Therapies For Clinically Localized Prostate Cancer

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Therapies for Clinically Localized Prostate Cancer

Author : Philipp Dahm
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (122 download)

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Book Synopsis Therapies for Clinically Localized Prostate Cancer by : Philipp Dahm

Download or read book Therapies for Clinically Localized Prostate Cancer written by Philipp Dahm and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: OBJECTIVE: To update findings from previous Agency for Healthcare Research and Quality (AHRQ)- and American Urological Association (AUA)-funded reviews evaluating therapies for clinically localized prostate cancer (CLPC). SOURCES: Bibliographic databases (2013-January 2020); ClinicalTrials.gov; systematic reviews METHODS: Controlled studies of CLPC treatments with duration ≥5 years for mortality and metastases and ≥1 year for quality of life and harms. One investigator rated risk of bias (RoB), extracted data, and assessed certainty of evidence; a second checked accuracy. We analyzed English-language studies with low or medium RoB. We incorporated findings from randomized controlled trials (RCTs) identified in the prior reviews if new RCTs provided information on the same intervention comparison. RESULTS: We identified 67 eligible references; 17 were unique RCTs. Among clinically rather than prostate-specific antigen (PSA) detected CLPC, Watchful Waiting (WW) may increase mortality and metastases versus Radical Prostatectomy (RP) at 20+ years. Urinary and erectile dysfunction were lower with WW versus RP. WW's effect on mortality may vary by tumor risk and age but not by race, health status, comorbidities, or PSA. Active Monitoring (AM) probably results in little to no difference in mortality in PSA-detected CLPC versus RP or external beam radiation (EBR) plus Androgen Deprivation (AD) regardless of tumor risk. Metastases were slightly higher with AM. Harms were greater with RP than AM and mixed between EBR plus AD versus AM. 3D-conformal EBR and AD plus low-dose-rate brachytherapy (BT) provided a small reduction in all-cause mortality versus three-dimensional conformal EBR and AD but little to no difference on metastases. EBR plus AD versus EBR alone may result in a small reduction in mortality and metastases in higher risk disease but may increase sexual harms. EBR plus neoadjuvant AD versus EBR plus concurrent AD may result in little to no difference in mortality and genitourinary toxicity. Conventionally fractionated EBR versus ultrahypofractionated EBR may result in little to no difference in mortality and metastases and urinary and bowel toxicity. Active Surveillance may result in fewer harms than photodynamic therapy and laparoscopic RP may result in more harms than robotic-assisted RP. Little information exists on other treatments. No studies assessed provider or hospital factors of RP comparative effectiveness. CONCLUSIONS: RP reduces mortality versus WW in clinically detected CLPC but causes more harms. Effectiveness may be limited to younger men or to those with intermediate-risk disease and requires many years to occur. AM results in little to no mortality difference versus RP or EBR plus AD. EBR plus AD reduces mortality versus EBR alone in higher risk CLPC but may worsen sexual function. Adding low-dose-rate BT to 3D-conformal EBR and AD may reduce mortality in higher risk CLPC. RCTs in PSA-detected and MRI staged CLPC are needed.

Consensus Development Conference on the Management of Clinically Localized Prostate Cancer

Author :
Publisher :
ISBN 13 :
Total Pages : 194 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis Consensus Development Conference on the Management of Clinically Localized Prostate Cancer by :

Download or read book Consensus Development Conference on the Management of Clinically Localized Prostate Cancer written by and published by . This book was released on 1988 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Management of Clinically Localized Prostate Cancer

Author :
Publisher :
ISBN 13 :
Total Pages : 8 pages
Book Rating : 4.:/5 (319 download)

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Book Synopsis The Management of Clinically Localized Prostate Cancer by :

Download or read book The Management of Clinically Localized Prostate Cancer written by and published by . This book was released on 1986 with total page 8 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer

Author : U. S. Department of Health and Human Services
Publisher : CreateSpace
ISBN 13 : 9781490543284
Total Pages : 188 pages
Book Rating : 4.5/5 (432 download)

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Book Synopsis Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer by : U. S. Department of Health and Human Services

Download or read book Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer written by U. S. Department of Health and Human Services and published by CreateSpace. This book was released on 2013-06-26 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prostate cancer is the most common nondermatologic cancer in men. In 2007 an estimated 218,890 men were diagnosed with, and 27,050 deaths were attributed to, prostate cancer in the United States. Approximately 90 percent of men with prostate cancer have disease considered confined to the prostate gland (clinically localized disease). Reported prostate cancer incidence has increased with introduction of the prostate-specific antigen (PSA) blood test. Disease specific mortality rates have declined, and an estimated 1.8 million men living in the United States have a diagnosis of prostate cancer. Clinically detected prostate cancer is primarily a disease of elderly men. Prostate cancer frequently has a relatively protracted course even if left untreated, and many men die with, rather than from, prostate cancer. Largely because of widespread PSA testing, the lifetime risk of being detected with prostate cancer in the United States has nearly doubled to 20 percent. However, the risk of dying of prostate cancer has remained at approximately 3 percent. Therefore, considerable overdetection and treatment may exist. The primary goal of treatment is to target the men most likely to need intervention in order to prevent prostate cancer death and disability while minimizing intervention-related complications. Common treatments include watchful waiting (active surveillance), surgery to remove the prostate gland (radical prostatectomy), external beam radiotherapy (EBRT) and interstitial radiotherapy (brachytherapy), freezing the prostate (cryotherapy), and androgen deprivation therapy (ADT). All treatments have risks of complications, although frequency and severity may vary. Patient treatment decisionmaking incorporates physician recommendations and estimated likelihood of cancer progression without treatment, as well as treatment-related convenience, costs, and potential for eradication and adverse effects (AEs). Patient characteristics, including race/ethnicity, age, and comorbidities, have an important role in predicting mortality; the likelihood of treatment-related urinary, bowel, and sexual dysfunction; treatment tradeoff preferences; and selection. However, little is known about how these characteristics modify the effect of treatment. Prior to the advent of widespread PSA testing, most prostate cancers were detected based on abnormalities on the digital rectal examination (DRE) or incidentally from tissue obtained at surgery for treatment of symptoms due to benign prostatic obstruction. The vast majority of prostate cancers currently detected in the United States are asymptomatic, clinically localized, and found on routine PSA testing. PSA testing detects more tumors, at an earlier stage, with smaller volume within each stage, and at an earlier period in a man's life than non-screen detected tumors. The clinical significance, natural history, and comparative effectiveness of treatments in PSA-detected cancers are not known but likely differ from those detected and treated in the pre-PSA era (before the late 1980s to early 1990s). This report summarizes evidence comparing the relative effectiveness and safety of treatment options for clinically localized prostate cancer. The report addresses the following questions: 1. What are the comparative risks, benefits, short- and long-term outcomes of therapies for clinically localized prostate cancer? 2. How do specific patient characteristics, e.g., age, race/ethnicity, presence or absence of comorbid illness, preferences (e.g., tradeoff of treatment-related adverse effects vs. potential for disease progression), affect the outcomes of these therapies, overall and differentially? 3. How do provider/hospital characteristics affect outcomes overall and differentially (e.g., geographic region and volume)? 4. How do tumor characteristics, e.g., Gleason score, tumor volume, screen vs. clinically detected tumors, affect the outcomes of these therapies, overall and differentially?

Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer

Author :
Publisher :
ISBN 13 :
Total Pages : 187 pages
Book Rating : 4.:/5 (74 download)

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Book Synopsis Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer by :

Download or read book Comparative Effectiveness of Therapies for Clinically Localized Prostate Cancer written by and published by . This book was released on 2008 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report summarizes evidence comparing the relative effectiveness and safety of treatment options for clinically localized prostate cancer. The report addresses the following questions: what are the comparative risks, benefits, short- and long-term outcomes of therapies for clinically localized prostate cancer? How do specific patient characteristics, e.g., age, race/ethnicity, presence or absence of comorbid illness, preferences (e.g., tradeoff of treatment-related adverse effects vs. potential for disease progression), affect the outcomes of these therapies, overall and differentially? How do provider/hospital characteristics affect outcomes overall and differentially (e.g., geographic region and volume)? How do tumor characteristics, e.g., Gleason score, tumor volume, screen vs. clinically detected tumors, affect the outcomes of these therapies, overall and differentially?--resource home page.

Therapies for Clinically Localized Prostate Cancer

Author : Fang Sun (M.D.)
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (91 download)

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Book Synopsis Therapies for Clinically Localized Prostate Cancer by : Fang Sun (M.D.)

Download or read book Therapies for Clinically Localized Prostate Cancer written by Fang Sun (M.D.) and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: OBJECTIVE: To comprehensively update a 2008 systematic review on treatments for cancer confined to the prostate gland, which is the definition of clinically localized disease. DATA SOURCES: We searched MEDLINE(r), PreMEDLINE, Embase(r), the Cochrane Library, the Database of Abstracts of Reviews of Effects, the Health Technology Assessment Database, gray literature, and the U.K. National Health Service Economic Evaluation Database for reports published from January 1, 2007, through March 7, 2014. REVIEW METHODS: We synthesized evidence from randomized controlled trials (RCTs) and nonrandomized comparative studies published in English that evaluated treatments and reported clinical or biochemical outcomes in patients with clinically localized prostate cancer. RESULTS: Eight RCTs and 44 nonrandomized comparative studies evaluating numerous treatment options met inclusion criteria. However, because most comparisons were represented by only one or two studies, the strength of evidence (SOE) was insufficient for the majority of comparisons. Two RCTs, the Scandinavian Prostate Cancer Group-4 (SPCG-4) and the Prostate Intervention Versus Observation Trial (PIVOT) compared radical prostatectomy (RP) and watchful waiting (WW) in localized prostate cancer patients. No meta-analysis was done because of the heterogeneity of included patients. While the SPCG-4 study found that RP reduced prostate cancer-specific mortality at 12 and 15 years, the PIVOT trial found no statistically significant difference at 12 years. The SPCG-4 study found that RP reduced all-cause mortality at 15 years, but neither the SPCG-4 nor the PIVOT trial found any significant difference at 12 years. The SOE for these outcomes was insufficient. However, both trials found significant reductions in progression to metastases in the RP group compared with the WW group (SOE: moderate). In the SPCG-4 trial, subgroup analyses showed reduced all-cause mortality among patients younger than 65 years and among patients with low tumor risk. In the PIVOT, reduced all-cause mortality was identified among men with prostate-specific antigen >10 ng/mL and among men with intermediate tumor risk. One RCT that compared three-dimensional conformal radiotherapy (3D-CRT) with 3D-CRT plus androgen-deprivation therapy (ADT) reported an improvement in overall survival and prostate cancer-specific mortality among men who received combined therapy (SOE: low). Six nonrandomized comparison studies reported that all-cause and prostate cancer-specific mortality was lower in patients treated with RP than in patients treated with external beam radiation therapy (SOE: low). The definition and severity of adverse events varied greatly across studies. Adverse events such as urinary incontinence and erectile dysfunction were reported mostly among men who underwent RP. Additionally, adverse events such as genitourinary toxicity, gastrointestinal toxicity, and erectile dysfunction were reported among men who received radiation therapy. CONCLUSIONS: This systematic review update found that the evidence for most treatment comparisons is largely inadequate to determine comparative risks and benefits of therapies for clinically localized prostate cancer. This conclusion is similar to that of the 2008 review, which found that no single therapy can be considered the preferred treatment for localized prostate cancer because of limitations in the body of evidence as well as the likely tradeoffs a patient must make between estimated treatment effectiveness, necessity, and adverse effects. Although limited evidence appears to favor surgery over WW or external beam radiotherapy, or favors 3D-CRT plus ADT over 3D-CRT alone, the patients most likely to benefit and the applicability of these study findings to contemporary patients and practice remain uncertain. More RCTs and better designed observational studies that can control for many of the known and unknown confounding factors that can affect long-term outcomes are needed to evaluate comparative risks and benefits of therapies for clinically localized prostate cancer.

Comparative Evaluation of Radiation Treatments for Clinically Localized Prostate Cancer

Author : Stanley Ip
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (96 download)

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Book Synopsis Comparative Evaluation of Radiation Treatments for Clinically Localized Prostate Cancer by : Stanley Ip

Download or read book Comparative Evaluation of Radiation Treatments for Clinically Localized Prostate Cancer written by Stanley Ip and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Coverage and Analysis Group at the Centers for Medicare and Medicaid Services (CMS) requested this report from The Technology Assessment Program (TAP) at the Agency for Healthcare Research and Quality (AHRQ). AHRQ assigned this report to the following Evidence-based Practice Center: Tufts EPC (Contract No. 290 2007 10055 I). Prostate cancer is the most common noncutaneous malignancy diagnosed in men in the United States. The vast majority of patients diagnosed today have clinically localized prostate cancer (T1-T2N0), which is the subject of this report. A Comparative Effectiveness Review of Therapies for Clinically Localized Prostate Cancer was undertaken on behalf of the Agency for Healthcare Research and Quality (AHRQ) by the Minnesota Evidence-based Practice Center (EPC) in 2007 (Wilt et al. Comparative effectiveness of therapies for clinically localized prostate cancer. Comparative Effectiveness Review No. 13, prepared by Minnesota Evidence-based Practice Center under contract no. 290-02-0009 Rockville, MD: Agency for Healthcare Research and Quality, February 2008. Available at effectivehealthcare.ahrq.gov/reports/final.cfm). The report concluded that "No one therapy can be considered the preferred treatment for localized prostate cancer due to limitations in the body of evidence as well as the likely tradeoffs an individual patient must make between estimated treatment effectiveness, necessity, and adverse effects. All treatment options result in adverse effects (primarily urinary, bowel, and sexual), although the severity and frequency may vary between treatments. Even if differences in therapeutic effectiveness exist, differences in adverse effects, convenience, and costs are likely to be important factors in individual patient decision making." As more studies on radiation treatments have been published since the Minnesota report, the Centers for Medicare and Medicaid Services (CMS) is interested in an update. After consultation with AHRQ and CMS, this technology assessment has been commissioned specifically to examine the recent comparative studies on radiation treatments of clinically localized prostate cancer.

Understanding Treatment Choices for Prostate Cancer

Author :
Publisher :
ISBN 13 :
Total Pages : 44 pages
Book Rating : 4.:/5 (327 download)

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Book Synopsis Understanding Treatment Choices for Prostate Cancer by :

Download or read book Understanding Treatment Choices for Prostate Cancer written by and published by . This book was released on 2000 with total page 44 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Therapies for Clinically Localized Prostate Cancer :: Update of a 2008 Systematic Review

Author : Fang Sun
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (99 download)

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Book Synopsis Therapies for Clinically Localized Prostate Cancer :: Update of a 2008 Systematic Review by : Fang Sun

Download or read book Therapies for Clinically Localized Prostate Cancer :: Update of a 2008 Systematic Review written by Fang Sun and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Active Surveillance for Localized Prostate Cancer

Author : Laurence Klotz
Publisher : Springer Science & Business Media
ISBN 13 : 1617799122
Total Pages : 212 pages
Book Rating : 4.6/5 (177 download)

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Book Synopsis Active Surveillance for Localized Prostate Cancer by : Laurence Klotz

Download or read book Active Surveillance for Localized Prostate Cancer written by Laurence Klotz and published by Springer Science & Business Media. This book was released on 2012-06-21 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Active Surveillance for Localized Prostate Cancer: A New Paradigm for Clinical Management will serve as a useful resource for physicians dealing with, and interested in, this complex and evolving branch of prostate cancer management. The book will also be of interest to scientifically literate patients and their families. The volume provides an introduction to the concept of active surveillance in oncology in general and prostate cancer specifically. The primary focus is to provide a comprehensive guide to the management of patients on surveillance. The volume covers the many complexities and nuances to this approach including, patient selection, risk assessment, how to overcome 'cancer hysteria' when counseling patients, identifying appropriate triggers for intervention, use of PSA kinetics and MR imaging information, technique and frequency of biopsies, secondary prevention interventions, and the relative roles of surveillance and focal therapy.

Future Research Needs for Comparative Effectiveness of Treatments of Localized Prostate Cancer

Author : U. S. Department of Health and Human Services
Publisher : Createspace Independent Pub
ISBN 13 : 9781484974209
Total Pages : 108 pages
Book Rating : 4.9/5 (742 download)

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Book Synopsis Future Research Needs for Comparative Effectiveness of Treatments of Localized Prostate Cancer by : U. S. Department of Health and Human Services

Download or read book Future Research Needs for Comparative Effectiveness of Treatments of Localized Prostate Cancer written by U. S. Department of Health and Human Services and published by Createspace Independent Pub. This book was released on 2013-05-14 with total page 108 pages. Available in PDF, EPUB and Kindle. Book excerpt: An estimated 1.8 million men living in the United States have a diagnosis of prostate cancer, with about 218,890 newly diagnosed men each year. Approximately 90 percent of men with prostate cancer have disease considered confined to the prostate gland (i.e., clinically localized disease). If left untreated, frequently men die with, rather than from, prostate cancer. Largely because of widespread prostate-specific antigen (PSA) testing, the lifetime risk of prostate cancer diagnosis in the United States has nearly doubled to 20 percent, while the risk of dying of prostate cancer has remained at approximately 3 percent. Therefore, considerable over detection and treatment may exist. Moreover, the treatment of localized prostate cancer is associated with substantial adverse effects. The primary goal of treatment is to target those men most likely to need intervention to prevent prostate cancer death and disability, while minimizing intervention-related complications. Common treatments include watchful waiting (active surveillance), surgery to remove the prostate gland (i.e., radical prostatectomy), radiotherapy (e.g., external-beam radiation or brachytherapy), freezing the prostate (i.e., cryotherapy), and androgen-deprivation therapy (ADT). All treatments for prostate cancer have risks of complications, although their frequency and severity may vary. Common adverse events include urinary, bowel, and sexual dysfunction. The vast majority of prostate cancers currently detected in the United States are asymptomatic, clinically localized, and found on routine PSA testing. PSA testing detects more tumors, at an earlier stage, with a smaller volume within each stage, and at an earlier period in a man's life than nonscreen-detected tumors. The clinical significance, natural history, and comparative effectiveness of treatments in PSA-detected cancers are not known but likely differ from those detected and treated in the pre-PSA era (before the late 1980s to early 1990s). The objective of this project is to pilot an approach for developing future research priorities and suggesting specific projects to address evidence gaps. From the results of this and comparable pilot projects conducted by other Agency for Healthcare Research and Quality (AHRQ) Evidence-based Practice Centers (EPCs), AHRQ will identify generalizable strategies and lessons learned. The topic of this pilot project, the comparative effectiveness of treatments for localized prostate cancer, was selected because of its importance. The Minnesota EPC completed a comparative effectiveness review (CER) on this topic in 2008 for AHRQ. This pilot project amends the list of recommendations from that report and creates prioritized lists of research gaps and proposed research studies. Subsequently, management strategies for local prostate cancer were in the first quartile of the Institute of Medicine's 100 initial priority topics for comparative effectiveness research: Compare the effectiveness of management strategies for localized prostate cancer (e.g., active surveillance, radical prostatectomy [conventional, robotic, and laparoscopic], and radiotherapy [conformal, brachytherapy, proton beam, and intensity-modulated radiotherapy]) on survival, recurrence, side effects, quality of life, and costs.

Optimizing Local Therapy for High-Risk Prostate Cancer: Evidence and Emerging Options

Author : Timothy Showalter
Publisher : Frontiers Media SA
ISBN 13 : 2889661016
Total Pages : 111 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Optimizing Local Therapy for High-Risk Prostate Cancer: Evidence and Emerging Options by : Timothy Showalter

Download or read book Optimizing Local Therapy for High-Risk Prostate Cancer: Evidence and Emerging Options written by Timothy Showalter and published by Frontiers Media SA. This book was released on 2020-10-30 with total page 111 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Active Surveillance for Localized Prostate Cancer

Author : Laurence Klotz
Publisher : Humana Press
ISBN 13 : 3319627104
Total Pages : 249 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Active Surveillance for Localized Prostate Cancer by : Laurence Klotz

Download or read book Active Surveillance for Localized Prostate Cancer written by Laurence Klotz and published by Humana Press. This book was released on 2017-09-29 with total page 249 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully updated and revised new edition provides a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in prostate cancer. The book reviews new data about molecular characteristics of the disease, profiles the new grading system for prostate cancer introduced in 2015, and provides new perspectives about imaging of prostate cancer, as well as the role of targeted biopsies. The text summarizes the role of biomarkers and MRI in patient selection and management and details the world wide results of active surveillance. Specific chapters address communication and ethical issues, QOL outcomes, economic aspects, and psycho-social aspects of surveillance. The role of focal therapy for low risk disease is summarized, and the data supporting preventive interventions during surveillance reviewed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in this common malignancy, as it provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts.

Technical Aspects of Focal Therapy in Localized Prostate Cancer

Author : Eric Barret
Publisher : Springer
ISBN 13 : 2817804848
Total Pages : 252 pages
Book Rating : 4.8/5 (178 download)

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Book Synopsis Technical Aspects of Focal Therapy in Localized Prostate Cancer by : Eric Barret

Download or read book Technical Aspects of Focal Therapy in Localized Prostate Cancer written by Eric Barret and published by Springer. This book was released on 2015-01-29 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focal therapy is a promising option for selected patients who have localized low or intermediate-risk prostate cancer, providing a compelling alternative between active surveillance and radical therapies by targeting the index lesion and preserving as much tissue as possible. Numerous cohort studies have already investigated multiple focal techniques, such as cryotherapy, high-intensity focused ultrasound, brachytherapy, photodynamic therapy, laser therapy, irreversible electroporation and cyberknife methods, all of which have demonstrated positive oncological outcomes with 70 to 90 % negative follow-up biopsy. These various ablative techniques have produced only minor side-effects concerning urinary function, a low rate of erectile dysfunction, and have demonstrated a limited rectal toxicity. As a result, the primary end-point has now shifted and a new strategy needs to be established for patient follow-up and for defining treatment failure. Written by international experts in the field, this book is mainly focused on new techniques, all of which are amply illustrated. Technical Aspects of Focal Therapy in Localized Prostate Cancer will be of great practical value to all urologists and oncologists.

Adenocarcinoma of the Prostate

Author : Andrew W. Bruce
Publisher : Springer Science & Business Media
ISBN 13 : 1447113985
Total Pages : 363 pages
Book Rating : 4.4/5 (471 download)

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Book Synopsis Adenocarcinoma of the Prostate by : Andrew W. Bruce

Download or read book Adenocarcinoma of the Prostate written by Andrew W. Bruce and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carcinoma of the prostate increasingly dominates the attention of urologists for both scientific and clinical reasons. The search for an explanation and the prediction of the variable behaviour of the malignant prostatic cell continues unabated. The search for more precise tumour staging and more effective treatment is equally vigorous. Editors Andrew Bruce and John Trachtenberg have assembled acknowledged leaders in prostate cancer to present those areas of direct interest to the clinician. There are a number of other topics that might have been considered but most of these, such as experimental tumour models or biochemical factors affecting cell growth, still lack immediate application for the clinician. Carcinoma of the prostate continues to have its highest incidence in the western world, and the difference in comparison with the incidence in the Far East appears to be real and not masked by diagnostic or other factors. A number of other epidemiological aspects need careful analysis: Is the incidence increasing? Is the survival improving? Is the prognosis worse in the younger patient? Epidemiological data are easily misused and misinterpreted so that a precise analysis of the known facts makes an important opening chapter to this book.

Imaging and Focal Therapy of Early Prostate Cancer

Author : Thomas J. Polascik
Publisher : Springer
ISBN 13 : 3319499114
Total Pages : 475 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Imaging and Focal Therapy of Early Prostate Cancer by : Thomas J. Polascik

Download or read book Imaging and Focal Therapy of Early Prostate Cancer written by Thomas J. Polascik and published by Springer. This book was released on 2017-02-22 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text encompass an up-to-date, comprehensive review of the state-of-the-art for gland preserving therapies. Fully updated and revised, this text evaluates the scientific evidence for the evolving trend to treat intermediate risk, clinically localized prostate cancer in a focally ablative manner with novel gland-preserving, focal therapy methods. Various ablative devices such as high intensity focused ultrasound, irreversible electroporation, photodynamic therapy, cryotherapy and laser ablation, among others, is discussed in regard to their strengths and limitations as a therapeutic modality. Emphasis is placed on patient selection and outcomes utilizing both advanced imaging techniques and pathologic evaluation. Current and new approaches to image cancer foci within the prostate (multiparametric ultrasonography, multiparametric magnetic resonance image, etc) are presented along with various biopsy techniques, including robotics to map prostate cancer. Patient selection based on imaging and genomic classification, adjuvants to enhance therapy, treatment strategy, outcomes and patient centered concerns is discussed, providing an acceptable balance between cancer control and improved quality of life for patients. Written by experts in the field and lavishly illustrated with detailed line-art and photographs, Imaging and Focal Therapy of Early Prostate Cancer, Second Edition is designed as a comprehensive resource for urologists, radiation oncologists, medical oncologists, radiologists, uropathologists, molecular biologists, biomedical engineers, other clinicians –- residents, fellows, nurses and allied professionals -- and researchers with an interest in the diagnosis and novel treatment of prostate cancer. It will provide insight into the latest research and clinical applications of image-guided diagnosis and minimally invasive focal, gland-preserving treatment for prostate cancer.

Irreversible Electroporation

Author : Boris Rubinsky
Publisher : Springer Science & Business Media
ISBN 13 : 364205420X
Total Pages : 320 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis Irreversible Electroporation by : Boris Rubinsky

Download or read book Irreversible Electroporation written by Boris Rubinsky and published by Springer Science & Business Media. This book was released on 2009-11-25 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Non-thermal irreversible electroporation is a new minimally invasive surgical p- cedure with unique molecular selectivity attributes – in fact it may be considered the first clinical molecular surgery procedure. Non-thermal irreversible electro- ration is a molecular selective mode of cell ablation that employs brief electrical fields to produce nanoscale defects in the cell membrane, which can lead to cell death, without an effect on any of the other tissue molecules. The electrical fields can be produced through contact by insertion of electrode needles around the undesirable tissue and non-invasively by electromagnetic induction. This new - dition to the medical armamentarium requires the active involvement and is of interest to clinical physicians, medical researchers, mechanical engineers, che- cal engineers, electrical engineers, instrumentation designers, medical companies and many other fields and disciplines that were never exposed in their training to irreversible electroporation or to a similar concept. This edited book is designed to be a comprehensive introduction to the field of irreversible electroporation to those that were not exposed or trained in the field before and can also serve as a reference manual. Irreversible electroporation is broad and interdisciplinary. Therefore, we have made an attempt to cover every one of the various aspects of the field from an introductory basic level to state of the art.