The Receptor Rage In Vascular And Cerebral Dysfunctions

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The Receptor RAGE in Vascular and Cerebral Dysfunctions

Author : Jean-Luc Wautier
Publisher : Cambridge Scholars Publishing
ISBN 13 : 1527527646
Total Pages : 169 pages
Book Rating : 4.5/5 (275 download)

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Book Synopsis The Receptor RAGE in Vascular and Cerebral Dysfunctions by : Jean-Luc Wautier

Download or read book The Receptor RAGE in Vascular and Cerebral Dysfunctions written by Jean-Luc Wautier and published by Cambridge Scholars Publishing. This book was released on 2019-02-01 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: After chemistry, the origins of biochemistry began at the end of the 19th century. The first major step was made when glycated hemoglobin, HbA1c, was found to be a precious index to follow an adapted antidiabetic treatment. This discovery led to the identification of cell receptors, present in vascular cells, leukocytes, neuronal cells. One such cell receptor, RAGE, has been shown to be a major contributor in cell alteration, the development of vascular complications in diabetes mellitus, ageing, and Alzheimer’s disease. This book shows that the axis AGE-RAGE and the activation of RAGE by other ligands open up a possible new therapeutic approach to prevent complications of diabetes mellitus and ageing. As such, it will particularly appeal to chemists, biochemists, biologists, immunologists, nutritionists, doctors, cardiologists, and neurologists. The collection is the fruit of a collaboration of eminent experts (Ann Marie Schmidt is Professor of Medicine, New York University, USA; Marie-Paule Wautier PhD is an engineer at Institut National de la Sante et de la Recherche Medicale, Paris, France; Eric Boulanger is a Professor of medicine, Lille University, France; Peter Nawroth is a Professor of Internal Medicine at Heidelberg University, Germany; David Stern is Vice-Chancellor for Health Affairs, University of Tennessee, USA; Jean-Luc Wautier is an Emeritus Professor of Medicine, University Denis Diderot Paris, France) who have greatly contributed to the story of the Receptor for Advanced Glycation End products (RAGE).

Magnesium in the Central Nervous System

Author : Robert Vink
Publisher : University of Adelaide Press
ISBN 13 : 0987073052
Total Pages : 354 pages
Book Rating : 4.9/5 (87 download)

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Book Synopsis Magnesium in the Central Nervous System by : Robert Vink

Download or read book Magnesium in the Central Nervous System written by Robert Vink and published by University of Adelaide Press. This book was released on 2011 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is the most complex organ in our body. Indeed, it is perhaps the most complex structure we have ever encountered in nature. Both structurally and functionally, there are many peculiarities that differentiate the brain from all other organs. The brain is our connection to the world around us and by governing nervous system and higher function, any disturbance induces severe neurological and psychiatric disorders that can have a devastating effect on quality of life. Our understanding of the physiology and biochemistry of the brain has improved dramatically in the last two decades. In particular, the critical role of cations, including magnesium, has become evident, even if incompletely understood at a mechanistic level. The exact role and regulation of magnesium, in particular, remains elusive, largely because intracellular levels are so difficult to routinely quantify. Nonetheless, the importance of magnesium to normal central nervous system activity is self-evident given the complicated homeostatic mechanisms that maintain the concentration of this cation within strict limits essential for normal physiology and metabolism. There is also considerable accumulating evidence to suggest alterations to some brain functions in both normal and pathological conditions may be linked to alterations in local magnesium concentration. This book, containing chapters written by some of the foremost experts in the field of magnesium research, brings together the latest in experimental and clinical magnesium research as it relates to the central nervous system. It offers a complete and updated view of magnesiums involvement in central nervous system function and in so doing, brings together two main pillars of contemporary neuroscience research, namely providing an explanation for the molecular mechanisms involved in brain function, and emphasizing the connections between the molecular changes and behavior. It is the untiring efforts of those magnesium researchers who have dedicated their lives to unraveling the mysteries of magnesiums role in biological systems that has inspired the collation of this volume of work.

Application For Nanotechnology For the Treatment of Brain Diseases and Disorders

Author : Bingyang Shi
Publisher : Frontiers Media SA
ISBN 13 : 2889714969
Total Pages : 97 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Application For Nanotechnology For the Treatment of Brain Diseases and Disorders by : Bingyang Shi

Download or read book Application For Nanotechnology For the Treatment of Brain Diseases and Disorders written by Bingyang Shi and published by Frontiers Media SA. This book was released on 2021-10-18 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Antioxidants and Functional Foods for Neurodegenerative Disorders

Author : Abhai Kumar
Publisher : CRC Press
ISBN 13 : 1000282740
Total Pages : 631 pages
Book Rating : 4.0/5 (2 download)

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Book Synopsis Antioxidants and Functional Foods for Neurodegenerative Disorders by : Abhai Kumar

Download or read book Antioxidants and Functional Foods for Neurodegenerative Disorders written by Abhai Kumar and published by CRC Press. This book was released on 2021-01-07 with total page 631 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are a growing problem across the world’s aging population. Oxidative stress in the brain plays a central role in a common pathophysiology of these diseases. This book presents scientific research on the potential of antioxidant therapy in the prevention and treatment of neurodegenerative disorders. This book outlines the roles of oxidative stress and diabetes mellitus in neurodegeneration, describes the molecular mechanisms of neurodegenerative disorders including the roles of environmental pollutants and inflammatory responses, and explores mitochondrial dysfunction. It then describes the protective abilities of antioxidants – including vitamin D, tocotrienol and coenzyme Q10 – against neurodegeneration. The book demonstrates the therapeutic potential of ketogenic diets, and highlights the roles of medicinal plants, phytopharmaceuticals, traditional medicines and food nutrients in neuroprotection. Key Features: Explains damage caused by numerous neurodegenerative disorders and the possible protection offered by antioxidants and functional foods. Describes molecular mechanisms of neurodegeneration by oxidative stress, advancing age, diabetes and mitochondrial dysfunctions. Demonstrates protection offered by nutraceuticals, antioxidants, botanical extracts and functional foods. The book contains twenty-three chapters divided into six sections written by leading researchers. This book is essential reading for health professionals, dietitians, food and nutrition scientists and anyone wanting to improve their knowledge of etiology of neurodegenerative diseases.

Cerebral Small Vessel Disease

Author : Leonardo Pantoni
Publisher : Cambridge University Press
ISBN 13 : 1107031664
Total Pages : 375 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Cerebral Small Vessel Disease by : Leonardo Pantoni

Download or read book Cerebral Small Vessel Disease written by Leonardo Pantoni and published by Cambridge University Press. This book was released on 2014-05 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Up-to-date discussion of the etiology, diagnosis, treatment, and prevention of this common cause of stroke and cognitive impairment.

Pharmacology of the Blood Brain Barrier: Targeting CNS Disorders

Author :
Publisher : Academic Press
ISBN 13 : 0128003383
Total Pages : 512 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Pharmacology of the Blood Brain Barrier: Targeting CNS Disorders by :

Download or read book Pharmacology of the Blood Brain Barrier: Targeting CNS Disorders written by and published by Academic Press. This book was released on 2014-10-21 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume of Advances in Pharmacology presents pharmacology of the blood brain barrier, focusing on targeting CNS disorders. With a variety of chapters and the best authors in the field, the volume is an essential resource for pharmacologists, immunologists and biochemists alike. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and biochemists

Cerebral Amyloid Angiopathy in Alzheimer’s Disease and Related Disorders

Author : M.M. Verbeek
Publisher : Springer Science & Business Media
ISBN 13 : 9401710074
Total Pages : 358 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Cerebral Amyloid Angiopathy in Alzheimer’s Disease and Related Disorders by : M.M. Verbeek

Download or read book Cerebral Amyloid Angiopathy in Alzheimer’s Disease and Related Disorders written by M.M. Verbeek and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cerebral amyloid angiopathy (CAA) is a distinctive abnormality of small cerebral blood vessels, one that has intrigued neuroscientists for decades. The time seems right for a book which examines the phenomenon of CAA using a multifaceted approach: What does it produce clinically? How might CAA be imaged? What are the crucial biochemical/cellular events within cerebral vessel walls that lead to CAA? How can in vitro or transgenic experimental systems be used to understand the etiology of, or even potential treatments for, CAA? The editors have assembled key figures in the field of CAA research to examine these (and other) questions in a series of focused chapters that address specific issues of importance in understanding CAA and its clinical manifestations. Comprehending the biology and pathogenesis of this fascinating vascular lesion may even provide clues to less common forms of cerebral microvascular disease that have been recognized for decades (hypertensive microangiopathy) or more recently (CADASIL).

Multidisciplinary Experiences in Renal Replacement Therapy

Author : Ane Claudia Fernandes Nunes
Publisher : BoD – Books on Demand
ISBN 13 : 1839626623
Total Pages : 160 pages
Book Rating : 4.8/5 (396 download)

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Book Synopsis Multidisciplinary Experiences in Renal Replacement Therapy by : Ane Claudia Fernandes Nunes

Download or read book Multidisciplinary Experiences in Renal Replacement Therapy written by Ane Claudia Fernandes Nunes and published by BoD – Books on Demand. This book was released on 2022-06-15 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Renal replacement therapy (RRT) is used to replace the capacity of blood filtration, which is completely lost in end-stage renal disease (ESRD). This book examines RRT from a multidisciplinary perspective. In nine comprehensive chapters over three sections, the book shows how clinical routines, especially RRT, are increasingly focused on the translational scenario of the health sciences. Chapters discuss health and wellness, hemodialysis, and clinical biomarkers of renal disease.

Brain Disorders in Critical Illness

Author : Robert D. Stevens
Publisher : Cambridge University Press
ISBN 13 : 1107434424
Total Pages : 457 pages
Book Rating : 4.1/5 (74 download)

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Book Synopsis Brain Disorders in Critical Illness by : Robert D. Stevens

Download or read book Brain Disorders in Critical Illness written by Robert D. Stevens and published by Cambridge University Press. This book was released on 2013-09-19 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain dysfunction is a major clinical problem in intensive care, with potentially debilitating long-term consequences for post-ICU patients of any age. The resulting extended length of stay in the ICU and post-discharge cognitive dysfunction are now recognized as major healthcare burdens. This comprehensive clinical text provides intensivists and neurologists with a practical review of the pathophysiology of brain dysfunction and a thorough account of the diagnostic and therapeutic options available. Initial sections review the epidemiology, outcomes, relevant behavioral neurology and biological mechanisms of brain dysfunction. Subsequent sections evaluate the available diagnostic options and preventative and therapeutic interventions, with a final section on clinical encephalopathy syndromes encountered in the ICU. Each chapter is rich in illustrations, with an executive summary and a helpful glossary of terms. Brain Disorders in Critical Illness is a seminal reference for all physicians and neuroscientists interested in the care and outcome of severely ill patients.

Translational Advances in Alzheimer's, Parkinson's, and Other Neurodegenerative Dementias

Author : Jiehui Jiang
Publisher : Frontiers Media SA
ISBN 13 : 2889763714
Total Pages : 845 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Translational Advances in Alzheimer's, Parkinson's, and Other Neurodegenerative Dementias by : Jiehui Jiang

Download or read book Translational Advances in Alzheimer's, Parkinson's, and Other Neurodegenerative Dementias written by Jiehui Jiang and published by Frontiers Media SA. This book was released on 2022-07-05 with total page 845 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Potential Biomarkers in Neurovascular Disorders, volume II

Author : Wen-Jun Tu
Publisher : Frontiers Media SA
ISBN 13 : 2832533027
Total Pages : 231 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Potential Biomarkers in Neurovascular Disorders, volume II by : Wen-Jun Tu

Download or read book Potential Biomarkers in Neurovascular Disorders, volume II written by Wen-Jun Tu and published by Frontiers Media SA. This book was released on 2023-10-31 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurovascular disorders are a group of pathological conditions resulting from the neurovascular injury. Neurovascular disorders include cerebral ischemia, intracerebral hemorrhage, subarachnoid hemorrhage, venous sinus thrombosis, glioma, carotid disease, cerebral small vessel disease, and vascular dementia, among others. Although we have accumulated more understanding of both the genetic links and the basic mechanisms behind the pathophysiology of neurovascular diseases over the years, the exact mechanisms are still unclear. Therefore, there is an urgency to identify important therapeutic targets.

Diabetes Mellitus: Associated Conditions, An Issue of Endocrinology and Metabolism Clinics of North America,

Author : Leonid Poretsky
Publisher : Elsevier Health Sciences
ISBN 13 : 0323287050
Total Pages : 353 pages
Book Rating : 4.3/5 (232 download)

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Book Synopsis Diabetes Mellitus: Associated Conditions, An Issue of Endocrinology and Metabolism Clinics of North America, by : Leonid Poretsky

Download or read book Diabetes Mellitus: Associated Conditions, An Issue of Endocrinology and Metabolism Clinics of North America, written by Leonid Poretsky and published by Elsevier Health Sciences. This book was released on 2014-03-05 with total page 353 pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of the Endocrinology and Metabolism Clinics, guest edited by Drs. Leonid Poretsky and Emilia Pauline Liao, will focus on Diabetes Mellitus: Associated Conditions. Articles in this issue include Metabolic syndrome; The role of glucocorticoids and insulin resistance in adipose tissue function and lipid metabolism; Cardiovascular disease; The Relationships between Cardiovascular Disease and Diabetes: Focus on Pathogenesis; Interventions for coronary artery disease; Peripheral Arterial Disease; Hypertension; Sleep apnea; Osteoporosis; Vitamin D deficiency; Diabetes and cancer; Dementia; Depression; and Polycystic Ovary Syndrome.

The Perioperative Neurocognitive Disorders

Author : Roderic G. Eckenhoff
Publisher : Cambridge University Press
ISBN 13 : 1107559200
Total Pages : 219 pages
Book Rating : 4.1/5 (75 download)

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Book Synopsis The Perioperative Neurocognitive Disorders by : Roderic G. Eckenhoff

Download or read book The Perioperative Neurocognitive Disorders written by Roderic G. Eckenhoff and published by Cambridge University Press. This book was released on 2019-03-28 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to perioperative cognitive disorders, the most common complications of anesthesia and surgery in older people.

Type II Diabetes Mellitus: A Multidisciplinary Approach, 1e (Clinics Collections), E-Book

Author : Joel J. Heidelbaugh
Publisher : Elsevier Health Sciences
ISBN 13 : 0323359574
Total Pages : 454 pages
Book Rating : 4.3/5 (233 download)

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Book Synopsis Type II Diabetes Mellitus: A Multidisciplinary Approach, 1e (Clinics Collections), E-Book by : Joel J. Heidelbaugh

Download or read book Type II Diabetes Mellitus: A Multidisciplinary Approach, 1e (Clinics Collections), E-Book written by Joel J. Heidelbaugh and published by Elsevier Health Sciences. This book was released on 2015-10-16 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinics Collections: Type II Diabetes Mellitus draws from Elsevier’s robust Clinics Review Articles database to provide multidisciplinary teams, including general practitioners, endocrinologists, and other healthcare professionals, with practical clinical insights on the evaluation and management of patients with this disease and other co-morbidities. Clinics Collections: Type II Diabetes Mellitus guides readers on how to apply current primary research findings on type II diabetes to everyday practice to help overcome management challenges, keep up with new and improved treatments, and improve patient outcomes. Areas of focus include diabetic complications associated with the foot, cardiovascular system, renal system, gastrointestinal system, ophthalmologic disorders, dermatologic disorders, neurologic and psychological disorders, special considerations, and more! Each article begins with keywords and key points for immediate access to the most critical information. Articles are presented in an easy-to-digest and concisely worded format. Elsevier Clinics Collections provide concise reviews of today’s most prevalent conditions and significant medical developments.

Cutting-Edge Approaches for CNS Protection and Repair: Focus on Vascular and Degenerative Disorders

Author : Johannes Boltze
Publisher : Frontiers Media SA
ISBN 13 : 2889711773
Total Pages : 1044 pages
Book Rating : 4.8/5 (897 download)

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Book Synopsis Cutting-Edge Approaches for CNS Protection and Repair: Focus on Vascular and Degenerative Disorders by : Johannes Boltze

Download or read book Cutting-Edge Approaches for CNS Protection and Repair: Focus on Vascular and Degenerative Disorders written by Johannes Boltze and published by Frontiers Media SA. This book was released on 2021-08-19 with total page 1044 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Studies on Renal Disorders

Author : Toshio Miyata
Publisher : Springer Science & Business Media
ISBN 13 : 1607618575
Total Pages : 781 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis Studies on Renal Disorders by : Toshio Miyata

Download or read book Studies on Renal Disorders written by Toshio Miyata and published by Springer Science & Business Media. This book was released on 2010-12-17 with total page 781 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conditions such as oxidative stress and hypoxia, which have a generalized impact on the oxygen metabolism, have been implicated in the genesis of kidney disease. This means that deepening our understanding of the pathobiology of oxygen metabolism in such diseases could be a fruitful path towards tangible clinical benefits. Studies in Renal Disorder collects reviews from leading researchers and clinical scientists working in exactly this field, providing an overview of the latest advances. The causal role of impaired oxygen metabolism in kidney disease has numerous clinical implications. It affects our understanding of the therapeutic benefits accruing from anti-hypertensive agents; the way we control hyperglycemia/hyperinsulinemia and hyperlipidemia; and our use of dietary approaches to the correction of obesity. The defensive mechanisms against oxidative stress, such as the Nrf2-Keap1 system, and hypoxia, such as the PHD-HIF system, have recently been explored in various cells, including kidney cells. These mechanisms include intracellular sensors for oxidative stress and hypoxia. This means that novel approaches targeting these sensors may offer clinical benefits in kidney disease in which oxidative stress and/or hypoxia is a final, common pathway.

Metabolic Syndrome

Author : Akhlaq A. Farooqui
Publisher : Springer Science & Business Media
ISBN 13 : 1461473187
Total Pages : 429 pages
Book Rating : 4.4/5 (614 download)

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Book Synopsis Metabolic Syndrome by : Akhlaq A. Farooqui

Download or read book Metabolic Syndrome written by Akhlaq A. Farooqui and published by Springer Science & Business Media. This book was released on 2013-06-14 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Metabolic syndrome as an important risk factor for stroke, Alzheimer disease, and depression presents readers with cutting edge and comprehensive information on relationship among metabolic syndrome, stroke, Alzheimer disease, and depression. It is hoped that this monograph will be useful to postgraduate students, faculty, research scientists, pharmacologists, nutritionists, and physicians, who are curious about the molecular mechanisms that link metabolic syndrome with stroke, Alzheimer disease, and depression.