Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Download The Role Of The Aryl Hydrocarbon Receptor Nuclear Translocator Arnt In Carcinogenesis full books in PDF, epub, and Kindle. Read online The Role Of The Aryl Hydrocarbon Receptor Nuclear Translocator Arnt In Carcinogenesis ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Author : Diana Y. Yoon
Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.:/5 ( download)
Download or read book The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Carcinogenesis written by Diana Y. Yoon and published by . This book was released on 2006 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Brandon Allen Yusko
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)
Download or read book The Role of the Aryl Hydrocarbon Receptor in Mediating the Migration and Survival of Head and Neck Squamous Cell Carcinoma written by Brandon Allen Yusko and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The human aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor in the Per-Arnt-Sim (PAS) family of the basic helix-loop-helix (bHLH) superfamily, first identified as a mediator of xenobiotic metabolism. Through the binding of small molecule agonist, predominantly polycyclic aromatic hydrocarbons (PAH) including, 2,3,7,8-tetrachlorodibezo-p-dioxin (TCDD) and benzo[a]pyrene, the AHR translocates to the nucleus. Following heat shock protein 90 displacement with the aryl hydrocarbon receptor nuclear translocator (ARNT), the AHR heterodimer can bind dioxin response elements in the sequence of target genes. Through this signaling process, the AHR not only mediates xenobiotic toxicity, but also participates in a myriad of cellular processes, such as immune surveillance, proliferation, metabolism, and carcinogenesis, through transcriptional regulation. In this way, the role of the AHR as a environmental sensor continues to broaden as advancements in basic research are made. Building on the previous work of the lab, we aimed to further explore the effects of AHR activation and inhibition on the progression of head & neck squamous cell carcinoma (HNSCC) with these studies. This dissertation outlines the work completed to establish the AHR as a mediator of HNSCC migration, invasion, and chemotherapy resistance. First, we aimed to generate a transcriptional profile of AHR modulation in the HNSCC line OSC19 using TCDD treatment as a potent AHR agonist, along with the novel antagonist IK-175. Using RNA-sequencing, we compiled a comprehensive list of differentially expressed genes and sets of enriched biological processes through gene ontology analysis. TCDD treatment enhanced expression of cytokines integral to local invasion of the stroma, inflammatory signaling, and immune cell recruitment and differentiation. Then, we worked to characterize the effects of AHR activation on HNSCC migratory potential in both 2D and 3D culture systems. Using several techniques to assess cell migration and motility, we provide evidence that AHR agonism promotes migratory potential through the upregulation of cytoskeletal reorganizing genes and the suppression of matrix metalloproteinase inhibitors. Finally, our focus turned to the ability of the AHR to influence chemotherapy resistance of HNSCC, with a focus on the chemotherapeutic agent 5-fluorouracil (5-FU). We found that treatment of OSC19 cells with IK-175 sensitized the cells to 5-FU, resulting in greater cell death after treatment and fewer viable colonies in a clonogenicity assay. Taken together, these findings further support the role of AHR as a microenvironmental sensor in the context of HNSCC and suggest AHR antagonism as a potential therapeutic measure to restrict tumor metastasis and increase chemotherapeutic efficacy for patients.
Author : Giampietro Gasparini
Publisher : Springer Science & Business Media
ISBN 13 : 159259915X
Total Pages : 335 pages
Book Rating : 4.5/5 (925 download)
Download or read book Biomarkers in Breast Cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2008-01-17 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.
Author : Costas Ioannides
Publisher : CRC Press
ISBN 13 : 9781439810705
Total Pages : 426 pages
Book Rating : 4.8/5 (17 download)
Download or read book Cytochromes P450 written by Costas Ioannides and published by CRC Press. This book was released on 1996-09-06 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochromes P450: Metabolic and Toxicological Aspects examines cytochrome P450 proteins and their role in toxicity/carcinogenicity and the metabolism of foreign chemicals. Studying the function of these proteins enables us to: Predict the pathways and outcome of chemical metabolism to rationalize species, sex, and age differences in toxicity Anticipate drug interactions Modify doses to fit the needs of patients Contributions from internationally acknowledged experts are organized into three sections. The first section provides an overview, the next profiles each of the cytochrome P450 families and subfamilies involved in chemical metabolism, and the last section discusses new issues and developments of current interest. This detailed and thorough examination of cytochrome P450 will be a useful source for research scientists, especially those working in the pharmaceutical industry, dealing with the safety evaluation of chemicals and the study of their metabolism, pharmacokinetics, and toxicological properties.
Author : Liliana Streba
Publisher : BoD – Books on Demand
ISBN 13 : 1838800050
Total Pages : 158 pages
Book Rating : 4.8/5 (388 download)
Download or read book Current Trends in Cancer Management written by Liliana Streba and published by BoD – Books on Demand. This book was released on 2019-09-25 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of cancer diagnosis, prognosis, and treatment is constantly advancing. From novel biomarkers to cutting-edge imaging solutions, changing chemotherapy protocols and novel immune-targeting agents, medical teams develop and test new ways to manage this ever-growing threat to the modern age. Imaging has been a reliable method for initial diagnosis and later surveillance of premalignant and cancerous lesions of the digestive tract. This book project aims to characterize the main diagnostic procedures and novel medical and surgical treatments, as well as provide an updated view on current guidelines, premalignant lesions management, and minimally invasive curative techniques.
Author : Jennifer L. Holmes
Publisher :
ISBN 13 :
Total Pages : 218 pages
Book Rating : 4.:/5 (379 download)
Download or read book Analysis of Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Protein Expression and Concentration in Aquatic and Mammalian Models written by Jennifer L. Holmes and published by . This book was released on 1997 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : D.J. Smith
Publisher : Springer Science & Business Media
ISBN 13 : 1461547032
Total Pages : 226 pages
Book Rating : 4.4/5 (615 download)
Download or read book Xenobiotics in Fish written by D.J. Smith and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaculture is rapidly becoming a major source of fish protein used to meet the nutritional needs of humans. As the aquaculture industry grows, exposure of farmed fish to environmental contaminants, and the need for chemical therapeutic agents for fish, will increase. This book is designed to bring together authorities worldwide on the regulation of environmental contaminants and food chemicals and researchers investigating the metabolism and disposition of foreign chemicals (xenobiotics) in fish species.
Author : Vladimir Uversky
Publisher : Academic Press
ISBN 13 : 012816851X
Total Pages : 426 pages
Book Rating : 4.1/5 (281 download)
Download or read book Dancing Protein Clouds: Intrinsically Disordered Proteins in the Norm and Pathology written by Vladimir Uversky and published by Academic Press. This book was released on 2019-09-15 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain. Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided Includes contributions from recognized experts in the field
Author : Sangdun Choi
Publisher : Springer
ISBN 13 : 9781493968008
Total Pages : 6330 pages
Book Rating : 4.9/5 (68 download)
Download or read book Encyclopedia of Signaling Molecules written by Sangdun Choi and published by Springer. This book was released on 2017-12-15 with total page 6330 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of this encyclopedia presents over 400 biologically important signaling molecules and the content is built on the core concepts of their functions along with early findings written by some of the world’s foremost experts. The molecules are described by recognized leaders in each molecule. The interactions of these single molecules in signal transduction networks will also be explored. This encyclopedia marks a new era in overview of current cellular signaling molecules for the specialist and the interested non-specialist alike. Currently, there are more than 30,000 genes in human genome. However, not all the proteins encoded by these genes work equally in order to maintain homeostasis. Understanding the important signaling molecules as completely as possible will significantly improve our research-based teaching and scientific capabilities.
Author : B. Anne Croy
Publisher : Academic Press
ISBN 13 : 0123947944
Total Pages : 829 pages
Book Rating : 4.1/5 (239 download)
Download or read book The Guide to Investigation of Mouse Pregnancy written by B. Anne Croy and published by Academic Press. This book was released on 2013-12-09 with total page 829 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy. Joining the ranks of much referenced mouse resources, The Guide to Investigation of Mouse Pregnancy is the only manual providing needed content on pregnancy in animal models for translational medicine and research. - Provides instruction on how to collect pre-clinical data on pregnancy in mouse models for eventual use in human applications - Describes the angiogenic tree the mother's uterus develops to support pregnancy and the monitoring of pregnancy-induced cardiovascular changes - Educates readers on placental cell lineages, decidual development including immune cells, epigenetic regulation, gene imprinting, stem cells, birth and lactation - Discusses how stress, environmental toxicants and other manipulations impact upon placental function and pregnancy success
Author : John H. Sampson
Publisher : Academic Press
ISBN 13 : 0128026251
Total Pages : 406 pages
Book Rating : 4.1/5 (28 download)
Download or read book Translational Immunotherapy of Brain Tumors written by John H. Sampson and published by Academic Press. This book was released on 2017-02-06 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: Translational Immunotherapy of Brain Tumors gives researchers and practitioners an up-to-date and comprehensive overview of the field. Chapters include adoptive immunotherapy, immunosuppression, CAR therapy of brain tumors, and dendritic cell therapy for brain tumors. Very few agents have been shown to be efficacious in the treatment of malignant gliomas. Recently, there have been a number of studies demonstrating the potential success of immunotherapy for brain tumors. Immunotherapeutics are becoming the most frequent drugs to be used in cancer therapy. These new breakthroughs, now approved by the FDA, are a part of multiple phase III international trials and ongoing research in malignant glioma, meaning that the information in this cutting-edge book will be of great importance to practitioners and researchers alike. Comprehensive overview, providing an update on immunology, translational immunotherapy, and clinical trials relating to malignant gliomas Edited by a prominent neurosurgeon with contributions by leading researchers in the field Ideal resource for researchers and practitioners interested in learning about mechanisms that use the immune system to treat brain tumors
Author : Morgan Walcheck
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (134 download)
Download or read book The Role of Aryl Hydrocarbon Receptor in the Development of Mutant-kras Driven Cancers written by Morgan Walcheck and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that is a member is the PER-ARNT-SIM superfamily of transcription factors. It has been traditionally characterized as an environmental sensor, but recently the AHR has been implicated in influencing the development of different cancers through its modulation of the immune system. Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal disease with a characteristic immunosuppressive microenvironment. The immunosuppressive microenvironment of PDAC renders immunotherapies targeting cancer ineffective. Therefore, the ability to manipulate the microenvironment and reactivate the immune system within the pancreas is of the utmost importance but requires further understanding of the development of the microenvironment. The first chapter reviews the current knowledge of how the tumor microenvironment influences the formation and progression of the PDAC pre-cursor lesions and how AHR can alter this environment. Chapter two describes the effects of AHR knockout on the development of PDAC in vivo through the creation of a novel mouse model. In the process of generating the novel mouse model, we discovered that the AHR significantly influences the development of T-cell acute lymphoblastic leukemia (T-ALL). Chapter 3 describes the experiments used to understand the development of T-ALL in our mouse models. Finally, the fourth chapter describes the novel finding of the sex-dependent Kras-driven development of anal squamous cell carcinoma (SCC) in the Kras-mutant (pancreas cancer) mouse model. Taken together, this work outlines the influence of the AHR on the development of Kras-driven PDAC and T-ALL and the sex-dependent development of Kras-driven anal SCC.
Author : Robert C. Roach
Publisher : Springer Science & Business Media
ISBN 13 : 9780306466960
Total Pages : 466 pages
Book Rating : 4.4/5 (669 download)
Download or read book Hypoxia written by Robert C. Roach and published by Springer Science & Business Media. This book was released on 2002-01-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypoxia remains a constant threat throughout life. It is for this reason that the International Hypoxia Society strives to maintain a near quarter century tradition of presenting a stimulating blend of clinical and basic science discussions. International experts from many fields have focused on the state-of-the-art discoveries in normal and pathophysiological responses to hypoxia. Topics in this volume include gene-environment interactions, a theme developed in both a clinical context regarding exercise and hypoxia, as well as in native populations living in high altitudes. Furthermore, experts in the field have combined topics such as skeletal muscle angiogenesis and hypoxia, high altitude pulmonary edema, new insights into the biology of the erythropoietin receptor, and the latest advances in cardiorespiratory control in hypoxia. This volume explores the fields of anatomy, cardiology, biological transport, and biomedical engineering among many others.
Author :
Publisher : Elsevier
ISBN 13 : 0080497195
Total Pages : 867 pages
Book Rating : 4.0/5 (84 download)
Download or read book Oxygen Sensing written by and published by Elsevier. This book was released on 2004-05-10 with total page 867 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ability of cells to sense and respond to changes in oxygenation underlies a multitude of developmental, physiological, and pathological processes. This volume provides a comprehensive compendium of experimental approaches to the study of oxygen sensing in 48 chapters that are written by leaders in their fields.
Author : Ayse Basak Engin
Publisher : Springer
ISBN 13 : 331948382X
Total Pages : 618 pages
Book Rating : 4.3/5 (194 download)
Download or read book Obesity and Lipotoxicity written by Ayse Basak Engin and published by Springer. This book was released on 2017-06-05 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the resultant health consequences and considerable increase in prevalence, obesity has become a major worldwide health problem. “Obesity and Lipotoxicity” is a comprehensive review of the recent researches to provide a better understanding of the lipotoxicity-related mechanisms of obesity and the potential for the development of new treatment strategies. This book overviews the biochemical pathways leading to obesity-related metabolic disorders that occur subsequent to lipotoxicity. Chapters examine the deleterious effects of nutrient excess at molecular level including the cellular and molecular aspects of breast cancer, resistance to leptin, insulin, adiponectin, and interconnection between the circadian clock and metabolic pathways during high-fat feeding. “Lipotoxicity and Obesity” will be a useful resource for clinicians and basic science researchers, such as biochemists, toxicologists, immunologists, nutritionists, adult and pediatric endocrinologists, cardiologists, as well as students who are thought in this field.
Author : Krishnakali Sarkar
Publisher :
ISBN 13 :
Total Pages : 92 pages
Book Rating : 4.:/5 (9 download)
Download or read book ARNT Isoforms Differentially Regulate Cancer Cell Growth Through a P53-dependent Mechanism written by Krishnakali Sarkar and published by . This book was released on 2015 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aryl hydrocarbon receptor nuclear translocator (ARNT) is an important player in xenobiotic and hypoxic responses. In addition to this, my mentor has shown that ARNT is an integral cofactor of NF-kB signaling. However, these initial observations of ARNT-mediated NF-kB modulation were based on simultaneous suppression of the two ARNT isoforms, isoform 1 and 3, and therefore precluded the isolated examination of each isoform's function. We show here that lymphoid malignancies exhibit higher levels of ARNT isoform 1 compared to ARNT isoform 3. However, normal T and B lymphocytes are seen to harbor equal levels of ARNT isoform 1 and 3. We hypothesize that the increase in ARNT isoform 1 is necessary for the growth of these cancer cells as suppression of isoform 1 resulted in S-phase cell cycle arrest. These findings reveal that ARNT isoform 1 potentiates cell growth by antagonizing a p53 cell cycle inhibitory mechanism and this further suggests that ARNT targeted therapies would benefit chemotherapy regimens.
Author : A. Schecter
Publisher : Springer Science & Business Media
ISBN 13 : 1489914625
Total Pages : 718 pages
Book Rating : 4.4/5 (899 download)
Download or read book Dioxins and Health written by A. Schecter and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book originated in a series of cross-disciplinary conversations in the years 1984-1990 between the editor, who is a physician-researcher involved in clinical and laboratory research, and a dioxin toxicologist. During the years in which the conversations took place, an extraordinary amount of new scientific literature was published related to dioxins, defined for purposes of this text as the chlorinated dibenzo-p-dioxins, dibenzofurans, polychlorinated biphe nyls (PCB's) and other compounds that are structurally and toxicologically similar to 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7 ,8-TCDD), the most extensively studied and most toxic of this group of chemicals. Dioxins also began to interest not only chemists and toxicologists, but also specialists from diverse disciplines such as wildlife and environmental science, immunology, neuroscience,public health, epidemiology, med icine, government, law, sociology, and journalism. Specialists from such varied disciplines, while familiar with their own literature, frequently did not have time to follow the dioxin literature outside their specialty area. In addition, each specialty had unique knowledge, methods, and perspectives. Cross disciplinary conversation was necessary, but all too frequently, specialists from the various disciplines did not speak the same language, resulting in misunderstanding.
