Theory of Phase Transitions in Polypeptides and Proteins

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Publisher : Springer Science & Business Media
ISBN 13 : 3642225926
Total Pages : 130 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Theory of Phase Transitions in Polypeptides and Proteins by : Alexander V. Yakubovich

Download or read book Theory of Phase Transitions in Polypeptides and Proteins written by Alexander V. Yakubovich and published by Springer Science & Business Media. This book was released on 2011-09-01 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are nearly 100 000 different protein sequences encoded in the human genome, each with its own specific fold. Understanding how a newly formed polypeptide sequence finds its way to the correct fold is one of the greatest challenges in the modern structural biology. The aim of this thesis is to provide novel insights into protein folding by considering the problem from the point of view of statistical mechanics. The thesis starts by investigating the fundamental degrees of freedom in polypeptides that are responsible for the conformational transitions. This knowledge is then applied in the statistical mechanics description of helix↔coil transitions in polypeptides. Finally, the theoretical formalism is generalized to the case of proteins in an aqueous environment. The major novelty of this work lies in combining (a) a formalism based on fundamental physical properties of the system and (b) the resulting possibility of describing the folding↔unfolding transitions quantitatively. The clear physical nature of the formalism opens the way to further applications in a large variety of systems and processes.

Elastomeric Proteins

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Publisher : Cambridge University Press
ISBN 13 : 1139438204
Total Pages : 409 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Elastomeric Proteins by : Peter R. Shewry

Download or read book Elastomeric Proteins written by Peter R. Shewry and published by Cambridge University Press. This book was released on 2010-02-04 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was originally published in 2002. Elastic proteins occur in a wide range of biological systems where they have evolved to fulfil precise biological roles. The best known include proteins in vertebrate muscles and connective tissues, such as titin, elastin and fibrillin, and spider silks. However, other examples include byssus and abductin from bivalve molluscs, resilin from arthropods and gluten from wheat. Interest in elastomeric proteins has been high for several reasons. Firstly, their biological and medical significance, particularly in human disease. Secondly, the unusual properties of proteins such as spider silks provide opportunities to develop materials. Thirdly, the development of scanning probe microscopy makes it possible to study structures and biomechanical properties of these proteins at the single molecule level. This book will be of value to anyone with an interest in the various aspects of elastomeric proteins.

Dynamics of Systems on the Nanoscale

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Publisher : Springer Nature
ISBN 13 : 3030992918
Total Pages : 554 pages
Book Rating : 4.0/5 (39 download)

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Book Synopsis Dynamics of Systems on the Nanoscale by : Ilia A. Solov'yov

Download or read book Dynamics of Systems on the Nanoscale written by Ilia A. Solov'yov and published by Springer Nature. This book was released on 2022-06-03 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the structure formation and dynamics of animate and inanimate matter on the nanometre scale. This is a new interdisciplinary field known as Meso-Bio-Nano (MBN) science that lies at the intersection of physics, chemistry, biology and material science. Special attention in the book is devoted to investigations of the structure, properties and dynamics of complex MBN systems by means of photonic, electronic, heavy particle and atomic collisions. This includes problems of fusion and fission, fragmentation, surfaces and interfaces, reactivity, nanoscale phase and morphological transitions, irradiation-driven transformations of complex molecular systems, collective electron excitations, radiation damage and biodamage, channeling phenomena and many more. Emphasis in the book is placed on the theoretical and computational physics research advances in these areas and related state-of-the-art experiments. Particular attention in the book is devoted to the utilization of advanced computational techniques and high-performance computing in studies of the dynamics of systems.

Permeability and Stability of Lipid Bilayers

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Publisher : CRC Press
ISBN 13 : 1351425382
Total Pages : 298 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Permeability and Stability of Lipid Bilayers by : E. Anibal Disalvo

Download or read book Permeability and Stability of Lipid Bilayers written by E. Anibal Disalvo and published by CRC Press. This book was released on 2017-12-14 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive and coherent picture of how molecules diffuse across a liquid that is, on average, only two molecules thick. It begins by characterizing bilayers structurally, using X-ray diffraction, and then mechanically by measuring elastic moduli and mechanisms of failure. Emphasis is placed on the stability and mechanical properties of plant membranes that are subject to very large osmotic and thermal stresses. Using this information, the transport of molecules of increasing complexity across bilayers is analyzed.

Peptide and Protein Drug Analysis

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Publisher : CRC Press
ISBN 13 : 9781420001334
Total Pages : 926 pages
Book Rating : 4.0/5 (13 download)

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Book Synopsis Peptide and Protein Drug Analysis by : Ronald Reid

Download or read book Peptide and Protein Drug Analysis written by Ronald Reid and published by CRC Press. This book was released on 1999-11-12 with total page 926 pages. Available in PDF, EPUB and Kindle. Book excerpt: Furthering efforts to simulate the potency and specificity exhibited by peptides and proteins in healthy cells, this remarkable reference supplies pharmaceutical scientists with a wealth of techniques for tapping the enormous therapeutic potential of these molecules-providing a solid basis of knowledge for new drug design. Provides a broad, comprehensive overview of peptides and proteins as mediators of cell movement, proliferation, differentiation, and communication. Written by more than 50 leading international authorities, Peptides and Protein Drug Analysis discusses strategies for dealing with the complexity of peptides and proteins in conformational flexibility and amino acid sequence variability analyzes drug formulations facilitated by solid-phase peptide synthesis and recombinant DNA technology examines chemical purity analysis by high-pressure chromatographic, capillary electrophoretic, gel electrophoretic, and isoelectric focusing methods highlights drug design elements derived from protein folding, bioinformatics, and computational chemistry demonstrates uses of unnatural mutagenesis and combinatorial chemistry explores mass spectrometry, protein sequence, and carbohydrate analysis illustrates bioassays and other new functional analysis methods surveys spectroscopic techniques such as ultraviolet, fluorescence, Fourier transform infrared, and nuclear magnetic resonance (NMR) addresses ways of distinguishing between levels of therapeutic and endogenous agents in cells reviews structural analysis tools such as ultracentrifugation and light, X-ray, and neutron scattering and more! Featuring over 3400 bibliographic citations and more than 500 tables, equations, and illustrations, Peptide and Protein Drug Analysis is a must-read resource for pharmacists; pharmacologists; analytical, organic, and pharmaceutical chemists; cell and molecular biologists; biochemists; and upper-level undergraduate and graduate students in these disciplines.

Multiscale Modeling of Complex Molecular Structure and Dynamics with MBN Explorer

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Publisher : Springer
ISBN 13 : 3319560875
Total Pages : 460 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Multiscale Modeling of Complex Molecular Structure and Dynamics with MBN Explorer by : Ilia A. Solov’yov

Download or read book Multiscale Modeling of Complex Molecular Structure and Dynamics with MBN Explorer written by Ilia A. Solov’yov and published by Springer. This book was released on 2017-05-16 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to MesoBioNano (MBN) Explorer – a multi-purpose software package designed to model molecular systems at various levels of size and complexity. In addition, it presents a specially designed multi-task toolkit and interface – the MBN Studio – which enables the set-up of input files, controls the simulations, and supports the subsequent visualization and analysis of the results obtained. The book subsequently provides a systematic description of the capabilities of this universal and powerful software package within the framework of computational molecular science, and guides readers through its applications in numerous areas of research in bio- and chemical physics and material science – ranging from the nano- to the mesoscale. MBN Explorer is particularly suited to computing the system’s energy, to optimizing molecular structure, and to exploring the various facets of molecular and random walk dynamics. The package allows the use of a broad variety of interatomic potentials and can, e.g., be configured to select any subset of a molecular system as rigid fragments, whenever a significant reduction in the number of dynamical degrees of freedom is required for computational practicalities. MBN Studio enables users to easily construct initial geometries for the molecular, liquid, crystalline, gaseous and hybrid systems that serve as input for the subsequent simulations of their physical and chemical properties using MBN Explorer. Despite its universality, the computational efficiency of MBN Explorer is comparable to that of other, more specialized software packages, making it a viable multi-purpose alternative for the computational modeling of complex molecular systems. A number of detailed case studies presented in the second part of this book demonstrate MBN Explorer’s usefulness and efficiency in the fields of atomic clusters and nanoparticles, biomolecular systems, nanostructured materials, composite materials and hybrid systems, crystals, liquids and gases, as well as in providing modeling support for novel and emerging technologies. Last but not least, with the release of the 3rd edition of MBN Explorer in spring 2017, a free trial version will be available from the MBN Research Center website (mbnresearch.com).

Molecular Biology of Protein Folding, Part A

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Publisher : Academic Press
ISBN 13 : 0080923380
Total Pages : 303 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Molecular Biology of Protein Folding, Part A by : P. Michael Conn

Download or read book Molecular Biology of Protein Folding, Part A written by P. Michael Conn and published by Academic Press. This book was released on 2008-12-19 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: The importance of protein folding has been recognized for many years. It is the underlying etiology in a large number of human diseases and it appears to be a novel method for cellular regulation of the expression of newly translated proteins. These volumes (Parts A & B) address this important topic. As a volume in Progress in Nucleic Acid Research and Molecular Biology, this book provides the latest information on the expanding research being conducted on protein folding. Follow the new editor-in-chief, P. Michael Conn, as he introduces this first thematic volume in the series – an in-depth aid to researchers who are looking for the best techniques and tools for understanding the complexities of protein folding Understand the advantages of protein folding over other therapeutic approaches and see how protein folding plays a critical role in the development of diseases such as Alzheimer’s and diabetes Decipher the rules of protein folding through compelling and timely reviews combined with chapters written by international authors in engineering, biochemistry, physics and computer science

Peptides, Polypeptides, and Proteins

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Publisher :
ISBN 13 :
Total Pages : 612 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis Peptides, Polypeptides, and Proteins by :

Download or read book Peptides, Polypeptides, and Proteins written by and published by . This book was released on 1983 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cumulated Index Medicus

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Publisher :
ISBN 13 :
Total Pages : 1258 pages
Book Rating : 4.:/5 (31 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 1974 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecules and Life

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Publisher : Springer Science & Business Media
ISBN 13 : 1461585945
Total Pages : 516 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Molecules and Life by : Mikhail V. Vol kenshtein

Download or read book Molecules and Life written by Mikhail V. Vol kenshtein and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: acids. The achievements of molecular biology testify to the success of material science in a realm which, until recently, appeared totally enig matic and mysterious. Further scientific developments should bring to mankind vast developments both in theoretical knowledge and in practical applications, namely, in agriculture, medicine, and technology. The purpose of this book is to explain molecular biophysics to all who might wish to learn about it, to biologists, to physicists, to chemists. This book contains descriptive sections, as well as sections devoted to rigorous mathematical treatment of a number of problems, some of which have been studied by the author and his collaborators. These sections may be omitted during a first reading. Each chapter has a selected bibliography. This book is far from an exhaustive treatise on molecular biophysics. It deals principally with questions related to the structures and functions of proteins and nucleic acids. M. V. Vol'kenshtein Leningrad, September, 1964 CONTENTS Chapter 1 Physics and Biology. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Physics and Life. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Molecular Physics. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Molecular Biophysics ................................... 9 Thermodynamics and Biology. . . . . . . . . . . . . . . . . . . . . 12 . . . . . . . Information Theory. . . . . . . . . . . . . . . . . . . . . . . . . . . 19 . . . . . . . . . . Chapter 2 Cells, Viruses, and Heredity. . . . . . . . . . . . . . . . . . . . . . . . 27 . . . . . . . . The Living Cell. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 . . . . . . . . . . . Cell Division. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 37 . . . . . . . . . . . . Viruses and Bacteriophages ........... . . . . . . . . . . . . . . . 44 . . . . Basic Laws of Genetics . . . . . . . . . . . . . . . . . . . . . . . . . 50 . . . . . . . . . Mutations and Mutability ........ , ................. " . . . . 60 Genetics of Bacteria and Phages " . . . . . . . . . . . . . . . . . . 66 . . . . . . Chapter 3 Biological Molecules. . . . . . . . . . . . . . . . . . . . . . . . . . . . 79 . . . . . . . . . . Amino Acids and Proteins . . . . . . . . . . . . . . . . . . . . . . . 79 . . . . . . . . Asymmetry of Biological Molecules ....................... 87 Primary Structure of Proteins ............................ 94 Nucleic Acids . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101 . . . . . . . . . . . . Some Biochemical Processes in the Cell. . . . . . . . . . . . . . . . 109 . . . . Chapter 4 Physics of Macromolecules. . . . . . . . . . . . . . . . . . . . . . . . 123 . . . . . . . . .

Amino-acid, Peptide & Protein Abstracts

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Publisher :
ISBN 13 :
Total Pages : 1016 pages
Book Rating : 4.E/5 ( download)

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Book Synopsis Amino-acid, Peptide & Protein Abstracts by :

Download or read book Amino-acid, Peptide & Protein Abstracts written by and published by . This book was released on 1978 with total page 1016 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Phase Transitions - 1973

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Publisher : Elsevier
ISBN 13 : 1483158624
Total Pages : 455 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Phase Transitions - 1973 by : H. K. Henisch

Download or read book Phase Transitions - 1973 written by H. K. Henisch and published by Elsevier. This book was released on 2013-10-22 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phase Transitions - 1973 is a collection of the proceedings of the Conference on Phase Transitions and Their Applications in Materials Science, held at Pennsylvania State University, Pennsylvania, on May 23-25, 1973. The papers explore some of the practical applications of solid-state phase transitions and consequent precursor property modifications in metals, ceramics, glasses, polymers, macromolecules, and biological systems. Comprised of 41 chapters, this book begins with an introduction to applications of phase transitions in materials science, followed by a syncretist classification of phase transitions. Subsequent chapters discuss phase transitions in materials such as liquid crystals, PLZT ceramics, disordered semiconductors, silver iodide single crystals, and aluminum alloys. The structural aspects of phase transitions are also considered, along with the statistical mechanics of glass transition; thermal expansion and phase transitions in silica; phase transformation of Fe-Mn alloys induced by shock loading; and order-disorder transitions in biopolymers. This monograph will be of interest to physicists and materials scientists.

Mathematical Physics - Proceedings Of The Xi Regional Conference

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Publisher : World Scientific
ISBN 13 : 9814480371
Total Pages : 211 pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Mathematical Physics - Proceedings Of The Xi Regional Conference by : Sohrab Rahvar

Download or read book Mathematical Physics - Proceedings Of The Xi Regional Conference written by Sohrab Rahvar and published by World Scientific. This book was released on 2005-05-09 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since 1984, a series of regional conferences on mathematical physics has been organized by physicists from Iran, Pakistan and Turkey to promote the research in mathematical and theoretical physics in the region. This volume, which derives from the XI Regional Conference on Mathematical Physics, comprises 8 review and 44 research articles on the most significant topics in mathematical and theoretical physics such as astrophysics and cosmology, conformal field theory, high energy physics, general relativity and plasma physics.The review articles are comprehensive and self-contained and report on the most important developments in the corresponding subjects. Each review article provides a complete list of references, which is especially useful for graduate students who are just starting their research activities; even ambitious undergraduates in physics can use these review papers as useful background material to go further into the subject and explore the research literature. They are contributed by prominent senior scientists: M Moniez (Laboratoire de l'Accelerateur Lineare, France) and V Sahni (Inter-University Centre for Astronomy and Astrophysics (IUCAA), India) in Astrophysics and Cosmology, W Nahm (Dublin Institute for Advanced Studies (DIAS), Ireland) in Conformal Field Theory, J Lukierski (University of Wroclaw, Poland) in Mathematical Physics, Riazuddin and Fayyazuddin (Quaid-i-Azam University, Pakistan) in High Energy Physics, N Dadhich (Inter-University Centre for Astronomy and Astrophysics (IUCAA), India) and A Qadir (National University of Science and Technology, Pakistan) in General Relativity, and N Tsintsadze (Tbilisi State University, Georgia) in Plasma Physics.

Protein Folding Dynamics

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Publisher :
ISBN 13 :
Total Pages : 350 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis Protein Folding Dynamics by : Marcos Rubén Betancourt

Download or read book Protein Folding Dynamics written by Marcos Rubén Betancourt and published by . This book was released on 1995 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fractal Symmetry of Protein Interior

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Publisher : Springer Science & Business Media
ISBN 13 : 3034806515
Total Pages : 92 pages
Book Rating : 4.0/5 (348 download)

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Book Synopsis Fractal Symmetry of Protein Interior by : Anirban Banerji

Download or read book Fractal Symmetry of Protein Interior written by Anirban Banerji and published by Springer Science & Business Media. This book was released on 2014-07-08 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: The essential question that fractal dimensions attempt to answer is about the scales in Nature. For a system as non-idealistic and complex as a protein, studying scale-invariance becomes particularly important. Fractal Symmetry of Protein Interior investigates the diverse facets of the various scales at which we describe protein biophysical and biochemical phenomena. Following a thorough introduction to fractal dimensions, fractal-dimension-based approaches, that have been employed to study protein interior biophysical properties, are described. The focus is on the question “which scales are scale-invariant?” Investigations related to scaling of biophysical and biochemical behaviors may one day help us to formulate a fundamental theory about protein biophysics; which, in turn, may help us to understand fundamental principles of proteins.

Computer Studies of Phase Transitions and Critical Phenomena

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Publisher : Springer Science & Business Media
ISBN 13 : 3642697097
Total Pages : 211 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Computer Studies of Phase Transitions and Critical Phenomena by : Ole G. University of Southern Denmark

Download or read book Computer Studies of Phase Transitions and Critical Phenomena written by Ole G. University of Southern Denmark and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on research carried out by the author in close collabora tion with a number of colleagues. In particular, I wish to thank Per Bak, A. John Berlinsky, Hans C. Fogedby, Barry Frank, S. 1. Knak Jensen, David Mukamel, David Pink, and Martin Zuckermann for fruitful and extremely stimulating cooperation. It is a pleasure for me to note that active interaction with most of these colleagues is still continuing. The work has been performed at several different institutions, notably the Department of Chemistry, Aarhus University, Denmark, and the Depart ment of Physics, University of British Columb~a, Canada. I wish to thank the Department of Chemistry at Aarhus University for providing me with splen did research facilities over the years. From May 1980 to August 1981, I visited the Department of Physics at the University of British Columbia and I would like to express my sincere gratitude to members ofthe department for provi ding me with excellent working conditions. My special thanks are due to Professor Myer Bloom who introduced me to the field of phase transitions in biological membranes and in whose biomembrane group I found an extre mely stimulating scientific atmosphere happily married with a most agreeable social climate. During the last two years when a major part ofthis work was carried out, I was supported by AlS De Danske Spritfabrikker through their Jubilreumsle gat of 1981. Their support is gratefully acknowledged.

U.S. Government Research Reports

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Publisher :
ISBN 13 :
Total Pages : 172 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis U.S. Government Research Reports by :

Download or read book U.S. Government Research Reports written by and published by . This book was released on 1963 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: