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The Synthesis Of Substituted Quinolizidines
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Book Synopsis The Synthesis of Substituted Quinolizidines by : Michael Roger Dick
Download or read book The Synthesis of Substituted Quinolizidines written by Michael Roger Dick and published by . This book was released on 1989 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of 1S-ethyl-4-substituted Quinolizidines and Other Potentially Bioactive Compounds by : Vladislav Semak
Download or read book Synthesis of 1S-ethyl-4-substituted Quinolizidines and Other Potentially Bioactive Compounds written by Vladislav Semak and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Part I: Synthesis and Stereochemistry of Some 3-substituted Quinolizidines Related to Biologically Active Phenethylamines ; Part II: Synthesis and Stereochemistry of Some 6-phenyl-6-propionoxyperhydrobenzo[c]quinolizines as Potential Analgetics by : Michael Eugene Rogers
Download or read book Part I: Synthesis and Stereochemistry of Some 3-substituted Quinolizidines Related to Biologically Active Phenethylamines ; Part II: Synthesis and Stereochemistry of Some 6-phenyl-6-propionoxyperhydrobenzo[c]quinolizines as Potential Analgetics written by Michael Eugene Rogers and published by . This book was released on 1972 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Dual Study. Part I: Synthesis and Stereochemistry of Some 1-substituted Quinolizidines as Analogs of Biologically Active Compounds ; Part II: Amino Derivatives of Thiophene-fused Cyclic Ketones as Potential CNS and Antimicrobial Agents by : Jimmy R. Daniel
Download or read book A Dual Study. Part I: Synthesis and Stereochemistry of Some 1-substituted Quinolizidines as Analogs of Biologically Active Compounds ; Part II: Amino Derivatives of Thiophene-fused Cyclic Ketones as Potential CNS and Antimicrobial Agents written by Jimmy R. Daniel and published by . This book was released on 1973 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Silyl Enol Ether Prins Cyclization by : Gidget C. Tay
Download or read book The Silyl Enol Ether Prins Cyclization written by Gidget C. Tay and published by . This book was released on 2015 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: A modular synthesis of the reportedly potent molluscicide, cyanolide A, was developed to provide facile access to a series of cyanolide A analogues. The synthesis of strategic derivatives was initiated in order to determine the structural features of cyanolide A required for molluscicidal activity. Cyanolide A was synthesized in twelve steps with an overall 2% yield. After extensive SAR studies, it was found that cyanolide A was not responsible for the reported molluscicidal activity observed in the original studies. A diastereoselective synthesis of cis-2,6-disubstituted tetrahydropyran-4-ones was developed. The key step of this methodology, a silyl enol ether Prins cyclization, was promoted by a condensation reaction between a hydroxy silyl enol ether and an aldehyde to afford substituted tetrahydropyran-4-ones. The cyclization was tolerant of many functional groups, and the modular synthesis of the hydroxy silyl enol ether allowed for the formation of more than thirty new tetrahydropyran-4-ones with up to 97% yield and >95:5 dr. The cyclization step forms new carbon-carbon and carbon-oxygen bonds, as well as a quaternary center with good diastereoselectivity. The method provides a versatile route for the synthesis of substituted tetrahydropyrans. The scope and diastereoselectivity of an intramolecular aza-Diels-Alder reaction starting from a variety of 2-cyano-1-aza-1,3-butadienes was explored. The key reactions involved in synthesizing the Diels-Alder precursors are an imine condensation and a Strecker reaction and subsequent oxidation. The method provides a route for the synthesis of substituted quinolizidine and indolizidine heterocycles containing a cyanoenamine functional group. A visual aid teaching tool, the DanceChemistry video series, has been developed to teach fundamental chemistry concepts through dance. These educational videos portray chemical interactions at the molecular level using dancers to represent chemical species. Students reported that the DanceChemistry videos helped them visualize chemistry ideas in a new and memorable way. Surveying the general laboratory course at the University of California, Irvine (n = 1266), 75% of the students said they wanted to use these videos to learn additional chemistry topics in the future. Data from pre- and post-surveys show an increase in students' average scores after watching a five minute DanceChemistry video. These instructional videos are disseminated broadly through a dedicated YouTube channel, DanceChemistry.
Book Synopsis Chapter I, The Synthesis, Conformational Analysis and Catalytic Properties of Four Chiral (non-racemic) 4-substituted Quinolizidines ; Chapter II, Alkylation Reactions of Derivatives of the Camphor Imine of T-butylglycine [microform] by : Luca Carmine Matassa
Download or read book Chapter I, The Synthesis, Conformational Analysis and Catalytic Properties of Four Chiral (non-racemic) 4-substituted Quinolizidines ; Chapter II, Alkylation Reactions of Derivatives of the Camphor Imine of T-butylglycine [microform] written by Luca Carmine Matassa and published by National Library of Canada. This book was released on 1989 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Development of New Methods for the Synthesis of Indolines and Quinolizidines by : Hui Li
Download or read book Development of New Methods for the Synthesis of Indolines and Quinolizidines written by Hui Li and published by . This book was released on 2015 with total page 1196 pages. Available in PDF, EPUB and Kindle. Book excerpt: I. (3 + 2) Cycloaddition reactions of oxyallyl cationic intermediates with indoles Cyclopenta-and cyclohexa[b]indolines are ubiquitous molecular skeletons in natural products and pharmaceutical agents. We have developed (3 +2) cycloaddition reactions of 3-substituted indoles with [alpha]-haloketones to access those scaffolds. Significant diastereo-and regiochemical control were observed. The reactions were found to proceed via an O-bound intermediate. Kinetic studies of the cycloaddition reactions and DFT calculations (B3LYP-D3/6-311++G**/MeOH) on cyclization mechanisms involving the 2-hydroxyallyl cation and its deprotonated oxyallyl cation have been performed. Both oxyallyl cationic intermediates were predicted to be viable reactive species. The synthetic potential of these reactions were demonstrated in the concise syntheses of structural cores of vincorine, isocorymine, and aspidophylline A. II. Vinylogous Mukaiyama-Michael reactions of Dihydropyridinones 2,3-Dihydro-4-pyridinones are versatile building blocks in constructing nitrogen-containing heterocyclic compounds. We have developed In(III)-catalyzed vinylogous Mukaiyama-Michael (vM-Michael) addition of O-silyl vinylketene acetals to dihydropyridinones. The reactions featured the employment of supersilyl groups to control the [alpha]-vs-[gamma] regioselectivity when [gamma]-substituted O-silyl vinylketene acetals were used. These transformations can allow easy access to quinolizidine-based alkaloids. This potential was demonstrated by formal synthesis of deoxynupharidine, lasubine I and II, as well as construction of the structural core of hupermine A. III. Discovery of the first known apoptotic monomeric nuphar analogs and enantioselective formal syntheses of 11 nuphar alkaloids (+)-6-Hydroxythiobinupharidine induces apoptosis of U937 human leukemia cells in a speed faster than any known small organic molecules. In order to obtain useful SAR information, we have designed and synthesized a stereochemically diverse collection of monomeric nuphar analogs bearing C6 hemiaminal hydroxyl groups. We have also achieved the concise enantioselective formal syntheses of eight dimeric and three monomeric nuphar alkaloids. The above syntheses involved the development of highly enantioselective chiral phosphoric acid-catalyzed vinylogous Mukaiyama-Mannich (vM-Mannich) reactions. The vM-Mannich reactions employed the supersilyl groups as a key element in controlling regio-, enantio- and diastereoselectivity. Biological evaluation of the monomeric nuphar quinolizidines identified analogs that are even more potent than the parent natural product (+)-6-Hydroxythiobinupharidine.
Book Synopsis 4+2 Cycloadditions of Iminoacetonitriles by : Kevin Matthew Maloney
Download or read book 4+2 Cycloadditions of Iminoacetonitriles written by Kevin Matthew Maloney and published by . This book was released on 2003 with total page 532 pages. Available in PDF, EPUB and Kindle. Book excerpt: Iminoacetonitriles participate as reactive dienophiles in intermolecular and intramolecular Diels-Alder cycloadditions leading to quinolizidines, indolizidines, and piperidines. The resultant a-amino nitrile cycloadducts are versatile synthetic intermediates which can be further elaborated by stereoselective alkylation, reduction, reductive cyclization, and Bruylants reactions. The first part of this thesis describes the full details of our studies on the synthesis of iminoacetonitriles, the scope of their Diels-Alder reactions, and the synthetic elaboration of the a-amino nitrile cycloadducts to provide access to a variety of substituted quinolizidine and indolizidine derivatives. The second part of this thesis reports on the total synthesis of quinolizidine ( - )-217A and our efforts directed toward the total synthesis of indolizidine ( - )-235B'.
Book Synopsis The Synthesis of 8-substituted Indolizidines from Enaminone Precursors by : Saleem Syed Sultan
Download or read book The Synthesis of 8-substituted Indolizidines from Enaminone Precursors written by Saleem Syed Sultan and published by . This book was released on 2012 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Study of the Synthesis and Properties of Some 4-substituted-3-nitroquinolines by : Charles G. McCarty
Download or read book A Study of the Synthesis and Properties of Some 4-substituted-3-nitroquinolines written by Charles G. McCarty and published by . This book was released on 1959 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Preparation of Substituted Indoles by : Dylan Bradley England
Download or read book The Preparation of Substituted Indoles written by Dylan Bradley England and published by . This book was released on 2006 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Synthesis and Chemistry of 2-substituted-5,6-dihydroimidazo[ij]quinolines and Certain Related Compounds by : Alfred Richardson
Download or read book The Synthesis and Chemistry of 2-substituted-5,6-dihydroimidazo[ij]quinolines and Certain Related Compounds written by Alfred Richardson and published by . This book was released on 1958 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Synthesis of 2- and 3-substituted Indoles by : Tlabo Caiphus Leboho
Download or read book The Synthesis of 2- and 3-substituted Indoles written by Tlabo Caiphus Leboho and published by . This book was released on 2008 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Synthesis of Some Substituted 3- Indoles by : Stephen D. Clemans
Download or read book The Synthesis of Some Substituted 3- Indoles written by Stephen D. Clemans and published by . This book was released on 1967 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Substituted 6,6a-dihydroisoindolo [2,1-a]quinolin-11(5H)-ones by : Zainab Admad Al-Jaroudi
Download or read book Synthesis of Substituted 6,6a-dihydroisoindolo [2,1-a]quinolin-11(5H)-ones written by Zainab Admad Al-Jaroudi and published by . This book was released on 2015 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Substituted Quinolylamines by : Gustave Bryant Bachman
Download or read book Synthesis of Substituted Quinolylamines written by Gustave Bryant Bachman and published by . This book was released on 1950 with total page 7 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Synthesis of 5-substituted-3-cyanotoluenes by : Myrtle Lynn Prewitt
Download or read book The Synthesis of 5-substituted-3-cyanotoluenes written by Myrtle Lynn Prewitt and published by . This book was released on 1982 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: