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The Skin And Gene Therapy
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Book Synopsis The Skin and Gene Therapy by : Ulrich R. Hengge
Download or read book The Skin and Gene Therapy written by Ulrich R. Hengge and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive guide to the novel field of gene therapy in the skin provides insight into the basic principles and methods of gene transfer into the skin and its applications. It enables the understanding of possibilities and implications such as immunization and treatment as well as safety aspects. Gene therapy in dermatology is the avantgarde of a new field in science with a great future for human health.
Book Synopsis Gene Technology and Gene Therapy in Dermatology by : Ulrich R. Hengge
Download or read book Gene Technology and Gene Therapy in Dermatology written by Ulrich R. Hengge and published by S. Karger AG (Switzerland). This book was released on 2002-01-01 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Basic concepts and recent advances in the field In recent years the skin has become an important target organ of gene technology and gene therapy. Its easy accessibility, well-established culture conditions and grafting techniques, as well as its function as an immune organ make it a promising candidate for the development of innovative treatment strategies. This special issue of Cells Tissues Organs gives an overview of the latest achievements in the field of skin gene therapy focusing on basic research and initial preclinical applications. It describes novel techniques of generating epidermal equivalents from hair follicle cells, the reaction of keratinocytes to exogenous DNA, and the genetic engineering of skin to be used as a bioreactor or a metabolic sink' in the treatment of metabolic disorders. Further potential applications of skin gene therapy include the treatment of chronic wounds, hypertrophic scars, keloids, and cancer, as well as its role in soft tissue reconstruction. Since gene therapy is a truly interdisciplinary field, this publication is recommended reading not only for dermatologists, geneticists, bioengineers, cell biologists and immunologists, but also for clinicians with an interest in cancer, metabolic diseases, skin biology and tissue engineering.
Book Synopsis Progress in Gene Technology and Skin Gene Therapy by : Ulrich R. Hengge
Download or read book Progress in Gene Technology and Skin Gene Therapy written by Ulrich R. Hengge and published by S Karger Ag. This book was released on 2004 with total page 88 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant progress has been made in gene technology and skin gene therapy in the last few years. Besides the development of suitable animal models, novel molecular technologies such as small inhibitory RNA are discussed, which enable the modification of sequence-specific gene expression. Progress is reported in the field of DNA vaccination against HIV-1 as well as in the correction of xeroderma pigmentosum using retroviral-based gene transfer. In addition to gene technology and skin gene therapy, recent advances in molecular diagnostics of malignancy are described. Microarray-based gene expression profiling is a powerful technology with which up to 22,000 genes can simultaneously be analyzed in a given tissue. It is used today by several groups to characterize malignant melanoma and other tumors on a molecular level, identifying important dysregulated pathways and gene products and comparing them with those of normal human melanocytes and benign nevi. Providing an overview of the latest techniques and achievements in the field, this publication is recommended to dermatologists, geneticists, bioengineers, cell biologists and immunologists, and anyone interested in learning more about new molecular approaches in biomedicine.
Book Synopsis First International Symposium on Gene Technology and Skin Gene Therapy by : International Symposium on Gene Technology and Skin Gene Therapy. 1, 2000, Essen
Download or read book First International Symposium on Gene Technology and Skin Gene Therapy written by International Symposium on Gene Technology and Skin Gene Therapy. 1, 2000, Essen and published by . This book was released on 2000 with total page 18 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Gene Therapy in Reconstructive and Regenerative Surgery by : Giorgio Giatsidis
Download or read book Gene Therapy in Reconstructive and Regenerative Surgery written by Giorgio Giatsidis and published by Springer. This book was released on 2018-08-02 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers an updated overview of the most recent research advances in the field, a comparison of established techniques and methods, a discussion on current experimental and translational challenges, and a commentary on potential opportunities and future directions. Dedicated chapters address and review the preclinical and clinical state-of-the-art of gene therapies for the reconstructive and regenerative surgery of skin and wounds, pathological scars, cartilage, tendons, skeletal muscles, and bio-engineered flaps. A brief guide to developing gene therapy clinical trials in the context of reconstructive and regenerative surgery is also provided. Biomedical and technological innovations are transforming our capacity to use gene therapies to safely and effectively repair, reconstruct, and regenerate tissues that are deficient or have been damaged by trauma and diseases. The targeted and controlled modulation of gene expression in tissues represents a game-changing, next-generation therapeutic tool for the modern reconstructive surgeon, expanding the horizon of regenerative surgery and tissue engineering. Through gene therapies, surgeons can direct (stem) cell differentiation and cell function, modulate the release of growth/transcriptional factors, affect the biological properties of regenerative scaffolds, control tissue inflammation, or induce immune-suppression in composite tissue allotransplants and xenotransplants. Written by renowned reconstructive surgeons and leading experts in each of these fields - from top academic institutions around the globe, the book provides an initial practical guide for veteran and newcomer surgeons alike, as well as for researchers interested in exploring the latest gene-based therapeutic strategies for reconstructive and regenerative surgery.
Book Synopsis Gene Therapy for Cancer by : Kelly K. Hunt
Download or read book Gene Therapy for Cancer written by Kelly K. Hunt and published by Springer Science & Business Media. This book was released on 2007-10-26 with total page 469 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three sections of this volume present currently available cancer gene therapy techniques. Part I describes the various aspects of gene delivery. In Part II, the contributors discuss strategies and targets for the treatment of cancer. Finally, in Part III, experts discuss the difficulties inherent in bringing gene therapy treatment for cancer to the clinic. This book will prove valuable as the volume of preclinical and clinical data continues to increase.
Book Synopsis Pharmaceutical Biotechnology by : Daan J. A. Crommelin
Download or read book Pharmaceutical Biotechnology written by Daan J. A. Crommelin and published by CRC Press. This book was released on 2002-11-14 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of pharmaceutical biotechnology is evolving rapidly. A whole new arsenal of protein pharmaceuticals is being produced by recombinant techniques for cancer, viral infections, cardiovascular and hereditary disorders, and other diseases. In addition, scientists are confronted with new technologies such as polymerase chain reactions, combinatorial chemistry and gene therapy. This introductory textbook provides extensive coverage of both the basic science and the applications of biotechnology-produced pharmaceuticals, with special emphasis on their clinical use. Pharmaceutical Biotechnology serves as a complete one-stop source for undergraduate pharmacists, and it is valuable for researchers and professionals in the pharmaceutical industry as well.
Book Synopsis Molecular Biology of the Skin by : Michael Darmon
Download or read book Molecular Biology of the Skin written by Michael Darmon and published by Academic Press. This book was released on 2012-12-02 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of the Skin: The Keratinocyte comprehensively reviews the major aspects of keratinocyte and epidermal differentiation, physiology, and pathology, primarily focusing on the molecular aspects. This exciting new resource discusses keratin genes, retinoic acid, and the use of transgenic animals in the study of dermatological pathology. The volume also highlights areas of genetic disease, new animal models to help in understanding dermatological disorders, and gene therapy using skin as a target. W.W. Franke, a pioneer in the study of the molecular biology of keratins, has written the foreword for the book.Molecular Biology of the Skin: The Keratinocyte is intended for use by dermatologists and basic researchers in cell and developmental biology. It will also be valuable for surgeons and other clinicians as well as researchers in gene therapy, virology, and pharmacology.* * Reviews keratinocyte (and epidermal) differentiation. physiology, and pathology, focusing on the molecular aspects* -Discusses keratin genes, retinoic acid, and the use of transgenic animals in the study of dermatalogical pathology* -Highlights genetic disease, new animal models, and gene therapy
Author :National Academies of Sciences, Engineering, and Medicine Publisher :National Academies Press ISBN 13 :0309672988 Total Pages :127 pages Book Rating :4.3/5 (96 download)
Book Synopsis Exploring Novel Clinical Trial Designs for Gene-Based Therapies by : National Academies of Sciences, Engineering, and Medicine
Download or read book Exploring Novel Clinical Trial Designs for Gene-Based Therapies written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-08-27 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognizing the potential design complexities and ethical issues associated with clinical trials for gene therapies, the Forum on Regenerative Medicine of the National Academies of Sciences, Engineering, and Medicine held a 1-day workshop in Washington, DC, on November 13, 2019. Speakers at the workshop discussed patient recruitment and selection for gene-based clinical trials, explored how the safety of new therapies is assessed, reviewed the challenges involving dose escalation, and spoke about ethical issues such as informed consent and the role of clinicians in recommending trials as options to their patients. The workshop also included discussions of topics related to gene therapies in the context of other available and potentially curative treatments, such as bone marrow transplantation for hemoglobinopathies. This publication summarizes the presentation and discussion of the workshop.
Book Synopsis Skin Fibroblast-mediated Gene Therapy by : Theodore D. Palmer
Download or read book Skin Fibroblast-mediated Gene Therapy written by Theodore D. Palmer and published by . This book was released on 1990 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Gene Therapy Plan by : Mitchell L. Gaynor, MD
Download or read book The Gene Therapy Plan written by Mitchell L. Gaynor, MD and published by Penguin Books. This book was released on 2016-04-05 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Mitchell Gaynor, integrative medicine pioneer, details what we can each do individually to keep our bodies healthy.
Book Synopsis Genetic Skin Disorders by : Virginia P. Sybert
Download or read book Genetic Skin Disorders written by Virginia P. Sybert and published by Oxford University Press. This book was released on 2017 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully revised and updated edition of GENETIC SKIN DISORDERS reflects the most current understanding of the diagnosis, treatment, genetic basis, and differential diagnoses of inherited skin disorders. Organized with the needs of busy clinicians in mind, it offers detailed clinical guidance on the signs, symptoms, mode of inheritance, recurrence risk, and diagnosis of over 300 skin disorders, all in an accessible, at-a-glance format. Annotated bibliographies highlight the most relevant and up-to-date medical literature. Newly compiled lists of support groups, both national and international, for patients and their families supplement the ample resources for medical professionals. Informed by the author's extensive clinical experience and suffused with a distinctive, witty voice, GENETIC SKIN DISORDERS is an ideal companion in the laboratory, clinic, or consulting room. FEATURES � Includes both disease-based chapters and an appendix of skin signs that simplifies differential diagnosis for specialists and general practitioners alike � More than 800 color photographs illustrate the full spectrum of hair, skin, and nail abnormalities � Updated to reflect current classification of inherited skin disorders and the molecular underpinnings of these conditions
Download or read book Gene Therapy written by Kenneth W. Culver and published by Mary Ann Liebert. This book was released on 1994 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Polymers and Nanomaterials for Gene Therapy by : Ravin Narain
Download or read book Polymers and Nanomaterials for Gene Therapy written by Ravin Narain and published by Woodhead Publishing. This book was released on 2016-01-09 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. - Explores current challenges in the research of genetic diseases - Discusses polymers for gene therapy and their function in designing advanced materials - Provides examples of organic and inorganic nanomaterials for gene therapy - Includes labeling, targeting, and assays - Looks at characterization, physico-(bio)chemical properties, and applications
Book Synopsis Molecular Diagnostics and Skin Gene Therapy 2 by :
Download or read book Molecular Diagnostics and Skin Gene Therapy 2 written by and published by . This book was released on 2003 with total page 5 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis A Handbook of Gene and Cell Therapy by : Clévio Nóbrega
Download or read book A Handbook of Gene and Cell Therapy written by Clévio Nóbrega and published by Springer Nature. This book was released on 2020-06-27 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a reference handbook for young researchers exploring gene and cell therapy. Gene therapy could be defined as a set of strategies modifying gene expression or correcting mutant/defective genes through the administration of DNA (or RNA) to cells, in order to treat disease. Important advances like the discovery of RNA interference, the completion of the Human Genome project or the development of induced pluripotent stem cells (iPSc) and the basics of gene therapy are covered. This is a great book for students, teachers, biomedical researchers delving into gene/cell therapy or researchers borrowing skills from this scientific field.
Download or read book Gene Therapy written by Blankenstein and published by Birkhäuser. This book was released on 2012-12-06 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: K. Sikora Gene therapy is one of the fastest developing areas in modern medical research. Transcending the classical preclinical and clinical disciplines, it is likely to have far reaching consequences in the practice of medicine, as we enter the next millennium. Currently, there are over 200 seperate active clinical trials with over 2,500 patients entered. These studies involve over 20 countries and include patients with a wide range of diseases, including cancer, HIV infection; cystic fibrosis (CF), haemophilia, diabetes, immune deficiencies, metabolic disorders, ischaemic heart disease and arthritis. Gene therapy can be defined as the deliberate transfer of DNA for therapeutic purposes. There is a further implication that only specific sequences containing rel evant genetic information are used; otherwise, transplantation procedures involving bone marrow, kidney or liver could be considered a form of gene therapy. The con cept of transfer of genetic information as a practical clinical tool arose from the gene-cloning technology, developed during the 1970s. Without the ability to isolate and replicate defined genetic sequences, it would be impossible to produce purified material for clinical use. The drive for the practical application of this technology came from the biotechnology industry with its quest for complex human biomole cules produced by recombinant techniques in bacteria. Within a decade, pharma ceutical-grade insulin, interferon, interleukin 2 and tumour necrosis factor were all involved in clinical trials. The next step was to obtain gene expression in vivo.
