The Role Of Magnesium And Vitamin D On Cardiometabolic Risk Factors In Overweight And Obese Adults

Author : Claire Berryman
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (894 download)

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Download or read book Effects of Daily Almond Consumption (1.5 Oz.) on Cardiometabolic Risk Factors in Individuals with Elevated LDL-cholesterol written by Claire Berryman and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Nut consumption is associated with a decreased risk of cardiovascular disease (CVD) morbidity and mortality. The benefits of nuts are likely due to their unsaturated fatty acid profile, fiber and phytosterol content, and other bioactive nutrients. Reductions in total cholesterol (TC) and LDL-C can be achieved by substituting foods high in unsaturated fat, like nuts, for those high in saturated fat and/or refined carbohydrates. Of all the tree nuts, almonds provide the most fiber, protein, and [alpha]-tocopherol per one ounce serving, and clinical evidence consistently shows lipid and lipoprotein improvements with almond consumption. Previous controlled-feeding almond studies employed diet designs that incrementally decreased some or all foods to accommodate the caloric addition of almonds. Thus, almonds have not been evaluated in a controlled-feeding setting using a diet design with only a single, calorie-matched food substitution to assess their effects on cardiometabolic risk factors. We hypothesized that substituting whole almonds for a high-carbohydrate snack, within the context of a low-fat, low-cholesterol background diet, would improve lipids, lipoproteins, and apolipoproteins and decrease abdominal adiposity in adults with elevated LDL-C. A randomized, 2-period (6 wk/period), crossover, controlled-feeding study of 52 individuals with elevated LDL-C (148.0 ± 2.7 mg/dL) was designed to compare a cholesterol-lowering diet with almonds (1.5 oz. of almonds/d) to an identical diet with an isocaloric muffin substitution (no almonds/d). Differences in the nutrient profiles of the control (58% CHO, 15% PRO, 26% total fat) and almond (51% CHO, 16% PRO, 32% total fat) diets were due to nutrients inherent to each snack; diets did not differ in saturated fat or cholesterol. The almond diet, relative to the control diet, decreased non-HDL-C (-6.8 ± 2.4 mg/dL; P = 0.01), LDL-C (-5.2 ± 1.9 mg/dL; P = 0.01), and remnant lipoproteins (-2.8 ± 1.2 mg/dL; P = 0.03); whereas, the control diet decreased HDL-C (-1.8 ± 0.6 mg/dL; P 0.01). Almond consumption also reduced abdominal fat (-0.07 ± 0.03 kg; P = 0.01) and leg fat (-0.12 ± 0.05 kg; P = 0.02), despite no differences in total body weight. It is well established that diets low in saturated fat and cholesterol decrease CVD risk factors, including TC and LDL-C. Consequently, this dietary change also results in decreased HDL-C concentrations. We have shown that a cholesterol-lowering diet incorporating almonds decreases HDL-C to a lesser extent than a traditional low-fat, low-cholesterol diet. HDL has atheroprotective properties that extend beyond absolute HDL-C concentrations, therefore we investigated the dietary effects of almonds on HDL biology and function. We hypothesized that incorporating 1.5 oz./d of almonds in a cholesterol-lowering diet would attenuate decreases in HDL function (i.e. cholesterol efflux) and HDL subspecies that are observed with traditional cholesterol-lowering diets. The almond diet decreased [alpha]-1 (-1.4 ± 0.7 vs. -3.4 ± 0.7 mg apoA1/dL; P = 0.001) and the [alpha]-1: pre[beta] ratio (-0.06 ± 0.16 vs. -0.55 ± 0.17; P = 0.02) significantly less than the control diet. In addition, the almond diet reduced small HDL [alpha]-3 compared to the control diet (-1.0 ± 0.6 vs. 0.1 ± 0.6 mg apoA1/dL; P = 0.04). There were no treatment effects on global or transporter-specific cholesterol efflux. Collectively, almonds reduced LDL-C, remnant lipoproteins, and central adiposity and improved HDL subparticle distribution, all of which are important risk factors for cardiometabolic dysfunction. Daily consumption of almonds, substituted for a high-carbohydrate snack, may be a simple dietary strategy to prevent the onset of cardiometabolic diseases in healthy individuals. Individual responses to dietary treatment varied widely in our study population. We were interested in examining the contributions of interindividual characteristics on treatment response variability. We hypothesized that the almond diet, relative to control, would provide greater benefits in individuals who were normal weight (BMI 25 kg/m2) versus overweight/obese (=25 kg/m2), individuals with low CRP (1.0 mg/L) versus those with higher CRP (=1.0 mg/L), and in individuals with higher cholesterol absorption (lathosterol-to-[beta]-sitosterol ratio