The Th2 Type Immune Response In Health And Disease

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The Th2 Type Immune Response in Health and Disease

Author : William C. Gause
Publisher : Springer
ISBN 13 : 1493929119
Total Pages : 183 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis The Th2 Type Immune Response in Health and Disease by : William C. Gause

Download or read book The Th2 Type Immune Response in Health and Disease written by William C. Gause and published by Springer. This book was released on 2015-12-08 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: The type 2 immune response that develops during infectious disease has undergone major paradigm shifts in the last several years as new cell types and pathways have been identified. It is now clear that the type 2 immune response, characterized by elevations in specific cytokines, including IL-4, IL-5 and IL-13, is associated with helminth infections in both humans and mice. This response is complex and includes effector functions that mediate resistance, contributing to expulsion and in some cases destruction, of the parasite. But just as importantly, the type 2 immune response can also mediate tolerance mechanisms, which can mitigate tissue injury as these large multicellular parasites transit through vital organs. The tolerance mechanisms include both tissue repair and immune regulatory effects. These latter aspects of the helminth-induced type 2 immune response are increasingly recognized as a potential resource that can be mined for the development of novel immunotherapies that may enhance wound healing, control of autoimmune and inflammatory diseases and regulation of metabolic homeostasis. In this book, leading researchers in this exciting and dynamic field discuss the latest findings and emerging concepts, providing an intellectual framework that can be used as a basis for new discoveries and potentially new treatments for diseases associated with inflammation.

Janeway's Immunobiology

Author : Kenneth Murphy
Publisher : Garland Science
ISBN 13 : 9780815344575
Total Pages : pages
Book Rating : 4.3/5 (445 download)

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Book Synopsis Janeway's Immunobiology by : Kenneth Murphy

Download or read book Janeway's Immunobiology written by Kenneth Murphy and published by Garland Science. This book was released on 2010-06-22 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.

Th1 and Th2 Cells in Health and Disease

Author : Sergio Romagnani
Publisher : S Karger Ag
ISBN 13 : 9783805562416
Total Pages : 0 pages
Book Rating : 4.5/5 (624 download)

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Book Synopsis Th1 and Th2 Cells in Health and Disease by : Sergio Romagnani

Download or read book Th1 and Th2 Cells in Health and Disease written by Sergio Romagnani and published by S Karger Ag. This book was released on 1996 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Th1 and Th2 cells, representing extremely polarized modalities of the specific effector immune response, play an important role in both protection against exogenous insults and the induction of several immunopathological reactions. This book provides an authoritative update on the developments in this fast-moving field from both basic and clinical perspectives. In 12 detailed chapters, leading immunologists highlight the physiological meaning of Th1 and Th2 cells, their functional properties and surface markers, the mechanisms responsible for their development, as well as their roles in protection against bacteria, protozoans, fungi, viruses and helminths. Also discussed are the roles of Th1 and Th2 cells in some immunopathological conditions, such as autoimmune and neurological disorders, allergy and HIV infection. By combining for the first time complete information on basic mechanisms together with the clinical implications of Th1/Th2-dominated immune responses, this book will be appreciated by a broad spectrum of readers, including immunobiologists and clinicians from many medical fields.

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Stress Challenges and Immunity in Space

Author : Alexander Choukèr
Publisher : Springer Nature
ISBN 13 : 3030169960
Total Pages : 756 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Stress Challenges and Immunity in Space by : Alexander Choukèr

Download or read book Stress Challenges and Immunity in Space written by Alexander Choukèr and published by Springer Nature. This book was released on 2019-11-27 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains how stress – either psychological or physical – can activate and/or paralyse human innate or adaptive immunity. Adequate immunity is crucial for maintaining health, both on Earth and in space. During space flight, human physiology is specifically challenged by complex environmental stressors, which are most pronounced during lunar or interplanetary missions. Adopting an interdisciplinary approach, the book identifies the impact of these stressors – the space exposome – on immunity as a result of (dys-)functions of specific cells, organs and organ networks. These conditions (e.g. gravitation changes, radiation, isolation/confinement) affect immunity, but at the same time provide insights that may help to prevent, diagnose and address immune-related health alterations. Written by experts from academia, space agencies and industry, the book is a valuable resource for professionals, researchers and students in the field of medicine, biology and technology. The chapters “The Impact of Everyday Stressors on the Immune System and Health”, “Stress and Radiation Responsiveness” and “Assessment of Radiosensitivity and Biomonitoring of Exposure to Space adiation” are available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Molecular Biology of the Cell

Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)

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Book Synopsis Molecular Biology of the Cell by :

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Innate Immunity in Health and Disease

Author : Shailendra K. Saxena
Publisher : BoD – Books on Demand
ISBN 13 : 1838807659
Total Pages : 416 pages
Book Rating : 4.8/5 (388 download)

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Book Synopsis Innate Immunity in Health and Disease by : Shailendra K. Saxena

Download or read book Innate Immunity in Health and Disease written by Shailendra K. Saxena and published by BoD – Books on Demand. This book was released on 2021-08-25 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.

Indoor Allergens

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309048311
Total Pages : 321 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Indoor Allergens by : National Research Council

Download or read book Indoor Allergens written by National Research Council and published by National Academies Press. This book was released on 1993-02-01 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 50 million Americans, one out of five, suffer from hay fever, asthma, and other allergic diseases. Many of these conditions are caused by exposure to allergens in indoor environments such as the house, work, and schoolâ€"where we spend as much as 98 percent of our time. Developed by medical, public health, and engineering professionals working together, this unique volume summarizes what is known about indoor allergens, how they affect human health, the magnitude of their effect on various populations, and how they can be controlled. The book addresses controversies, recommends research directions, and suggests how to assist and educate allergy patients, as well as professionals. Indoor Allergens presents a wealth of information about common indoor allergens and their varying effects, from significant hay fever to life-threatening asthma. The volume discusses sources of allergens, from fungi and dust mites to allergenic chemicals, plants, and animals, and examines practical measures for their control. Indoor Allergens discusses how the human airway and immune system respond to inhaled allergens and assesses patient testing methods, covering the importance of the patient's medical history and outlining procedures and approaches to interpretation for skin tests, in vitro diagnostic tests, and tests of patients' pulmonary function. This comprehensive and practical volume will be important to allergists and other health care providers; public health professionals; specialists in building design, construction, and maintenance; faculty and students in public health; and interested allergy patients.

Type 2 Immunity

Author : R. Lee Reinhardt
Publisher : Humana
ISBN 13 : 9781493978953
Total Pages : 0 pages
Book Rating : 4.9/5 (789 download)

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Book Synopsis Type 2 Immunity by : R. Lee Reinhardt

Download or read book Type 2 Immunity written by R. Lee Reinhardt and published by Humana. This book was released on 2018-06-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides researchers the opportunity to investigate type-2-associated diseases in their laboratories. Beginning with chapters describing various models of type-2 immunity, the volume then continues by detailing cellular protocols designed to identify, characterize, and assess the function of key adaptive and innate immune cells involved in type-2 inflammation; approaches to isolate and evaluate specific cellular subsets at the genetic, epigenetic, and molecular level; protocols to assess type-2 immunity and its relationship to organismal and metabolic systems (ex. Microbiome). This book concludes with a section that explores the use of primary human cells in evaluating relevance to the clinic. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Vital and authoritative, Type 2 Immunity: Methods and Protocols aims to provide a broad network of methods that can be used to develop a hypothesis and investigate its potential from bench to beside.

Cooperation of Liver Cells in Health and Disease

Author : Z. Kmiec
Publisher : Springer Science & Business Media
ISBN 13 : 3642565530
Total Pages : 154 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Cooperation of Liver Cells in Health and Disease by : Z. Kmiec

Download or read book Cooperation of Liver Cells in Health and Disease written by Z. Kmiec and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is only during the last decade that the functions of sinusoidal endothelial cells, Kupffer cells, hepatic stellate cells, pit cells and other intrahepatic lymphocytes have been better understood. The development of methods for isolation and co-culturing various types of liver cells has established that they communicate and cooperate via secretion of various intercellular mediators. This monograph summarizes multiple data that suggest the important role of cellular cross-talk for the functions of both normal and diseased liver. Special features of the book include concise presentation of the majority of detailed data in 19 tables. Original schemes allow for the clear illustration of complicated intercellular relationships. This is the first ever presentation of the newly emerging field of liver biology, which is important for hepatic function in health and disease and opens new avenues for therapeutic interventions.

Immunointervention in Autoimmunity by Th1/Th2 Regulation

Author : Luciano Adorini
Publisher :
ISBN 13 :
Total Pages : 200 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Immunointervention in Autoimmunity by Th1/Th2 Regulation by : Luciano Adorini

Download or read book Immunointervention in Autoimmunity by Th1/Th2 Regulation written by Luciano Adorini and published by . This book was released on 1997 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Cytokines of the Immune System

Author : Zlatko Dembic
Publisher : Academic Press
ISBN 13 : 0124200109
Total Pages : 323 pages
Book Rating : 4.1/5 (242 download)

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Book Synopsis The Cytokines of the Immune System by : Zlatko Dembic

Download or read book The Cytokines of the Immune System written by Zlatko Dembic and published by Academic Press. This book was released on 2015-05-23 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cytokines of the Immune System catalogs cytokines and links them to physiology and pathology, providing a welcome and hugely timely tool for scientists in all related fields. In cataloguing cytokines, it lists their potential for therapeutic use, links them to disease treatments needing further research and development, and shows their utility for learning about the immune system. This book offers a new approach in the study of cytokines by combining detailed guidebook-style cytokine description, disease linking, and presentation of immunologic roles. - Supplies new ideas for basic and clinical research - Provides cytokine descriptions in a guidebook-style, cataloging the origins, structures, functions, receptors, disease-linkage, and therapeutic potentials - Offers a textbook-style view on the immune system with the immunologic role of each cytokine

Encyclopedia of Immunobiology

Author :
Publisher : Academic Press
ISBN 13 : 0080921523
Total Pages : 3161 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis Encyclopedia of Immunobiology by :

Download or read book Encyclopedia of Immunobiology written by and published by Academic Press. This book was released on 2016-04-27 with total page 3161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Immunobiology, Five Volume Set provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices

The Geohelminths

Author : Celia V. Holland
Publisher : Springer Science & Business Media
ISBN 13 : 0306473836
Total Pages : 341 pages
Book Rating : 4.3/5 (64 download)

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Book Synopsis The Geohelminths by : Celia V. Holland

Download or read book The Geohelminths written by Celia V. Holland and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 341 pages. Available in PDF, EPUB and Kindle. Book excerpt: The soil-transmitted nematode parasites, or geohelminths, are - called because they have a direct life cycle, which involves no intermediate hosts or vectors, and are transmitted by faecal contamination of soil, foodstuffs and water supplies. They all inhabit the intestine in their adult stages but most species also have tissue-migratoryjuvenile stages, so the disease manifestations they cause can therefore be both local and systemic. The geohelminths together present an enormous infection burden on humanity. Those which cause the most disease in humans are divided into three main groupings, Ascaris lumbricoides (the large roundworm), Trichuris trichiura (whipworm), and the blood-feeding hookworms (Ancylostoma duodenale and Necator americanus ), and this book concentrates on these. These intestinal parasites are highly prevalent worldwide, A. lumbricoides is estimated to infect 1471 million (over a quarter ofthe world’s population), hookworms 1277 million, and T. trichiura 1049 million. The highly pathogenic Strongyloides species might also be classified as geohelminths, but they are not dealt with here because the understanding of their epidemiology, immunology and genetics has not advanced as rapidly as for the others. This is primarily because of the often covert nature of the infections, with consequent difficulties for analysis. If there is ever a second edition of this book, then there will hopefully be much to say about this infection.

Thermotherapy for Neoplasia, Inflammation, and Pain

Author : M. Kosaka
Publisher : Springer Science & Business Media
ISBN 13 : 4431670351
Total Pages : 556 pages
Book Rating : 4.4/5 (316 download)

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Book Synopsis Thermotherapy for Neoplasia, Inflammation, and Pain by : M. Kosaka

Download or read book Thermotherapy for Neoplasia, Inflammation, and Pain written by M. Kosaka and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the multitude of different forms of thermotherapy in connection with aspects of thermal physiology and cell biology. The aim is to elucidate the scientific background of therapeutic actions and to promote effective new applications at the beginning of the 21st century. Significant to these purposes is cooperation between experts in the fields of thermal biology, hyper thermic oncology, rheumatology, and balneology, as represented by the editors. Emphasis has been placed on a balanced choice of contributions, in the hope that this will enable the reader to draw helpful connections between the principles and prac tice of thermotherapy. It is apparent that a wealth of published data exists concerning thermotherapy on the one hand and thermal physiology on the other. However, in the former field empirical aspects of therapeutic usefulness prevail, while in the latter, aspects of basic science are in the foreground. Accordingly, the sources where published data may be found are quite different and as a consequence many findings of potential mutual interest published in medical journals have gone unnoticed by readers of physio logical journals, and vice versa. It is hoped that this book will bridge the gap and encourage researchers' efforts to integrate the available knowledge to attain optimal coordination of clinical and theoretical aspects.

Aging

Author : L. Robert
Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318026530
Total Pages : 226 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Aging by : L. Robert

Download or read book Aging written by L. Robert and published by Karger Medical and Scientific Publishers. This book was released on 2014-05-16 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging inspired a large number of theories trying to rationalize the aging process common to all living beings. In this publication the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are reviewed. Furthermore theoretical and experimental evidence of the most important theoretical elements based on Darwinian evolution, cellular aging, role of cell membranes, free radicals and oxidative processes, receptor-mediated reactions, the extracellular matrix and immune functions as well as the most important environmental and intrinsic mechanisms involved in the aging process and in its pathological consequences are discussed. These presentations of theories and related experimental facts give a global overview of up to date concepts of the biology of the aging process and are of essential reading not only for specialists in this field but also for practitioners of scientific, medical, social and experimental sciences.

Immune Regulation

Author : Marc Feldmann
Publisher : Springer Science & Business Media
ISBN 13 : 1461249961
Total Pages : 384 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Immune Regulation by : Marc Feldmann

Download or read book Immune Regulation written by Marc Feldmann and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leukocyte culture conferences have a long pedigree. This volume records some of the scientific highlights of the 16th such annual con ference, and is a witness to the continuing evolution and popularity of leukocyte culture and of immunology. There is strong evidence of the widening horizons of immunology, both technically, with the obviously major impact of molecular biology into our understanding of cellular processes, and also conceptually. Traditionally, the 'proceedings' of these conferences have been published. But have the books produced really recorded the major part of the conference, the informal, friendly, but intense and some times heated exchanges that take place between workers in tackling very similar problems and systems and which are at the heart of every successful conference? Unfortunately this essence cannot be incorpo rated by soliciting manuscripts. For this reason, we have changed the format of publication, retaining published versions of the symposium papers, but requesting the workshop chairmen to produce a summary of the major new observations and areas of controversy highlighted in their sessions, as a vehicle for defining current areas of interest and debate. Not an easy task, as the workshop topics were culled from the abstracts submitted by the participants, rather than being on predefined topics. The unseasonal warmth in Cambridge was reflected in the atmos phere of the conference, the organization of which benefited from the administrative skills of Jean Bacon, Philippa Wells, Mr. Peter Irving, and Mrs.