Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
The Role Of The Epithelial Mesenchymal Transition In Aggressive Tumour Phenotypes
Download The Role Of The Epithelial Mesenchymal Transition In Aggressive Tumour Phenotypes full books in PDF, epub, and Kindle. Read online The Role Of The Epithelial Mesenchymal Transition In Aggressive Tumour Phenotypes ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis The Role of the Epithelial-mesenchymal Transition in Aggressive Tumour Phenotypes by :
Download or read book The Role of the Epithelial-mesenchymal Transition in Aggressive Tumour Phenotypes written by and published by . This book was released on 2014 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The epithelial-mesenchymal transition (EMT) is an evolutionarily conserved developmental process characterized by the loss of intercellular contacts, changes in cell polarity and increased migration and invasion. EMT has recently been shown to have a significant impact on chemotherapy response and metastatic progression in cancer cells. We hypothesized that because EMT contributes to aggressive cancer phenotypes, expression profiles of key EMT modulators could be profiled in ovarian and prostate tumours to distinguish aggressive from non-aggressive disease. Our results demonstrated that increased EMT gene expression was correlated with chemotherapy resistance in ovarian cancer, and with higher Gleason pattern in prostate cancer, confirming an association between EMT and increased risk for cancer progression. This underscores the potential for EMT gene signatures to be used as clinically relevant predictive and prognostic biomarkers. Functional studies using in vitro models of Cisplatin-resistant ovarian cancer and invasive prostate cancer demonstrated that inhibition of EMT signaling, both through the dysregulation of key transcription factors (SNAI1, SNAI2, ZEB1), and repressed expression of phenotypically important genes such as VIM, SPARC, CLTC and HIF1A resulted in loss of aggressive attributes in these cell lines. This included re-sensitization of our ovarian cancer cells to the effects of Cisplatin, while significantly reducing cell migration and invasion in our prostate cancer cells, both in 2- and 3-dimensional culture models. Furthermore, using our prostate cancer knockdown cell lines, we were able to assess gene expression changes in response to single gene repression. As a result, those genes that appear to have the highest degree of connectivity within the context of our EMT network were identified, thus contributing to the overall understanding of EMT regulation. Ultimately, we have been able to assess the role of the epithelial-mesenchymal transition in aggressive tumour behaviours, such as resistance to chemotherapy and progression towards metastatic events. The results of this work indicate that gene expression signatures associated with EMT may be useful as predictive and prognostic biomarkers in various cancer types. Furthermore, gene knockdown studies have provided insight into EMT signaling network regulation, as well as the functional contribution of a number of genes to alterations in migratory and invasive cancer cell programs.
Book Synopsis Epithelial-Mesenchymal Plasticity in Cancer Metastasis by : Mohit Kumar Jolly
Download or read book Epithelial-Mesenchymal Plasticity in Cancer Metastasis written by Mohit Kumar Jolly and published by MDPI. This book was released on 2020-12-29 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent studies have highlighted that epithelial-mesenchymal transition (EMT) is not only about cell migration and invasion, but it can also govern many other important elements such as immunosuppression, metabolic reprogramming, senescence-associated secretory phenotype (SASP), stem cell properties, therapy resistance, and tumor microenvironment interactions. With the on-going debate about the requirement of EMT for cancer metastasis, an emerging focus on intermediate states of EMT and its reverse process mesenchymal-epithelial transition (MET) offer new ideas for metastatic requirements and the dynamics of EMT/MET during the entire metastatic cascade. Therefore, we would like to initiate discussions on viewing EMT and its downstream signaling networks as a fulcrum of cellular plasticity, and a facilitator of the adaptive responses of cancer cells to distant organ microenvironments and various therapeutic assaults. We hereby invite scientists who have prominently contributed to this field, and whose valuable insights have led to the appreciation of epithelial-mesenchymal plasticity as a more comprehensive mediator of the adaptive response of cancer cells, with huge implications in metastasis, drug resistance, tumor relapse, and patient survival.
Book Synopsis The Epithelial-to-Mesenchymal Transition (EMT) in Cancer by : Joëlle Roche
Download or read book The Epithelial-to-Mesenchymal Transition (EMT) in Cancer written by Joëlle Roche and published by MDPI. This book was released on 2018-04-09 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "The Epithelial-to-Mesenchymal Transition (EMT) in Cancer" that was published in Cancers
Book Synopsis Molecular and Cell Biology of Cancer by : Rita Fior
Download or read book Molecular and Cell Biology of Cancer written by Rita Fior and published by Springer. This book was released on 2019-06-27 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook takes you on a journey to the basic concepts of cancer biology. It combines developmental, evolutionary and cell biology perspectives, to then wrap-up with an integrated clinical approach. The book starts with an introductory chapter, looking at cancer in a nut shell. The subsequent chapters are detailed and the idea of cancer as a mass of somatic cells undergoing a micro-evolutionary Darwinian process is explored. Further, the main Hanahan and Weinberg “Hallmarks of Cancer” are revisited. In most chapters, the fundamental experiments that led to key concepts, connecting basic biology and biomedicine are highlighted. In the book’s closing section all of these concepts are integrated in clinical studies, where molecular diagnosis as well as the various classical and modern therapeutic strategies are addressed. The book is written in an easy-to-read language, like a one-on-one conversation between the writer and the reader, without compromising the scientific accuracy. Therefore, this book is suited not only for advanced undergraduates and master students but also for patients or curious lay people looking for a further understanding of this shattering disease
Book Synopsis Epithelial-mesanchymal Interactions by : Raul Fleischmajer (ed)
Download or read book Epithelial-mesanchymal Interactions written by Raul Fleischmajer (ed) and published by . This book was released on 1968 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cell & Molecular Biology of Prostate Cancer by : Heide Schatten
Download or read book Cell & Molecular Biology of Prostate Cancer written by Heide Schatten and published by Springer. This book was released on 2018-09-18 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume covers classic and modern cell and molecular biology of prostate cancer, as well as novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation novel biomarkers, inflammation, centrosome pathologies, microRNAs, cancer initiation and genetics, epigenetics, mitochondrial dysfunctions and apoptosis, cancer stem cells, angiogenesis and progression to metastasis, and treatment strategies including clinical trials related to prostate cancer. Cell & Molecular Biology of Prostate Cancer is one of two companion books comprehensively addressing the biology and clinical aspects of prostate cancer. Prostate Cancer: Molecular & Diagnostic Imaging and Treatment Stategies, the companion volume, discusses both classic and the most recent imaging approaches including analysis of needle biopsies, applications of nanoparticle probes and peptide-based radiopharmaceuticals for detection, early diagnosis and treatment of prostate cancer. Taken together, these volumes form one comprehensive and invaluable contribution to the literature.
Book Synopsis Approaching Complex Diseases by : Mariano Bizzarri
Download or read book Approaching Complex Diseases written by Mariano Bizzarri and published by Springer Nature. This book was released on 2020-04-17 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume – for pharmacologists, systems biologists, philosophers and historians of medicine – points to investigate new avenues in pharmacology research, by providing a full assessment of the premises underlying a radical shift in the pharmacology paradigm. The pharmaceutical industry is currently facing unparalleled challenges in developing innovative drugs. While drug-developing scientists in the 1990s mostly welcomed the transformation into a target-based approach, two decades of experience shows that this model is failing to boost both drug discovery and efficiency. Selected targets were often not druggable and with poor disease linkage, leading to either high toxicity or poor efficacy. Therefore, a profound rethinking of the current paradigm is needed. Advances in systems biology are revealing a phenotypic robustness and a network structure that strongly suggest that exquisitely selective compounds, compared with multitarget drugs, may exhibit lower than desired clinical efficacy. This appreciation of the role of polypharmacology has significant implications for tackling the two major sources of attrition in drug development, efficacy and toxicity. Integrating network biology and polypharmacology holds the promise of expanding the current opportunity space for druggable targets.
Book Synopsis Cancer Metastasis by : Yasemin Basbinar
Download or read book Cancer Metastasis written by Yasemin Basbinar and published by BoD – Books on Demand. This book was released on 2018-12-05 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastasis of cancer cells from primary tumor site to secondary locations is considered a late event in multistep tumorigenesis, and causes most cancer-related mortality. The process from the spreading of cancer cells to the seeding of newly formed tumor colonizations is governed by sequential events, including local invasion, intravasation into stroma and blood vessels, survival in circulation, extravasation, and colonization at secondary tumor sites. Cancer research provides information on the fate of metastatic cancer cells in each sequential movement or heterogeneous tumor microenvironment. However, the complexity of this mechanism remains the most stringent concept of cancer management. This book provides information for cancer researchers on metastatic phenotypes of cancer cells, and diverse promoting factors and molecular mechanisms of metastasis.
Book Synopsis The Unfolded Protein Response in Cancer by : Robert Clarke
Download or read book The Unfolded Protein Response in Cancer written by Robert Clarke and published by Springer. This book was released on 2019-03-01 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents state-of-the-art information on each of the arms of the unfolded protein response (UPR), how their activation/repression are regulated, integrated, and coordinated, how UPR components affect cancer cell biology and responsiveness to therapeutic interventions, and how UPR components/activities offer potentially novel targets for drug discovery, repurposing, and development. The volume will provide the most recent information on the signaling and regulation of the UPR, explore examples of how the UPR and/or specific components contribute to cancer biology, and identify and explore specific examples of potently new actionable targets for drug discovery and development from within the UPR and its regulation. Unique to the volume will be a specific focus on the UPR and its role in cancer biology, as well as a discussion of the role of the UPR in drug responses and resistance in cancer.
Book Synopsis The TGF-[beta] Family by : Rik Derynck
Download or read book The TGF-[beta] Family written by Rik Derynck and published by CSHL Press. This book was released on 2008 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transforming growth factor-[beta] (TGF-[beta]), identified nearly three decades ago, is a secreted polypeptide that functions in critical cell cycle processes, including cellular proliferation, differentiation, and development: It belongs to a large protein family that, in humans, contains 33 members, including activins, inhibins, bone morphogenetic proteins, growth and differentiation factors, and Mullerian inhibiting substance. This volume draws on the world's leading laboratories to comprehensively cover all aspects of the biology of TGF-[beta] and related factors. In addition to providing historical and background information, it describes the cell biology and signaling pathways of TGF-[beta] members in detail, including the roles of TGF-[beta] factors in the development and physiology of humans and model organisms. The last few chapters are devoted to the role of TGF-[beta] members in cancer and other diseases, as well as the possibilities for therapeutics based on knowledge of signaling pathways and macromolecular structures. It serves as a comprehensive reference work for both specialists and researchers less familiar with the field.
Book Synopsis MicroRNAs in Cancer by : Cesar Lopez-Camarillo
Download or read book MicroRNAs in Cancer written by Cesar Lopez-Camarillo and published by CRC Press. This book was released on 2013-02-22 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNA (miRNA) biology is a cutting-edge topic in basic as well as biomedical research. This is a specialized book focusing on the current understanding of the role of miRNAs in the development, progression, invasion, and metastasis of diverse types of cancer. It also reviews their potential for applications in cancer diagnosis, prognosis, and th
Book Synopsis Ultrastructural Pathology by : Norman F. Cheville
Download or read book Ultrastructural Pathology written by Norman F. Cheville and published by John Wiley & Sons. This book was released on 2009-06-30 with total page 997 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultrastructural Pathology
Book Synopsis Signal Transduction in Cancer by : David A. Frank
Download or read book Signal Transduction in Cancer written by David A. Frank and published by Springer Science & Business Media. This book was released on 2002-12-31 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."
Author :Constantinos Koumenis Publisher :Springer Science & Business Media ISBN 13 :146145915X Total Pages :293 pages Book Rating :4.4/5 (614 download)
Book Synopsis Tumor Microenvironment and Cellular Stress by : Constantinos Koumenis
Download or read book Tumor Microenvironment and Cellular Stress written by Constantinos Koumenis and published by Springer Science & Business Media. This book was released on 2013-11-23 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
Book Synopsis The Cancer Stem Cell Niche by : Susie Nilsson
Download or read book The Cancer Stem Cell Niche written by Susie Nilsson and published by Academic Press. This book was released on 2021-02-09 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Cancer Stem Cell Niche, Volume Five in the Advances in Stem Cells and their Niches series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of timely topics, including Acute lymphoblastic leukemia and the bone marrow microenvironment, Stem cell niches in bone and their roles in cancer metastasis, The role of vasculature in cancer stem cell niches, The lung cancer stem cell niche, The prostate cancer stem cell niche: Genetic drivers and therapeutic approaches, Impact of prostate cancer stem cell niches on prostate cancer tumorigenesis and progression, The testicular cancer stem cell niche. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Stem Cells and their Niches series Includes the latest information on the Cancer Stem Cell Niche
Book Synopsis Cancer Evolution by : Charles Swanton
Download or read book Cancer Evolution written by Charles Swanton and published by Perspectives Cshl. This book was released on 2017 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.
Book Synopsis The Basic Science of Oncology by : Ian Tannock
Download or read book The Basic Science of Oncology written by Ian Tannock and published by McGraw Hill Professional. This book was released on 2005 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise text examines cancer causation and biology as well as the biology underlying cancer treatment. Thoroughly updated and reorganized with five new chapters, the Fourth Edition emphasizes new development in molecular biology, hormone therapy, and the pharmacology of anti-cancer drugs. Features updated coverage of the basic science of radiotherapy and experimental radiation in addition to expansive coverage of new drugs developments.
![Download The TGF-[beta] Family PDF Online Free](https://books.google.com/books/content/images/frontcover/QW5xq75p5gYC?fife=w200-h370)
