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The Total Synthesis Of Waihoensene And Studies Toward The Syntheses Of Vallesamidine And Lyconadin C
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Book Synopsis The Total Synthesis of Waihoensene and Studies Toward the Syntheses of Vallesamidine and Lyconadin C by : Lisa-Catherine Rosenbaum
Download or read book The Total Synthesis of Waihoensene and Studies Toward the Syntheses of Vallesamidine and Lyconadin C written by Lisa-Catherine Rosenbaum and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Pauson-Khand Reaction by : Ramon Rios Torres
Download or read book The Pauson-Khand Reaction written by Ramon Rios Torres and published by John Wiley & Sons. This book was released on 2012-03-01 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Pauson-Khand reaction is an important reaction in the field of organic chemistry. It involves the transition-metal catalysed cycloaddition of an alkyne, an alkene and carbon monoxide, to produce cyclopentenones. The importance of this reaction originates from its high value in transforming simple components into the synthetically useful cyclopentenone unit, in which a high degree of molecular complexity can be achieved in a single step, with impressive stereochemical and regiochemical control. The Pauson-Khand Reaction investigates the nature and many variations of this reaction. Topics covered include: the mechanisms of Pauson‐Khand-type reactions non chiral intramolecular and intermolecular versions of Pauson‐Khand reactions asymmetric Pauson‐Khand reaction using chiral auxiliaries the enantioselective Pauson‐Khand reaction Pauson‐Khand reactions catalysed by metals other than cobalt unconventional Pauson‐Khand reactions the Pauson‐Khand reaction in total synthesis Presenting a comprehensive overview of this fundamental reaction, The Pauson-Khand Reaction will find a place on the bookshelves of any organic or organometallic chemist.
Book Synopsis Part A: Studies directed toward the syntheses of the cores of Kedarcidin, Maduropeptin and C-1027 by : Rich Garrett Carter
Download or read book Part A: Studies directed toward the syntheses of the cores of Kedarcidin, Maduropeptin and C-1027 written by Rich Garrett Carter and published by . This book was released on 1997 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Part I. Total Synthesis of (-)-ratjadone Part II. Studies Toward the Total Synthesis of Zoanthenol by : David C. Ihle
Download or read book Part I. Total Synthesis of (-)-ratjadone Part II. Studies Toward the Total Synthesis of Zoanthenol written by David C. Ihle and published by . This book was released on 2003 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward The Total Synthesis of Manzamine A by : Brian B. Filippini
Download or read book Studies Toward The Total Synthesis of Manzamine A written by Brian B. Filippini and published by . This book was released on 1995 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Model Studies Towards the Total Synthesis of Lyconadin A Via an Acyl Radical Cascade Reaction by : Koudi Zhu
Download or read book Model Studies Towards the Total Synthesis of Lyconadin A Via an Acyl Radical Cascade Reaction written by Koudi Zhu and published by . This book was released on 2006 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lyconadin A is an alkaloid possessing a unique structure and antitumor activity. The total synthesis of Lyconadin A was proposed via an acyl radical cascade reaction. To investigate the possibility and stereoselectivity of the cascade cyclization, phenyl selenoester 16 was chosen as a model substrate to study the 7-exo-5-exo radical cyclization. A synthetic route to phenyl selenoester 16 was developed. The 7-exo-5-exo radical cyclization was found to occur with a high yield and excellent stereoselectivty. Attempts were also tried to synthesize another radical precursor 14 albeit with less success. A synthetic pathway to the synthesis of 14 as well as its potential use in the context of the synthesis of Lyconadin A was proposed.
Book Synopsis Studies Toward the Toward the Total Synthesis of the Alkaloids Gelsedine and Manzamine A by : Scott A. Ballentine
Download or read book Studies Toward the Toward the Total Synthesis of the Alkaloids Gelsedine and Manzamine A written by Scott A. Ballentine and published by . This book was released on 2000 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Towards the Total Synthesis of Samaderine C and Related Analogues by : David Burns
Download or read book Studies Towards the Total Synthesis of Samaderine C and Related Analogues written by David Burns and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of (±) and (+)-Lyconadin A and Mechanistic Studies of Oxidative C-N Bond Formation by : Scott P. West
Download or read book Total Synthesis of (±) and (+)-Lyconadin A and Mechanistic Studies of Oxidative C-N Bond Formation written by Scott P. West and published by . This book was released on 2010 with total page 490 pages. Available in PDF, EPUB and Kindle. Book excerpt: An overview of the Lycopodium alkaloids is presented covering their isolation, structural classification and biosynthesis. The isolation, biological activity and biosynthesis of the miscellaneous group of the Lycopodium alkaloids are discussed in detail. Synthetic studies on the miscellaneous Lycopodium alkaloids are summarized and an overview of a previous total synthesis of (+)-lyconadin A and an approach to lyconadin A is presented. The development of a unified strategy to access several miscellaneous Lycopodium alkaloids has been achieved. Utilizing this approach, the racemic and enantioselective syntheses of lyconadin A were achieved in 17 steps. Key strategic bond formations in the synthesis include olefin cross-metathesis, intramolecular Heck reaction, Curtius rearrangement, and intramolecular reductive amination. The lyconadin pentacycle was assembled by an unprecedented oxidative C-N bond-forming reaction from a dianion intermediate. The enantioselective route utilizes a Corey-Bakshi-Shibata reduction and a diastereoselective hydrogenation to set three key stereocenters. An overview of oxidative bond-forming reactions from dianion intermediates is presented. The mechanism of the oxidative C-N bond formation was examined. NMR studies and DFT calculations were conducted to investigate the structure of the dianion intermediate. Several oxidants were found to promote C-N bond formation by oxidation of the dianion intermediate. The reactivity studies revealed that the C-N bond formation may proceed by polar or SET mechanisms and that the mechanistic pathway is dependent on the type of oxidant utilized.
Book Synopsis Studies Towards the Total Synthesis of Cochinchistemonine by : Jean Tassel
Download or read book Studies Towards the Total Synthesis of Cochinchistemonine written by Jean Tassel and published by . This book was released on 2011 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward Total Synthesis of ( - )-deguelin by : Bao Li
Download or read book Studies Toward Total Synthesis of ( - )-deguelin written by Bao Li and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthetic Studies Toward the Total Synthesis of Upenamide by : Katherine Marie Peplowski
Download or read book Synthetic Studies Toward the Total Synthesis of Upenamide written by Katherine Marie Peplowski and published by . This book was released on 2007 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward the Total Synthesis of Madindoline, and Interleukin-6 Inhibitor by : Shelley Kay Wolf
Download or read book Studies Toward the Total Synthesis of Madindoline, and Interleukin-6 Inhibitor written by Shelley Kay Wolf and published by . This book was released on 2000 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward the Total Synthesis of Stemonamine and Croomine Joseph D'Antuono by : Joseph D'Antuono
Download or read book Studies Toward the Total Synthesis of Stemonamine and Croomine Joseph D'Antuono written by Joseph D'Antuono and published by . This book was released on 1988 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Studies Toward the Enantioselective Total Synthesis of Manzamine A by : Matthew David Kowalski
Download or read book Studies Toward the Enantioselective Total Synthesis of Manzamine A written by Matthew David Kowalski and published by . This book was released on 2008 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Total Synthesis of Gomisin O by : Soumya Mitra
Download or read book Total Synthesis of Gomisin O written by Soumya Mitra and published by . This book was released on 2007 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Gomisins are oriental medicinal plant lignans characterized by a highly electron-rich dibenzocyclooctadiene core structure with a stereogenic axis about the biaryl bond, exhibiting atropisomerism. The cyclooctane ring is additionally substituted with several stereogenic methyl and hydroxyl groups. Most members of this family possess anti-HIV, anti-hepatitis, analgesic, anti-tussive and central nervous system depressant activities. A convergent, highly efficient total syntheses of gomisins O and E are discussed in this thesis with complete control of absolute and relative stereochemistry. The key steps involved in the total synthesis are a novel indium-mediated methylcrotylation, a diastereoselective B-alkyl Suzuki-Miyaura alkylborane coupling and an intramolecular oxidative biaryl cuprate cross-coupling with total atropdiastereocontrol. Eupomatilones are structurally novel fluxional plant lignans with varying degree of oxygenation on the biphenyl system. The [alpha]-methylene-[gamma]-lactone moiety attached to the biphenyl, as found in eupomatilones 1, 2 and 5, readily forms covalent bonds to cellular proteins and is a cause of chronic actinic dermatitis (CAD). This moiety also forms photo adducts with DNA base thymine in sunlight and has been also shown to target the I[kappa][beta] kinase addition to the transcription factor regulator nuclear factor (NF-kappaB), signifying their potential role in cellular signaling processes. Herein, we discuss a successful asymmetric strategy for the synthesis of a few members of this unique family of lignans. The key to the synthesis depends on an optimized Suzuki-Miyaura biaryl cross-coupling reaction with heavily electron-rich coupling partners. In addition to this, the synthesis is novel in demonstrating the first example of an asymmetric carbomethoxycrotylboration approach to the synthesis of the [alpha]-methylene-[gamma]-lactone moiety, involving application of Miyaura's boryl-copper chemistry. A novel route to the synthesis of the carbomethoxycrotylboronate reagent in enantiomerically pure form is described herein. Mayolides are cembrane diterpenes found in the lipids of marine soft corals exhibiting potent anti-cancer properties. Mayolide A is an [alpha]-methylene-[gamma]-lactone derivative and also the first secocembrane diterpenoid to be isolated. In this thesis, we would discuss the synthetic strategy developed and the progress made towards the total synthesis of this structurally novel molecule, utilizing the carbomethoxycrotylation strategy developed during the total synthesis of eupomatilones as one of the key steps.
Book Synopsis Studies Toward the Total Synthesis of Xenovulene A by : Peijun Li
Download or read book Studies Toward the Total Synthesis of Xenovulene A written by Peijun Li and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
