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The Search For Bioactive Compounds From Microorganisms
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Book Synopsis The Search for Bioactive Compounds from Microorganisms by : Satoshi Omura
Download or read book The Search for Bioactive Compounds from Microorganisms written by Satoshi Omura and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biologically active compounds isolated from microorganisms continue to be vital to the development of new drugs and agricultural chemicals. This book was prepared by current and past members of the laboratory of Dr. Satoshi Omura of the Kitasato Institute in Japan. Dr. Omura and his colleagues have discovered and studied a number of important antibiotics, and in their work they have pioneered new methods for screening microbes for interesting and important compounds. This book presents strategies and methods for identifying novel molecules with several types of biological activity. In addition, the book discusses the identification of microbial compounds of agrochemical importance, presents information on chemical screening methods, and concludes with chapters on microbial strain selection, fermentation technology, and genetic engineering of antibiotic-producing microorganisms. This book will be of great interest to scientists working in the very active and competitive fields of antibiotic and agrochemical discovery.
Book Synopsis The Search for Bioactive Compounds from Microorganisms by : Satoshi Ōmura
Download or read book The Search for Bioactive Compounds from Microorganisms written by Satoshi Ōmura and published by Springer. This book was released on 1992-01-01 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Bioactive Compounds from Microbes by : Roberto Mazzoli
Download or read book Bioactive Compounds from Microbes written by Roberto Mazzoli and published by Frontiers Media SA. This book was released on 2017-06-02 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microorganisms have had a long and surprising history. They were “invisible” until invention of microscope in the 17th century. Until that date, although they were extensively (but inconsciously) employed in food preservation, beer and wine fermentation, cheese, vinegar, yogurt and bread making, as well as being the causative agents of infectious diseases, they were considered as “not-existing”. The work of Pasteur in the middle of the 19th century revealed several biological activities performed by microorganisms including fermentations and pathogenicity. Due to the urgent issue to treat infectious diseases (the main cause of death at those times) the “positive potential” of the microbial world has been neglected for about one century. Once the fight against the “evil” strains was fulfilled also thanks to the antibiotics, industry began to appreciate bacteria’s beneficial characteristics and exploit selected strains as starters for both food fermentations and aroma, enzyme and texturing agent production. However, it was only at the end of the 20th century that the probiotic potential of some bacteria such as lactic acid bacteria and bifidobacteria was fully recognized. Very recently, apart from the probiotic activity of in toto bacteria, attention has begun to be directed to the chemical mediators of the probiotic effect. Thanks also to the improvement of techniques such as transcriptomics, proteomics and metabolomics, several bioactive compounds are continuously being discovered. Bioactive molecules produced by bacteria, yeasts and virus-infected cells proved to be important for improving or impairing human health. The most important result of last years’ research concerns the discovery that a very complex network of signals allows communication between organisms (from intra-species interactions to inter-kingdom signaling). Based on these findings a completely new approach has arisen: the system biology standpoind. Actually, the different organisms colonizing a certain environmental niche are not merely interacting with each other as individuals but should be considered as a whole complex ecosystem continuously exchanging information at the molecular level. In this context, this topic issue explores both antagonistic compounds (i.e. antibiotics) and “multiple function” cooperative molecules improving the physiological status of both stimulators and targets of this network. From the applicative viewpoint, these molecules could be hopefully exploited to develop new pharmaceuticals and/or nutraceuticals for improving human health.
Book Synopsis The Search for Biological Active Agent(s) From Actinobacteria, 2nd Edition by : Learn-Han Lee
Download or read book The Search for Biological Active Agent(s) From Actinobacteria, 2nd Edition written by Learn-Han Lee and published by Frontiers Media SA. This book was released on 2020-03-27 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is a large market demand for new drugs. The existing chronic or common ailments without cures, development of new diseases with unknown causes, and the widespread existence of antibiotic-resistant pathogens, have driven this field of research further by looking at all potential sources of natural products. To date, microbes have made a significant contribution to the health and well-being of people globally. The discoveries of useful metabolites produced by microbes have resulted in a significant proportion of pharmaceutical products in today’s market. Therefore, the investigation and identification of bioactive compound(s) producing microbes is always of great interest to researchers. Actinobacteria are one of the most important and efficient groups of natural metabolite producers. Among the numerous genera, Streptomyces have been recognized as prolific producers of useful natural compounds, as they provide more than half of the naturally-occurring antibiotics isolated to-date and continue to emerge as the primary source of new bioactive compounds. Certainly, these potentials have attracted ample research interest and a wide range of biological activities have been subsequently screened by researchers with the utilization of different In vitro and In vivo model of experiments. Literature evidence has shown that a significant number of interesting compounds produced by Actinobacteria were exhibiting either strong anticancer or neuroprotective activity. The further in depth studies have then established the modulation of apoptotic pathway was involved in those observed bioactivities. These findings indirectly prove the biopharmaceutical potential possessed by Actinobacteria and at the same time substantiate the importance of diverse pharmaceutical evaluations on Actinobacteria. In fact, many novel compounds discovered from Actinobacteria with strong potential in clinical applications have been developed into new drugs by pharmaceutical companies. Together with the advancement in science and technology, it is predicted that there would be an expedition in discoveries of new bioactive compounds producing Actinobacteria from various sources, including soil and marine sources. In light of these current needs, and great interest in the scope of this research, this book seeks to contribute on the investigation of different biological active compound(s) producing actinobacteria which are exhibiting antimicrobial, antioxidant, neuroprotective, anticancer activities and similar.
Book Synopsis Microbial Bioactive Compounds by : Ravindra Soni
Download or read book Microbial Bioactive Compounds written by Ravindra Soni and published by Springer Nature. This book was released on 2023-12-29 with total page 297 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book delves into microbial production and its implications for various industries and presents the latest advancements in the field of bioactive compound production by microorganisms. Divided into 16 chapters, the book covers a wide range of topics, starting with the emerging trends in microbial production techniques, followed by the potential of fungi and algae in producing bioactive compounds, and the applications of bioactive compounds in medicine, agriculture, and industry. Contributions from expert scientists emphasize the significance of metabolic engineering and modern analytical techniques for the extraction, purification, and structural characterization of microbial bioactive compounds. The authors also present alternative technologies and methodologies for the recovery and extraction of these compounds from microbial sources and highlight the health-promoting benefits of natural plant-derived bioactive compounds. Particular attention is given to nanocarriers and their potential for managing the delivery of bioactive compounds in therapeutic applications. The importance of actinomycetes and their bioactive potential in the agricultural sector is also discussed. In this book, readers will also find out about the importance of microbial community dynamics in Antarctica, their ecological potential, and their industrial application. The last chapter of the book offers an industrial perspective of microbial pigments and their applications. This book is a valuable resource for researchers, academics, and industry professionals seeking to understand and harness the potential of microbial bioactive compounds for sustainable development, industrial applications, and improved human well-being.
Book Synopsis Natural Bioactive Compounds by : Rajeshwar P. Sinha
Download or read book Natural Bioactive Compounds written by Rajeshwar P. Sinha and published by Academic Press. This book was released on 2020-10-06 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural Bioactive Compounds: Technological Advancements deals with the latest breakthroughs in the field of screening, characterization and novel applications of natural bioactive compounds from diverse group of organisms ranging from bacteria, viruses, cyanobacteria, algae, fungi, bryophytes, higher plants, sponges, corals and fishes. Written by some of the most reputed scientists in the field, this book introduces the reader to strategies and methods in the search for bioactive natural products. It is an essential read for researchers and students interested in bioactive natural products, their biological and pharmacological properties, their possible use as chemopreventive or chemotherapeutic agents, and other future potential applications. Explores natural sources of bioactive compounds, including cyanobacteria, bacteria, viruses, fungi and higher plants Discusses the potential applications of biological products, such as their use in medicine (antibiotics, cancer research, immunology), as food additives, supplements and technological substances Analyzes the contributions of emerging or developing technologies for the study of bioactive natural compounds (characterization and purification)
Book Synopsis Marine Microorganisms by : Leo M.L. Nollet
Download or read book Marine Microorganisms written by Leo M.L. Nollet and published by CRC Press. This book was released on 2016-09-19 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: The marine environment covers 70% of the earth’s surface and accounts for 98% of the potentially habitable space. The bioactives from marine microorganisms include antibiotic compounds, polysaccharides, inhibitors, enzymes, peptides, and pigments. These are used in various fields of biology that range from nutraceuticals to cosmeceuticals. Recent scientific investigations have revealed that marine microbial compounds exhibit various beneficial biological effects, such as anti-inflammatory, anti-cancer, anti-HIV, anti-hypertensive, and anti-diabetic. Marine Microorganisms: Extraction and Analysis of Bioactive Compounds sheds light on the extraction, clean-up, and detection methods of major compounds from marine organisms. The book includes information on the different classes of marine microorganisms and the different bioactives that can be extracted from bacteria, fungi and microalgae. Divided into 7 chapters, the book covers bioactive marine natural products, such as marine microbes, seaweeds, and marine sponges as potential sources of drug discovery, and focuses on analysis methods of the biocomponents from marine microorganisms. A useful reference tool for researchers and students, this book provides current knowledge about isolation and analysis methods of the bioactives and provides insight into the various bioactives of marine microbes toward nutraceutical and pharmaceutical development.
Book Synopsis Bioactive Compounds from Terrestrial Extremophiles by : Lesley-Ann Giddings
Download or read book Bioactive Compounds from Terrestrial Extremophiles written by Lesley-Ann Giddings and published by Springer. This book was released on 2014-11-21 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: A discussion of the chemical compounds produced by organisms living under extreme conditions that may have potential as drugs or leads to novel drugs for human use. This SpringerBrief deals with bioactive materials from terrestrial extremophiles.
Book Synopsis MICROBIAL TRANSFORMATIONS OF BIOACTIVE COMPOUNDS by : John P. Rosazza
Download or read book MICROBIAL TRANSFORMATIONS OF BIOACTIVE COMPOUNDS written by John P. Rosazza and published by CRC Press. This book was released on 1982-07 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 1: Notes on the historical development of microbial transformations; The methodology of microbial transformations of organic compounds; Microbial transformations of antibiotics; Microbial transformation of important industrial hydrocarbons; Microbial transformations of prostaglandins. Volume 2: Microbial transformations as a means of preparing mammalian drug metabolites; Transformations of xenobiotics by the intestinal microflora; Microbial transformations of alkaloids; Microbial transformations of cannabinoids; Microbial transformations of pesticides.
Book Synopsis Bioactive Compounds from Extremophiles by : Lesley-Ann Giddings
Download or read book Bioactive Compounds from Extremophiles written by Lesley-Ann Giddings and published by Springer. This book was released on 2015-01-07 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt: This SpringerBrief sheds new light on bioactive materials from extremophiles with the focus on the biosynthesis processes and related genomics. It deals with all aspects of the chemical compounds produced by organisms living under extreme conditions that may have potential as drugs or lead to novel drugs for human use.
Book Synopsis Bioactive Compounds from Natural Sources, Second Edition by : Corrado Tringali
Download or read book Bioactive Compounds from Natural Sources, Second Edition written by Corrado Tringali and published by CRC Press. This book was released on 2011-09-27 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Bioactive Compounds from Natural Sources was published in a period of renewed attention to biologically active compounds of natural origin. This trend has continued and intensified—natural products are again under the spotlight, in particular for their possible pharmacological applications. Largely focusing on natural products as lead compounds in drug discovery, Bioactive Compounds from Natural Sources, Second Edition: Natural Products as Lead Compounds in Drug Discovery is actually a completely new volume containing surveys of selected recent advances in an interdisciplinary area covering chemistry of natural products, medicinal chemistry, biochemistry, and other related topics. Written by some of the most reputed scientists in the field, this second edition includes new chapters from authors who contributed to the first edition as well as many chapters compiled by new authors. Introducing the reader to strategies and methods in the search for bioactive natural products, this book covers topics including: Natural sources of bioactive compounds such as aquatic cyanobacteria, filamentous fungi, and tropical plants, The tremendous potentiality of metabolic engineering of natural products biosynthesis The contribution of emerging or developing technologies to the study of bioactive natural compounds, namely computational methods and circular dichroism The potential of natural or natural-derived compounds for specific therapeutic applications: treatment of viral diseases, regulation of hypoxia-inducible factor, antimalarials, modulation of angiogenesis, and antitumor and wound-healing activity Selected examples of natural product families and related synthetic analogues, namely polyphenols and campthotecins Compiled for researchers and Ph.D. students working in interdisciplinary fields, this book will also be appreciated by readers without a background in chemistry interested in bioactive natural products, their biological and pharmacological properties, and their possible use as chemopreventive or chemotherapeutic agents. Conversely, the biological and pharmacological data and methods are accessible by chemists.
Book Synopsis Bioactive Molecules from Extreme Environments II. by : Daniela Giordano
Download or read book Bioactive Molecules from Extreme Environments II. written by Daniela Giordano and published by . This book was released on 2021 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue, as a continuation of the previous Special Issue, “Bioactive Molecules from Extreme Environments” (https://www.mdpi.com/journal/marinedrugs/special_issues/Extreme_Environments accessed on 4 November 2021), includes 10 research articles and 2 reviews, providing a wide overview of the chemical biodiversity offered by different marine organisms inhabiting extreme environments to be used for biotechnological and pharmaceutical applications. The six articles in this Special Issue are focused on the polar regions, which represent an untapped source of marine natural products and are still largely unexplored compared to more accessible sites. Many of these articles refer to Antarctica, which is the coldest and most inaccessible continent on the Earth, where extreme temperatures, light and ice have selected biological communities with a unique suite of bioactive metabolites. The marine organisms of Arctic and Antarctic environments are a reservoir of natural compounds, exhibiting huge structural diversity and significant bioactivities that could be used in human applications.
Book Synopsis Bioactive Compounds from Plants by : Derek J. Chadwick
Download or read book Bioactive Compounds from Plants written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: Useful throughout history for their medical as well as other benefits, plant-derived compounds have gained particular importance recently, due to environmental factors. The isolation and characterization of plant products, the identification of their role in the plant, and ways of synthesizing identical compounds or more potent analogues are covered. Also includes methods of culturing plant tissues and genetic engineering as a means of increasing the yield of desired substances from plants. Special emphasis is placed on plants previously unknown to Western scientists.
Book Synopsis Biotechnology of Antibiotics and Other Bioactive Microbial Metabolites by : G. Lancini
Download or read book Biotechnology of Antibiotics and Other Bioactive Microbial Metabolites written by G. Lancini and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: In response to the field's need for an introductory text, the authors have distilled the vast and scattered literature relating to the biotechnology of microbial secondary metabolites. General biology, biosynthesis, the search for novel metabolites, and techniques for strain improvement are all discussed to provide undergraduate and graduate students with a concise, readable overview of the field.
Book Synopsis Bioactive Compounds by : Leila Queiroz Zepka
Download or read book Bioactive Compounds written by Leila Queiroz Zepka and published by BoD – Books on Demand. This book was released on 2021-09-29 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioactive Compounds - Biosynthesis, Characterization, and Applications is an authoritative compilation of chapters on bioactive compounds with proven activities. It provides valuable information about biosynthesized active compounds that can be used for the further development of products in various industries. Chapters cover such topics as biosynthesis, characterization, separation, and purification, and applications of bioactive molecules. It describes and discusses bioresources of animal, vegetal, and microbial origin as potential sources of flavonoids, polysaccharides, sterols, polyphenols, amino acids, and others. This book provides insight into future developments in the field and, as such, is an essential resource for academicians, industrial researchers, and practitioners in biomolecules with biological activity. Key features: • Describes several classes of bioactive compounds and their associated activities • Highlights potential contributions of bioactive compounds as alternatives in the prevention and/or treatment of diseases • Contains information relevant to the development and use of new products
Book Synopsis Characterization of Bioactive Compounds in Foods and Plants Using Advanced Analytical Techniques by : Marina Russo
Download or read book Characterization of Bioactive Compounds in Foods and Plants Using Advanced Analytical Techniques written by Marina Russo and published by Mdpi AG. This book was released on 2022-01-11 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the 1990s, food chemistry opened a new chapter in foods and plants investigation. An increasing attention to secondary metabolites and micro-constituents of nutraceutical interest present in foods has been noticed, supporting previous studies on macronutrient composition. Thanks to positive scientific opinions on the presence of bioactive molecules in plants and foods, the previous vision of exploring foods exclusively from a "caloric" point of view has been changed to looking at foodstuffs as having positive effects on human health. This book focuses on the optimization and validation of advanced analytical methodologies dedicated to the characterization and valorization of foods and plants containing bioactive molecules. Qualitative and quantitative characterization, food security, traceability, and innovation in the field of nutraceutical and functional nutrition will be of particular interest in order to stimulate a dialogue on correct nutrition concepts in a constantly changing cultural, technological, and climate context.
Book Synopsis Analysis of Marine Samples in Search of Bioactive Compounds by :
Download or read book Analysis of Marine Samples in Search of Bioactive Compounds written by and published by Elsevier. This book was released on 2014-08-26 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Seas and oceans offer a wide range of temperature, pressure, light and chemical conditions thus allowing a wide diversity of marine organisms from shallow coastal waters to the deep ocean. These resources can be used to obtain new products and develop services, and in turn help to provide solutions to the challenges that affect our planet, including offering a sustainable supply of food and energy, new industrial materials and processes, new bioactive compounds, and new health treatments. Marine compounds have been identified as having antibacterial, anticoagulant, antifungal, antimalarial, antiprotozoal, antituberculosis, and antiviral activities. The major sources of these bioactive compounds are marine sponges, coelenterates, and microorganisms, followed by algae, echinoderms, tunicates, molluscs, and bryozoans. The discovery of bioactive compounds from marine samples is a hot topic considering the current need for sustainable use of marine resources. This book is a comprehensive overview of the analytical techniques employed in the discovery and characterization of bioactive compounds isolated from (all possible) marine samples and gives future perspectives of analytical methodologies. This overview includes an assessment of the sampling and preparation of extracts, the separation and isolation of bioactive compounds, their structural characterization and the application of bioassays in the discovery of bioactive compounds. Comprehensive coverage of analytical techniques and applications Clear diagrams to adequately support important topics Real examples of applications of analytical techniques in the search for new bioactive compounds
