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Author : Savo Lazic
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)
Download or read book The Role of the Second Heart Field in Zebrafish Heart Development written by Savo Lazic and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ann Milada Cavanaugh
Publisher :
ISBN 13 :
Total Pages : 112 pages
Book Rating : 4.:/5 (918 download)
Download or read book The Role of Cardiac Neural Crest Cells in Zebrafish Heart Development written by Ann Milada Cavanaugh and published by . This book was released on 2015 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early stages of cardiac development are well conserved among vertebrates. However, later morphological development results in a more complicated 4 chambered heart in mammals, while fish retain a simple two chambered heart. The onset of these morphological changes coincide with contribution of cells to the heart from the second heart field (SHF). Interestingly, despite the great morphological differences in the structures derived from precursors in the SHF in mammals and zebrafish, the signals regulating SHF development are conserved. Cardiac neural crest cells (CNCCs), which also contribute to later stages of cardiac development are well studied in chick and mouse models, but very little is known about the role of CNCCs in zebrafish heart development. It is possible that as with the SHF the molecular mechanisms of CNCC development is conserved among all vertebrates. In this study I aim to better define the role of CNCCs in zebrafish and determine how well the role for CNCCs is conserved. I show that there are two waves of CNCCs which contribute to the heart in zebrafish. The first invades the developing heart tube between 24 hpf and 30 hpf and gives rise to CNC derived cardiomyocytes. CNCCs with a myocardial fate have an invasive morphology as they enter the heart, and disrupt local adhesion molecules in neighboring cells. The second wave of CNCCs migrates along aortic arch artery 6, onto the ventral aorta by 80 hpf, and ultimately invades the BA. I find that both populations of CNC derived cells persist to adulthood. These two populations are separated not only by developmental time, but also by their response to FGF signaling as they migrate to the heart. The first wave is independent of Tbx1, and FGF signaling, and the second wave relies on FGF signaling for migration to the ventral aorta and BA. Ablation of NC leads to a variety of cardiac defects including reduced heart rate, defects in myocardial maturation, development of the BA and aorta, and defects in SHF contribution to the heart, as well as a dramatic increase of bmp4 expression, and a reduction of tbx1 expression. Many of the cardiac phenotypes I observe in NC ablated embryos are similar to those reported in other species, making zebrafish an ideal model to study signaling which may be important for CNC development in vertebrates.
Author : Dipak K. Dube
Publisher : Springer Science & Business Media
ISBN 13 : 9780817642266
Total Pages : 304 pages
Book Rating : 4.6/5 (422 download)
Download or read book Myofibrillogenesis written by Dipak K. Dube and published by Springer Science & Business Media. This book was released on 2001-10-19 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Myofibrillogenesis has been studied extensively over the last 100 years. Until recently, we have not had a comprehensive understanding of this fundamental process. The emergence of new technologies in molecular and cellular biology, combined with classical embryology, have started to unravel some of the complexities of myofibril assembly in striated muscles. In striated muscles, the contractile proteins are arranged in a highly ordered three dimensional lattice known as the sarcomere. The assembly of a myofibril involves the precise ordering of several proteins into a linear array of sarcomeres. Multiple isoforms in many of these proteins further complicate the process, making it difficult to define the precise role of each component. This volume has been compiled as a comprehensive reference on myofibrillogenesis. In addition, the book includes reviews on myofibrillar disarray under various pathological conditions, such as familial hypertrophic cardiomyopathy (FHC), and incorporates a section on the conduction system in the heart. Much of the information in this volume has not been described elsewhere. Presented in a manner to be of value to students and teachers alike, "Myofibrillogenesis" will be an invaluable reference source for all in the fields of muscle biology and heart development.
Author : Jhelum Choubey
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (133 download)
Download or read book Characterizing the Contribution of First and Second Heart Field-derived Cells in Zebrafish Cardiac Development written by Jhelum Choubey and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vertebrate heart development occurs through contribution from two spatio-temporally distinct progenitor populations termed the First Heart Field (FHF) and Second Heart Field (SHF). In the mammalian heart, the FHF gives rise to the left ventricle and parts of both atria, whereas the SHF contributes to the right ventricle, inflow and outflow tracts, and portions of the atria. Here I employed a cmlc2 driven CreERT and switch reporter lines to lineage trace the two populations in the adult zebrafish heart. Late differentiating cells, as displayed through EGFP-positive cells consistently made a significant contribution to the cortical layer of the adult heart, which has been shown to be a major source of new cardiomyocytes following cardiac injury. Cells derived from the proposed SHF population give rise to the primordial layer, as well as the trabeculae in the ventricular base. The cortical and primordial layers are partially derived from the SHF progenitor population.
Author : Robert M. Santer
Publisher : Springer
ISBN 13 :
Total Pages : 120 pages
Book Rating : 4.3/5 (91 download)
Download or read book Morphology and Innervation of the Fish Heart written by Robert M. Santer and published by Springer. This book was released on 1985 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Benoit G. Bruneau
Publisher :
ISBN 13 : 9781621823599
Total Pages : pages
Book Rating : 4.8/5 (235 download)
Download or read book Heart Development and Disease written by Benoit G. Bruneau and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Development of the heart is a complex process and can lead to serious congenital disease if the process goes awry. This book provides a detailed description of the cell lineages involved in heart development and how their migration and morphogenesis are controlled. It also examines the genetic and environmental bases for congenital heart disease and how model systems are revealing more about the processes involved"--
Author : Benoit Bruneau G.
Publisher : Academic Press
ISBN 13 : 0123877865
Total Pages : 425 pages
Book Rating : 4.1/5 (238 download)
Download or read book Heart Development written by Benoit Bruneau G. and published by Academic Press. This book was released on 2012-03-30 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The developing heart is the first functional organ, and its proper formation and function is essential for life. This volume compiles the exciting new advances that have been made in understanding the regulation of heart development, the genes and pathways involved, and the impact these have in heart disease. A stellar collection of scientists tackles an important facet of heart development, providing a comprehensive set of reviews. Cutting-edge science Authority of contributors Exciting field of research
Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470868031
Total Pages : 300 pages
Book Rating : 4.4/5 (78 download)
Download or read book Development of the Cardiac Conduction System written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2005-01-21 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pacemaking and conduction system (PCS) is vital for generating and synchronizing the heart beat. Dysfunction of this system can be a direct cause of cardiac conduction disturbance, arrhythmias and sudden cardiac death. A wealth of information has been collected over many years on the unique histological, morphological and phenotypic characteristics of specialized cardiac tissues. The cellular and molecular mechanisms that govern development of the PCS are now starting to be understood. This book draws together contributions from an international and interdisciplinary group of experts working on both basic and clinical aspects of cardiac development. It features reviews of the structure and function of the developing PCS, discussion of the molecular and cellular mechanisms regulating embryological development of this system and studies on the fundamental basis of PCS pathology. The book also considers how novel therapeutic interventions based on understanding of the developmental biology of cardiac pacemaking and conduction tissues might ultimately impact on clinical medicine.
Author : Masaki Ieda
Publisher : Springer
ISBN 13 : 3319561065
Total Pages : 274 pages
Book Rating : 4.3/5 (195 download)
Download or read book Cardiac Regeneration written by Masaki Ieda and published by Springer. This book was released on 2017-10-27 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Volume of the series Cardiac and Vascular Biology offers a comprehensive and exciting, state-of-the-art work on the current options and potentials of cardiac regeneration and repair. Several techniques and approaches have been developed for heart failure repair: direct injection of cells, programming of scar tissue into functional myocardium, and tissue-engineered heart muscle support. The book introduces the rationale for these different approaches in cell-based heart regeneration and discusses the most important considerations for clinical translation. Expert authors discuss when, why, and how heart muscle can be salvaged. The book represents a valuable resource for stem cell researchers, cardiologists, bioengineers, and biomedical scientists studying cardiac function and regeneration.
Author : Toshio Nakanishi
Publisher : Springer Nature
ISBN 13 : 9811511853
Total Pages : 374 pages
Book Rating : 4.8/5 (115 download)
Download or read book Molecular Mechanism of Congenital Heart Disease and Pulmonary Hypertension written by Toshio Nakanishi and published by Springer Nature. This book was released on 2020-02-28 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book focuses on the molecular mechanism of congenital heart disease and pulmonary hypertension, offering new insights into the development of pulmonary circulation and the ductus arteriosus. It describes in detail the molecular mechanisms involved in the development and morphogenesis of the heart, lungs and ductus arteriosus, covering a range of topics such as gene functions, growth factors, transcription factors and cellular interactions, as well as stem cell engineering technologies. The book also presents recent advances in our understanding of the molecular mechanism of lung development, pulmonary hypertension and molecular regulation of the ductus arteriosus. As such, it is an ideal resource for physicians, scientists and investigators interested in the latest findings on the origins of congenital heart disease and potential future therapies involving pulmonary circulation/hypertension and the ductus arteriosus.
Author : Nadia Rosenthal
Publisher : Academic Press
ISBN 13 : 0123813328
Total Pages : 630 pages
Book Rating : 4.1/5 (238 download)
Download or read book Heart Development and Regeneration written by Nadia Rosenthal and published by Academic Press. This book was released on 2010-06-18 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry. Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances. Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases. Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration. Authored by world experts in heart development and disease New research on epigenetic modifiers in cardiac development Comprehensive coverage of stem cells and prospects for cardiac regeneration Up-to-date research on transcriptional and proteomic circuits in cardiac disease Full-color, detailed illustrations
Author : Michael T. Ashworth
Publisher : Cambridge University Press
ISBN 13 : 1107116287
Total Pages : 361 pages
Book Rating : 4.1/5 (71 download)
Download or read book Pathology of Heart Disease in the Fetus, Infant and Child written by Michael T. Ashworth and published by Cambridge University Press. This book was released on 2019-08-22 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clearly presents the pathology of heart disease from fetus to adolescence, integrating histology and macroscopy with effects of treatment.
Author : Margaret L. Kirby
Publisher : Oxford University Press
ISBN 13 : 019517819X
Total Pages : 288 pages
Book Rating : 4.1/5 (951 download)
Download or read book Cardiac Development written by Margaret L. Kirby and published by Oxford University Press. This book was released on 2007-03-22 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the only in-depth, single author survey of heart development. It will provide a more systematic, up-to-date synthesis of the subject than any other volume, spanning the range from classical anatomical studies to recent findings in molecular biology. It also covers topics that are often omitted from discussions of heart development, such as myocardial function, cardiac innervation, and conduction development and clinical correlates will be discussed throughout. The book is beautifully illustrated by Karen Waldo, an artist who has collaborated with Dr. Kirby for many years.
Author : Zhiyuan Gong
Publisher : World Scientific
ISBN 13 : 9814482854
Total Pages : 684 pages
Book Rating : 4.8/5 (144 download)
Download or read book Fish Development And Genetics: The Zebrafish And Medaka Models written by Zhiyuan Gong and published by World Scientific. This book was released on 2004-11-02 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: The zebrafish is the most important fish model in developmental and genetic analyses. This book contains 19 review articles covering a broad spectrum of topics, from development to genetic tools. The contents range from early development, the role of maternal factors and gastrulation, to tissue differentiation and organogenesis, such as development of the organizer, notochord, floor plate, nervous system, somites, muscle, skeleton and endoderm. The genetic tools cover morpholino knock-down, transgenics, fish cloning, transposons and genome evolution. The book also includes two chapters on genome mapping and embryonic stem cells in medaka, another important model fish. Summarizing the state-of-the-art studies of the zebrafish model and focusing on the molecular aspects of development, this book is a valuable reference for students learning the basic aspects of the zebrafish model, and for researchers seeking resources in zebrafish research.
Author : Roger R. Markwald
Publisher : Springer Science & Business Media
ISBN 13 : 9780817640378
Total Pages : 256 pages
Book Rating : 4.6/5 (43 download)
Download or read book Living Morphogenesis of the Heart written by Roger R. Markwald and published by Springer Science & Business Media. This book was released on 1998-12-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The overall scope of this new series will be to evolve an understanding of the genetic basis of (1) how early mesoderm commits to cells of a heart lineage that progres sively and irreversibly assemble into a segmented, primary heart tube that can be remodeled into a four-chambered organ, and (2) how blood vessels are derived and assembled both in the heart and in the body. Our central aim is to establish a four-dimensional, spatiotemporal foundation for the heart and blood vessels that can be genetically dissected for function and mechanism. Since Robert DeHaan's seminal chapter "Morphogenesis of the Vertebrate Heart" published in Organogenesis (Holt Rinehart & Winston, NY) in 1965, there have been surprisingly few books devoted to the subject of cardiovascular morpho genesis, despite the enormous growth of interest that occurred nationally and internationally. Most writings on the subject have been scholarly compilations of the proceedings of major national or international symposia or muItiauthored volumes, often without a specific theme. What is missing are the unifying concepts that can make sense out of a burgeoning database of facts. The Editorial Board of this new series believes the time has come for a book series dedicated to cardiovas cular morphogenesis that will serve not only as an important archival and didactic reference source for those who have recently come into the field but also as a guide to the evolution of a field that is clearly coming of age.
Author : Paul A. Iaizzo
Publisher : Springer
ISBN 13 : 331919464X
Total Pages : 806 pages
Book Rating : 4.3/5 (191 download)
Download or read book Handbook of Cardiac Anatomy, Physiology, and Devices written by Paul A. Iaizzo and published by Springer. This book was released on 2015-11-13 with total page 806 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the latest information on the anatomic features, underlying physiologic mechanisms, and treatments for diseases of the heart. Key chapters address animal models for cardiac research, cardiac mapping systems, heart-valve disease and genomics-based tools and technology. Once again, a companion of supplementary videos offer unique insights into the working heart that enhance the understanding of key points within the text. Comprehensive and state-of-the art, the Handbook of Cardiac Anatomy, Physiology and Devices, Third Edition provides clinicians and biomedical engineers alike with the authoritative information and background they need to work on and implement tomorrow’s generation of life-saving cardiac devices.
Author : Bruce M. Carlson
Publisher : Elsevier
ISBN 13 : 0080477968
Total Pages : 400 pages
Book Rating : 4.0/5 (84 download)
Download or read book Principles of Regenerative Biology written by Bruce M. Carlson and published by Elsevier. This book was released on 2011-10-10 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the explosion of knowledge from molecular biology and the burgeoning interest in generating or regenerating tissues or organs through various bioengineering or stem cell approaches, many scientists and students have shown a renewed interest in the phenomenon of regeneration. Because relatively few have had the luxury of being able to approach the phenomenon of regeneration from a broad biological perspective, Dr. Carlson has produced a book that outlines the fundamental principles of regeneration biology. Subject matters focus principally on regeneration in vertebrate systems, but also invertebrate regeneration. In order to manipulate regenerative processes, it is important to understand the underlying principles of regeneration. Principles of Regnerative Biology is the key introductory reference for all developmental biologists, geneticists, and tissue and stem cell researchers. Creates a general understanding of one of the most fascinating and complex phenomena in biology Discusses the ability and diversity of regeneration in various organisms Explains the history and origins of cells in regenerating systems Includes information on stem cells and its important role in regeneration
