The Saga of the Nerve Growth Factor

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Publisher : World Scientific
ISBN 13 : 9810226047
Total Pages : 502 pages
Book Rating : 4.8/5 (12 download)

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Book Synopsis The Saga of the Nerve Growth Factor by : Rita Levi-Montalcini

Download or read book The Saga of the Nerve Growth Factor written by Rita Levi-Montalcini and published by World Scientific. This book was released on 1997 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is a collection of articles written by Nobel Laureate Rita Levi-Montalcini and published from 1942 to 1995. Studies described in the first part set the stage for the discovery of a protein molecule which became known as the Nerve Growth Factor (NGF), described in detail in the second part. The NGF synthesized in minute amounts in all vertebrate tissues, plays an essential role in the differentiation and survival of several nerve cell populations in the peripheral and central nervous system. The discovery of the NGF was defined by the Nobel Foundation as a milestone in developmental neurobiology, and the author was awarded in 1986 with this prestigious award. Studies pursued in subsequent years and still in progress, have unveiled other fundamental properties of the NGF, described in the third part of this volume.

Enteric Glia

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Publisher : Biota Publishing
ISBN 13 : 1615046615
Total Pages : 72 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Enteric Glia by : Brian D. Gulbransen

Download or read book Enteric Glia written by Brian D. Gulbransen and published by Biota Publishing. This book was released on 2014-07-01 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: The enteric nervous system (ENS) is a complex neural network embedded in the gut wall that orchestrates the reflex behaviors of the intestine. The ENS is often referred to as the “little brain” in the gut because the ENS is more similar in size, complexity and autonomy to the central nervous system (CNS) than other components of the autonomic nervous system. Like the brain, the ENS is composed of neurons that are surrounded by glial cells. Enteric glia are a unique type of peripheral glia that are similar to astrocytes of the CNS. Yet enteric glial cells also differ from astrocytes in many important ways. The roles of enteric glial cell populations in the gut are beginning to come to light and recent evidence implicates enteric glia in almost every aspect of gastrointestinal physiology and pathophysiology. However, elucidating the exact mechanisms by which enteric glia influence gastrointestinal physiology and identifying how those roles are altered during gastrointestinal pathophysiology remain areas of intense research. The purpose of this e-book is to provide an introduction to enteric glial cells and to act as a resource for ongoing studies on this fascinating population of glia. Table of Contents: Introduction / A Historical Perspective on Enteric Glia / Enteric Glia: The Astroglia of the Gut / Molecular Composition of Enteric Glia / Development of Enteric Glia / Functional Roles of Enteric Glia / Enteric Glia and Disease Processes in the Gut / Concluding Remarks / References / Author Biography

NGF and Related Molecules in Health and Disease

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Publisher : Elsevier
ISBN 13 : 0080497500
Total Pages : 563 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis NGF and Related Molecules in Health and Disease by : L. Aloe

Download or read book NGF and Related Molecules in Health and Disease written by L. Aloe and published by Elsevier. This book was released on 2003-12-10 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book highlights different aspects of current understanding of neurotrophin-receptor signal transduction pathways, including the signaling endosome hypothesis. Findings on the synaptotrophic potential of NGF and related neurotrophins, neurotrophin involvement in neuronal stem cell biology, biological activity of the NGF precursor proNGF, and nociception- and antinociception-associated activity of NGF and/or BDNF are also presented and discussed. Several chapters deal with the involvement of various neurotrophins in the control of different nonneuronal processes, such as immune, inflammatory and allergic reactions, tissue repair and wound healing. The findings showed that neurotrophins play important roles in the pathobiology of a surprising variety of seemingly unrelated non-neurological diseases, including bronchial asthma, rheumatoid arthritis, systemic sclerosis, hair growth disorders, psoriasis, corneal and skin ulcers, atherosclerosis, metabolic syndrome, crush syndrome, and Behçet's disease. There are also chapters on the involvement of NGF and related molecules in neurological diseases, including Huntington's disease, the multiple sclerosis-like model of experimental allergic encephalomyelitis, peripheral neuropathies, neuroblastoma, Parkinson's disease, Alzheimer's disease, and even motion sickness syndrome, also psychiatric disorders, including depression and schizophrenia. Finally, potential important therapeutic benefits are presented, for diabetic neuropathy, gastrointestinal dysmotility, CNS neurodegenerative disease, spinal cord injuries, cutaneous and corneal ulcers, as well as peripheral ischemic vasculopathy.

In Praise Of Imperfe

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Publisher :
ISBN 13 :
Total Pages : 254 pages
Book Rating : 4.:/5 (42 download)

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Book Synopsis In Praise Of Imperfe by : Rita Levi-Montalcini

Download or read book In Praise Of Imperfe written by Rita Levi-Montalcini and published by . This book was released on 1988-05-08 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The autobiography of Levi-Montalcini, who won the Nobel Prize for Medicine in 1986. Born in Torino into a middle-class Jewish family, she experienced the rise of fascism and antisemitism in the 1930s-40s (discussed on pp. 73-105). After the promulgation of the racial laws in 1938, it was impossible for her to pursue research at the Neurological Clinic and she continued her work in private. She survived the war hiding in a small town in Italy and later emigrated to the United States.

Fundamental Neuroscience

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Publisher : Academic Press
ISBN 13 : 0080561020
Total Pages : 1277 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Fundamental Neuroscience by : Larry Squire

Download or read book Fundamental Neuroscience written by Larry Squire and published by Academic Press. This book was released on 2008-04-02 with total page 1277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental Neuroscience, Third Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts.Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness Additional text boxes describing key experiments, disorders, methods, and concepts Multiple model system coverage beyond rats, mice, and monkeys Extensively expanded index for easier referencing

Pain Management and the Opioid Epidemic

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Publisher : National Academies Press
ISBN 13 : 0309459575
Total Pages : 483 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine

Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Neurotrophic Factors

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Publisher : Springer Science & Business Media
ISBN 13 : 3642451063
Total Pages : 514 pages
Book Rating : 4.6/5 (424 download)

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Book Synopsis Neurotrophic Factors by : Gary R. Lewin

Download or read book Neurotrophic Factors written by Gary R. Lewin and published by Springer Science & Business Media. This book was released on 2014-03-25 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington’s syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.

Recent Advances in NGF and Related Molecules

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Publisher : Springer Nature
ISBN 13 : 3030740463
Total Pages : 302 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Recent Advances in NGF and Related Molecules by : Laura Calzà

Download or read book Recent Advances in NGF and Related Molecules written by Laura Calzà and published by Springer Nature. This book was released on 2021-08-27 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than fifty years after its initial discovery by Rita Levi Montalcini and Stanley Cohen and the proposal of the neurotrophic theory, nerve growth factor (NGF) has become the prototype of a family of biologically active molecules called neurotrophic factors (NTFs). This book addresses important advances in NTF research, from basic science to clinical medicine. It focuses mainly on NGF, but also includes individual chapters dealing with the brain-derived neurotrophic factor (BDNF) and ligands of the glial cell line-derived neurotrophic factor (GDNF) family, which have attracted increasing interest in the neuroscience community because of their diverse effects in the normal and diseased brain. In the first part of the book, the authors provide the necessary background for the following chapters and discuss the basic mechanisms and pathways of NGF signal transduction. In the following sections, they then examine the regenerative activity and neuroprotective capacity of NGF during development and in normal and diseased tissues in adulthood and discuss the role of NGF in Alzheimer's disease and nociception. In addition, the role of NGF in processing sensory information and its influence on behavior is further discussed. The book concludes with an overview of the diagnostic and therapeutic potential of NTF in psychiatric disorders and obesity management, as well as a highlight of NGF research in veterinary medicine. Many of the authors of this volume participated in the Second International Rita Levi-Montalcini Meeting, held in Bologna, Italy, in 2019. The book covers a wide range of important topics in past and current NTF research and will appeal to basic researchers and clinicians alike.

New Foundation of Biology

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Publisher : Elsevier
ISBN 13 : 0080537510
Total Pages : 517 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis New Foundation of Biology by : I. Berczi

Download or read book New Foundation of Biology written by I. Berczi and published by Elsevier. This book was released on 2001-07-19 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new scientific discipline, acknowledged 65 years after its discovery, was the focus of the first Conference on Neuroimmune Biology in Canada. The papers presented at the conference, and in this volume, are dedicated to Dr. Hans Selye who is recognized as discovering the existence of a hypothalamic-pituitary-adrenal-thymus axis. This axis plays an important role in the adaptation of higher animals and man to various physical, chemical, biological and emotional challenges.The conference and participants also honored Dr. Andor Szentivanyi whose opening paper, "Studies on the hypothalamic regulation of histamine synthesis", is contained in the introduction to this book. Dr. Szentivanyi has dedicated his long research career to the clarification of the role of the central nervous system in immune and inflammatory reactions, and his experimental results are presented here.With an ultimate goal to achieve a more thorough understanding of higher organisms in their entire complexity, this book, the first in the series http://serval.elsevier.com/locate/series/nibNeuroImmune Biology presents a coordinated and integrated view of the growing body of knowledge rapidly accumulating in this area.

Theory of Cortical Plasticity

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Publisher : World Scientific
ISBN 13 : 9789812387912
Total Pages : 336 pages
Book Rating : 4.3/5 (879 download)

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Book Synopsis Theory of Cortical Plasticity by : Leon N. Cooper

Download or read book Theory of Cortical Plasticity written by Leon N. Cooper and published by World Scientific. This book was released on 2004 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: This invaluable book presents a theory of cortical plasticity and shows how this theory leads to experiments that test both its assumptions and consequences. It elucidates, in a manner that is accessible to students as well as researchers, the role which the BCM theory has played in guiding research and suggesting experiments that have led to our present understanding of the mechanisms underlying cortical plasticity. Most of the connections between theory and experiment that are discussed require complex simulations. A unique feature of the book is the accompanying software package, Plasticity. This is provided complete with source code, and enables the reader to repeat any of the simulations quoted in the book as well as to vary either parameters or assumptions. Plasticity is thus a research and an educational tool. Readers can use it to obtain hands-on knowledge of the structure of BCM and various other learning algorithms. They can check and replicate our results as well as test algorithms andrefinements of their own.

White Night

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Publisher : Penguin
ISBN 13 : 9780451461407
Total Pages : 424 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis White Night by : Jim Butcher

Download or read book White Night written by Jim Butcher and published by Penguin. This book was released on 2007 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: Assigned to investigate a series of deaths of magic practitioners, all of whom lacked the ability to become full-fledged wizards, professional Chicago wizard Harry Dresden is shocked when the evidence points to his half-brother Thomas as the killer, until he uncovers a conspiracy within the White Council of Wizards that threatens both him and his family. 100,000 first printing.

The Hostage Brain

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Publisher : Rockefeller Univ. Press
ISBN 13 : 9780874700565
Total Pages : 336 pages
Book Rating : 4.7/5 (5 download)

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Book Synopsis The Hostage Brain by : Bruce S. McEwen

Download or read book The Hostage Brain written by Bruce S. McEwen and published by Rockefeller Univ. Press. This book was released on 1994 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Neurobiology of Multiple Sclerosis

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Publisher : Academic Press
ISBN 13 : 0080544274
Total Pages : 759 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis The Neurobiology of Multiple Sclerosis by :

Download or read book The Neurobiology of Multiple Sclerosis written by and published by Academic Press. This book was released on 2007-06-07 with total page 759 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple sclerosis (MS) is an immune-mediated neurodegenerative disorder of the human central nervous system (CNS) which usually affects young adults with certain genetic backgrounds who are then exposed to certain precipitating environmental antigen(s). Despite major advances of the past two decades in understanding the pathophysiology of MS, and in spite of the introduction of new immunomodulatory and immuno-suppressive agents which may slow down disease progression and delay the onset of disability, the "cause and the "cure for MS remain elusive. This volume of International Review of Neurobiology focuses on MS and related disorders. The volume can be divided into various sections with the main emphasis on MS pathogenesis, clinical features and epidemiology, neuroimaging, and treatment. The ultimate goal of this book is to encourage further research into the pathogenesis of this elusive disease.

Matsushita Leadership

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Publisher : Simon and Schuster
ISBN 13 : 1471109577
Total Pages : 442 pages
Book Rating : 4.4/5 (711 download)

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Book Synopsis Matsushita Leadership by : John P. Kotter

Download or read book Matsushita Leadership written by John P. Kotter and published by Simon and Schuster. This book was released on 2012-12-11 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: He was one of the most inspirational role models of all time. Thrown into poverty at age four, Konosuke Matsushita (Mat-SOSH-ta) struggled with the early deaths of family members, an apprenticeship which demanded sixteen-hour days at age nine, all the problems associated with starting a business with neither money nor connections, the death of his only son, the Great Depression, the horror of World War II in Japan, and more. Yet John P. Kotter shows in this fascinating and instructive book how, instead of being ground down by these hardships, Matsushita grew to be a fabulously successful entrepreneur and business leader, the founder of Japan's General Electric: the $65 billion a year Matsushita Electric Corporation. His accomplishments as a leader, author, educator, philanthropist, and management innovator are astonishing, and outshine even Soichiro Honda, J.C. Penney, Sam Walton, and Henry Ford. In this immensely readable book, Kotter relates how Matsushita created a large business, invented management practices that are increasingly being used today, helped lead his country's economic miracle after World War II wrote dozens of books in his latter years, founded a graduate school of leadership, created Japan's version of a Nobel Prize, and gave away hundreds of millions to good causes. The Matsushita story expands our notion of the possible, even for a sickly youngster who did not have the benefit of a privileged background, education, good looks, or a charismatic presence. It tells us much about leadership, entrepreneurship, a drive for lifelong learning, and their roots. It demonstrates the power of a longterm outlook, idealistic goals, and humility in the face of great success. Matsushita Leadershipis both a biography and a set of lessons for careers and corporations in the 21st century. An inspirational story and a business primer, the implications are powerful, for organizations and for living a meaningful life.

Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology

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Publisher : Springer
ISBN 13 : 3319341367
Total Pages : 445 pages
Book Rating : 4.3/5 (193 download)

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Book Synopsis Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology by : Richard M. Kostrzewa

Download or read book Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology written by Richard M. Kostrzewa and published by Springer. This book was released on 2016-07-13 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is authored by leading experts who made major discoveries in neuroteratology research focused on modeling human neural developmental disorders. Individual chapters address ADHD (attention-deficit hyperactivity disorder), Lesch-Nyhan disease, psychoses and schizophrenia, autism, and models of Parkinson’s Disease and tardive dyskinesia. The effects of perinatal stress and agonist insults on life-long outcomes are addressed, as well as the overall effects of perinatal neurotoxins on development of specific neural phenotypic systems. The book provides a unique compendium on how perinatal insults of various types can produce effects in brain that persist throughout the life span. Researchers can derive insight into experimental approaches in this research field; clinicians can develop insights into the influences of the many noxious and seemingly innocuous substances that might influence brain development in children.

Embryogenesis Explained

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Publisher : World Scientific
ISBN 13 : 9814740691
Total Pages : 784 pages
Book Rating : 4.8/5 (147 download)

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Book Synopsis Embryogenesis Explained by : Natalie K Gordon

Download or read book Embryogenesis Explained written by Natalie K Gordon and published by World Scientific. This book was released on 2016-09-15 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: The greatest mystery of life is how a single fertilized egg develops into a fully functioning, sometimes conscious multicellular organism. Embryogenesis Explained offers a new theory of how embryos build themselves, and combines simple physics with the most recent biochemical and genetic breakthroughs, based on the authors' prediction and then discovery of differentiation waves. They explain their ideas in a form accessible to the lay person and a broad spectrum of scientists and engineers. The diverse subjects of development, genetics and evolution, and their physics, are brought together to explain this major, previously unanswered scientific question of our time.As a follow up on The Hierarchical Genome, this book is a shorter but conceptually expanded work for the reader who is interested in science. It is useful as a starting point for the curious layman or the scientist or professional encountering the problem of embryogenesis without the formal biology background. There is also material useful for the seasoned biologist caught up in the new rush of information about the role of mechanics in developmental biology and cellular level mechanics in medicine.

Neurodegeneration: From Genetics to Molecules, Volume II

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889741494
Total Pages : 213 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Neurodegeneration: From Genetics to Molecules, Volume II by : Victoria Campos-Peña

Download or read book Neurodegeneration: From Genetics to Molecules, Volume II written by Victoria Campos-Peña and published by Frontiers Media SA. This book was released on 2022-01-24 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: