The NeuroCOVID-19 Syndrome: Cognitive and Psychological Profiles, Physiopathology, and Impact on Neurologically Vulnerable Populations

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Publisher : Frontiers Media SA
ISBN 13 : 2832552447
Total Pages : 103 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis The NeuroCOVID-19 Syndrome: Cognitive and Psychological Profiles, Physiopathology, and Impact on Neurologically Vulnerable Populations by : Ludivine Chamard-Witkowski

Download or read book The NeuroCOVID-19 Syndrome: Cognitive and Psychological Profiles, Physiopathology, and Impact on Neurologically Vulnerable Populations written by Ludivine Chamard-Witkowski and published by Frontiers Media SA. This book was released on 2024-08-16 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Coronavirus Disease 2019 (COVID-19) global pandemic, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has led to the identification of a broad range of post-acute Covid neurological symptoms including cognitive impairments, specific executive dysfunctions with sensorimotor deficits (paresthesia, numbness, or weakness of specific body parts), changes in sleep, changes in taste or smell, hallucinations, emotional distress (anxiety, depression), and fatigue/asthenia. Alarmingly, those post-acute sequelae of COVID-19 (PASC) can occur several weeks after infection, arise after severe, mild, or even asymptomatic SARS-CoV2 infection, and are characterized by the persistence, worsening, or new onset of chronic and debilitating neurological symptoms, which have led to the use of NeuroCOVID syndrome terminology. A link between COVID-19-related neurological symptoms and other neurological diseases has not been clearly established, but an increasing number of studies report an increase in mortality post-SARS-CoV-2 infection and an atypical clinical presentation of COVID-19 in patients with dementia. Another intriguing discovery is that survivors that did not suffer from neurodegenerative diseases before the COVID-19 infection seem to be at high risk for subsequent development of neurological disease and in particular Alzheimer’s disease, and to develop early-dementia symptoms. However, the pathophysiology of those associations is not yet delineated, and more research is needed on NeuroCOVID in both the general population and in specific subgroups affected by neurological disorders. As the COVID-19 pandemic could cause a significant rise in the number of dementia patients in the long term, there is an urgent need to understand how PASC is associated with neurodegenerative disorders or with a worsening of neurologic symptoms in neurologically vulnerable populations.

Neuroimmune Pharmacology

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Publisher : Springer
ISBN 13 : 3319440225
Total Pages : 1045 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Neuroimmune Pharmacology by : Tsuneya Ikezu

Download or read book Neuroimmune Pharmacology written by Tsuneya Ikezu and published by Springer. This book was released on 2016-12-22 with total page 1045 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Neuroimmune Pharmacology bridges the disciplines of neuroscience, immunology and pharmacology from the molecular to clinical levels with particular thought made to engage new research directives and clinical modalities. Bringing together the foremost field authorities from around the world, Neuroimmune Pharmacology will serve as an invaluable resource for the basic and applied scientists of the current decade and beyond.

Understanding Coronavirus

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Publisher : Cambridge University Press
ISBN 13 : 1009086650
Total Pages : 167 pages
Book Rating : 4.0/5 (9 download)

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Book Synopsis Understanding Coronavirus by : Raul Rabadan

Download or read book Understanding Coronavirus written by Raul Rabadan and published by Cambridge University Press. This book was released on 2021-10-14 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the identification of the first cases of the coronavirus in December 2019, there has been a significant amount of confusion regarding the origin and spread of the so-called 'coronavirus', SARS-CoV-2, and the cause of the disease COVID-19. Conflicting messages from the media and officials across different countries and organizations, the abundance of disparate sources of information, unfounded conspiracy theories on the origins of the virus, unproven therapies, and inconsistent public health measures, have all served to increase anxiety in the population. Where did the virus come from? How is it transmitted? How does it cause disease? Is it like flu? What is a pandemic? In this concise and accessible introduction, a leading expert provides answers to these commonly asked questions. This revised and updated edition now also covers how the virus mutates, how important these mutations are, how vaccines work, and what we can expect in the near and long-term future.

Coronavirus Disease - COVID-19

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Author :
Publisher : Springer Nature
ISBN 13 : 3030637611
Total Pages : 964 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Coronavirus Disease - COVID-19 by : Nima Rezaei

Download or read book Coronavirus Disease - COVID-19 written by Nima Rezaei and published by Springer Nature. This book was released on 2021-05-10 with total page 964 pages. Available in PDF, EPUB and Kindle. Book excerpt: In December 2019, the world witnessed the occurrence of a new coronavirus to humanity. The disease spread quickly and became known as a pandemic globally, affecting both society and the health care system, both the elderly and young groups of people, and both the men’s and women’s groups. It was a universal challenge that immediately caused a surge in scientific research. Be a part of a world rising in fighting against the pandemic, the Coronavirus Disease - COVID-19 was depicted in the early days of the pandemic, but updated by more than 200 scientists and clinicians to include many facets of this new infectious pandemic, including i, characteristics, ecology, and evolution of coronaviruses; ii, epidemiology, genetics, and pathogenesis (immune responses and oxidative stress) of the disease; iii, diagnosis, prognosis, and clinical manifestations of the disease in pediatrics, geriatrics, pregnant women, and neonates; iv, challenges of co-occurring the disease with tropical infections, cardiovascular diseases, hypertension, and cancer and to the settings of dentistry, hematology, ophthalmology, and pharmacy; v, transmission, prevention, and potential treatments, ranging from supportive ventilator support and nutrition therapy to potential virus- and host-based therapies, immune-based therapies, photobiomodulation, antiviral photodynamic therapy, and vaccines; vi, the resulting consequences on social lives, mental health, education, tourism industry and economy; and vii, multimodal approaches to solve the problem by bioinformatic methods, innovation and ingenuity, globalization, social and scientific networking, interdisciplinary approaches, and art integration. We are approaching December 2020 and the still presence of COVID-19, asking us to call it COVID (without 19).

Obsessive-Compulsive and Related Disorders

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Publisher : OUP Oxford
ISBN 13 : 019101687X
Total Pages : 167 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Obsessive-Compulsive and Related Disorders by : Samar Reghunandanan

Download or read book Obsessive-Compulsive and Related Disorders written by Samar Reghunandanan and published by OUP Oxford. This book was released on 2015-06-25 with total page 167 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing clinicians and patients with the latest developments in research, this new edition is a succinct and practical introduction to the diagnosis, evaluation and management of OCD and other related disorders. Part of the Oxford Psychiatry Library series, this pocketbook includes individual chapters on the phenomenology, pathogenesis, pharmacotherapy and psychotherapy of OCD and other related disorders, and features fully updated content and research. The book also includes a helpful resources chapter, and an Appendix with summaries of the major rating scales used to assess patients with OCD, which will be of use to both clinicians and patients. Obsessive-compulsive disorder (OCD) and Obsessive-compulsive-related disorders (OCRDs) are anxiety disorders characterized by obsessions and compulsions, and varying degrees of anxiety and depression. OCRDs are considered to be one of the most disabling of psychiatric disorders and they present a tremendous economic and social burden, both for the affected individual, their family, and for society at large. In contrast to other psychiatric conditions of a comparable or lesser prevalence and patient burden, relatively little is understood about the aetiology, and cognitive effects of OCRDs.

The Protective Arm of the Renin Angiotensin System (RAS)

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Author :
Publisher : Academic Press
ISBN 13 : 0128014857
Total Pages : 312 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis The Protective Arm of the Renin Angiotensin System (RAS) by : Thomas Unger

Download or read book The Protective Arm of the Renin Angiotensin System (RAS) written by Thomas Unger and published by Academic Press. This book was released on 2015-04-18 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Protective Arm of the Renin Angiotensin System: Functional Aspects and Therapeutic Implications is the first comprehensive publication to signal the protective role of a distinct part of the renin–angiotensin system (RAS), providing readers with early insight into a complex system which will become of major medical importance in the near future. Focusing on recent research, The Protective Arm of the Renin Angiotensin System presents a host of new experimental studies on specific components of the RAS, namely angiotensin AT2 receptors (AT2R), the angiotensin (1–7) peptide with its receptor Mas, and the enzyme ACE 2, which exert significant beneficial, health-promoting actions by counterbalancing the well-known harmful arm of the RAS with its classical angiotensin AT1 receptor. This innovative concept of the protective arm of the RAS, examined in this reference, represents an indispensable background and will be a strong support for biomedical students, researchers, cardiologists, surgeons, nephrologists, diabetologists, and endocrinologists, as well as any other physician or researcher concerned with RAS physiology, pathophysiology and clinical implications. - Provides a complete understanding of the protective side of the Renin Angiotensin System (RAS) involving angiotensin AT2 receptor, ACE2, and Ang(1-7)/Mas receptor - Combines the knowledge of editors who pioneered research on the protective renin angiotensin system including; Dr. Thomas Unger, one of the founders of AT2 receptor research; Dr. Ulrike M. Steckelings, who contributed significantly to first preclinical studies with a novel specific AT2-agonist, and Dr. Robson Santos who pioneered research on angiotensin-(1-7) and its receptor Mas. - Shows that the protective RAS axes are able to ameliorate the course of several cardiovascular, renal, metabolic and neurological diseases - Provides the basis for the understanding of a novel therapeutic approach to stimulate components of the protective arm of the RAS.

 Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease

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Publisher : Frontiers Media SA
ISBN 13 : 2889633977
Total Pages : 263 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis  Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease by : Mohamed Boutjdir

Download or read book  Cardioimmunology: Inflammation and Immunity in Cardiovascular Disease written by Mohamed Boutjdir and published by Frontiers Media SA. This book was released on 2020-01-30 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt:

WAIS-IV, WMS-IV, and ACS

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Publisher : Academic Press
ISBN 13 : 0123869536
Total Pages : 623 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis WAIS-IV, WMS-IV, and ACS by : James A. Holdnack

Download or read book WAIS-IV, WMS-IV, and ACS written by James A. Holdnack and published by Academic Press. This book was released on 2013-06-20 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides users of the Wechsler Adult Intelligence Scale (WAIS-IV) with information on applying the WAIS-IV, including additional indexes and information regarding use in special populations for advanced clinical use and interpretation. The book offers sophisticated users of the WAIS-IV and Wechsler Memory Scale (WMS-IV) guidelines on how to enhance the clinical applicability of these tests. The first section of the book provides an overview of the WAIS-IV, WMS-IV, and new Advanced Clinical Solutions for Use with the WAIS-IV/WMS-IV (ACS). In this section, examiners will learn: - Normal versus atypical score variability - Low-score prevalence in healthy adults versus clinical populations - Assessing whether poor performance reflects a decline in function or is the result of suboptimal effort New social cognition measures found in the ACS are also presented. The second part focuses on applying the topics in the first section to specific clinical conditions, including recommended protocols for specific clientele (e.g. using demographically adjusted norms when evaluating individuals with brain injury). Common clinical conditions are discussed, including Alzheimer's disease, mild cognitive impairment, traumatic brain injury, and more. Each chapter provides case examples applying all three test batteries and using report examples as they are obtained from the scoring assistant. Finally, the use of the WAIS-IV/WMS-IV and the ACS in forensic settings is presented. - Coverage of administration and scoring of WAIS-IV, WMS-IV and ACS - Information contained on the use of WAIS-IV with special populations - Case studies in each chapter - Written by the creators of WAIS-IV, WMS-IV and ACS

The Madness of Fear

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Publisher : Oxford University Press
ISBN 13 : 0190881208
Total Pages : 225 pages
Book Rating : 4.1/5 (98 download)

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Book Synopsis The Madness of Fear by : Edward Shorter

Download or read book The Madness of Fear written by Edward Shorter and published by Oxford University Press. This book was released on 2018-06-27 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the real disease entities in psychiatry? This is a question that has bedeviled the study of the mind for more than a century yet it is low on the research agenda of psychiatry. Basic science issues such as neuroimaging, neurochemistry, and genetics carry the day instead. There is nothing wrong with basic science research, but before studying the role of brain circuits or cerebral chemistry, shouldn't we be able to specify how the various diseases present clinically? Catatonia is a human behavioral syndrome that for almost a century was buried in the poorly designated psychiatric concept of schizophrenia. Its symptoms are well-know, and some of them are serious. Catatonic patients may die as their temperatures accelerate; they become dehydrated because they refuse to drink; they risk inanition because they refuse to eat or move. Autistic children with catatonia may hit themselves repeatedly in the head. We don't really know what catatonia is, in the sense that we know what pneumonia is. But we can identify it, and it is eminently treatable. Clinicians can make these patients better on a reliable basis. There are few other disease entities in psychiatry of which this is true. So why has there been so little psychiatric interest in catatonia? Why is it simply not on the radar of most clinicians? Catatonia actually occurs in a number of other medical illnesses as well, but it is certainly not on the radar of most internists or emergency physicians. In The Madness of Fear, Drs. Shorter and Fink seek to understand why this "vast field of ignorance" exists. In the history of catatonia, they see a remarkable story about how medicine flounders, and then seems to find its way. And it may help doctors, and the public, to recognize catatonia as one of the core illnesses in psychiatry.

Autoimmune Neurology

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Publisher : Elsevier
ISBN 13 : 0444634460
Total Pages : 569 pages
Book Rating : 4.4/5 (446 download)

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Book Synopsis Autoimmune Neurology by :

Download or read book Autoimmune Neurology written by and published by Elsevier. This book was released on 2016-03-11 with total page 569 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autoimmune Neurology presents the latest information on autoimmune neurologic disease, the immune response to the body where organs run wild, causing the immune system to attack itself. Autoimmunity is a main element in numerous nervous system diseases and can target any structure within the central or peripheral nervous system. Over the past 20 years, significant advances in our understanding of the pathophysiology of autoimmune disorders, including the use of biomarkers has led to new diagnosis and treatment options. Neurologic conditions associated with autoimmune reactions include dementia, neuromuscular disease, epilepsy, sleep disorders, diabetes, and other common neurologic disorders and disease. This current tutorial-reference will be a must-have title for clinical neurologists, research neurologists, neuroscientists, and any medical professional working with autoimmune disease and disorders. - Includes comprehensive coverage of autoimmune neurology - Details the latest techniques for the study, diagnosis, and treatment of diseases and disorders, including dementia, neuromuscular disease, epilepsy, and sleep disorders - Presents a focused reference for clinical practitioners and the clinical neurology and neurology research communities

Neurotrauma and Critical Care of the Brain

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Publisher : Thieme
ISBN 13 : 1626233403
Total Pages : 1124 pages
Book Rating : 4.6/5 (262 download)

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Book Synopsis Neurotrauma and Critical Care of the Brain by : Jack Jallo

Download or read book Neurotrauma and Critical Care of the Brain written by Jack Jallo and published by Thieme. This book was released on 2018-04-04 with total page 1124 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book really is a complete primer on the head injured patient. Without a map such as the one this book metaphorically provides, the voyage to mastery can be hazardous for both practitioner and patient."— Journal of the American Medical Association Neurotrauma and Critical Care of the Brain, 2nd edition by renowned neurosurgeons Jack Jallo and Christopher Loftus incorporates salient components of the highly praised first edition. The updated text reflects cutting-edge discussion on traumatic brain injury management in a neurocritical care setting. Contributions from top experts in neurosurgery, neurology, critical care, cardiac and pulmonary care, and trauma surgery provide a concise review of a complex and evolving field. The book lays a solid foundation with discussion of TBI classification, pathophysiology, key blood biomarkers, noninvasive neuromonitoring in severe TBI patients, multimodality monitoring in neurocritical care, and brain imaging modalities. From the prehospital setting to intensive care, top experts share clinical pearls and core guidelines on the management of mild, moderate, and severe TBI and complications. Chapters new to this edition include concomitant injuries, orbital/facial fractures, vascular injuries, spine fractures, autonomic dysfunction, and temperature management. Key Highlights Specialized topics include wartime penetrating injuries, cardiovascular complications of TBI, venous thromboembolism prophylaxis, ethical considerations, TBI costs in the U.S. and the financial return on helmets Management of pediatric brain injuries in the NICU with illustrative cases Nearly 200 high quality illustrations facilitate understanding of complex anatomy and techniques Summary tables provide a handy overview of injury type, causes, characteristics, and recommended imaging modalities This remarkable resource is essential reading for neurosurgeons, neurologists, trauma physicians, critical care and rehabilitation medicine specialists, and residents in these specialties. Paired with Neurotrauma and Critical Care of the Spine, 2nd edition, this dynamic duo is the most up-to-date neurocritical care reference available today.

Basic Emergency Care: Approach to the Acutely Ill and Injured

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Author :
Publisher : World Health Organization
ISBN 13 : 924151308X
Total Pages : 240 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Basic Emergency Care: Approach to the Acutely Ill and Injured by : World Health Organization

Download or read book Basic Emergency Care: Approach to the Acutely Ill and Injured written by World Health Organization and published by World Health Organization. This book was released on 2018-12-17 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developed by WHO and the International Committee of the Red Cross, in collaboration with the International Federation for Emergency Medicine, "Basic Emergency Care (BEC): Approach to the acutely ill and injured" is an open-access training course for frontline healthcare providers who manage acute illness and injury with limited resources.BEC teaches a systematic approach to the initial assessment and management of time-sensitive conditions where early intervention saves lives. It includes modules on: the ABCDE and SAMPLE history approach, trauma, difficulty in breathing, shock, and altered mental status. The practical skills section covers the essential time-sensitive interventions for these key acute presentations.The BEC package includes a Participant Workbook and electronic slide decks for each module. BEC integrates the guidance from WHO Emergency Triage, Assessment and Treatment (ETAT) for children, WHO Pocket Book of Hospital Care for Children, WHO Integrated Management of Pregnancy and Childbirth and the Integrated Management of Adult/Adolescent Illness (IMAI).

Infections of the Nervous System

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Author :
Publisher : Butterworth-Heinemann
ISBN 13 :
Total Pages : 304 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Infections of the Nervous System by : Peter G. E. Kennedy

Download or read book Infections of the Nervous System written by Peter G. E. Kennedy and published by Butterworth-Heinemann. This book was released on 1987 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infections of the Nervous System aims to continue the legacy of its predecessor, Modern Trends in Neurology. Its goal is to produce annually a monograph on a topic in clinical neurology in which progress through research has brought about new concepts of patient management. This book is organized into 13 chapters. It highlights the areas or subjects in which significant advances have been made which also have relevance to the treatment of patients. It covers a number of important aspects of different infectious diseases of the nervous system including acute bacterial meningitis, tuberculosis o ...

Technical Specifications for Oxygen Concentrators

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Author :
Publisher : World Health Organization
ISBN 13 : 9241509880
Total Pages : 68 pages
Book Rating : 4.2/5 (415 download)

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Book Synopsis Technical Specifications for Oxygen Concentrators by : World Health Organization

Download or read book Technical Specifications for Oxygen Concentrators written by World Health Organization and published by World Health Organization. This book was released on 2016-10-25 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this guidance document is for the appropriate selection procurement utilization and maintenance of oxygen concentrators. This document also focuses on recommendations for the appropriate use and maintenance of oxygen concentrators in an effort to increase the availability management and quality of oxygen concentrators and ultimately to improve health outcomes in LRS. This document is intended to serve as a resource for the planning and provision of local and national oxygen concentrator systems for use by administrators clinicians and technicians who are interested in improving access to oxygen therapy and reducing global mortality associated with hypoxaemia.

Introduction to Toxicological Screening Methods and Good Laboratory Practice

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Author :
Publisher : Springer Nature
ISBN 13 : 9811660921
Total Pages : 205 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Introduction to Toxicological Screening Methods and Good Laboratory Practice by : Saravana Babu Chidambaram

Download or read book Introduction to Toxicological Screening Methods and Good Laboratory Practice written by Saravana Babu Chidambaram and published by Springer Nature. This book was released on 2022-02-11 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.

Biological Aspects of Suicidal Behavior

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Publisher : Karger Medical and Scientific Publishers
ISBN 13 : 3318055832
Total Pages : 182 pages
Book Rating : 4.3/5 (18 download)

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Book Synopsis Biological Aspects of Suicidal Behavior by : W. P. Kaschka

Download or read book Biological Aspects of Suicidal Behavior written by W. P. Kaschka and published by Karger Medical and Scientific Publishers. This book was released on 2016 with total page 182 pages. Available in PDF, EPUB and Kindle. Book excerpt: Suicide is one of the most important causes of death in modern societies. To develop more effective preventive measures, we have to be aware of and learn more about its neurobiological foundations. In recent years, the tools of modern neurosciences have increasingly been utilized to characterize the pathophysiology of complex human behaviors such as suicide. To improve suicide risk assessment and suicide prevention, a better understanding of its pathophysiology is crucial. This includes research from a variety of disciplines such as neuropsychological, psychosocial and cultural studies but also findings from biochemistry, neuropathology, electrophysiology, immunology, neuroimaging, genetics, and epigenetics. Important results have, for example, been obtained in the field of gene-environment interaction and suicidal behavior. We have just begun to understand how early-life adversity may increase suicide risk by epigenetic mechanisms. Based on such insights, novel therapeutic interventions and preventive measures can be developed. Furthermore, a better understanding of the pathophysiological mechanisms involved in suicidal behavior could reveal the mechanism of compounds like lithium salts. In this book, suicidal behavior and its prevention is discussed by international experts in the light of the most recent results from a broad spectrum of neurosciences.

Atypical Parkinsonian Disorders

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Publisher : Springer Science & Business Media
ISBN 13 : 159259834X
Total Pages : 515 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Atypical Parkinsonian Disorders by : Irene Litvan

Download or read book Atypical Parkinsonian Disorders written by Irene Litvan and published by Springer Science & Business Media. This book was released on 2007-10-27 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of what is known not only about the cause and treatment of atypical parksonian disorders, but also the issues that clinicians, researchers, patients, and caregivers face in dealing with them. The authors cover the basic science (history, epidemiology, genetics, pathology, nosology, computer modeling, and animal models), detailed clinical and laboratory assessments, and available diagnostic tools, including neuropsychiatric, neurologic, neuropsychologic, speech, electrophysiologic, and imaging evaluations. Current and future therapeutic approaches are also detailed, along with extensive discussions about future research directions.