Three Dimensional Near-infrared Optical Imaging Using Ultrasound Guidance for Breast Cancer Detection and Diagnosis

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ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (119 download)

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Book Synopsis Three Dimensional Near-infrared Optical Imaging Using Ultrasound Guidance for Breast Cancer Detection and Diagnosis by : Minming Huang

Download or read book Three Dimensional Near-infrared Optical Imaging Using Ultrasound Guidance for Breast Cancer Detection and Diagnosis written by Minming Huang and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation focuses on the study of three-dimensional near-infrared (NIR) imaging reconstruction using ultrasound localization for breast cancer detection and diagnosis. With the 3D NIR forward model for reflection geometry built and investigated, successful reconstruction of both absorption and scattering coefficients has been obtained and evaluated using both a phantom study and initial clinic data. In this work, we first introduce a dual mesh optical reconstruction method with depth correction using a priori ultrasound information. It can significantly improve the reconstructed absorption distributions in deeper target layers. Clinical results have shown improved correlation between reconstructed total hemoglobin concentrations and the histological micorvessel density counts. Next, a combined Tikhonov regularization and dual mesh scheme based on finite element method (FEM) is proposed to solve the inter-parameter cross talk between the scattering coefficient and absorption coefficient. In this approach, the optimal regularization factor is given by the standard L-curve. Different regularization factors have been assigned to the target region and non-target region to incorporate the priori target information from the co-registered ultrasound images. Both phantom experiments and clinic examples have shown that this new approach has the ability to reconstruct the absorption and diffusion coefficients simultaneously, and the reconstructed target absorption and diffusion maps have no depth dependence effect. Finally, a simple two-layer model is generated and studied to solve a clinical issue related to the chest wall, which is a mixture of bones and muscles. For small breasts, the chest wall appears within 2–3 cm distance from the skin surface. As a result, the simple one layer model is not accurate. Furthermore, for some cases, there is also an obvious chest wall mismatch between the reference site and lesion site. To solve this clinical issue, a simplified two-layer model is generated and a fitting method is adopted to estimate the optical properties of both layers. Then a correction method is applied to correct for the chest wall mismatch between the lesion site and reference site. With this scheme, phantom targets located on top of the chest wall phantom layer can be reconstructed with good contrast and resolution.

Three Dimensonal Near-infrared Optical Imaging Using Ultrasound Guidance for Breast Cancer Detection and Diagnosis

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ISBN 13 :
Total Pages : 280 pages
Book Rating : 4.:/5 (628 download)

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Book Synopsis Three Dimensonal Near-infrared Optical Imaging Using Ultrasound Guidance for Breast Cancer Detection and Diagnosis by : Minming Huang

Download or read book Three Dimensonal Near-infrared Optical Imaging Using Ultrasound Guidance for Breast Cancer Detection and Diagnosis written by Minming Huang and published by . This book was released on 2005 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Three-dimensional Ultrasound Imaging and Its Applications in Combined Near-infrared Optical Imaging and Co-registered Photoacoustic Imaging

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ISBN 13 : 9780549045342
Total Pages : 114 pages
Book Rating : 4.0/5 (453 download)

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Book Synopsis Three-dimensional Ultrasound Imaging and Its Applications in Combined Near-infrared Optical Imaging and Co-registered Photoacoustic Imaging by : Puyun Guo

Download or read book Three-dimensional Ultrasound Imaging and Its Applications in Combined Near-infrared Optical Imaging and Co-registered Photoacoustic Imaging written by Puyun Guo and published by . This book was released on 2007 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation focuses on three-dimensional (3-D) ultrasound and its applications as an adjunct modality for biomedical optical imaging.

Mammography and Beyond

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Publisher : National Academies Press
ISBN 13 : 0309075505
Total Pages : 34 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Mammography and Beyond by : National Research Council

Download or read book Mammography and Beyond written by National Research Council and published by National Academies Press. This book was released on 2001-06-04 with total page 34 pages. Available in PDF, EPUB and Kindle. Book excerpt: X-ray mammography screening is the current mainstay for early breast cancer detection. It has been proven to detect breast cancer at an earlier stage and to reduce the number of women dying from the disease. However, it has a number of limitations. These current limitations in early breast cancer detection technology are driving a surge of new technological developments, from modifications of x-ray mammography such as computer programs that can indicate suspicious areas, to newer methods of detection such as magnetic resonance imaging (MRI) or biochemical tests on breast fluids. To explore the merits and drawbacks of these new breast cancer detection techniques, the Institute of Medicine of the National Academy of Sciences convened a committee of experts. During its year of operation, the committee examined the peer-reviewed literature, consulted with other experts in the field, and held two public workshops. In addition to identifying promising new technologies for early detection, the committee explored potential barriers that might prevent the development of new detection methods and their common usage. Such barriers could include lack of funding from agencies that support research and lack of investment in the commercial sector; complicated, inconsistent, or unpredictable federal regulations; inadequate insurance reimbursement; and limited access to or unacceptability of breast cancer detection technology for women and their doctors. Based on the findings of their study, the committee prepared a report entitled Mammography and Beyond: Developing Technology for Early Detection of Breast Cancer, which was published in the spring of 2001. This is a non-technical summary of that report.

Breast Cancer Diagnosis Using Ultrasound and Diffusive Light

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ISBN 13 :
Total Pages : 99 pages
Book Rating : 4.:/5 (742 download)

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Book Synopsis Breast Cancer Diagnosis Using Ultrasound and Diffusive Light by :

Download or read book Breast Cancer Diagnosis Using Ultrasound and Diffusive Light written by and published by . This book was released on 2001 with total page 99 pages. Available in PDF, EPUB and Kindle. Book excerpt: We have developed a novel near-infrared optical technique with ultrasound localization. During the last year, we have made significant progress on using our technique to improve breast cancer diagnosis. Initial results with a group of biopsied patients have shown that early stage invasive cancers present two-fold greater total hemoglobin concentration than fibroadenomas and benign lesions. Initial results of advanced cancers have shown good correlation between cancer angiogenesis distributions imaged by the hybrid imaging technique and histological microvessel density counts. We believe our unique has a great potential to improve current practice on breast cancer diagnosis and monitor treatment responses of advanced cancers.

3D Near Infrared Diffuse Wave Imaging With Ultrasound Localization

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ISBN 13 :
Total Pages : 13 pages
Book Rating : 4.:/5 (742 download)

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Book Synopsis 3D Near Infrared Diffuse Wave Imaging With Ultrasound Localization by :

Download or read book 3D Near Infrared Diffuse Wave Imaging With Ultrasound Localization written by and published by . This book was released on 2005 with total page 13 pages. Available in PDF, EPUB and Kindle. Book excerpt: This proposal is focused on the three-dimensional NIR imaging reconstruction using ultrasound localization for cancer detection and diagnosis. During the reported period, we have achieved simultaneous reconstruction of optical absorption and scattering coefficients of heterogeneities using a dual-mesh scheme based on finite element method, and introduced a new simple two-layer model to correct diffusive wave distortion caused by underlying chest wall of patients.

Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography

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ISBN 13 :
Total Pages : 93 pages
Book Rating : 4.:/5 (713 download)

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Book Synopsis Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography by :

Download or read book Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography written by and published by . This book was released on 2009 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: The goal of the research project, "Time-Resolved and Spectroscopic Three-Dimensional Optical Breast Tomography," was to develop a safe and affordable breast cancer detection modality that uses noninvasive near-infrared (NIR) light for imaging and diagnosing tumors in human breast with high resolution and specificity. In order to realize that goal three different approaches were developed. These are Optical Tomography using Independent Component Analysis (OPTICA), Round Trip Matrix (RTM) approach, and Center of Intensity Time Gated Imaging (CITGI). OPTICA is the most developed of these approaches. It has been demonstrated that OPTICA can detect, obtain the threedimensional location information and cross-section images of small absorbing, scattering, and fluorescent targets in model media, and tumor(s) in realistic model breast with considerable accuracy. Further accomplishments include development of a forward model for determining the backscattered polarized light intensity distribution, and initial development of a technique to determine scattering coefficient, absorption coefficient, and anisotropy factor (g) of breast tissue specimens. Besides detection and localization of tumors in breast, these results may have potential applications in optical biopsy, and lumpectomy. The graduate student supported by the project received his Ph. D., adding another scientist to the ongoing fight against breast cancer.

Optical Imaging of Breast Cancers

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ISBN 13 :
Total Pages : 334 pages
Book Rating : 4.:/5 (862 download)

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Book Synopsis Optical Imaging of Breast Cancers by : Yan Xu

Download or read book Optical Imaging of Breast Cancers written by Yan Xu and published by . This book was released on 2013 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Ultrasound-guided Optical Techniques for Cancer Diagnosis

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ISBN 13 :
Total Pages : 91 pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Ultrasound-guided Optical Techniques for Cancer Diagnosis by : Atahar Kamal Mostafa

Download or read book Ultrasound-guided Optical Techniques for Cancer Diagnosis written by Atahar Kamal Mostafa and published by . This book was released on 2019 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: Worldwide, breast cancer is the most common cancer among women. In the United States alone, the American cancer society has estimated there will be 271,270 new breast cancer cases in 2019, and 42,260 lives will be lost to the disease. Ultrasound (US), mammography, and magnetic resonance imaging (MRI) are regularly used for breast cancer diagnosis and therapy monitoring. However, they sometimes fail to diagnose breast cancer effectively. These shortcomings have motivated researchers to explore new modalities. One of these modalities, diffuse optical tomography (DOT), utilizes near-infrared (NIR) light to reveal the optical properties of tissue. NIR-based DOT images the contrast between a suspected lesion's location and the background tissue, caused by the higher NIR absorption of the hemoglobin which characterizes tumors. The limitation of high light scattering inside tissue is minimized by using ultrasound image to find the tumor location.This thesis focuses on developing a compact, low-cost ultrasound guided diffuse optical tomography imaging system and on improving optical image reconstruction by extracting the tumor's location and size from co-registered ultrasound images. Several electronic components have been redesigned and optimized to save space and cost and to improve the user experience. In terms of software and algorithm development, manual extraction of tumor information from ultrasound images has been replaced by using a semi-automated ultrasound image segmentation algorithm that reduces the optical image reconstruction time and operator dependency. This system and algorithm have been validated with phantom and clinical data and have demonstrated their efficacy. An ongoing clinical trial will continue to gather more patient data to improve the robustness of the imaging algorithm.Another part of this research focuses on ovarian cancer diagnosis. Ovarian cancer is the most deadly of all gynecological cancers, with a less than 50% five-year survival rate. This cancer can evolve without any noticeable symptom, which makes it difficult to diagnose in an early stage. Although ultrasound-guided photoacoustic tomography (PAT) has demonstrated potential for early detection of ovarian cancer, clinical studies have been very limited due to the lack of robust PAT systems.In this research, we have customized a commercial ultrasound system to obtain real-time co-registered PAT and US images. This system was validated with several phantom studies before use in a clinical trial. PAT and US raw data from 30 ovarian cancer patients was used to extract spectral and statistical features for training and testing classifiers for automatic diagnosis. For some challenging cases, the region of interest selection was improved by reconstructing co-registered Doppler images. This study will be continued in order to obtain quantitative tissue properties using US-guided PAT.

Contrast-Enhanced Mammography

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Publisher : Springer
ISBN 13 : 303011063X
Total Pages : 160 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Contrast-Enhanced Mammography by : Marc Lobbes

Download or read book Contrast-Enhanced Mammography written by Marc Lobbes and published by Springer. This book was released on 2019-04-29 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive guide to contrast-enhanced mammography (CEM), a novel advanced mammography technique using dual-energy mammography in combination with intravenous contrast administration in order to increase the diagnostic performance of digital mammography. Readers will find helpful information on the principles of CEM and indications for the technique. Detailed attention is devoted to image interpretation, with presentation of case examples and highlighting of pitfalls and artifacts. Other topics to be addressed include the establishment of a CEM program, the comparative merits of CEM and MRI, and the roles of CEM in screening populations and monitoring of response to neoadjuvant chemotherapy. CEM became commercially available in 2011 and is increasingly being used in clinical practice owing to its superiority over full-field digital mammography. This book will be an ideal source of knowledge and guidance for all who wish to start using the technique or to learn more about it.

Developing Technologies for Early Detection of Breast Cancer

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Publisher : National Academies Press
ISBN 13 : 0309183952
Total Pages : 24 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Developing Technologies for Early Detection of Breast Cancer by : National Research Council

Download or read book Developing Technologies for Early Detection of Breast Cancer written by National Research Council and published by National Academies Press. This book was released on 2000-07-06 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt: In November 1999, the Institute of Medicine, in consultation with the Commission on Life Sciences, the Commission on Physical Sciences, Mathematics, and Applications, and the Board on Science, Technology and Economic Policy launched a one year study on technologies for early detection of breast cancer. The committee was asked to examine technologies under development for early breast cancer detection, and to scrutinize the process of medical technology development, adoption, and dissemination. The committee is gathering information on these topics for its report in a number of ways, including two public workshops that bring in outside expertise. The first workshop on "Developing Technologies for Early Breast Cancer Detection" was held in Washington DC in February 2000. The content of the presentations at the workshop is summarized here. A second workshop, which will focus on the process of technology development and adoption, will be held in Washington, DC on June 19-20. A formal report on these topics, including conclusions and recommendations, will be prepared by the committee upon completion of the one-year study.

Mathematics and Physics of Emerging Biomedical Imaging

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Publisher : National Academies Press
ISBN 13 : 0309552923
Total Pages : 261 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Mathematics and Physics of Emerging Biomedical Imaging by : Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging

Download or read book Mathematics and Physics of Emerging Biomedical Imaging written by Committee on the Mathematics and Physics of Emerging Dynamic Biomedical Imaging and published by National Academies Press. This book was released on 1996-03-13 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This cross-disciplinary book documents the key research challenges in the mathematical sciences and physics that could enable the economical development of novel biomedical imaging devices. It is hoped that the infusion of new insights from mathematical scientists and physicists will accelerate progress in imaging. Incorporating input from dozens of biomedical researchers who described what they perceived as key open problems of imaging that are amenable to attack by mathematical scientists and physicists, this book introduces the frontiers of biomedical imaging, especially the imaging of dynamic physiological functions, to the educated nonspecialist. Ten imaging modalities are covered, from the well-established (e.g., CAT scanning, MRI) to the more speculative (e.g., electrical and magnetic source imaging). For each modality, mathematics and physics research challenges are identified and a short list of suggested reading offered. Two additional chapters offer visions of the next generation of surgical and interventional techniques and of image processing. A final chapter provides an overview of mathematical issues that cut across the various modalities.

Photoacoustic Tomography

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Publisher : CRC PressI Llc
ISBN 13 : 9781439882245
Total Pages : 400 pages
Book Rating : 4.8/5 (822 download)

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Book Synopsis Photoacoustic Tomography by : Minghua Xu

Download or read book Photoacoustic Tomography written by Minghua Xu and published by CRC PressI Llc. This book was released on 2014-09-30 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt:

LED-Based Photoacoustic Imaging

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Publisher : Springer Nature
ISBN 13 : 9811539847
Total Pages : 393 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis LED-Based Photoacoustic Imaging by : Mithun Kuniyil Ajith Singh

Download or read book LED-Based Photoacoustic Imaging written by Mithun Kuniyil Ajith Singh and published by Springer Nature. This book was released on 2020-04-07 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the use of LEDs in biomedical photoacoustic imaging. In chapters written by key opinion leaders in the field, it covers a broad range of topics, including fundamentals, principles, instrumentation, image reconstruction and data/image processing methods, preclinical and clinical applications of LED-based photoacoustic imaging. Apart from preclinical imaging studies and early clinical pilot studies using LED-based photoacoustics, the book includes a chapter exploring the opportunities and challenges of clinical translation from an industry perspective. Given its scope, the book will appeal to scientists and engineers in academia and industry, as well as medical experts interested in the clinical applications of photoacoustic imaging.

Biomedical Optics

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Publisher : John Wiley & Sons
ISBN 13 : 0470177004
Total Pages : 378 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Biomedical Optics by : Lihong V. Wang

Download or read book Biomedical Optics written by Lihong V. Wang and published by John Wiley & Sons. This book was released on 2012-09-26 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This entry-level textbook, covering the area of tissue optics, is based on the lecture notes for a graduate course (Bio-optical Imaging) that has been taught six times by the authors at Texas A&M University. After the fundamentals of photon transport in biological tissues are established, various optical imaging techniques for biological tissues are covered. The imaging modalities include ballistic imaging, quasi-ballistic imaging (optical coherence tomography), diffusion imaging, and ultrasound-aided hybrid imaging. The basic physics and engineering of each imaging technique are emphasized. A solutions manual is available for instructors; to obtain a copy please email the editorial department at [email protected].

Radioguided Surgery

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Publisher : Springer Science & Business Media
ISBN 13 : 0387383271
Total Pages : 319 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Radioguided Surgery by : Giuliano Mariani

Download or read book Radioguided Surgery written by Giuliano Mariani and published by Springer Science & Business Media. This book was released on 2010-05-10 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: This multidisciplinary textbook is designed to be the standard on the subject and is geared for use by physicians who are involved in the care and/or diagnosis of cancer patients. Comprehensive coverage is provided on all aspects of radioguided surgery. Practical information is readily accessible and throughout there is an emphasis on improved decision making. Tables present the indications, performance, and interpretation of procedures at a glance. A wealth of illustrations, including a full-color insert, enhances the application of new concepts.

Breast Cancer Diagnosis

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Publisher : Springer
ISBN 13 :
Total Pages : 192 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Breast Cancer Diagnosis by : Gerald S. Johnston

Download or read book Breast Cancer Diagnosis written by Gerald S. Johnston and published by Springer. This book was released on 1975-11 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast carcinoma is a dreaded disease. The incidence of breast cancer, which appears to be increasing, is 1 in 1500 women with an annual death rate of 4,000 from this disease in the United States (1). It is a cancer which threatens its victims with mutilation as weIl as early death. Although response to therapy has not been good, improved methods for earlier and more complete diagnosis are providing hope for better results. When a woman presents herself for routine breast examination, what diagnostic procedures are indicated? If a breast mass is present, what diagnostic and therapeutic methods are employed? When the mass proves to be malignant, what then? Should biopsy and mastectomy be a combined procedure? Should a positive biopsy be followed by a complete diagnostic work-up before definitive therapy is undertaken? While some answers may seem obvious and others less obvious, common medical practices vary considerably in response to all of these situations. No easy formula exists. Each patient must be given individual consideration and her* treatment carefully planned to incorporate all the diagnostic findings. Experience to date indicates that some diagnostic and therapeutic procedures have established efficacy while others are not very helpful and still others need more evaluation before their usefulness can be . assessed fully. Traditionally, treatment of breast cancer has been surgical. Through the years poor results from surgery, along with acquisition of knowledge of the lymphatic spread of this malignancy, prompted more and more extensive surgical procedures.