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Author : Victor Almon McKusick
Publisher :
ISBN 13 :
Total Pages : 238 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Morbid Anatomy of the Human Genome written by Victor Almon McKusick and published by . This book was released on 1988 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Oversight and Investigations
Publisher :
ISBN 13 :
Total Pages : 142 pages
Book Rating : 4.3/5 (91 download)
Download or read book OTA Report on the Human Genome Project written by United States. Congress. House. Committee on Energy and Commerce. Subcommittee on Oversight and Investigations and published by . This book was released on 1988 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John C. Avise
Publisher : Oxford University Press
ISBN 13 : 0199741689
Total Pages : 237 pages
Book Rating : 4.1/5 (997 download)
Download or read book Inside the Human Genome written by John C. Avise and published by Oxford University Press. This book was released on 2010-02-12 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Humanity's physical design flaws have long been apparent--we get hemorrhoids and impacted wisdom teeth, for instance--but do the imperfections extend down to the level of our genes? Inside the Human Genome is the first book to examine the philosophical question of why, from the perspectives of biochemistry and molecular genetics, flaws exist in the biological world. Distinguished evolutionary geneticist John Avise offers a panoramic yet penetrating exploration of the many gross deficiencies in human DNA--ranging from mutational defects to built-in design faults--while at the same time offering a comprehensive treatment of recent findings about the human genome. The author shows that the overwhelming scientific evidence for genomic imperfection provides a compelling counterargument to intelligent design. He also develops a case that theologians should welcome rather than disavow these discoveries. The evolutionary sciences can help mainstream religions escape the shackles of Intelligent Design, and thereby return religion to its rightful realm--not as the secular interpreter of the biological minutiae of our physical existence, but rather as a respectable philosophical counselor on grander matters of ultimate concern.
Author : Peter S. Harper
Publisher : Oxford University Press
ISBN 13 : 0199720134
Total Pages : 570 pages
Book Rating : 4.1/5 (997 download)
Download or read book A Short History of Medical Genetics written by Peter S. Harper and published by Oxford University Press. This book was released on 2008-10-24 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: An eminent geneticist, veteran author, OMMG Series Editor, and noted archivist, Peter Harper presents a lively account of how our ideas and knowledge about human genetics have developed over the past century from the perspective of someone inside the field with a deep interest in its historical aspects. Dr. Harper has researched the history of genetics and has had personal contact with a host of key figures whose memories and experiences extend back 50 years, and he has interviewed and recorded conversations with many of these important geneticists. Thus, rather than being a conventional history, this book transmits the essence of the ideas and the people involved and how they interacted in advancing- and sometimes retarding- the field. From the origins of human genetics; through the contributions of Darwin, Mendel, and other giants; the identification of the first human chromosome abnormalities; and up through the completion of the Human Genome project, this Short History is written in the author's characteristic clear and personal style, which appeals to geneticists and to all those interested in the story of human genetics.
Author : John Barranger
Publisher : Elsevier
ISBN 13 : 0323147283
Total Pages : 523 pages
Book Rating : 4.3/5 (231 download)
Download or read book Molecular Basis of Lysosomal Storage Disorders written by John Barranger and published by Elsevier. This book was released on 2012-12-02 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Basis of Lysosomal Storage Disorders contains the proceedings of the 1983 Conference on the Molecular Basis of Lysosomal Storage Disorders, held at the National Institutes of Health in Bethesda, Maryland. The papers focus on the molecular biology of, and therapeutic approaches to, lysosomal storage disorders, such as mucopolysaccharidoses, sphingolipidoses, and Gaucher disease. Organized into six sections comprised of 29 chapters, this book begins with an overview of enzymes, activator proteins, and stabilizers that underlie lysosomal storage disorders. It then discusses some developments in enzyme purification, receptors for glycoprotein enzymes, factors that control endocytosis, and the intracellular fate of lysosomal hydrolases. Some chapters explain the enzyme biosynthesis, bone marrow transplantation, and enzyme replacement, along with cell hybridization, chromosome localization, phenotype discrimination, and cloning of genes for human lysosomal enzymes. This book is helpful to biochemists, physiologists, pathologists, geneticists, clinical investigators, and practicing physicians concerned with the study, care, and treatment of patients with hereditary metabolic disorders, as well as undergraduate and graduate level students involved in research in this discipline.
Author : Robert M. Cook-Deegan
Publisher : W. W. Norton & Company
ISBN 13 : 9780393313994
Total Pages : 420 pages
Book Rating : 4.3/5 (139 download)
Download or read book The Gene Wars written by Robert M. Cook-Deegan and published by W. W. Norton & Company. This book was released on 1994 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cook-Deegan, a former director of the Biomedical Ethics Advisory Committee of the US Congress and an advisor to the National Center for Human Genome Research, gives a firsthand account of the struggle to launch the Human Genome Project. Using primary documents and interviews, Cook-Deegan explains scientific details, chronicles the origins of the project, covers the conflicts and partnerships between the organizations involved, and examines ethical, legal, and social issues of DNA research. Includes bandw photos. Annotation copyright by Book News, Inc., Portland, OR
Author : Andrew J. Hogan
Publisher : JHU Press
ISBN 13 : 1421420740
Total Pages : 279 pages
Book Rating : 4.4/5 (214 download)
Download or read book Life Histories of Genetic Disease written by Andrew J. Hogan and published by JHU Press. This book was released on 2016-11 with total page 279 pages. Available in PDF, EPUB and Kindle. Book excerpt: A history of genetic testing warns that such tests may tell us more than we want to know. Medical geneticists began mapping the chromosomal infrastructure piece by piece in the 1970s by focusing on what was known about individual genetic disorders. Five decades later, their infrastructure had become an edifice for prevention, allowing today’s expecting parents to choose to test prenatally for hundreds of disease-specific mutations using powerful genetic testing platforms. In Life Histories of Genetic Disease, Andrew J. Hogan explores how various diseases were “made genetic” after 1960, with the long-term aim of treating and curing them using gene therapy. In the process, he explains, these disorders were located in the human genome and became targets for prenatal prevention, while the ongoing promise of gene therapy remained on the distant horizon. In narrating the history of research that contributed to diagnostic genetic medicine, Hogan describes the expanding scope of prenatal diagnosis and prevention. He draws on case studies of Prader-Willi, fragile X, DiGeorge, and velo-cardio-facial syndromes to illustrate that almost all testing in medical genetics is inseparable from the larger—and increasingly “big data”–oriented—aims of biomedical research. Hogan also reveals how contemporary genetic testing infrastructure reflects an intense collaboration among cytogeneticists, molecular biologists, and doctors specializing in human malformation. Hogan critiques the modern ideology of genetic prevention, which suggests that all pregnancies are at risk for genetic disease and should be subject to extensive genomic screening. He examines the dilemmas and ethics of the use of prenatal diagnostic information in an era when medical geneticists and biotechnology companies have begun offering whole genome prenatal screening—essentially searching for any disease-causing mutation. Hogan’s focus and analysis is animated by ongoing scientific and scholarly debates about the extent to which the preventive focus in contemporary medical genetics resembles the aims of earlier eugenicists. Written for historians, sociologists, and anthropologists of science and medicine, as well as bioethics scholars, physicians, geneticists, and families affected by genetic conditions, Life Histories of Genetic Disease is a profound exploration of the scientific culture surrounding malformation and mutation.
Author : Peter Harper
Publisher : CRC Press
ISBN 13 : 1444128590
Total Pages : 417 pages
Book Rating : 4.4/5 (441 download)
Download or read book Practical Genetic Counselling written by Peter Harper and published by CRC Press. This book was released on 2010-08-27 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: Easy to use, and useful when kept close at hand in the room where you work. The book is a pleasure to read: the style elegant and authoritative.' Lancet'...this book is a wonderful reference to enable primary physicians to be informed about their patients.' Annals of Internal MedicineUniversally used across the world by genetic counsellors, medical
Author : Georgina M. Montgomery
Publisher : John Wiley & Sons
ISBN 13 : 1119130700
Total Pages : 726 pages
Book Rating : 4.1/5 (191 download)
Download or read book A Companion to the History of American Science written by Georgina M. Montgomery and published by John Wiley & Sons. This book was released on 2019-09-23 with total page 726 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Companion to the History of American Science offers a collection of essays that give an authoritative overview of the most recent scholarship on the history of American science. Covers topics including astronomy, agriculture, chemistry, eugenics, Big Science, military technology, and more Features contributions by the most accomplished scholars in the field of science history Covers pivotal events in U.S. history that shaped the development of science and science policy such as WWII, the Cold War, and the Women’s Rights movement
Author : Milo Keynes
Publisher : CRC Press
ISBN 13 : 0203392159
Total Pages : 170 pages
Book Rating : 4.2/5 (33 download)
Download or read book A Century of Mendelism in Human Genetics written by Milo Keynes and published by CRC Press. This book was released on 2004-03-15 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1901 William Bateson, Professor of Biology at Cambridge, published a renewed version of a lecture which he had delivered the year before to the Royal Horticultural Society in London (reprinted in the book as an appendix). In this lecture he recognized the importance of the work completed by Gregor Mendel in 1865, and brought it to the notice of
Author : J. Wirz
Publisher : Springer Science & Business Media
ISBN 13 : 9401154945
Total Pages : 288 pages
Book Rating : 4.4/5 (11 download)
Download or read book The future of DNA written by J. Wirz and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid progress in biological and biomedical sciences in the last twenty years has brought with it an extensive development of the methods of molecular genetics. This has had impacts on society in many fields. Practical applications in medicine, pharmacology, agriculture, food design and biotechnology are firmly established and will grow enormously in the years to come. The scientific views of DNA and genes which underpin these applications are challenging our fundamental concepts of life, nature, society and humanity. It is beyond doubt that these developments need to be evaluated and reflected upon, both from a scientific and philosophical point of view, as well as from a cultural and social perspective. This book provides a wide range of discussions about the effects of DNA thinking in science and society, in biology and in relation to what it is to be human. Insights are provided into trans-disciplinary approaches and divergent views are compared. The reports on the plenary discussions and the many workshops show progress towards a power-free dialogue, i.e. an exchange of thoughts, free of economic and political pressure. The viewpoints of a variety of specialists, including scientists (microbiologists, molecular geneticists and clinical researchers), clinicians, philosophers and members of NGOs are presented. The contents will be of particular interest to those involved in genetic engineering, from students to policy makers, who face the challenge of the new technology in their work and who are looking for a substantial expansion and complementation of their basis for judgement forming.
Author : Muin J. Khoury
Publisher : Monographs in Epidemiology and
ISBN 13 : 0195052889
Total Pages : 394 pages
Book Rating : 4.1/5 (95 download)
Download or read book Fundamentals of Genetic Epidemiology written by Muin J. Khoury and published by Monographs in Epidemiology and. This book was released on 1993 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease aetiology. The authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations.
Author : Soraya de Chadarevian
Publisher : University of Chicago Press
ISBN 13 : 022668511X
Total Pages : 318 pages
Book Rating : 4.2/5 (266 download)
Download or read book Heredity under the Microscope written by Soraya de Chadarevian and published by University of Chicago Press. This book was released on 2020-07-02 with total page 318 pages. Available in PDF, EPUB and Kindle. Book excerpt: By focusing on chromosomes, Heredity under the Microscope offers a new history of postwar human genetics. Today chromosomes are understood as macromolecular assemblies and are analyzed with a variety of molecular techniques. Yet for much of the twentieth century, researchers studied chromosomes by looking through a microscope. Unlike any other technique, chromosome analysis offered a direct glimpse of the complete human genome, opening up seemingly endless possibilities for observation and intervention. Critics, however, countered that visual evidence was not enough and pointed to the need to understand the molecular mechanisms. Telling this history in full for the first time, Soraya de Chadarevian argues that the often bewildering variety of observations made under the microscope were central to the study of human genetics. Making space for microscope-based practices alongside molecular approaches, de Chadarevian analyzes the close connections between genetics and an array of scientific, medical, ethical, legal, and policy concerns in the atomic age. By exploring the visual evidence provided by chromosome research in the context of postwar biology and medicine, Heredity under the Microscope sheds new light on the cultural history of the human genome.
Author : Maxine Singer
Publisher : University Science Books
ISBN 13 : 9780935702705
Total Pages : 702 pages
Book Rating : 4.7/5 (27 download)
Download or read book Exploring Genetic Mechanisms written by Maxine Singer and published by University Science Books. This book was released on 1997-05-07 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: An outstanding group of scientists have collaborated in the collection of case studies that comprise this major text-reference book. It examines in detail how genes operate in diverse living systems, including viruses, cells and more complex organisms; investigates how genotypes can be altered; and looks at the mapping and sequencing of human and other genomes. Students and professionals in biochemistry, molecular biology and genetics will enjoy this book.
Author : David A. Price Evans
Publisher : Cambridge University Press
ISBN 13 : 9780521412964
Total Pages : 686 pages
Book Rating : 4.4/5 (129 download)
Download or read book Genetic Factors in Drug Therapy written by David A. Price Evans and published by Cambridge University Press. This book was released on 1993-12-16 with total page 686 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive work of reference to survey in depth the wide-ranging variability in the response of individuals to drugs.
Author : F. Farzaneh
Publisher : Garland Science
ISBN 13 : 1000140962
Total Pages : 314 pages
Book Rating : 4.0/5 (1 download)
Download or read book Functional Analysis of the Human Genome written by F. Farzaneh and published by Garland Science. This book was released on 2020-09-10 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: An excellent review of the relationship between structure and function in the human genome, and a detailed description of some of the important methodologies for unravelling the function of genes and genomic structures.
Author : N. S. Spurr
Publisher : John Wiley & Sons
ISBN 13 : 1444313479
Total Pages : 1038 pages
Book Rating : 4.4/5 (443 download)
Download or read book ICRF Handbook of Genome Analysis written by N. S. Spurr and published by John Wiley & Sons. This book was released on 2009-06-03 with total page 1038 pages. Available in PDF, EPUB and Kindle. Book excerpt: The combined power of genetic analysis and recombinant DNA technology to analyse entire genomes has moved biomedical research into a new and revolutionary phase. The complete sequencing and mapping of the human genome, as well as the genomes of other model organisms, will be the basis for our future understanding of human disease, and will allow us to answer fundamental questions about development and evolution. T The new ICRF Handbook of Genome Analysis is the essential guide to the enormous range of techniques available to the researcher for both the genetic and physical mapping of the genome, as well as the sequencing and analysis of DNA. It is both a protocol manual and a comprehensive information resource. Written by international experts, each chapter presents a state-of-the-art review of a methodology. Methods are fully described and evaluated; their advantages and disadvantages discussed; and their suitability for different investigations considered. Step-by-step protocols, including computer analyses, are given for 123 essential experimental procedures. 'Troubleshooting' sections discuss possible reasons for failure and offer remedies. The primary focus is on human genetics and the benefits of an understanding of the genome for the diagnosis and treatment of human disease. The book also considers the current state of progress in the analysis of genomes of many model organisms, including plants. A major part of the work provides detail on Internet resources as well as basic data on human and other genomes, including mapped disease genes and mouse knockouts. Covers not only the human genome in relation to cancers and other human diseases, but also the genomes of all important model organisms Contains 123 easy-to-follow protocols for essential experimental procedures Reviews a vast range of other information resources, including journals and the Internet * provides an invaluable listing of suppliers of laboratory materials Has been written by international experts from their own practical experience Is mandated by the Imperial Cancer Research Fund - a leader in research in this field Has a sturdy spiral binding within a hardback case for ease of use in the lab
