The Role of Microtubules in Cell Biology, Neurobiology, and Oncology

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Publisher : Springer Science & Business Media
ISBN 13 : 1597453366
Total Pages : 629 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis The Role of Microtubules in Cell Biology, Neurobiology, and Oncology by : Antonio Tito Fojo

Download or read book The Role of Microtubules in Cell Biology, Neurobiology, and Oncology written by Antonio Tito Fojo and published by Springer Science & Business Media. This book was released on 2009-01-14 with total page 629 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the first comprehensive exploration of the dynamic potential of microtubules anti-cancer targets. Written by leading anti-cancer researchers, this groundbreaking volume collects the most current microtubule research available and investigates the potential of microtubules in cancer therapy.

Microtubules

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Publisher : Springer Science & Business Media
ISBN 13 : 364269652X
Total Pages : 499 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Microtubules by : Pierre Dustin

Download or read book Microtubules written by Pierre Dustin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: The decision, in 1975, to write alone a monograph on micro tubules was not without risks. While I was familiar from its start in Brussels in 1934 with the work on col chicine and other mitotic poisons, the literature on microtubules was, 8 years ago, already increasing at an impressive rate. However, this monograph, which, contrary to other works on microtubules, tried to cover the whole field of research, from the fundamentals of the tubulin molecule and the possible role of these organelles in some aspects of human pathology, to some medical applications of microtubule poisons, has been accepted as a useful tool for workers in these fields. Since 1976, (date of the last references mentioned in the monograph) until the middle of 1983, papers on microtubule research have literally been pouring in, at the rate of several hundred a year. This may justify a second edition, although the considerable difficulties in keeping the size of the book within the same limits while not forgetting to mention some important work, could not be overlooked. The need for an entirely revised and rewritten edition prompted this new venture and was possible with the help of the considerable amount of reprints kindly sent to me day after day over the years. This work would have been unthinkable if the author had not maintained the same enthusiasm for microtubule research, which has been disclosing new facts every day.

Microtubules, in vitro

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Publisher : Academic Press
ISBN 13 : 0124078885
Total Pages : 472 pages
Book Rating : 4.1/5 (24 download)

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Book Synopsis Microtubules, in vitro by : John J. Correia

Download or read book Microtubules, in vitro written by John J. Correia and published by Academic Press. This book was released on 2013-08-20 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: There continues to be intense interest in the microtubule cytoskeleton; the assembly, structure and regulation of microtubules; and the numerous motors and accessory proteins that control cell cycle, dynamics, organization and transport. The field continues to grow and explore new aspects of these issues driven immensely by developments in optical imaging and tracking techniques. This Second Edition brings together current research and protocols in the field of microtubules in vitro and will serve as a valuable tool for cell biologists, biophysicists and pharmacologists who study the microtubule cytoskeleton, as well as for researchers in the biomedical and biotechnology communities with interest in developing drugs that target microtubules, MAPS and motors. Chapters reflect experimental procedures and new developments in the field of microtubule in vitro research Combines classical approaches and modern technologies Presents easy-to-use protocols and thorough background information, compiled by leaders in the field

The Role of Microtubules in the Biology of the Oligodendrocyte

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Publisher :
ISBN 13 :
Total Pages : 310 pages
Book Rating : 4.:/5 (89 download)

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Book Synopsis The Role of Microtubules in the Biology of the Oligodendrocyte by : Katharine F. Lunn

Download or read book The Role of Microtubules in the Biology of the Oligodendrocyte written by Katharine F. Lunn and published by . This book was released on 1996 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Microtubules: in vivo

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Publisher : Academic Press
ISBN 13 : 9780123813503
Total Pages : 552 pages
Book Rating : 4.8/5 (135 download)

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Book Synopsis Microtubules: in vivo by :

Download or read book Microtubules: in vivo written by and published by Academic Press. This book was released on 2010-09-24 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules: in vivo includes chapters by experts around the world on many aspects of microtubule imaging in living and fixed cells; assays to study microtubule function in a wide array of model organisms and cultured cells; high resolution approaches to study of the cytoskeleton. The authors share their years of experience, outlining potential pitfalls and critical factors to consider in experimental design, experimental implementation and data interpretation. Includes chapters by experts around the world on many aspects of microtubule imaging in living and fixed cells; assays to study microtubule function in a wide array of model organisms and cultured cells; high resolution approaches to study of the cytoskeleton The authors share their years of experience, outlining potential pitfalls and critical factors to consider in experimental design, experimental implementation and data interpretation

Biological Functions of Microtubules and Related Structures

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Publisher : Academic Press
ISBN 13 : 1483272206
Total Pages : 474 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Biological Functions of Microtubules and Related Structures by : Hikoichi Sakai

Download or read book Biological Functions of Microtubules and Related Structures written by Hikoichi Sakai and published by Academic Press. This book was released on 2013-10-22 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Functions of Microtubules and Related Structures is a compendium of papers presented at the 13th Oji International Seminar on The Biological Functions of Microtubules and Related Structures, held at Komaba Eminence in Tokyo in November, 1981. The papers discuss the molecular function of tubulin in various biological processes or events. The book is divided into six sections focusing on the various aspects of the functions and structures of microtubules -- the biochemistry and molecular biology of tubulin, including regulation of microtubule assembly; microtubule-dynein systems and other proteins in cell motility; microtubules and related proteins in mitosis; the interactions of cytoskeletal components; the cytoskeleton; and microtubules in membrane functions and transport. Biochemists, biologists, and molecular biologists will find the book interesting.

Microtubules

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Publisher : Wiley-Liss
ISBN 13 :
Total Pages : 466 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Microtubules by : Jeremy S. Hyams

Download or read book Microtubules written by Jeremy S. Hyams and published by Wiley-Liss. This book was released on 1994 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules reflects the enormous and significant advances in microtubule research of the past decade. It provides up-to-date information on the art of microtubule research, building on the success of Dr. Hyams's 1979 landmark text. A distinguished group of editors and contributors presents reviews dealing with three central topics: the biochemistry and assembly of the tubulin dimer; associated proteins and regulation of microtubule function; and microtubule organization and function in the cell.

Glioma Cell Biology

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Publisher : Springer
ISBN 13 : 3709114314
Total Pages : 466 pages
Book Rating : 4.7/5 (91 download)

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Book Synopsis Glioma Cell Biology by : Aleksi Sedo

Download or read book Glioma Cell Biology written by Aleksi Sedo and published by Springer. This book was released on 2014-11-14 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gliomas are fatal diseases, but also represent good models for tumor research with the aim to eventually discover new and appropriate therapeutics against this disease. Glioma experimental research models are of help to investigate tumorigenesis (tumor stem cell theory versus "classical" opinions), tumor angiogenesis (since they are highly vascularized) and tumor invasion (since they grow without limits). In addition, they have a very special microenvironment (the brain) and limited tumor stroma cells (mainly microglia and endothelial cells). This book addresses the molecular mechanisms of the various tumor stages, describes the interaction with the tumor microenvironment and furthermore depicts experimental models for Glioma research and future therapeutic concepts. The book is composed and written for Scientists and Medical Doctors in Oncology, Neurosciences and Molecular Biology. ​

Cytoskeleton and Human Disease

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Publisher : Springer Science & Business Media
ISBN 13 : 161779788X
Total Pages : 463 pages
Book Rating : 4.6/5 (177 download)

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Book Synopsis Cytoskeleton and Human Disease by : Maria Kavallaris

Download or read book Cytoskeleton and Human Disease written by Maria Kavallaris and published by Springer Science & Business Media. This book was released on 2012-04-23 with total page 463 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cytoskeleton is comprised of a variety of specialized proteins, and is a dynamic structure that is involved in the majority of key cellular events. There is increasing interest in the role of the cytoskeleton in human disease. This volume brings together human disease states where cytoskeletal disruptions are driving disease. Our emerging understanding of the molecular and cellular events that drive cytoskeletal mediated diseases including cancer, heart disease, myopathies and skin disorders, are also helping shape targeted therapeutic approaches to treating these diseases.

Microtubules, in vitro

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Publisher : Academic Press
ISBN 13 : 9780080888583
Total Pages : 699 pages
Book Rating : 4.8/5 (885 download)

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Book Synopsis Microtubules, in vitro by : Leslie Wilson

Download or read book Microtubules, in vitro written by Leslie Wilson and published by Academic Press. This book was released on 2010-07-03 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: There continues to be intense interest in the microtubule cytoskeleton; the assembly, structure and regulation of microtubules; and the numerous motors and accessory proteins that control cell cycle, dynamics, organization and transport. The field continues to grow and explore new aspects of these issues driven immensely by developments in optical imaging and tracking techniques. This volume (complemented by the forthcoming companion volume by Cassimeris and Tran) brings together current research and protocols in the field of microtoubules in vitro and will serve as a valuable tool for cell biologists, biophysicists and pharmacologists who study the microtubule cytoskeleton, as well as for researchers in the biomedical and biotechnology communities with interest in developing drugs that target microtubules, MAPS and motors. * Chapters reflect both experimental procedures and new developments in the field of microtubule in vitro research. * Combines classical approaches and modern technologies * Presents easy-to-use protocols and thorough background information, compiled by leaders in the field

Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS-Directed Therapies

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Publisher : Sapienza Università Editrice
ISBN 13 : 8893772426
Total Pages : 354 pages
Book Rating : 4.8/5 (937 download)

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Book Synopsis Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS-Directed Therapies by : Ludovica Monti

Download or read book Tubulin and Microtubules as Drug Targets for Potential Cancer Chemotherapy and CNS-Directed Therapies written by Ludovica Monti and published by Sapienza Università Editrice. This book was released on 2022-11-30 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules are essential cellular constituents of eukaryotes formed by tubulin subunits. This book is a collection of medicinal chemistry research projects that utilizes microtubules as drug targets for human diseases of global health impact. The main chapters (2 – 4) include an in-depth description of different synthetic and biological approaches to characterize the therapeutic potential of novel synthetic molecules for cancer, Alzheimer’s disease, and neglected tropical diseases. This book also includes three short chapters (5 – 7) of additional collaborative projects focused on varied drug discovery topics, including SAR studies of new lead compounds targeting carbonic anhydrase enzymes, FAAH and TRPV1, and novel bioisosteres of the carboxylic acid functional group.

The SAGE Encyclopedia of Cancer and Society

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Publisher : SAGE Publications
ISBN 13 : 1483345742
Total Pages : 1631 pages
Book Rating : 4.4/5 (833 download)

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Book Synopsis The SAGE Encyclopedia of Cancer and Society by : Graham A. Colditz

Download or read book The SAGE Encyclopedia of Cancer and Society written by Graham A. Colditz and published by SAGE Publications. This book was released on 2015-08-12 with total page 1631 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of the Encyclopedia of Cancer and Society was published in 2007 and received a 2008 Editors’ Choice Award from Booklist. It served as a general, non-technical resource focusing on cancer from the perspective of the social and behavioral sciences, exploring social and economic impacts, the “business” of cancer, advertising of drugs and treatment centers, how behavior change could offer great potential for cancer prevention, environmental risks, food additives and regulation, the relation between race and ethnicity and cancer risk, socioeconomic status, controversies—both scientific and political—in cancer treatment and research, country-by-country entries on cancer around the world, and more. Given various developments in the field including new drug treatments, political controversies over use of the vaccines Gardasil and Cervarix with young girls to prevent cervical cancer, and unexpected upticks in the prevalence of adult smoking within the U.S. following decades of decline, the SAGE Encyclopedia of Cancer and Society, Second Edition serves as an updated and more current encyclopedia that addresses concerns pertaining to this topic. Key Features: · Approximately half of the 700 first-edition articles revised and updated · 30+ new entries covering new developments since 2006 · Signed entries with cross-references · Further Readings accompanied by pedagogical elements · New Reader’s Guide · Updated Chronology, Resource Guide, Glossary, and through new Index The SAGE Encyclopedia of Cancer and Society, Second Edition serves as a reliable and precise source for students and researchers with an interest in social and behavioral sciences and seeks to better understand the continuously evolving subject matter of cancer and society.

Stem Cell Biology in Neoplasms of the Central Nervous System

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Publisher :
ISBN 13 : 9783319165387
Total Pages : pages
Book Rating : 4.1/5 (653 download)

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Book Synopsis Stem Cell Biology in Neoplasms of the Central Nervous System by : Moneeb Ehtesham

Download or read book Stem Cell Biology in Neoplasms of the Central Nervous System written by Moneeb Ehtesham and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the most current reviews on how cancer stem cells (CSCs) hypothesis dictates that the continued proliferation of a tumor is dependent on a sub-population of self-renewing and asymmetrically dividing neoplastic stem cells that supply a largely differentiated tumor. This volume provides a comprehensive overview of the characteristics of CSCs, their role in central nervous system (CNS) tumors, and the recent CSC-specific treatment modalities being used. The emerging focus on CSCs in brain tumors represents a paradigm shift in our understanding of the pathogenesis of these neoplasms. Importantly, the realization that a distinct sub-population of cells contributes disproportionately to the growth and sustenance of central nervous system tumors has important implications for the treatment of such tumors. To treat CNS tumors, there is now a growing need to treat CSCs to achieve adequate tumor control.

Microtubule Dynamics

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Publisher : Humana Press
ISBN 13 : 9781493961856
Total Pages : 319 pages
Book Rating : 4.9/5 (618 download)

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Book Synopsis Microtubule Dynamics by : Anne Straube

Download or read book Microtubule Dynamics written by Anne Straube and published by Humana Press. This book was released on 2017-04-30 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microtubules are at the heart of cellular self-organization, and their dynamic nature allows them to explore the intracellular space and mediate the transport of cargoes from the nucleus to the outer edges of the cell and back. In Microtubule Dynamics: Methods and Protocols, experts in the field provide an up-to-date collection of methods and approaches that are used to investigate microtubule dynamics in vitro and in cells. Beginning with the question of how to analyze microtubule dynamics, the volume continues with detailed descriptions of how to isolate tubulin from different sources and with different posttranslational modifications, methods used to study microtubule dynamics and microtubule interactions in vitro, techniques to investigate the ultrastructure of microtubules and associated proteins, assays to study microtubule nucleation, turnover, and force production in cells, as well as approaches to isolate novel microtubule-associated proteins and their interacting proteins. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Definitive and practical, Microtubule Dynamics: Methods and Protocols provides the key protocols needed by novices and experts on how to perform a broad range of well-established and newly-emerging techniques in this vital field.

Homology Molecular Modeling

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Publisher : BoD – Books on Demand
ISBN 13 : 1839628057
Total Pages : 147 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Homology Molecular Modeling by : Rafael Trindade Maia

Download or read book Homology Molecular Modeling written by Rafael Trindade Maia and published by BoD – Books on Demand. This book was released on 2021-03-10 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Homology modeling is an extremely useful and versatile technique that is gaining more and more space and demand in research in computational and theoretical biology. This book, “Homology Molecular Modeling - Perspectives and Applications”, brings together unpublished chapters on this technique. In this book, 7 chapters are intimately related to the theme of molecular modeling, carefully selected and edited for academic and scientific readers. It is an indispensable read for anyone interested in the areas of bioinformatics and computational biology. Divided into 4 sections, the reader will have a didactic and comprehensive view of the theme, with updated and relevant concepts on the subject. This book was organized from researchers to researchers with the aim of spreading the fascinating area of molecular modeling by homology.

The isotypes of α, β and γ tubulin: From evolutionary origins to roles in metazoan development and ligand binding differences

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832521452
Total Pages : 173 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis The isotypes of α, β and γ tubulin: From evolutionary origins to roles in metazoan development and ligand binding differences by : Jeffrey Moore

Download or read book The isotypes of α, β and γ tubulin: From evolutionary origins to roles in metazoan development and ligand binding differences written by Jeffrey Moore and published by Frontiers Media SA. This book was released on 2023-04-25 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Amino Acids, Peptides and Proteins: Volume 45

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Publisher : Royal Society of Chemistry
ISBN 13 : 183916705X
Total Pages : 130 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Amino Acids, Peptides and Proteins: Volume 45 by : Maxim Ryadnov

Download or read book Amino Acids, Peptides and Proteins: Volume 45 written by Maxim Ryadnov and published by Royal Society of Chemistry. This book was released on 2024-02-02 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: