The Survival Impact Of Lenalidomide Maintenance Therapy In Patients With Multiple Myeloma

Download The Survival Impact Of Lenalidomide Maintenance Therapy In Patients With Multiple Myeloma full books in PDF, epub, and Kindle. Read online The Survival Impact Of Lenalidomide Maintenance Therapy In Patients With Multiple Myeloma ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

The Survival Impact of Lenalidomide Maintenance Therapy in Patients with Multiple Myeloma

Author : Hannah Marie Cherniawsky
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (135 download)

DOWNLOAD NOW!

Book Synopsis The Survival Impact of Lenalidomide Maintenance Therapy in Patients with Multiple Myeloma by : Hannah Marie Cherniawsky

Download or read book The Survival Impact of Lenalidomide Maintenance Therapy in Patients with Multiple Myeloma written by Hannah Marie Cherniawsky and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Historically, the treatment of multiple myeloma in transplant eligible patients has included induction chemotherapy followed by autologous stem cell transplant (ASCT) and a watch and wait approach until relapse. The introduction of maintenance chemotherapy has changed the traditional observation period into active treatment time. We examined the impact of lenalidomide maintenance on survival outcomes in the front line and relapsed setting. Our population included patients treated with bortezomib based induction followed by ASCT who went on to receive lenalidomide maintenance or no maintenance. Patient data was taken from the Myeloma Canada Research Network Canadian Multiple Myeloma Database (MCRN CMM-DB) which includes data from 13 academic cancer centers across Canada. Our data demonstrates that lenalidomide maintenance is associated with improved progression free (PFS) and overall survival (OS) as well as higher rates of favourable responses. We did not observe any unanticipated adverse effects. Rates of discontinuation for reasons other than relapse were low. Analysis of relapsed patients demonstrates that lenalidomide maintenance did not results in worse second PFS (time from second line therapy to second relapse, death or last follow-up) in patients who received the drug again in second line therapy. Lenalidomide maintenance was associated with improve overall survival from time of initiation of relapse therapy. Additionally, lenalidomide maintenance did not negatively impact second PFS, OS from time of initiation of relapse therapy, and rates of favourable response when lenalidomide used again in second line treatment. Our data is the first analysis of transplant eligible patients from the MCRN CMM-DB. Our data supports the continued use of lenalidomide maintenance as standard of care following ASCT. Importantly, our data suggests that the use of lenalidomide maintenance does not negatively impact survival or response outcomes when used again in second line therapy. As such, use of or relapse on lenalidomide maintenance should not be considered an exclusion criteria for use of lenalidomide in second line therapy.

Management Of Biochemical Relapse During Lenalidomide Maintenance Therapy Post ASCT In Multiple Myeloma

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (125 download)

DOWNLOAD NOW!

Book Synopsis Management Of Biochemical Relapse During Lenalidomide Maintenance Therapy Post ASCT In Multiple Myeloma by :

Download or read book Management Of Biochemical Relapse During Lenalidomide Maintenance Therapy Post ASCT In Multiple Myeloma written by and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: BACKGROUND: Patients with multiple myeloma (MM) who underwent autologous stem cell transplantation (ASCT), are known to benefit from maintenance therapy post-transplant. With signs of early relapse, physicians can either change maintenance therapy or use a new therapeutic regimen.OBJECTIVES: The purpose of this study is to analyze the clinical outcomes beyond biochemical relapse of patients with MM on maintenance therapy. Time to next treatment (TNT), progression free survival (PFS) and overall survival (OS) are assessed. Different approaches for relapse such as increase in lenalidomide (R) dose, addition of dexamethasone (D) or Bortezomib (V) or shift to different lines of treatment are possible.SETTING: A retrospective single center study approved by the institutional review board of the American University of Beirut Medical Center, Lebanon.METHODS: Between January 2011 and May 2017, 51 patients with MM who underwent ASCT, received Bortezomib/Lenalidomide/Dexamethasone (VRD) consolidation and maintenance therapy, mainly lenalidomide(R) 10mg/day for 21 days every 28 days, were included. RESULTS: The median age at transplant was 55 years (46-75). 46 (90%) patients received R maintenance, 3 patients received VRD maintenance for higher risk features. Median duration of R maintenance was 22 months (3-62). R dose was changed for toxicity in 17 (33%) patients (grade I-II). 29 (57%) patients relapsed. 13 (25%) patients changed treatment to different protocols. 6 patients (11%) were observed. 10 (20%) patients had increased lenalidomide dose with dexamethasone. 5 patients (31%) of these 2 groups required change of treatment later. The median follow up was 38 months (1-85). Median TNT was 32 months (7-62). At 2 years, the estimated PFS and OS were 39% and 97.5% respectively. The median OS and PFS2 (from therapy change) were 54 and 29 months for patients in the observation group versus 52 and 27 months in the R/D group as well as 45 months and 33 months with treatment change, respectively. No statistically significant difference was noted. CONCLUSION: Our small monocentric study is limited by its retrospective design and small sample size. However, it suggests that increasing lenalidomide dose/adding dexamethasone in selected patients can postpone change to different lines of treatment without affecting survival.

The Myeloma Survival Guide

Author : Jim Tamkin, MD, FACP, FACE
Publisher : Springer Publishing Company
ISBN 13 : 0826128238
Total Pages : 293 pages
Book Rating : 4.8/5 (261 download)

DOWNLOAD NOW!

Book Synopsis The Myeloma Survival Guide by : Jim Tamkin, MD, FACP, FACE

Download or read book The Myeloma Survival Guide written by Jim Tamkin, MD, FACP, FACE and published by Springer Publishing Company. This book was released on 2017-07-28 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive guide to living a longer, fuller life with myeloma The Myeloma Survival Guide makes sense of the difficult questions myeloma patients face, dealing with every aspect of life after diagnosis, from creating a wellness team to navigating treatment options to building a financial safety net. Jim Tamkin, MD, who lived with myeloma for 11 years, and Dave Visel share the insights they've gained as a doctor, patient, and caregiver, including: Everything you need to know about drugs and treatments, including stem cell transplants How to deal with the pain and side effects of chemotherapy, radiation, and surgery Insurance and tax benefits to save money and get you the care you deserve Take-charge tools you can use today to feel better tomorrow The second edition has been thoroughly updated and includes a new chapter on pills and medical adherence. "An invaluable guide to patients with newly diagnosed multiple myeloma. Not only have they provided clear information on the disease and its treatment, but most importantly also convey critical guidance on how to deal with the very personal life-impacting effects of this disease for patients and family members alike." –Kenneth C. Anderson, MD, Kraft Family Professor of Medicine, Harvard Medical School, and Director, Jerome Lipper Multiple Myeloma Center and LeBow Institute for Myeloma Therapeutics, Dana-Farber Cancer Institute Jim Tamkin, MD, FACP, FACE, lived with myeloma for 11 years. He co-founded the TBA (Their Best Advice) Foundation with Dave Visel in 2009 to provide myeloma patients with the resources they need to cope with the disease. He worked as an internist and endocrinologist in Los Angeles until his death in March 2011. Dave Visel is co-founder of the TBA Foundation and author of Living with Cancer: A Practical Guide. He is a retired advertising copywriter and marketing executive, and is a caregiver to his wife, Karen, who has leukemia. They live in Los Angeles. www.TBAfoundation.org

Update on Multiple Myeloma

Author : Khalid Ahmed Al-Anazi
Publisher :
ISBN 13 : 178985217X
Total Pages : 236 pages
Book Rating : 4.7/5 (898 download)

DOWNLOAD NOW!

Book Synopsis Update on Multiple Myeloma by : Khalid Ahmed Al-Anazi

Download or read book Update on Multiple Myeloma written by Khalid Ahmed Al-Anazi and published by . This book was released on 2019-02 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive overview of the recent developments in the clinical and research fields of multiple myeloma. It is divided into three main sections that cover a wide range of topics, including: epidemiology and pathogenesis of the disease, genetic targets and pathways, resistance to novel therapies, angiogenesis and anti-angiogenesis, hematopoietic stem cell transplantation, role of radiology and radiotherapy in myeloma, infectious complications, and management of multiple myeloma in resource-poor countries.

Multiple Myeloma

Author : Morie A. Gertz
Publisher : Springer Science & Business Media
ISBN 13 : 1461485207
Total Pages : 311 pages
Book Rating : 4.4/5 (614 download)

DOWNLOAD NOW!

Book Synopsis Multiple Myeloma by : Morie A. Gertz

Download or read book Multiple Myeloma written by Morie A. Gertz and published by Springer Science & Business Media. This book was released on 2013-10-01 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive, state-of-the-art guide to the diagnosis, treatment, and biology of multiple myeloma and related plasma disorders. Edited and written by a multidisciplinary group of recognized authorities from the Mayo Clinic, it presents clear guidelines on diagnosis and therapy and covers all aspects of multiple myeloma, from molecular classification and diagnosis, to risk stratification and therapy. Closely related plasma cell disorders such as solitary plasmacytoma, Waldenstrom macroglobulinemia, and light chain amyloidosis are discussed in detail as well. The book addresses often overlooked topics, including the role of radiation therapy, vertebral augmentation, and supportive care. Our understanding of this group of disorders is developing at an unprecedented rate, and Multiple Myeloma meets the need among oncologists and hematologists for a clear, timely, and authoritative resource on their biology, diagnosis, and treatment.

Measuring Health

Author : Ian McDowell
Publisher : Oxford University Press
ISBN 13 : 0199725306
Total Pages : 765 pages
Book Rating : 4.1/5 (997 download)

DOWNLOAD NOW!

Book Synopsis Measuring Health by : Ian McDowell

Download or read book Measuring Health written by Ian McDowell and published by Oxford University Press. This book was released on 2006-03-09 with total page 765 pages. Available in PDF, EPUB and Kindle. Book excerpt: Worldwide economic constraints on health care systems have highlighted the importance of evidence-based medicine and evidence-based health policy. The resulting clinical trials and health services research studies require instruments to monitor the outcomes of care and the output of the health system. However, the over-abundance of competing measurement scales can make choosing a measure difficult at best. Measuring Health provides in-depth reviews of over 100 of the leading health measurement tools and serves as a guide for choosing among them.LNow in its third edition, this book provides a critical overview of the field of health measurement, with a technical introduction and discussion of the history and future directions for the field. This latest edition updates the information on each of the measures previously reviewed, and includes a complete new chapter on anxiety measurement to accompany the one on depression. It has also added new instruments to those previously reviewed in each of the chapters in the book.LChapters cover measurements of physical disability, social health, psychological well-being, anxiety, depression, mental status testing, pain, general health status and quality of life. Each chapter presents a tabular comparison of the quality of the instruments reviewed, followed by a detailed description of each method, covering its purpose and conceptual basis, its reliability and validity and, where possible, shows a copy of the actual scale. To ensure accuracy of the information, each review has been approved by the original author of each instrument or by an acknowledged expert.

Principles of Molecular Oncology

Author : Miguel H. Bronchud
Publisher : Springer Science & Business Media
ISBN 13 : 1592596649
Total Pages : 716 pages
Book Rating : 4.5/5 (925 download)

DOWNLOAD NOW!

Book Synopsis Principles of Molecular Oncology by : Miguel H. Bronchud

Download or read book Principles of Molecular Oncology written by Miguel H. Bronchud and published by Springer Science & Business Media. This book was released on 2003-12-03 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: At the midpoint of the 20th century, our knowledge of cancer was based on epide- ology and pathology, and treatment consisted of surgery and radiation therapy. At mid-century, Medawar and colleagues initiated the understanding of transplantation immunology, Farber described the first use of an antifolic drug to treat leukemia, and Jacobson and coworkers described the irradiation-protection effect of spleen cells. These observations opened the door to the development of chemotherapy and tra- plantation in the treatment of cancer. Despite the rapid development of these new disciplines, progress was usually based on empiric observations and clinical trials. The rapid advances in molecular biology at the end of the 20th century mark a new era in our knowledge of cancer. Molecular immunology, molecular genetics, mole- lar pharmacology, and the Human Genome Project are in the process of providing a level of understanding of cancer undreamed of in the past. Optimism is based on the firm belief that understanding at the molecular level will lead to better and earlier di- nosis, to new forms of treatment, and, most importantly, eventually to prevention of many types of cancer.

Multiple Myeloma

Author : Thomas Moehler
Publisher : Springer Science & Business Media
ISBN 13 : 3540857729
Total Pages : 349 pages
Book Rating : 4.5/5 (48 download)

DOWNLOAD NOW!

Book Synopsis Multiple Myeloma by : Thomas Moehler

Download or read book Multiple Myeloma written by Thomas Moehler and published by Springer Science & Business Media. This book was released on 2011-04-21 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple myeloma is currently still an incurable disease, but during the past decade knowledge of its molecular pathogenesis has increased rapidly. This has led to remarkable progress in both diagnosis and therapy, including in particular the approval of novel and first-in-class drugs such as thalidomide, bortezomib, and lenalidomide. This book, written by internationally acknowledged experts, covers a wide range of topics relating to multiple myeloma, including history, epidemiology, pathophysiology, clinical features, staging, and prognostic systems. The principal focus, however, is on therapy, with detailed information on the various promising treatment options which give hope that this cancer will be transformed into a chronic disease or even become curable. Individualized therapy and the variety of supportive treatment options, as described in this volume, will help in achieving this goal, as well as in reducing adverse events and improving quality of life.

Post-Authorization Safety Studies of Medicinal Products

Author : Ayad K. Ali
Publisher : Academic Press
ISBN 13 : 0128092084
Total Pages : 364 pages
Book Rating : 4.1/5 (28 download)

DOWNLOAD NOW!

Book Synopsis Post-Authorization Safety Studies of Medicinal Products by : Ayad K. Ali

Download or read book Post-Authorization Safety Studies of Medicinal Products written by Ayad K. Ali and published by Academic Press. This book was released on 2018-06-27 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post-Authorization Safety Studies of Medicinal Products: The PASS Book bridges the gap in the literature by providing a complete look at post-authorization safety studies and important pharmacoepidemiology and pharmacovigilance aspects. It covers various types and limitations of active surveillance programs, including the use of large databases and disparate data sources for rapid signal detection, as well as novel and advanced design and analysis approaches for causal interference from observational data. This book serves as an important reference for pharmacovigilance scientists and pharmacoepidemiologists who are searching for the appropriate study design to answer safety research questions. Readers will be able to effectively and efficiently design and interpret findings from post-authorization safety studies with the goal of improving the benefit-risk balance of a drug in order to optimize patient safety. - Discusses all types of observational studies in post-marketing drug safety assessment, from spontaneous reporting systems, to pragmatic trials, with examples from real-world settings - Presents various types of post-authorization safety studies - Offers solutions to the common challenges in the design and conduct of these studies - Highlights active surveillance programs, including common data models for rapid signal detection of drug safety issues

Multiple Myeloma and Other Plasma Cell Neoplasms

Author : Meletios A. Dimopoulos
Publisher : Springer
ISBN 13 : 331925586X
Total Pages : 247 pages
Book Rating : 4.3/5 (192 download)

DOWNLOAD NOW!

Book Synopsis Multiple Myeloma and Other Plasma Cell Neoplasms by : Meletios A. Dimopoulos

Download or read book Multiple Myeloma and Other Plasma Cell Neoplasms written by Meletios A. Dimopoulos and published by Springer. This book was released on 2018-02-16 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive source of up-to-date information on plasma cell neoplasms. Key features include the provision of new criteria for the diagnosis of symptomatic multiple myeloma requiring treatment and the description of novel therapies for myeloma and other plasma cell neoplasms that have only very recently been licensed by the U.S. Food and Drug Administration. Examples include lenalidomide as first-line therapy, panobinostat in combination with bortezomib plus dexamethasone for relapsed/refractory myeloma, ibrutinib for Waldenström’s macroglobulinemia, and new therapeutic regimens for systemic amyloidosis and POEMS syndrome. Information is also provided on drug combinations that have shown encouraging results and are very near to approval. Other important aspects covered in the book are the role of different imaging modalities in workup and the significance of newly acquired data relating to prognosis and minimal residual disease. Readers will find Multiple Myeloma and Other Plasma Cell Neoplasms to be a rich source of knowledge that will be invaluable in improving patient management.

Contemporary Management of Multiple Myeloma

Author : Ravi Vij
Publisher : JP Medical Ltd
ISBN 13 : 9350252651
Total Pages : 234 pages
Book Rating : 4.3/5 (52 download)

DOWNLOAD NOW!

Book Synopsis Contemporary Management of Multiple Myeloma by : Ravi Vij

Download or read book Contemporary Management of Multiple Myeloma written by Ravi Vij and published by JP Medical Ltd. This book was released on 2011-11-08 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a practical guide to multiple myeloma. Beginning with the epidemiology, etiology and biology of the disease, the text then discusses clinical scenarios, diagnosis and various treatment options, including induction therapy, hematopoietic stem cell transplantation and treatment of relapsed/refractory cases. Authored by a US-based specialist, this book provides 166 detailed illustrations, tables, figures and algorithms to help understanding.

Encyclopedia of Cancer

Author : Manfred Schwab
Publisher : Springer Science & Business Media
ISBN 13 : 3540368477
Total Pages : 3307 pages
Book Rating : 4.5/5 (43 download)

DOWNLOAD NOW!

Book Synopsis Encyclopedia of Cancer by : Manfred Schwab

Download or read book Encyclopedia of Cancer written by Manfred Schwab and published by Springer Science & Business Media. This book was released on 2008-09-23 with total page 3307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive encyclopedic reference provides rapid access to focused information on topics of cancer research for clinicians, research scientists and advanced students. Given the overwhelming success of the first edition, which appeared in 2001, and fast development in the different fields of cancer research, it has been decided to publish a second fully revised and expanded edition. With an A-Z format of over 7,000 entries, more than 1,000 contributing authors provide a complete reference to cancer. The merging of different basic and clinical scientific disciplines towards the common goal of fighting cancer makes such a comprehensive reference source all the more timely.

Cutaneous T-Cell Lymphoma

Author : Herschel S. Zackheim
Publisher : CRC Press
ISBN 13 : 9780849321016
Total Pages : 152 pages
Book Rating : 4.3/5 (21 download)

DOWNLOAD NOW!

Book Synopsis Cutaneous T-Cell Lymphoma by : Herschel S. Zackheim

Download or read book Cutaneous T-Cell Lymphoma written by Herschel S. Zackheim and published by CRC Press. This book was released on 2004-10-28 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutaneous T-cell lymphoma (CTCL) is a general term for many lymphomas of the skin including mycosis Fungoides and Sezary syndrome. This book presents the state of the art in CTCL epidemiology, clinical features, pathology, immunochemistry, diagnostic molecular techniques, staging and prognosis, and treatment. Edited by one of the leading experts in the disease, Cutaneous T-Cell Lymphoma: Mycosis Fungoides and Sezary Syndrome provides comprehensive coverage of the disease and presents techniques for diagnosis and state-of-the-art treatment modalities, such as ultraviolet light, steroids, and topical chemotherapeutics.

Understanding Multiple Myeloma

Author : Cristina Gasparetto
Publisher : Jones & Bartlett Learning
ISBN 13 : 1284169103
Total Pages : 158 pages
Book Rating : 4.2/5 (841 download)

DOWNLOAD NOW!

Book Synopsis Understanding Multiple Myeloma by : Cristina Gasparetto

Download or read book Understanding Multiple Myeloma written by Cristina Gasparetto and published by Jones & Bartlett Learning. This book was released on 2017-12-15 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The only text to provide both the doctor’s and patient’s views, Understanding Multiple Myeloma gives you authoritative, practical answers to your questions about treatment options, post-treatment quality of life, sources of support, and much more.

Blood and Marrow Transplant Handbook

Author : Richard T. Maziarz
Publisher : Springer
ISBN 13 : 3319138324
Total Pages : 437 pages
Book Rating : 4.3/5 (191 download)

DOWNLOAD NOW!

Book Synopsis Blood and Marrow Transplant Handbook by : Richard T. Maziarz

Download or read book Blood and Marrow Transplant Handbook written by Richard T. Maziarz and published by Springer. This book was released on 2015-04-20 with total page 437 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated and expanded edition developed by the Blood and Marrow Stem Cell Transplant team at Oregon Health & Science University Knight Cancer Institute features the latest medical management guidelines and standards of care for hematopoietic stem cell transplant patients. Spanning the timeline from the initial consultation throughout the transplant process, this handbook includes indications for transplantation and donor selection, treatment guidelines for addressing complications during and after transplant, and recommendations for long-term follow up care. Concise, comprehensive, and easy-to-use, Blood and Marrow Transplant Handbook, 2nd Edition presents a multidisciplinary approach to information for physicians and advanced practice medical providers who care for transplant patients, and also residents, fellows, and other trainees.

Real-World Analysis Of Characteristics And Main Outcomes Of Multiple Myeloma Patients

Author : Ferreira Flu00e1via
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (125 download)

DOWNLOAD NOW!

Book Synopsis Real-World Analysis Of Characteristics And Main Outcomes Of Multiple Myeloma Patients by : Ferreira Flu00e1via

Download or read book Real-World Analysis Of Characteristics And Main Outcomes Of Multiple Myeloma Patients written by Ferreira Flu00e1via and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: CONTEXT: Treatment of multiple myeloma (MM) has recently been improved with the introduction of novel agents. In low- and middle-income countries, the evaluation of clinical features and treatment outcomes is not often reported, and is necessary for tailoring successful local strategies.OBJECTIVE: To evaluate the impact of clinical characteristics in the outcomes of MM patients.DESIGN: Retrospective analysis of medical records.SETTING: Insurance-based hematology center in Su00e3o Paulo, Brazil.PATIENTS OR OTHER PARTICIPANTS: All patients treated for MM between January 2000 and January 2018. INTERVENTIONS: No intervention was intended.MAIN OUTCOMES MEASURES: Progression-free survival (PFS), Overall survival (OS).RESULTS: Of 193 patients included, 68% were female, 65% were Durie-Salmon IIIA-B, and median age at diagnosis was 70 (44-87). Treatment was started within one month of MM diagnosis in 77 patients (40%). Median follow-up time was 25 months. For first-line (FL) treatment, bortezomib-based regimens were received by 76% of patients. Median PFS was 24 months for FL treatment. Median PFS for patients receiving autologous stem-cell transplant (autoSCT) and/or maintenance therapy (MT) after FL was 30 months, and 24 months for those without auto-SCT or MT (p

Off Our Chests - A Candid Tour Through the World of Cancer

Author : John Marshall
Publisher : Ideapress Publishing
ISBN 13 : 9781646870486
Total Pages : pages
Book Rating : 4.8/5 (74 download)

DOWNLOAD NOW!

Book Synopsis Off Our Chests - A Candid Tour Through the World of Cancer by : John Marshall

Download or read book Off Our Chests - A Candid Tour Through the World of Cancer written by John Marshall and published by Ideapress Publishing. This book was released on 2021-05-04 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: A surprisingly open memoir co-authored by the married duo of a world class oncologist and a cancer survivor about love, pain, hope, strength and resilience while navigating the overwhelming breast cancer advocacy movement. Off Our Chests recounts the story of Liza and John's experience with her diagnosis and treatment. Written in alternating voices, Liza details her treatment, the complex decisions she had to make throughout her course of chemotherapy and radiation, including clinical trial participation and an elective double mastectomy, the added complexity of being treated at the cancer center of which John was the chief of hematology and oncology, and the emotional impact of knowing she may die as a young woman with young children. John, who lost his own mother to cancer at the age of 13, provides an inside look into the world of cancer care and research, but also the perspective of someone who understands the medicine but who was unprepared for assuming the role of caregiver and worried husband. John adds insights into his world of running the clinical operations of the cancer center where Liza would receive her care, commentary on the breast cancer machine, the need for clinical research, the high cost of cancer care, and an easy to understand explanation of the clinical and scientific background of oncology. While they both felt that they were already expert commentators on their own "Cancer Channel" during the course of Liza's illness, they both came to realize how little understanding they truly had of what a cancer diagnosis does to the patient, caregivers, children, family members, and friends. Liza and John share their most intimate thoughts, including many that were previously unsaid--even between the two of them. Both gain an understanding of the other's life, a deeper appreciation of what it means to be a cancer patient, and of the emotional strains of being an oncologist where so many of the patients die on their watch.