Therapeutic Potential Of Capsaicin Like Molecules

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Capsaicin as a Therapeutic Molecule

Author : Omar M. E. Abdel-Salam
Publisher : Springer Science & Business Media
ISBN 13 : 3034808283
Total Pages : 325 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Capsaicin as a Therapeutic Molecule by : Omar M. E. Abdel-Salam

Download or read book Capsaicin as a Therapeutic Molecule written by Omar M. E. Abdel-Salam and published by Springer Science & Business Media. This book was released on 2014-03-20 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides an up-to-date account of the achievements pertaining to the application of capsaicin and capsaicin-like molecules in the therapy of various human ailments such as pain, non-allergic rhinitis, obesity, tumors and gastrointestinal, dermatologic and urologic disorders. It discusses the basic functions of the capsaicin receptor (TRPV1), its mechanisms of action and its role in physiological and pathological processes. The text focuses on the most recent progress in the use of capsaicin and capsaicin-like molecules as a therapeutic agent and highlights potential pharmaceutical implications of further TRPV1 research. The chapters are written by noted experts in their fields of endeavor. This book offers both clinicians and researchers valuable resource and reference material on the subject that will stimulate future research.

TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades

Author : Wolfgang B. Liedtke, MD, PH.D.
Publisher : CRC Press
ISBN 13 : 1420005847
Total Pages : 502 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades by : Wolfgang B. Liedtke, MD, PH.D.

Download or read book TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades written by Wolfgang B. Liedtke, MD, PH.D. and published by CRC Press. This book was released on 2006-09-29 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of st

Transient Receptor Potential (TRP) Channels

Author : Veit Flockerzi
Publisher : Springer Science & Business Media
ISBN 13 : 3540348913
Total Pages : 610 pages
Book Rating : 4.5/5 (43 download)

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Book Synopsis Transient Receptor Potential (TRP) Channels by : Veit Flockerzi

Download or read book Transient Receptor Potential (TRP) Channels written by Veit Flockerzi and published by Springer Science & Business Media. This book was released on 2007-02-07 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides up-to-date information on the molecular and functional properties and pharmacology of mammalian TRP channels. Leading experts in the field have written 35 essays which describe properties of a single TRP protein/channel or portray more general principles of TRP function and important pathological situations linked to mutations of TRP genes or their altered expression.

Molecular Targets and Therapeutic Uses of Spices

Author : Bharat B. Aggarwal
Publisher : World Scientific
ISBN 13 : 9812837906
Total Pages : 457 pages
Book Rating : 4.8/5 (128 download)

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Book Synopsis Molecular Targets and Therapeutic Uses of Spices by : Bharat B. Aggarwal

Download or read book Molecular Targets and Therapeutic Uses of Spices written by Bharat B. Aggarwal and published by World Scientific. This book was released on 2009 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditional uses of spices : an overview / Ajaikumar B. Kunnumakkara ... [et al.] -- Black pepper (Piper nigrum) and its bioactive compound, piperine / Krishnapura Srinivasan -- Cardamom (Elettaria cardamomum) and its active constituent, 1,8-cineole / Archana Sengupta and Shamee Bhattacharjee -- Molecular targets and health benefits of cinnamon / Kiran Panickar ... [et al.] -- Cloves (eugenol) / Yoshinori Kadoma ... [et al.] -- Coriander / Sanjeev Shukla and Sanjay Gupta -- Fenugreek (diosgenin) / Jayadev Raju and Chinthalapally V. Rao -- Diallyl sulfide from garlic / Girija Kuttan and Punathil Thejass -- Ginger (6-gingerol) / Nidhi Nigam, Jasmine George, and Yogeshwer Shukla -- Kalonji (thymoquinone) / Ahmed O. Kaseb and Abdel-Hafez A. Selim -- Kokum (garcinol) / Manoj K. Pandey, Ajaikumar B. Kunnumakkara, and Bharat B. Aggarwal -- Capsaicin : a hot spice in the chemoprevention of cancer / Joydeb Kumar Kundu and Young-Joon Surh -- Rosemary (rosmarinic acid) / Jongsung Lee ... [et al.] -- Mint and its constituents / Ajaikumar B. Kunnumakkara ... [et al.] -- Turmeric (curcumin) / Jen-Kun Lin and Shoei-Yn Lin Shiau.

Bioactive Molecules in Food

Author : Jean-Michel Mérillon
Publisher : Springer Nature
ISBN 13 : 3319780301
Total Pages : 2353 pages
Book Rating : 4.3/5 (197 download)

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Book Synopsis Bioactive Molecules in Food by : Jean-Michel Mérillon

Download or read book Bioactive Molecules in Food written by Jean-Michel Mérillon and published by Springer Nature. This book was released on 2019-01-25 with total page 2353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work provides comprehensive information about the bioactive molecules presented in our daily food and their effect on the physical and mental state of our body. Although the concept of functional food is new, the consumption of selected food to attain a specific effect existed already in ancient civilizations, namely of China and India. Consumers are now more attentive to food quality, safety and health benefits, and the food industry is led to develop processed- and packaged-food, particularly in terms of calories, quality, nutritional value and bioactive molecules. This book covers the entire range of bioactive molecules presented in daily food, such as carbohydrates, proteins, lipids, isoflavonoids, carotenoids, vitamin C, polyphenols, bioactive molecules presented in wine, beer and cider. Concepts like French paradox, Mediterranean diet, healthy diet of eating fruits and vegetables, vegan and vegetarian diet, functional foods are described with suitable case studies. Readers will also discover a very timely compilation of methods for bioactive molecules analysis. Written by highly renowned scientists of the field, this reference work appeals to a wide readership, from graduate students, scholars, researchers in the field of botany, agriculture, pharmacy, biotechnology and food industry to those involved in manufacturing, processing and marketing of value-added food products.

Pain Management and the Opioid Epidemic

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309459575
Total Pages : 483 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine

Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Compounded Topical Pain Creams

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 030967218X
Total Pages : 353 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Compounded Topical Pain Creams by : National Academies of Sciences, Engineering, and Medicine

Download or read book Compounded Topical Pain Creams written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-21 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain is both a symptom and a disease. It manifests in multiple forms and its treatment is complex. Physical, social, economic, and emotional consequences of pain can impair an individual's overall health, well-being, productivity, and relationships in myriad ways. The impact of pain at a population level is vast and, while estimates differ, the Centers for Disease Control and Prevention reported that 50 million U.S. adults are living in pain. In terms of pain's global impact, estimates suggest the problem affects approximately 1 in 5 adults across the world, with nearly 1 in 10 adults newly diagnosed with chronic pain each year. In recent years, the issues surrounding the complexity of pain management have contributed to increased demand for alternative strategies for treating pain. One such strategy is to expand use of topical pain medicationsâ€"medications applied to intact skin. This nonoral route of administration for pain medication has the potential benefit, in theory, of local activity and fewer systemic side effects. Compounding is an age-old pharmaceutical practice of combining, mixing, or adjusting ingredients to create a tailored medication to meet the needs of a patient. The aim of compounding, historically, has been to provide patients with access to therapeutic alternatives that are safe and effective, especially for people with clinical needs that cannot otherwise be met by commercially available FDA-approved drugs. Compounded Topical Pain Creams explores issues regarding the safety and effectiveness of the ingredients in these pain creams. This report analyzes the available scientific data relating to the ingredients used in compounded topical pain creams and offers recommendations regarding the treatment of patients.

TRP Channels as Therapeutic Targets

Author : Arpad Szallasi
Publisher : Academic Press
ISBN 13 : 0124200796
Total Pages : 530 pages
Book Rating : 4.1/5 (242 download)

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Book Synopsis TRP Channels as Therapeutic Targets by : Arpad Szallasi

Download or read book TRP Channels as Therapeutic Targets written by Arpad Szallasi and published by Academic Press. This book was released on 2015-04-09 with total page 530 pages. Available in PDF, EPUB and Kindle. Book excerpt: TRP Channels as Therapeutic Targets: From Basic Science to Clinical Use is authored by experts across academia and industry, providing readers with a complete picture of the therapeutic potential and challenges associated with using TRP channels as drug targets. This book offers a unique clinical approach by covering compounds that target TRP channels in pre-clinical and clinical phases, also offering a discussion of TRP channels as biomarkers. An entire section is devoted to the novel and innovative uses of these channels across a variety of diseases, offering strategies that can be used to overcome the adverse effects of first generation TRPV1 antagonists. Intended for all researchers and clinicians working toward the development of successful drugs targeting TRP channels, this book is an essential resource chocked full of the latest clinical data and findings. - Contains comprehensive coverage of TRP channels as therapeutic targets, from emerging clinical indications to completed clinical trials - Discusses TRP channels as validated targets, ranging from obesity and diabetes through cancer and respiratory disorders, kidney diseases, hypertension, neurodegenerative disorders, and more - Provides critical analysis of the complications and side effects that have surfaced during clinical trials, offering evidence-based suggestions for overcoming them

Mechanisms of Vascular Disease

Author : Robert Fitridge
Publisher : University of Adelaide Press
ISBN 13 : 1922064009
Total Pages : 589 pages
Book Rating : 4.9/5 (22 download)

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Book Synopsis Mechanisms of Vascular Disease by : Robert Fitridge

Download or read book Mechanisms of Vascular Disease written by Robert Fitridge and published by University of Adelaide Press. This book was released on 2011 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: New updated edition first published with Cambridge University Press. This new edition includes 29 chapters on topics as diverse as pathophysiology of atherosclerosis, vascular haemodynamics, haemostasis, thrombophilia and post-amputation pain syndromes.

Current Therapy in Pain

Author : Howard S. Smith
Publisher : Elsevier Health Sciences
ISBN 13 : 1416048367
Total Pages : 697 pages
Book Rating : 4.4/5 (16 download)

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Book Synopsis Current Therapy in Pain by : Howard S. Smith

Download or read book Current Therapy in Pain written by Howard S. Smith and published by Elsevier Health Sciences. This book was released on 2009-01-01 with total page 697 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique resource focuses on the diagnosis and treatment of painful conditions-both acute and chronic-from a multi-disciplinary perspective. Joined by a team of nearly 200 international contributors representing a wide range of specialties, Dr. Smith presents the best management options within and across specialties. Succinct treatment and therapy guidelines enable you to quickly access clinically useful information, for both inpatient and outpatient pain management, while a 2-color format enhances readability and ease of use and highlights key concepts. And, as an Expert Consult title, it includes access to the complete contents online, fully searchable, plus links to Medline and PubMed abstracts-providing rapid, easy consultation from any computer! Includes access to the complete text online, fully searchable, plus links to Medline and PubMed abstracts-providing quick and convenient reference from anyplace with an Internet connection. Offers a cross-discipline approach to pain management for a comprehensive view of the best treatment options within and across specialties including internal medicine, gynecology, physical medicine and rehabilitation, orthopedics, and family medicine. Provides succinct treatment and therapy guidelines, enabling you to locate useful information quickly. Organizes guidance on acute and chronic therapies in a templated format, to facilitate consistent, quick-access consultation appropriate for inpatient or outpatient pain management. Features a 2-color format that enhances readability and ease of use and highlights key concepts. Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

Nanoliposomes

Author : Mozafari, Reza M
Publisher : Trafford
ISBN 13 : 9781412055451
Total Pages : 238 pages
Book Rating : 4.0/5 (554 download)

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Book Synopsis Nanoliposomes by : Mozafari, Reza M

Download or read book Nanoliposomes written by Mozafari, Reza M and published by Trafford. This book was released on 2005 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the nanotechnology era much of the enhanced speed and effectiveness of equipments, techniques or material is due to their downsizing to nanometric scale. One such enhancement has been occurring in the field of nanoencapsulation. Nanoencapsulation of bioactive materials is a multidisciplinary approach to improve the efficiency and decrease the side effects of drugs, vaccines, cosmetics, slimming agents and nutraceuticals. Nanoliposomes are among the best encapsulation and controlled release systems with the ability to incorporate and protect various types of bioactives as well as deliver them to the target site inside the human or animal body. This book is an ideal source for learning about, or teaching lipid-based carrier systems, including nanoliposomes, archaeosomes, immunoliposomes, virosomes, ultradeformable vesicles and stealth liposomes from basics to post-graduate levels. Several methods of preparation and characterization of these carriers along with their in vitro and in vivo behavior are explained. Application of the nanocarriers in various areas including pharmaceutics, biotechnology, gene delivery and therapy, food technology and origin of life are covered. Particular emphasis is given to the manufacture of carrier systems without employing potentially harmful substances (e.g. volatile solvents or detergents) on small and large scale. The book also contains a unique technical glossary which is especially useful for those new to the field.

The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

Author : Bharat B. Aggarwal
Publisher : Springer Science & Business Media
ISBN 13 : 0387464018
Total Pages : 502 pages
Book Rating : 4.3/5 (874 download)

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Book Synopsis The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease by : Bharat B. Aggarwal

Download or read book The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease written by Bharat B. Aggarwal and published by Springer Science & Business Media. This book was released on 2007-08-06 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: The medicinal uses of Curcumin (also called turmeric) have been known and described for more than 5000 years. A large body of recent research suggests that curcumin is potentially useful in the treatment of inflammatory diseases, through modulation of numerous molecular targets. This is the first monograph to focus on the potential use of curcumin in the treatment of cancer, diabetes, cardiovascular diseases, arthritis, Alzheimer’s, psoriasis and more.

Vanilloid Receptor TRPV1 in Drug Discovery

Author : Arthur Gomtsyan
Publisher : John Wiley & Sons
ISBN 13 : 9780470588277
Total Pages : 480 pages
Book Rating : 4.5/5 (882 download)

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Book Synopsis Vanilloid Receptor TRPV1 in Drug Discovery by : Arthur Gomtsyan

Download or read book Vanilloid Receptor TRPV1 in Drug Discovery written by Arthur Gomtsyan and published by John Wiley & Sons. This book was released on 2010-02-12 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines the emerging therapeutic role of TRPV1 TRPV1 is considered an integrator of noxious stimuli and therefore may be at a crossroads for pain transmission pathways. Because of its potential for managing multiple pain types, including osteoarthritis, chronic low back pain, neuropathic pain, and cancer pain, some consider it "the holy grail" of pain management. This dedicated reference summarizes available data related to the potential therapeutic utility for TRPV1 ligands. With contributions from many of the world's leading experts on TRP channels, Vanilloid Receptor TRPV1 in Drug Discovery covers the important TRPV1 target for drugs to treat painful conditions such as inflammation, arthritis, and cancer pain. The book discusses: Recent advances in biology, chemistry, and pharmacology at both the preclinical and clinical stage of the dynamic area of TRPV1 drug discovery research The potential for drugs targeting TRPV1 in painful conditions such as inflammation, arthritis, and cancer The development of analgesic drugs Other applications for TRPV1, including the treatment of respiratory disease and diabetes Featuring data relevant to the therapeutic potential of TRPV1 and the medicinal chemistry involved in designing TRPV1 antagonists, Vanilloid Receptor TRPV1 in Drug Discovery is a key tool for researchers in the pharmaceutical industry and academia involved in pain, ion channels, and analgesic drug development.

Key Topics in Critical Care, Second Edition

Author : T. M. Craft
Publisher : CRC Press
ISBN 13 : 184184358X
Total Pages : 1496 pages
Book Rating : 4.8/5 (418 download)

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Book Synopsis Key Topics in Critical Care, Second Edition by : T. M. Craft

Download or read book Key Topics in Critical Care, Second Edition written by T. M. Craft and published by CRC Press. This book was released on 2004-11-10 with total page 1496 pages. Available in PDF, EPUB and Kindle. Book excerpt: High quality critical care medicine is a crucial component of advanced health care. Completely revised and updated, Key Topics in Critical Care, Second Edition provides a broad knowledge base in the major areas of critical care, enabling readers to rapidly acquire an understanding of the principles and practice of this area of modern clinical medicine. Expanded to include the latest hot topics, the new edition puts an increased emphasis on recent reviews and contains added references to key landmark papers. Using the trademark Key Topics style, each topic has been written by an expert in the field and includes a succinct overview of the subject with references to current publications for further reading. The book provides a framework for candidates of postgraduate medical examinations such as FRCS, MRCP, and FRCA and a reference that can be consulted in emergency situations. New topics include: Critical illness polyneuromyopathy End of life care Inotropes and vasopressors Medical emergency team (outreach critical care) Status epilepticus Venous thromboembolism

Pain Relief

Author : Cecilia Maldonado
Publisher : BoD – Books on Demand
ISBN 13 : 9535131877
Total Pages : 364 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Pain Relief by : Cecilia Maldonado

Download or read book Pain Relief written by Cecilia Maldonado and published by BoD – Books on Demand. This book was released on 2017-05-24 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the beginning of times, pain treatment has been the motive of research giving birth to multiple groups of pharmacological families and therapies. Pain perception is a construction built over the biological phenomenon of signal transduction surrounded by different factors such as gender, age, and sociocultural status, among others. The concept of pain as the solely biological manifestation of defense is nowadays considered as a narrow-minded view of this topic. In this regard concepts such as newborns feel no pain or older people complain about everything therefore should not be paid attention when referring pain, are being left behind in the understanding that pain alleviation is a human right and everybody feeling pain should be helped for its relief. This book comprises many aspects of pain treatment and the drugs involved in it. From old analgesics with new mechanisms of action for pain alleviation to analgesics potential for diminishing oxidative stress; from pharmacological therapies to electrical ones, going through alternative medicine; and from pain treatment in dentistry to chronic pain therapies, also boarding the treatment of migraine, different experts share their knowledge on the topic.

Natural Products as Source of Molecules with Therapeutic Potential

Author : Valdir Cechinel Filho
Publisher : Springer
ISBN 13 : 3030005453
Total Pages : 531 pages
Book Rating : 4.0/5 (3 download)

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Book Synopsis Natural Products as Source of Molecules with Therapeutic Potential by : Valdir Cechinel Filho

Download or read book Natural Products as Source of Molecules with Therapeutic Potential written by Valdir Cechinel Filho and published by Springer. This book was released on 2018-12-07 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the highly relevant and complex subject of research on drugs from natural products, discussing the current hot topics in the field. It also provides a detailed overview of the strategies used to research and develop these drugs. Respected experts explore issues involved in the production chain and when looking for new medicinal agents, including aspects such as therapeutic potential, functional foods, ethnopharmacology, metabolomics, virtual screening and regulatory scenarios. Further, the book describes strategic methods of isolation and characterization of active principles, biological assays, biotechnology of plants, synthesis, clinical trials and the use of tools to identity active principles.

Pharmacology of Pain

Author : Pierre Beaulieu
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1496331915
Total Pages : 978 pages
Book Rating : 4.4/5 (963 download)

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Book Synopsis Pharmacology of Pain by : Pierre Beaulieu

Download or read book Pharmacology of Pain written by Pierre Beaulieu and published by Lippincott Williams & Wilkins. This book was released on 2015-06-01 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacology of Pain provides a complete review of the pharmacology of pain, including mechanisms of drug actions, clinical aspects of drug usage, and new developments. This authoritative book describes the different systems involved in the perception, transmission, and modulation of pain and discusses the available options for pharmacological treatment of pain. Who should buy this book? Pharmacology of Pain is a particularly useful resource for: Basic researchers and clinicians, including physicians, dentists, pharmacists, nurses, and physical therapists Other professionals in the field of pain research and treatment Students and trainees