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The Pharmacogenetics Of Breast Cancer Treatment
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Book Synopsis Pharmacogenetics of Breast Cancer by : Brian Leyland-Jones
Download or read book Pharmacogenetics of Breast Cancer written by Brian Leyland-Jones and published by CRC Press. This book was released on 2020-04-27 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenetics is becoming increasingly relevant in the diagnosis, treatment, and recovery of cancer patients. A major problem facing oncologists is the outstanding varied efficacy of treatment. Promising advances in pharmacogenetics have allowed the development of effective agents which will enable personalized cancer chemotherapy to become rout
Book Synopsis The Pharmacogenetics of Breast Cancer Treatment by : J. E. Abraham
Download or read book The Pharmacogenetics of Breast Cancer Treatment written by J. E. Abraham and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacogenetics: Making cancer treatment safer and more effective by : William G. Newman
Download or read book Pharmacogenetics: Making cancer treatment safer and more effective written by William G. Newman and published by Springer Science & Business Media. This book was released on 2010-07-20 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemotherapy has made a dramatic difference to improved survival in patients with cancer. However, not all patients respond and some experience serious side effects. "Pharmacogenetics: Making cancer treatment safer and more effective" is an up to date summary of the exciting new field of how genetic testing can tailor more effective prescription in oncology. It is targeted at oncologists and professionals involved in the treatment of patients with cancer. It provides a core background in genetics and pharmacological principles before providing chapters from acknowledged experts in the field on genetic tests in specific cancer types, including breast, bowel and lung cancer. Clinical cases are used to illustrate the practical application of this knowledge. Chapters on ethics, health economics and the industry aspects of pharmacogenetics set out the challenges and opportunities afforded by this new science.
Book Synopsis Pharmacogenetics of Cytochromes in Breast Cancer Treatment by : Paola Biason
Download or read book Pharmacogenetics of Cytochromes in Breast Cancer Treatment written by Paola Biason and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response by : Federico Innocenti
Download or read book Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response written by Federico Innocenti and published by Springer Science & Business Media. This book was released on 2008-10-30 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomics and Pharmacogenomics in Anticancer Drug Development and Clinical Response provides the most comprehensive body of knowledge available on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients. As a consequence of the intrinsic chromosomal and genetic instability of the tumor genome, it is generally believed that tailoring of chemotherapy in cancer - tients might be achieved by molecular analysis of patient tumor DNA. In addition, to reduce the toxicity risk of patients, the tumor DNA information should be in- grated with the available data on polymorphic drug-metabolizing enzyme and tra- porter genes mediating the exposure of patients to active drugs and/or their active metabolites. The chapters of this book clearly show how DNA information from both the host (germline) and the tumor should be taken into account for rational selection of drug therapies in cancer patients, an aspect that received little attention, despite its importance. The availability of new molecular approaches to the selection of drug therapy is an emerging need, because the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many treated patients do not experience signi?cant bene?ts from the treatment, while they often experience moderate to severe toxicities. In addition, the development and clinical use of novel molecularly targeted agents (alone or in combination with classical cytotoxic therapy) requires the und- standing of the molecular features of the tumors and the identi?cation of tumor markers of response.
Book Synopsis Pharmacogenetics and Individualized Therapy by : Anke-Hilse Maitland-van der Zee
Download or read book Pharmacogenetics and Individualized Therapy written by Anke-Hilse Maitland-van der Zee and published by John Wiley & Sons. This book was released on 2012-04-02 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: This resource provides thorough coverage of pharmacogenetics and its impact on pharmaceuticals, therapeutics, and clinical practice. It opens with the basics of pharmacogenetics, including drug disposition and pharmacodynamics. The following section moves into specific disease areas, including cardiovascular, psychiatry, cancer, asthma/COPD, adverse drug reactions, transplantation, inflammatory bowel disease, and pain medication. Clinical practice and ethical issues make up the third section, with the fourth devoted to technologies like genotyping, genomics, and proteomics. In the fifth part, chapters discuss the impact of key regulatory issues on the pharmaceutical industry.
Book Synopsis Pharmacogenomics by : Mark A. Rothstein
Download or read book Pharmacogenomics written by Mark A. Rothstein and published by John Wiley & Sons. This book was released on 2003-04-09 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Through analyses of the complex underlying issues, this interdisciplinary volume frames the agenda for dealing with genetic variation and incorporating pharmacogenomics into health care. The three sections of this book, Research Issues, Clinical Issues, and Social Perspectives address key elements integral to a comprehensive discussion of this emerging field. This groundbreaking text... Examines new research strategies, methodologies, and ethical and social considerations of pharmacogenomics Addresses practical considerations of anticipated changes in education, training, oversight, guidelines and protocols, and continuing education requirements Provides analyses of the potential enormous impact of pharmacogenomics, such as in the standard of care and treatment, including perspectives from the fields of anthropology, law, ethics, and economics
Book Synopsis Role of Sulfation Pharmacogenetics in Breast Cancer Treatment with 2-Methoxyestradiol by : Araba A. Adjei
Download or read book Role of Sulfation Pharmacogenetics in Breast Cancer Treatment with 2-Methoxyestradiol written by Araba A. Adjei and published by . This book was released on 2001 with total page 15 pages. Available in PDF, EPUB and Kindle. Book excerpt: 2-ME2 is an endogenous estrogen metabolite that inhibits the proliferation of breast and other human cancer cell lines. 2-ME2 also has potent anti-angiogenic and anti-tubulin properties, and it may inhibit estrogen- induced carcinogenesis in the mammary gland. We set out to test the hypothesis that 2-ME2 might be a substrate for sulfate conjugation and, therefore, that individual variations in the sulfation of 2-ME2 might contribute to individual differences in its metabolism, pharmacokinetics and therapeutic efficacy. As a first step, we tested 2-ME2 as a substrate for 7 human sulfotransferase (SULT) isoforms -- as well as all of the common allozymes for SULT 1 Al and 1A2.
Book Synopsis Pharmacogenetics and Pharmacogenomics in Latin America: Ethnic Variability, New Insights in Advances and Perspectives: A RELIVAF-CYTED Initiative by : Luis Abel Quiñones
Download or read book Pharmacogenetics and Pharmacogenomics in Latin America: Ethnic Variability, New Insights in Advances and Perspectives: A RELIVAF-CYTED Initiative written by Luis Abel Quiñones and published by Frontiers Media SA. This book was released on 2022-02-17 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Medicine by : Sinem Nalbantoglu
Download or read book Molecular Medicine written by Sinem Nalbantoglu and published by BoD – Books on Demand. This book was released on 2019-11-06 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular medicine is an applied science focused on human genes/transcripts, proteins, metabolites, and metabolic networks that describes molecular and cellular processes of health and disease onset and progression. Molecular medicine-based integrative identification and characterization of biomarker targets and their clinical translations is essential to explain/decipher the mechanism(s) underlying physiological pathways and pathological conditions, and acquire cell-targeted early interventional and therapeutic strategies in the context of precision medicine and public health. Principally, Molecular Medicine provides an overview of the latest headlines/developments of systems and molecular medicine, highlighting the emerging high-throughput technologies, promising potential applications, and progress in biomedical research and development strategies.
Book Synopsis Molecular Targeted Therapy in Oncology: Lessons from Pharmacogenetics and Pharmacoepigenetics by : Saber Imani
Download or read book Molecular Targeted Therapy in Oncology: Lessons from Pharmacogenetics and Pharmacoepigenetics written by Saber Imani and published by Frontiers Media SA. This book was released on 2022-04-06 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacogenomics by : Federico Innocenti
Download or read book Pharmacogenomics written by Federico Innocenti and published by Humana Press. This book was released on 2013-07-04 with total page 359 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding an individual's genetic makeup is the key to creating personalized drugs with greater efficacy and safety, and pharmacogenomics aims to study the complex genetic basis of inter-patient variability in response to drug therapy. Based upon the success of its first edition, the second edition of Pharmacogenomics: Methods And Protocols aims to continue providing readers with high-quality content on the most innovative and commonly adopted technologies in the field of pharmacogenomics as presented by experts in the field. Broken into several sections, this detailed volume examines techniques for interrogating variation in human genes and genomes, functional assessment of genetic variation, both in vitro and in vivo, as well as tools for translation and implementation of pharmacogenetic markers. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to the respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Comprehensive and thoroughly updated, Pharmacogenomics: Methods And Protocols, Second Edition serves as an essential reference and an invaluable source on the latest information in this field.
Book Synopsis Applying Pharmacogenomics in Therapeutics by : Xiaodong Feng
Download or read book Applying Pharmacogenomics in Therapeutics written by Xiaodong Feng and published by CRC Press. This book was released on 2016-01-06 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent advances in high-throughput gene sequencing and other omics biotechnologies have served as a springboard for the field of pharmacogenomics. Pharmacogenomics is now generally accepted as the major determinant of variable drug safety, efficacy, and cost-effectiveness. Therefore, widespread use of pharmacogenomics for patient care has become a
Book Synopsis Immunopharmacogenomics by : Yusuke Nakamura
Download or read book Immunopharmacogenomics written by Yusuke Nakamura and published by Springer. This book was released on 2015-09-18 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book proposes immunogenomics, or immunopharmacogenomics, as the next-generation big science to uncover the role that the immune system plays in the pathogenesis of many diseases, by summarizing the importance of the deep sequencing of T-cell and B-cell receptors. Immunogenomics/immunopharmacogenomics, a genetic characterization of the immune system made possible by next-generation sequencing (NGS), will be important for the further understanding of the pathogenesis of various disease conditions. Abnormal immune responses in the body lead to development of autoimmune diseases and food allergies. Rejection of recipient cells and tissues, as well as severe immune reactions to donor cells, is also the result of uncontrolled immune responses in the recipient body. There have been many reports indicating that activated immune responses caused by the interaction of drugs and HLA are present in drug-induced skin hypersensitivity and liver toxicity. The importance of the host immune responses has been recognized in cancer treatments, not only for immunotherapy but also for cytotoxic agents and molecular targeted drugs. Hence, characterization of the T-cell receptor and B-cell receptor repertoire by means of NGS deep sequencing will ultimately make possible the identification of the molecular mechanisms that underlie various diseases and drug responses. In addition, this approach may contribute to the identification of antigens associated with the onset or progression of autoimmune diseases as well as food allergies. Although the germline alterations and somatic mutations have been extensively analyzed, changes or alterations of the immune responses during the course of various disease conditions or during various treatments have not been analyzed. It is also clear that computational analyses to draw meaningful inferences of functional recognition receptors on the immune cells remain a huge challenge.
Book Synopsis Tamoxifen Metabolism and Pharmacogenetics in Breast Cancer by :
Download or read book Tamoxifen Metabolism and Pharmacogenetics in Breast Cancer written by and published by . This book was released on 2013 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pharmacogenomics and Personalized Medicine by : Erika Cecchin
Download or read book Pharmacogenomics and Personalized Medicine written by Erika Cecchin and published by MDPI. This book was released on 2021-01-20 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pharmacogenomics is one of the emerging approaches to precision medicine, tailoring drug selection and dosing to the patient’s genetic features. In recent years, several pharmacogenetic guidelines have been published by international scientific consortia, but the uptake in clinical practice is still poor. Many coordinated international efforts are ongoing in order to overcome the existing barriers to pharmacogenomic implementation. On the other hand, existing validated pharmacogenomic markers can explain only a minor part of the observed clinical variability in the therapeutic outcome. New investigational approaches are warranted, including a study of the pharmacogenomic role of the immune system genetics and of previously neglected rare genetic variants, reported to account for a large part of inter-individual variability in drug metabolism. In this book, we have collected a series of articles covering many aspects of pharmacogenomics. These include clinical implementation of pharmacogenomics in clinical practice, development of tools or infrastructures to support this process, research of new pharmacogenomics markers to increase drug efficacy and safety, and the impact of rare genetic variants in pharmacogenomics.
Book Synopsis 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine by : Nosheen Masood
Download or read book 'Essentials of Cancer Genomic, Computational Approaches and Precision Medicine written by Nosheen Masood and published by Springer Nature. This book was released on 2020-03-20 with total page 499 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.
