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Author : Marwan E El-Sabban
Publisher :
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.E/5 ( download)
Download or read book The Role of Endothelial Cell-tumor Cell Interaction in Tumor Metastasis written by Marwan E El-Sabban and published by . This book was released on 1993 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
![Download The Role of Tumor Cell-vascular Endothelial Cell Interaction in the Metastasis of Subclones of a Human CLL B Cell Line [microform] PDF Online Free](https://books.google.com/books/content/images/frontcover/mTULywAACAAJ?fife=w200-h370)
Author : Lan Chen
Publisher : National Library of Canada = Bibliothèque nationale du Canada
ISBN 13 : 9780315936409
Total Pages : pages
Book Rating : 4.9/5 (364 download)
Download or read book The Role of Tumor Cell-vascular Endothelial Cell Interaction in the Metastasis of Subclones of a Human CLL B Cell Line [microform] written by Lan Chen and published by National Library of Canada = Bibliothèque nationale du Canada. This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sara Pui Yu Che
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.:/5 (954 download)
Download or read book Interaction Of Tumor-Derived Tissue Factor With Endothelial Cells In The Context Of Cancer Metastasis written by Sara Pui Yu Che and published by . This book was released on 2016 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: The metastatic cascade comprises of a series of events, which tumor cells must complete to form macrometastases at a secondary site. Due to its spread and aggressive nature, metastatic tumor is difficult to treat, and tumor metastasis remains the main cause of death in cancer patients. Most epithelial tumors over-express tissue factor (TF), the initiator of the extrinsic pathway of coagulation cascade. This over-expression of TF has been shown to tumor progression and metastasis in different studies. In this thesis, we studied two mechanisms by which tumor-derived TF can interact with endothelial cells to promote cancer metastasis. Endothelial cells act as a natural barrier between the tumor cells in circulation and secondary organs. Tumor cells must arrest on endothelial cells in order to extravasate and enter a new organ. Most previous studies have focused on the classical receptor-ligand interactions involved in leukocyte recruitment during inflammation, such as selectins and integrins. We hypothesized that TFexpressing tumor cells can mediate adhesion to the endothelium by interacting with its endogenous inhibitor, tissue factor pathway inhibitor (TFPI), which is constitutively expressed on endothelial cells. Using in vitro models, we found that high TF-expressing tumor cells bound to recombinant TFPI and endothelial cells under static conditions; however, under shear, the tumor cells adhered to recombinant TFPI, but not endothelial cells. We postulate that the TFPI expres- sion in our endothelial cell model (human umbilical vein) was too low to mediate adhesion. Unfortunately, due to the lack of availability of other primary endothelial cells that express higher TFPI (e.g. lung microvascular endothelium), we could not test this theory further. Endothelial cells, highly dynamic and responsive to its local environment, perform a range of functions in the body. Endothelial responses could be hijacked by tumor cells to promote a tumor-permissive metastatic environment. Tumor cells secrete extracellular vesicles (EV) that can interact with distant cells and re-educate them to a pro-tumor phenotype. Tumor cells secrete two types of EV - microvesicles (100-1000nm) and exosomes (30-100nm). In this part of the thesis, we evaluated the isolation of exosomes and microvesicles using common established protocols - filtration and differential centrifugation. We found that the isolation methods highly impacted the size distribution, the purity and TF-mediated procoagulant activity in the isolated fractions. We then evaluated whether tumor-derived TF-expressing EV (consist of microvesicles and exosomes) promote pro-metastatic behaviors in endothelial cells in vitro. We observed binding and uptake of EV by endothelial cells. These EV also signaled to endothelial cells and promoted a pro-adhesive (upregulation of E-selectin and intercellular cellular adhesion molecule-1), pro-inflammatory (increased secretion of monocyte chemotactic protein-1 and interleuking-8) and procoagulant (increase in TF-mediated procoagulant activity) phenotype in endothelial cells. The mechanism was dependent on TF-mediated FXa generation by EV, and activation of protease-activated receptor-1 followed by transactivation of epidermal growth factor receptor on endothelial cells.
Author : George G. Skouteris
Publisher : IOS Press
ISBN 13 : 9789051994568
Total Pages : 322 pages
Book Rating : 4.9/5 (945 download)
Download or read book Intermolecular Cross-talk in Tumor Metastasis written by George G. Skouteris and published by IOS Press. This book was released on 1999 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metastasis of tumours is a sequence of events taking place after the appearance of a primary tumour. The potency of a tumour to metastasise greatly depends on the molecular interactions between tumour components (cellular differentiation and heterogeneity, surface antigenic determinants etc.) and the micro-environment. The complexity and diversity in the composition of tissue micro-environment is in great extent determining the metastatic behaviour or a primary tumour. Extracellular matrix composition, rearrangement of cytoskeleton, cell antigenicity , expression of metastasis-related novel genes, cell adhesion and novel therapeutical approaches such as blockage of angiogenesis, are the major topics discussed in detail in this volume.
Author : loannis K. Zervantonakis
Publisher :
ISBN 13 :
Total Pages : 117 pages
Book Rating : 4.:/5 (846 download)
Download or read book Engineering the Tumor Microenvironment Using Microfluidics written by loannis K. Zervantonakis and published by . This book was released on 2013 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt: 90% of cancer related deaths are due to metastatic disease and there is a need for a better understanding of cell-microenvironment interactions to identify new therapeutic targets. A key step during cancer metastasis is cancer cell intravasation (entry of cancer cells into the blood vessels) that results in tumor cell dissemination into distant organs. During this process, tumor cells navigate a complex microenvironment and interact with multiple cell types. This thesis is aimed to develop a microfluidic-based intravasation assay that allows for direct observation of tumor cell motility combined with quantitation of the endothelial barrier function. Compared with traditional in vitro assays, microfluidic assays enable "user-defined" design of the cellular and acellular microenvironment with spatio-temporal control and live high-resolution imaging. Formation of confluent endothelial layers in the device was confirmed with immunofluorescence staining for endothelial cell-cell junctions and we compared our diffusive permeability values with published in vivo and in vitro data. We employ this microfluidic assay to investigate the role of endothelial barrier function during tumor cell intravasation to address a critical question in cancer research: does tumor cell intravasation require a leaky endothelium? To induce vessel leakiness we perturb the barrier using biochemical factors, endothelial cells with low expression of basement membrane proteins and signaling with macrophages. Under all these conditions, tumor cell intravasation rates increased and we confirmed these results for multiple tumor cell types. Characterization of macrophage secreted factors and M1/M2 polarization status, identified that blocking macrophage-secreted TNF-a restored endothelial permeability and reduced tumor cell intravasation. In agreement with these results, we also found that the number and dynamics of tumor-endothelial interactions were dependent on endothelial barrier function. A novel feature of the developed assay is the ability to image in real-time the process of tumor cell intravasation, while also enabling accurate control and quantitation of the functional characteristics of the endothelial barrier. Our results not only demonstrate the important role of cell-cell paracrine signaling and biochemical factors in regulating tumor cell intravasation, but also have important implications for strategies aimed to disrupt or normalize vasculature in vivo. Keywords: 3D Microfluidics, Endothelial permeability, Cancer cell Intravasation, Macrophages.
Author : F. William Orr
Publisher : CRC Press
ISBN 13 : 9780849361548
Total Pages : 326 pages
Book Rating : 4.3/5 (615 download)
Download or read book Microcirculation in Cancer Metastasis written by F. William Orr and published by CRC Press. This book was released on 1991-07-25 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although mechanisms involved in the spread of cancer have been the subject of a major research endeavor over the past decade, metastatic tumors still account for significant clinical morbidity and the failure of cancer treatment. Not only are the vascular pathways the most common route for the dissemination of cancer cells, but interactions between the cells and the circulation act as important rate-regulators for the metastatic process. This authoritative, multi-authored volume addresses the importance of microcirculation in cancer metastasis. The book begins with up-to-date reviews on the biology of endothelial cells and the structure and physiology of the normal and tumor microcirculations, and then emphasizes interactions between components of the microcirculation and cancer cells. Metastasis is discussed through chapters exploring the entry of cancer cells into the circulation, the biophysics and morphology of cancer cell traffic and arrest, interactions with host cells and the basement membranes, and angiogenesis. This fascinating book will interest oncologists, pathologists, and students of metastasis or the microcirculation.
Author : Claudia Mierke
Publisher : Iph001
ISBN 13 : 9780750317511
Total Pages : 500 pages
Book Rating : 4.3/5 (175 download)
Download or read book Physics of Cancer written by Claudia Mierke and published by Iph001. This book was released on 2018-10-24 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised second edition is improved linguistically with multiple increases of the number of figures and the inclusion of several novel chapters such as actin filaments during matrix invasion, microtubuli during migration and matrix invasion, nuclear deformability during migration and matrix invasion, and the active role of the tumor stroma in regulating cell invasion.
Author : Debabrata Banerjee
Publisher : Springer Nature
ISBN 13 : 3030832821
Total Pages : 171 pages
Book Rating : 4.0/5 (38 download)
Download or read book Tumor Microenvironment: Cellular, Metabolic and Immunologic Interactions written by Debabrata Banerjee and published by Springer Nature. This book was released on 2021-12-09 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor micronenvironment’s various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.
Author : Roy Zent
Publisher : Springer Science & Business Media
ISBN 13 : 1441908145
Total Pages : 316 pages
Book Rating : 4.4/5 (419 download)
Download or read book Cell-Extracellular Matrix Interactions in Cancer written by Roy Zent and published by Springer Science & Business Media. This book was released on 2010-01-23 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer was thought to originate from alterations in intercellular signaling that resulted in the transformation of cells, their uncontrolled proliferation and metastasis. There is now an increasing body of evidence demonstrating that the surrounding matrix and cell-matrix interactions are also major players in this process. Cells adhere and receive signals from various extracellular matrices via transmembrane receptors, the best known of which are the heterodimeric glycoproteins, integrins.
Author : Kenneth V. Honn
Publisher : Springer Science & Business Media
ISBN 13 : 1461326354
Total Pages : 430 pages
Book Rating : 4.4/5 (613 download)
Download or read book Mechanisms of Cancer Metastasis written by Kenneth V. Honn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The past twenty years have witnessed significant advances in the treatment of cancer by surgery and radiation therapy. Gains with cytotoxic chemotherapy have been much more modest. Of the approximately 900,000 newly diagnosed cases of cancer each year, 50010 result in death of the patient. The primary cause of these deaths is metastasis. Although the term metastasis was first coined by Recamier in 1829, only in the past ten years have there been intensive scientific investigations into the mechanisms by which tumor cells metastasize. What has emerged is a complex process of host-tumor cell interactions which has been termed the metastatic cascade. Due to the complexity of the metastatic process, the study of metastasis is multifaceted and involves elements of such areas as differentiation, en zymology, genetics, hematology, immunology, membrane biochemistry and molecular biology. The major objectives of this book were to present the most recent advances in our understanding of how tumor cells metastasize to secondary sites by the leading experts in the biology of tumor invasion and metastasis. We hope that this book will lead to new concepts for the treatment of subclinical metastatic cancer. The chapters in this book address both the basic science of metastasis and potential clinical therapies directed toward interruption of the metastatic cascade or toward eradication of subclinical metastases. Many relevant topics have been omitted due to space considerations and thus the topics included reflect the prej udices of the editors.
Author : Christian Stock
Publisher : Springer Nature
ISBN 13 : 3030998002
Total Pages : 188 pages
Book Rating : 4.0/5 (39 download)
Download or read book From Malignant Transformation to Metastasis written by Christian Stock and published by Springer Nature. This book was released on 2022-04-24 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second book of the three-volume collection "Ion Transport in Tumor Biology" helps readers gain comprehensive knowledge of the pathophysiology of cancer. The authors highlight that ion transport proteins, channels and transporters - collectively referred to as the transportome - are significantly involved in the development and progression of cancer. Nearly 90% of malignant tumor diseases originate from epithelial cells, the function of which, for the most part, is based on the transportome. This volume focuses on molecular principles by showing that dysregulated expression and/or function of ion transporters have been correlated with malignancy in the vast majority of tumor diseases. Within the story of the various chapters, the authors line out various malfunctions of the transportome and where they can be found at different stages of the metastatic cascade. The authors describe how the interactions between the tumor cells' transportome and the environment reinforce mesenchymal behaviour of cancer cells and contribute to their uncontrolled proliferation, migration, invasion, intra- and extravasation up to the formation of metastases. As part of a three-volume collection, this book will fascinate members of the active research community, as well as clinicians from the cancer field.
Author : Itzhak D. Goldberg
Publisher : Birkhäuser
ISBN 13 : 3034890702
Total Pages : 304 pages
Book Rating : 4.0/5 (348 download)
Download or read book Epithelial—Mesenchymal Interactions in Cancer written by Itzhak D. Goldberg and published by Birkhäuser. This book was released on 2013-03-07 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The contribution of epithelia-mesenchyme interaction to normal development (eg., tissue formation) and to neoplasia has become a subject of increasing interest to scientists because of recent progress in deciphering the molecular signals that mediate this interaction. Clearly, some of the same types of molecules (eg., growth factors and their receptors, proteolytic enzymes, cell adhesion molecules, and structural proteins of the extracellular matrix) mediate exchange of information between epithelia and mesenchyme during normal development and malignant growth. However, defects in the regulation of this exchange appear to contribute to malignancy by allowing growth promoting, invasogenic, and angiogenic factors to accumulate within the microenvironment of the tumor. For example, recent studies suggest that abnormal interactions between tumor epithelial cells and stromal mesenchymal cells contribute to the overproduction and accumulation of scatter factor (hepatocyte growth factor), an invasogenic and angiogenic cytokine, in certain types of tumor. The production and and activation of type IV collagenase, a matrix-degrading enzyme required for tumor cell invasion, appears to require intimate cooperation between tumor and stromal cells. The material contained in this volume highlights the state-of-the-art of knowledge of the molecular mechanisms by which epithelia and mesenchyme collaborate, and the abnormalities in these mechanisms that may lead to the development of cancer.
Author : Menashe Bar-Eli
Publisher : Springer Science & Business Media
ISBN 13 : 1402083416
Total Pages : 155 pages
Book Rating : 4.4/5 (2 download)
Download or read book Regulation of Gene Expression in the Tumor Environment written by Menashe Bar-Eli and published by Springer Science & Business Media. This book was released on 2008-08-25 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now becoming very clear that the development and progression of tumor towards the malignant (metastatic) phenotype depends tightly on the interaction between the tumor cells and the tumor microenvironment. Tumor cells respond to stimuli generated within the tumor microenvironment for their growth advantage while the tumor cell themselves reshape and remodel the architecture and function of their extracellular matrices. The term tumor microenvironment is a wide umbrella consisting of stromal cells such as fibroblasts and endothelial cells and infiltration immune cells including T and B cells, macrophages, and other inflammatory cells (PMNs). These different components of the tumor microenvironment could have stimulatory and inhibitory effects on tumor progression by regulating the gene expression repertoire within the tumor cells on one hand and the stroma cells on the other. In this volume we have seven contributors who will discuss several different aspects on the cross talk within the tumor microenvironment components leading to the acquisition of the metastatic phenotype. It is our hope that these state-of-the-art studies will shed further light on our understanding of these complicated processes.
Author : Alecsandru Ioan Baba
Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)
Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alan Wells
Publisher : Springer Science & Business Media
ISBN 13 : 1402040091
Total Pages : 360 pages
Book Rating : 4.4/5 (2 download)
Download or read book Cell Motility in Cancer Invasion and Metastasis written by Alan Wells and published by Springer Science & Business Media. This book was released on 2006-06-22 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cancer Morbidity and mortality result from invasive and metastatic spread. Currently, no therapies are aimed at the underlying mechanisms that enable this progression due to only nascent recognition of the distinct biology which occurs only during tumor dissemination. Recent advances have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book includes state-of-the-art updates by international leaders in these studies. Chapters first present the novel model systems that enable new investigations and insights. Chapters then describe in depth the key processes and molecules that may be therapeutically targeted. Finally, the role of cell motility and its signals is explored in a number of key tumor types. This compilation should be useful to researchers in basic and translational oncology as well as those developing novel agents to prevent tumor invasion and metastasis.
Author : Kenneth V. Honn
Publisher : Springer Science & Business Media
ISBN 13 : 146133831X
Total Pages : 637 pages
Book Rating : 4.4/5 (613 download)
Download or read book Hemostatic Mechanisms and Metastasis written by Kenneth V. Honn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tracey A. Martin
Publisher : Springer Science & Business Media
ISBN 13 : 9400760280
Total Pages : 315 pages
Book Rating : 4.4/5 (7 download)
Download or read book Tight Junctions in Cancer Metastasis written by Tracey A. Martin and published by Springer Science & Business Media. This book was released on 2013-02-26 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been a dramatic increase in knowledge of tight junctions in the past decade. The molecular structure of tight junctions, cellular functions and the pathophysiological roles of tight junctions are becoming clear. Of the most important functions, the role of the cellular structure in cancer spread and drug delivery are increasingly realised. It is now clear that there are fundamental changes to tight junctions during the process of cancer development. Tight junctions are also critical to the metastatic process of cancer cells. The cellular structure is also crucial in drug therapies, namely, the permeability and bioavailability of the drugs, penetration of barriers such as the blood brain barrier. This current volume aims to summarise the current knowledge of tight junctions, their role in cancer and cancer metastasis and is of interest to scientists and clinicians.
