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The Use Of Supported Palladium Catalysts And Other Clean Chemical Technologies In The Synthesis Of Drug Molecules
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Book Synopsis The Use of Supported Palladium Catalysts and Other Clean Chemical Technologies in the Synthesis of Drug Molecules by :
Download or read book The Use of Supported Palladium Catalysts and Other Clean Chemical Technologies in the Synthesis of Drug Molecules written by and published by . This book was released on 2005 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Use of Clean Chemical Technologies in the Synthesis of Drug Molecules by : Mark Gronnow
Download or read book Use of Clean Chemical Technologies in the Synthesis of Drug Molecules written by Mark Gronnow and published by LAP Lambert Academic Publishing. This book was released on 2011-02 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this work was to apply green chemistry techniques and principles, to the synthesis of typical pharmaceutical intermediates and to bridge the "gap" between academia and industry. Two synthetic routes have been the focus for study; synthesis of the drug, salbutamol and secondly a generic synthesis which combines many typical reactions important to the pharmaceutical industry, such as a Suzuki coupling, reduction, bromination and alkylation. These reactions provide opportunities to demonstrate clean alternatives to transformations of complex molecules which are regularly carried out by the pharmaceutical industry. Suzuki C-C bond forming reactions were studied under microwave activation utilising immobilised palladium for the first time, and with significant success. A novel, renewable, high surface area catalyst support has been prepared and used to develop a catalyst which is highly active in Suzuki, Heck and Sonogashira coupling reactions. A novel green chemistry metric has been developed. By measuring the electricity required for reactions using different methods of synthesis and different products can be compared in terms of energy utilisation.
Book Synopsis Green Techniques for Organic Synthesis and Medicinal Chemistry by : Wei Zhang
Download or read book Green Techniques for Organic Synthesis and Medicinal Chemistry written by Wei Zhang and published by John Wiley & Sons. This book was released on 2018-01-18 with total page 1127 pages. Available in PDF, EPUB and Kindle. Book excerpt: An updated overview of the rapidly developing field of green techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.
Book Synopsis Palladium Reagents and Catalysts by : Jiro Tsuji
Download or read book Palladium Reagents and Catalysts written by Jiro Tsuji and published by John Wiley & Sons. This book was released on 2006-02-08 with total page 670 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jiro Tsuji, one of the pioneers in this field of organic synthesis, provides synthetic organic chemists with a remarkable overview of the many applications of organopalladium chemistry. Tsuji discusses the recent developments in the field as well as the explosive growth over the last five years. Highlighting the most recent discoveries in this rapidly expanding field, the book; Focuses on new aspects of organopalladium chemistry, putting emphasis on synthetic applications Investigates the new perspectives on the synthetic uses of contemporary organopalladium chemistry This volume, together with Innovations in Organic Synthesis, Tsuji's previous title, provides complete coverage of over 40 years of organopalladium chemistry. Palladium Reagents and Catalysts: New Perspectives for the 21st Century is an essential reference source and companion for students, and both industrial and academic research chemists working in organic synthesis, particularly on synthesis of natural products and medicinal compounds. Those studying development of new synthetic methodology and organometallic chemistry will also find this book valuable.
Book Synopsis Palladium-catalyzed C-N Cross-coupling Reactions Toward the Synthesis of Drug-like Molecules by : Camille Z. McAvoy
Download or read book Palladium-catalyzed C-N Cross-coupling Reactions Toward the Synthesis of Drug-like Molecules written by Camille Z. McAvoy and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of methodologies for C-N bond formation reactions is an important scientific challenge because of many academic and industrial applications. This work will focus particularly on palladium-catalyzed cross-couplings of amine-containing compounds with aryl halides. The scope of the BrettPhos precatalyst for the cross-coupling of ortho-substituted aryl iodides with amides is studied using substrates with a variety of functional groups. Due to potential metal-chelating issues with some of the substrates used in this study, a proposed ligand synthesis is discussed in which one of the methoxy groups of BrettPhos is replaced with a morpholine capable of occupying palladium's open coordination site during its catalytic cycle. A final C-N bond formation study focuses on the cross-coupling of aryl halides with amidine salts. For this cross-coupling, a methodology has been developed that can be applied to various electron-rich, electron-poor, and electron-neutral substrates. Furthermore, the products of this cross-coupling can be used for a subsequent electrocyclization through a reaction with aldehyde, demonstrating that a relatively simple two-pot methodology can be used to make relatively complex substrates with pharmaceutical applications. Both amides and amidines are common moieties in drug-like molecules because of the various biological activities of these functional groups. Potential medicinal applications of the developed cross-coupling of amidine salts with aryl halides methodology are described. Thus, methodologies for various palladium-catalyzed, C-N cross-couplings as well as a potential ligand synthesis to be used for palladium catalysis are herein discussed.
Book Synopsis The Synthesis of Solid Supported Palladium Nanoparticles by : Kendra W. Brinkley
Download or read book The Synthesis of Solid Supported Palladium Nanoparticles written by Kendra W. Brinkley and published by . This book was released on 2015 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalysis is one of the pillars of the chemical industry. While the use of catalyst is typically recognized in the automobile industry, their impact is more widespread as; catalysts are used in the synthesis of 80% of the US commercial chemicals. Despite the improved selectivity provided by catalyst, process inefficiencies still threaten the sustainability of a number of synthesis methods, especially in the pharmaceutical industry. Recyclable solid supported catalysts offer a unique opportunity to address these inefficiencies. Such systems coupled with continuous synthesis techniques, have the potential to significantly reduce the waste to desired product ratio (E-factor) of the production techniques. This research focuses developing sustainable processes to synthesize organic molecules by using continuous synthesis methods. In doing so, solid supported metal catalyst systems were identified, developed, and implemented to assist in the formation of carbon-carbon bonds. Newly developed systems, which utilized metal nanoparticles, showed reactivity and recyclability, comparable to commercially available catalyst. Nanoparticles are emerging as useful materials in a wide variety of applications including catalysis. These applications include pharmaceutical processes by which complex and useful organic molecules can be prepared. As such, an effective and scalable synthesis method is required for the preparation of nanoparticle catalysts with significant control of the particle size, uniform dispersion, and even distribution of nanoparticles when deposited on the surface of a solid support. This project describes the production of palladium nanoparticles on a variety of solid supports and the evaluation of these nanoparticles for cross coupling reactions. This report highlights novel synthesis techniques used in the formation of palladium nanoparticles using traditional batch reactions. The procedures developed for the batch formation of palladium nanoparticles on different solid supports, such as graphene and carbon nanotubes, are initially described. The major drawbacks of these methods are discussed, including limited scalability, variation of nanoparticle characteristics from batch to batch, and technical challenges associated with efficient heating of samples. Furthermore, the necessary conditions and critical parameters to convert the batch synthesis of solid supported palladium nanoparticles to a continuous flow process are presented. This strategy not only alleviates the challenges associated with the robust preparation of the material and the limitations of scalability, but also showcases a new continuous reactor capable of efficient and direct heating of the reaction mixture under microwave irradiation. This strategy was further used in the synthesis of zinc oxide nanoparticles. Particles synthesized using this strategy as well as traditional synthesis methods, were evaluated in the context industrially relevant applications.
Book Synopsis Palladium Assisted Synthesis of Heterocycles by : Navjeet Kaur
Download or read book Palladium Assisted Synthesis of Heterocycles written by Navjeet Kaur and published by CRC Press. This book was released on 2019-05-01 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of the recent applications of palladium catalysts in organic synthesis. The book demonstrates that it is a highly dynamic research field. This methodology has emerged as a powerful tool for the efficient and chemoselective synthesis of heterocyclic molecules. In the past few years, several strategies have been pointed out to pursue more efficient, sustainable, and environment friendly chemical processes. Among those strategies, catalysis and the design of new processes that avoid the use of toxic reagents have been the focus of intense research.
Book Synopsis Palladium in Organic Synthesis by : Jiro Tsuji
Download or read book Palladium in Organic Synthesis written by Jiro Tsuji and published by Springer Science & Business Media. This book was released on 2005-07-06 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: with contributions by numerous experts
Book Synopsis Supported Palladium Catalysts In Organic Synthesis by : Arjun Kumbhar
Download or read book Supported Palladium Catalysts In Organic Synthesis written by Arjun Kumbhar and published by LAP Lambert Academic Publishing. This book was released on 2013 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research in catalysis particularly cross coupling reactions catalyzed by transition metals is a major field in applied sciences and involves many areas of chemistry. In the last few years, there is upsurge in the area of heterogeneous catalysis for chemical industries. Transition metal chemistry (particularly Pd based) complements traditional functional-group-based chemistry and significantly broadens the scope of organic chemistry. For the past 20 years, numerous research groups have developed new metal complexes and ligands, expanding the scope of these transformations. The importance of these transformations and their impact on synthetic chemistry have been recently recognized by awarding Nobel Prize in Chemistry for the year 2010 to Professor Heck, Negishi and Suzuki jointly.
Book Synopsis Handbook of Organopalladium Chemistry for Organic Synthesis by : Ei-ichi Negishi
Download or read book Handbook of Organopalladium Chemistry for Organic Synthesis written by Ei-ichi Negishi and published by John Wiley & Sons. This book was released on 2003-11-24 with total page 1697 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organized to provide maximum utility to the bench synthetic chemist. The editor is well-known for his work in exploring, developing, and applying organopalladium chemistry. Contributors include over 24 world authorities in the field.
Book Synopsis Organic Synthesis with Palladium Compounds by : Jiro Tsuji
Download or read book Organic Synthesis with Palladium Compounds written by Jiro Tsuji and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Around 30 years ago the transition metal chemistry received great impulses. In the focus have been reactions of nickel and cobalt and herein especially their carbonyls. Also industrial processes have been developed. When the technical oxidation of ethylene with palladium chloride had been discovered, and a great number oflaboratory reactions, many groups have turned towards this subject. Apart from two important industrial processes - acetaldehyde and vinylacetate from ethylene - a great number of conversions and catalytic reactions with palladium compounds have been researched. Their mechanisms have been cleared up and have con tributed to a better understanding of the complex chemistry of palladium. Last but not least these reactions have also served for more understanding of organic transition metal compounds and catalyses in general. Numerous conventional reactions appear today in a different light. The effects of co-
Book Synopsis Synthesis, Immobilization Strategies, and Mechanistic Analysis of Surface-supported Molecular Palladium Cross-coupling Catalysts for Single-molecule Fluorescence Spectroscopy by : Angela Marquard
Download or read book Synthesis, Immobilization Strategies, and Mechanistic Analysis of Surface-supported Molecular Palladium Cross-coupling Catalysts for Single-molecule Fluorescence Spectroscopy written by Angela Marquard and published by . This book was released on 2017 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Single-molecule fluorescence spectroscopy is a compelling technique for studying the dynamics of catalytic reactions because heterogeneity in catalyst populations can be directly observed. Understanding the nature of diversity in catalyst behavior will lead to the design of better, more efficient catalysts. Synthetic challenges emerge when developing chemical systems for single-molecule spectroscopy techniques, because the molecules need to be fluorescently labeled and anchored to a surface for long-term imaging. A reliable attachment to the surface is critical for successful single-molecule spectroscopy investigations. Robust surface linkages play an important role in the stability and recyclability of surface-supported molecular catalysts as well. This thesis focuses on the design and synthesis of suitable fluorescent chemical systems for single-molecule fluorescence spectroscopy investigations of catalyst transformations and highlights the challenges related to developing and implementing surface attachment strategies for surface-supported molecular catalysts. A fluorescent Pd-PEPPSI precatalyst complex is designed and synthesized for single-molecule fluorescence spectroscopy experiments, and the mechanism of catalyst initiation is examined using both bulk NMR and single-molecule fluorescence spectroscopy. Various surface-attachment strategies are investigated for the immobilization of molecular Pd-PEPPSI complexes onto both polymers and metal oxides. Multiple characterization techniques are employed to analyze the nature of the surface linkage chemistries and gain insight into the stability and degradation mechanisms of surface-supported molecular palladium catalysts.
Book Synopsis Solid-Phase Organic Syntheses, Volume 2 by : Peter J. H. Scott
Download or read book Solid-Phase Organic Syntheses, Volume 2 written by Peter J. H. Scott and published by John Wiley & Sons. This book was released on 2012-07-02 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Integrates solid-phase organic synthesis with palladium chemistry The Wiley Series on Solid-Phase Organic Syntheses keeps researchers current with major accomplishments in solid-phase organic synthesis, providing full experimental details. Following the validated, tested, and proven experimental procedures, readers can easily perform a broad range of complex syntheses needed for their own experiments and industrial applications. The series is conveniently organized into themed volumes according to the specific type of synthesis. This second volume in the series focuses on palladium chemistry in solid-phase synthesis, exploring palladium catalysts and reactions, procedures for preparation and utilization, ligands, and linker reactions. The first part of the volume offers a comprehensive overview of the field. Next, the chapters are organized into three parts: Part Two: Palladium-Mediated Solid-Phase Organic Syntheses Part Three: Immobilized Catalysts and Ligands Part Four: Palladium-Mediated Multifunctional Cleavage Each chapter is written by one or more leading international experts in palladium chemistry. Their contributions reflect a thorough examination and review of the current literature as well as their own first-hand laboratory experience. References at the end of each chapter serve as a gateway to the field's literature. The introduction of palladium-mediated, cross-coupling reactions more than thirty years ago revolutionized the science of carbon-carbon bond formation. It has now become a cornerstone of today's synthetic organic chemistry laboratory. With this volume, researchers in organic and medicinal chemistry have access to a single resource that explains the fundamentals of palladium chemistry in solid-phase synthesis and sets forth clear, step-by-step instructions for conducting their own syntheses.
Book Synopsis Palladium Reagents and Catalysts by : Jiro Tsuji
Download or read book Palladium Reagents and Catalysts written by Jiro Tsuji and published by . This book was released on 1995 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic chemistry of organopalladium compounds; Classification of the reactions involving Pd(II) compounds and Pd(O) complexes.
Book Synopsis The Synthesis of Carbon Supported Palladium Catalysts by Strong Electrostatic Adsorption by : Erik Kratzer
Download or read book The Synthesis of Carbon Supported Palladium Catalysts by Strong Electrostatic Adsorption written by Erik Kratzer and published by . This book was released on 2006 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles by : Hyung Yoon
Download or read book Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles written by Hyung Yoon and published by Springer Nature. This book was released on 2020-09-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents Pd- and Ni-catalyzed transformations generating functionalized heterocycles. Transition metal catalysis is at the forefront of synthetic organic chemistry since it offers new and powerful methods to forge carbon–carbon bonds in high atom- and step-economy. In Chapter 1, the author describes a Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, known as carboiodination. In the context of the Pd-catalyzed variant, the chapter explores the production of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It then discusses Ni-catalyzed reactions to generate oxindoles and an enantioselective variant employing a dual ligand system. Chapter 2 introduces readers to a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation to synthesize alkyl nitriles, a method that generates high yields of borylated chromans as a single diastereomer, and highlights its synthetic utility. Lastly, Chapter 3 presents a Pd-catalyzed domino process harnessing carbopalladation, C–H activation and π-system insertion (benzynes and alkynes) to generate spirocycles. It also describes the mechanistic studies performed on these reactions.
Book Synopsis Sustainable Synthesis of Pharmaceuticals by : Mariette M Pereira
Download or read book Sustainable Synthesis of Pharmaceuticals written by Mariette M Pereira and published by Royal Society of Chemistry. This book was released on 2018-03-26 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a growing interest in the development of sustainable processes for the synthesis of pharmaceuticals and this book bridges the divide between industrial examples and the fundamental chemistry. It explains the basic principles of using transition metal catalysis with several green approaches for the synthesis of pharmaceuticals. The topic is an important one for green chemistry and the chapters in this book on hydroformylation, green oxidation and olefin metathesis will also be of interest to both medicinal and organic chemists. Written by leading experts in the field, it provides a valuable and easy tool for scientists and industrialists who require information regarding this topic.
