molecular biologists.
Book Synopsis Signal Transduction in Cancer Metastasis by : Wen-Sheng Wu
Download or read book Signal Transduction in Cancer Metastasis written by Wen-Sheng Wu and published by Springer Science & Business Media. This book was released on 2010-10-04 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. It highlights the initial stage of tumor metastasis.
Book Synopsis The Cadherin Interaction as a Rate Limiting Step in Breast Cancer Metastasis to the Liver by :
Download or read book The Cadherin Interaction as a Rate Limiting Step in Breast Cancer Metastasis to the Liver written by and published by . This book was released on 2008 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our overall objective is to identify molecular elements that enable breast cancer cells to establish metastatic growths. Finding rationale approaches to inhibit rate-limiting events of the metastatic growth is preferable to using systemic therapeutics that are cytotoxic on a systemic level. Cadherins make up a family of adhesion molecules that mediate Ca2+-dependent cell-cell adhesion at points of cell-cell adhesion. Epithelial-cadherin (E-cadherin), the prototype classical cadherin present on the surface of most epithelial cells, has a cytoplasmic domain that anchors the cell adhesion molecule to the actin cytoskeleton via catenin-based complexes. It is generally considered that E-cadherin directs homotypic binding, organizing cells of the same lineage into a functional tissue during morphogenesis. Thus, E-cadherin is central to epithelial cell differentiation and suppress ion of proliferation and migration. Finding E-cadherin downregulated or even lost in invasive and metastatic carcinomas buttressed this role of E-cadherin in modulating the epithelial phenotype [3]. It has been hypothesized that loss of E-cadherin allows individual tumor cells to break from the primary tumor mass at the same time as enabling autocrine pro-proliferative and migratory signaling to ensue from receptors and ligands physiologically separated by cell polarity and the E-cadherin-based tight junctions. This was supported experimentally when poorly differentiated and invasive carcinoma cells could be made less so by transfection with E-cadherin cDNA, with well-differentiated carcinomas becoming more aggressive when antibodies blocked. This supported a designation as a tumor suppressor, even placing E-cadherin at the apex of a tumor suppressor system. More recent reports of E-cadherin being expressed at the site of metastatic foci in the liver, lung and lymph nodes have caused reconsideration of E-cadherin downregulation as required for tumor dissemination.
Book Synopsis Cancer Metastasis by : Yasemin Basbinar
Download or read book Cancer Metastasis written by Yasemin Basbinar and published by BoD – Books on Demand. This book was released on 2018-12-05 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastasis of cancer cells from primary tumor site to secondary locations is considered a late event in multistep tumorigenesis, and causes most cancer-related mortality. The process from the spreading of cancer cells to the seeding of newly formed tumor colonizations is governed by sequential events, including local invasion, intravasation into stroma and blood vessels, survival in circulation, extravasation, and colonization at secondary tumor sites. Cancer research provides information on the fate of metastatic cancer cells in each sequential movement or heterogeneous tumor microenvironment. However, the complexity of this mechanism remains the most stringent concept of cancer management. This book provides information for cancer researchers on metastatic phenotypes of cancer cells, and diverse promoting factors and molecular mechanisms of metastasis.
Book Synopsis Cancer Metastasis by : Richard G. Vile
Download or read book Cancer Metastasis written by Richard G. Vile and published by Wiley-Blackwell. This book was released on 1995-04-25 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise description of the metastasis process and its therapeutic relevance in controlling the clinical outcome of the tumor. Explains why the clinical importance of metastasis could be the most life-threatening element in the tumorigenic procedure.
Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba
Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Inflammation and Metastasis by : Yoshiro Maru
Download or read book Inflammation and Metastasis written by Yoshiro Maru and published by Springer Nature. This book was released on 2021-10-06 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, now in a thoroughly revised and updated second edition, provides the latest information on cancer metastasis from the perspective of inflammation and presents new ideas on the complicated mechanisms of metastasis and potential therapeutic targets. Key features include discussion of mechanisms recently identified to be involved in the resolution phase of inflammation, presentation of the latest evidence regarding the roles of endogenous TLR4 ligands in metastasis, and thorough explanation of the concept of homeostatic inflammation and current understanding of the significance of its dysregulation for metastasis. Structure-based thinking is another important element of the book, and it is proposed that inflammation forms a functional triangle with angiogenesis and coagulation, at the center of which cancer is located. Examples of the many additional specific topics covered in this edition include the functional involvement of new types of RNA in cancer, the insights offered by recent advances in bioinformatics, and the potential of a casein kinase 1α inhibitor in the treatment of acute myeloid leukemia. The book will be a valuable update and resource for both experienced and younger researchers. Homeostasis, originated from an idea of internal milieu by Claude Bernard, is eventually maintained by endogenous elements. The essential features of inflammation are leukocyte mobilization and increased vascular permeability, which could take place in many homeostatic or physiological conditions at low levels. Homeostatic inflammation is a concept to explain pathological settings such as metastasis in which irrespective of its level those inflammatory features are misused with endogenous molecules (see Chap. 14,15). As inflammation comprises many biological fields, targeting a single molecule for a disease could potentially make a therapeutic contribution to other diseases. For example, one focus is applied here to the roles of calprotectin in lung metastasis, which is implicated in psychiatric disorders and COVID-19 as shown by recent evidence.
