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The Use Of Fish Physiology Literature For Predicting Fish Acute Toxicity Syndromes
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Book Synopsis The Use of Fish Physiology Literature for Predicting Fish Acute Toxicity Syndromes by : SP. Bradbury
Download or read book The Use of Fish Physiology Literature for Predicting Fish Acute Toxicity Syndromes written by SP. Bradbury and published by . This book was released on 1991 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: We investigated the efficacy of discriminating fish acute toxicity syndromes (FATS) on the basis of literature sources of fish physiological responses exposed to four xenobiotic chemicals. The following FATS were included in a discriminant function model: nonpolar narcosis, acetylcholinesterase (AChE) inhibition, oxidative phosphorylation uncoupling, and respiratory membrane irritation. Two xenobiotics, chlorine and zinc sulfate, were suspected of eliciting a toxic syndrome already known to the model, while the other two, rotenone and cyanide, were presumed to elicit a response syndrome unknown to the model. The model correctly discriminated the toxic responses for fish exposed to chlorine and zinc sulfate into the respiratory irritant syndrome, while classifications of fish exposed to rotenone and cyanide were conflicting and suggested a new FATS would be required. We then identified a respiratory blocker syndrome for fish exposed to rotenone and cyanide, and the model discriminated well between these five FATS groups. Moreover, to evaluate disparities between the exposure system used to develop the four original FATS model and the literature values, we tested rotenone with our exposure system and experimental design. Three of four rotenone-exposed fish were discriminated from the original four FATS, yet results observed were slightly different for rotenone-exposed fish in comparison with rotenone values from the literature. The reasons for these discrepancies were due to the lack of inclusion of several important discriminating variables from literature sources, differences in exposure, and because different species were used in the rotenone exposures. Yet, despite these differences these data suggest that literature sources can be used in a quantitative fashion to improve our understanding of mechanisms associated with toxicity.
Book Synopsis Aquatic Toxicology and Risk Assessment by : Monte A. Mayes
Download or read book Aquatic Toxicology and Risk Assessment written by Monte A. Mayes and published by ASTM International. This book was released on 1991 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proceedings of the 14th ASTM Symposium on [title], held in San Francisco, April 1990, comprise 26 peer-reviewed papers in the areas of: the Animal Welfare Act, biomarkers, risk assessment, toxicant reduction strategies, carcinogenesis, bioconcentration, toxicity evaluation, organ system toxicolo
Book Synopsis Fundamentals Of Aquatic Toxicology by : Gary M. Rand
Download or read book Fundamentals Of Aquatic Toxicology written by Gary M. Rand and published by CRC Press. This book was released on 2020-08-06 with total page 1152 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is divided into three parts. The first part describes basic toxicological concepts and methodologies used in aquatic toxicity testing, including the philosophies underlying testing strategies now required to meet and support regulatory standards. The second part of the book discusses various factors that affect transport, transformation, ultimate distribution, and accumulation of chemicals in the aquatic environment, along with the use of modelling to predict fate.; The final section of the book reviews types of effects or endpoints evaluated in field studies and the use of structure-activity relationships in aquatic toxicology to predict biological activity and physio-chemical properties of a chemical. This section also contains an extensive background of environmental legislation in the USA and within the European Community, and an introduction to hazard/risk assessment with case studies.
Book Synopsis Environmental Health Perspectives by :
Download or read book Environmental Health Perspectives written by and published by . This book was released on 1986 with total page 1130 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Current Environmental Engineering Summaries by : Engineering Information, Inc
Download or read book Current Environmental Engineering Summaries written by Engineering Information, Inc and published by . This book was released on 1993 with total page 1136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Environmental Toxicology and Chemistry by :
Download or read book Environmental Toxicology and Chemistry written by and published by . This book was released on 2003 with total page 928 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pollution Abstracts written by and published by . This book was released on 1997 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Water Pollution and Fish Physiology by : Alan G. Heath
Download or read book Water Pollution and Fish Physiology written by Alan G. Heath and published by CRC Press. This book was released on 2018-02-06 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise synthesis of how toxic chemical pollutants affect physiological processes in teleost fish. This Second Edition of the well-received Water Pollution and Fish Physiology has been completely updated, and chapters have been added on immunology and acid toxicity. The emphasis, as in the first edition, is on understanding mechanisms of sublethal effects on fish and their responses to these environmental stressors. The first chapter covers the basic principles involved in understanding how fish respond, in general, to environmental alterations. Each subsequent chapter is devoted to a particular organ system or physiological function and begins with a short overview of normal physiology of that system/function. This is followed by a review of how various toxic chemicals may alter normal conditions in fish. Chapters covering environmental hypoxia, behavior, cellular enzymes, and acid toxicity are also included. The book closes with a discussion on the practical application of physiological and biochemical measurements of fish in water pollution control in research and regulatory settings.
Book Synopsis Methods for Measuring the Acute Toxicity of Effluents and Receiving Waters to Freshwater and Marine Organisms by :
Download or read book Methods for Measuring the Acute Toxicity of Effluents and Receiving Waters to Freshwater and Marine Organisms written by and published by DIANE Publishing. This book was released on 2002 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Engineering Index Annual written by and published by . This book was released on 1992 with total page 2264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since its creation in 1884, Engineering Index has covered virtually every major engineering innovation from around the world. It serves as the historical record of virtually every major engineering innovation of the 20th century. Recent content is a vital resource for current awareness, new production information, technological forecasting and competitive intelligence. The world?s most comprehensive interdisciplinary engineering database, Engineering Index contains over 10.7 million records. Each year, over 500,000 new abstracts are added from over 5,000 scholarly journals, trade magazines, and conference proceedings. Coverage spans over 175 engineering disciplines from over 80 countries. Updated weekly.
Download or read book The Zoological Record written by and published by . This book was released on with total page 1308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Drug-like Properties: Concepts, Structure Design and Methods by : Li Di
Download or read book Drug-like Properties: Concepts, Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint
Book Synopsis Selected Water Resources Abstracts by :
Download or read book Selected Water Resources Abstracts written by and published by . This book was released on 1990 with total page 710 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Toxicity Testing in the 21st Century by : National Research Council
Download or read book Toxicity Testing in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2007-10-05 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.
Book Synopsis Short-term Methods for Estimating the Chronic Toxicity of Effluents and Receiving Waters to Freshwater Organisms by :
Download or read book Short-term Methods for Estimating the Chronic Toxicity of Effluents and Receiving Waters to Freshwater Organisms written by and published by . This book was released on 1994 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chemometrics and Cheminformatics in Aquatic Toxicology by : Kunal Roy
Download or read book Chemometrics and Cheminformatics in Aquatic Toxicology written by Kunal Roy and published by John Wiley & Sons. This book was released on 2022-01-06 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: CHEMOMETRICS AND CHEMINFORMATICS IN AQUATIC TOXICOLOGY Explore chemometric and cheminformatic techniques and tools in aquatic toxicology Chemometrics and Cheminformatics in Aquatic Toxicology delivers an exploration of the existing and emerging problems of contamination of the aquatic environment through various metal and organic pollutants, including industrial chemicals, pharmaceuticals, cosmetics, biocides, nanomaterials, pesticides, surfactants, dyes, and more. The book discusses different chemometric and cheminformatic tools for non-experts and their application to the analysis and modeling of toxicity data of chemicals to various aquatic organisms. You’ll learn about a variety of aquatic toxicity databases and chemometric software tools and webservers as well as practical examples of model development, including illustrations. You’ll also find case studies and literature reports to round out your understanding of the subject. Finally, you’ll learn about tools and protocols including machine learning, data mining, and QSAR and ligand-based chemical design methods. Readers will also benefit from the inclusion of: A thorough introduction to chemometric and cheminformatic tools and techniques, including machine learning and data mining An exploration of aquatic toxicity databases, chemometric software tools, and webservers Practical examples and case studies to highlight and illustrate the concepts contained within the book A concise treatment of chemometric and cheminformatic tools and their application to the analysis and modeling of toxicity data Perfect for researchers and students in chemistry and the environmental and pharmaceutical sciences, Chemometrics and Cheminformatics in Aquatic Toxicology will also earn a place in the libraries of professionals in the chemical industry and regulators whose work involves chemometrics.
Book Synopsis Handbook of Acute Toxicity of Chemicals to Fish and Aquatic Invertebrates by : W. Waynon Johnson
Download or read book Handbook of Acute Toxicity of Chemicals to Fish and Aquatic Invertebrates written by W. Waynon Johnson and published by . This book was released on 1980 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt:
