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Author : John D. Minna
Publisher :
ISBN 13 :
Total Pages : 10 pages
Book Rating : 4.:/5 (319 download)
Download or read book Molecular Genetics of Lung Cancer written by John D. Minna and published by . This book was released on 1988 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David N Cooper
Publisher : Springer Science & Business Media
ISBN 13 : 3540269541
Total Pages : 399 pages
Book Rating : 4.5/5 (42 download)
Download or read book The Molecular Genetics of Lung Cancer written by David N Cooper and published by Springer Science & Business Media. This book was released on 2005-11-20 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the leading cause of cancer mortality in Western countries. It also provides an archetypal example of how inherited predisposing genetic variants may interact with an environmental influence (smoking) to modulate individual cancer risk. The Molecular Genetics of Lung Cancer describes how the new techniques, methods and approaches of molecular genetics are being used to unravel the complexities of the mechanisms underlying lung tumorigenesis by analysis at the DNA, RNA and protein levels with potentially important implications for tumour classification, diagnosis, prognosis and treatment as well as providing new insights into how lung tumours arise and how they progress to malignancy.
Author : David Cooper
Publisher : Springer
ISBN 13 : 9783540803652
Total Pages : 392 pages
Book Rating : 4.8/5 (36 download)
Download or read book The Molecular Genetics of Lung Cancer written by David Cooper and published by Springer. This book was released on 2009-09-02 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is the leading cause of cancer mortality in Western countries. It also provides an archetypal example of how inherited predisposing genetic variants may interact with an environmental influence (smoking) to modulate individual cancer risk. The Molecular Genetics of Lung Cancer describes how the new techniques, methods and approaches of molecular genetics are being used to unravel the complexities of the mechanisms underlying lung tumorigenesis by analysis at the DNA, RNA and protein levels with potentially important implications for tumour classification, diagnosis, prognosis and treatment as well as providing new insights into how lung tumours arise and how they progress to malignancy.
Author : Shern D. Sirisuk
Publisher :
ISBN 13 :
Total Pages : 92 pages
Book Rating : 4.:/5 (385 download)
Download or read book Molecular Genetics of Lung Cancer written by Shern D. Sirisuk and published by . This book was released on 1997 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John D. Minna
Publisher :
ISBN 13 :
Total Pages : 3 pages
Book Rating : 4.:/5 (114 download)
Download or read book Molecular Genetics of Lung Cancer written by John D. Minna and published by . This book was released on 1988 with total page 3 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mehdi Pirooznia
Publisher : Frontiers Media SA
ISBN 13 : 2832542964
Total Pages : 233 pages
Book Rating : 4.8/5 (325 download)
Download or read book Recent Advances in the Molecular Genetics and Precision Medicine of Lung Carcinoma written by Mehdi Pirooznia and published by Frontiers Media SA. This book was released on 2024-01-25 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung Carcinoma is the 2nd most common cancer worldwide, with more than 2.2 million cases recorded globally in the year 2020, as well as 1.8 million deaths. It is the most common cancer in men and the 2nd most common cancer in women, with an estimated lifetime risk of developing the disease of 1 in 15 for men and 1 in 17 for women. Whilst being the most prevalent cancer, it is important to note that smoking is the single biggest risk factor for developing Lung Cancer, with over 70% of cases being estimated to have been caused by tobacco smoke, and excessive smoking potentially leading to as much as a 25x increase in the likelihood of the disease developing. Mortality rates have been steadily dropping globally due to declining smoking rates, especially in younger generations who are now more aware of the potential dangers, but also because of the increasing advancements being made in our understanding of the disease. Improved screening methods mean many more cases are now caught earlier than they would otherwise have been, and our ever-advancing ranges of treatments can begin earlier than they could have previously. Recent advances in sequencing technology, computational approaches, and our biological understanding of lung cancer have revolutionized how we diagnose, prognosticate, and treat lung carcinoma. Genetic studies into this disease have revealed a plethora of information which can be used to combat the Cancer, such as novel biomarkers and gene signatures, as well as opening the door to more of a ‘personalized medicine’ approach.
Author : Adi F. Gazdar
Publisher :
ISBN 13 :
Total Pages : 160 pages
Book Rating : 4.:/5 ( download)
Download or read book The Biology and Molecular Genetics of Lung Cancer written by Adi F. Gazdar and published by . This book was released on 1994 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Philip T. Cagle
Publisher : Springer Science & Business Media
ISBN 13 : 1461431972
Total Pages : 217 pages
Book Rating : 4.4/5 (614 download)
Download or read book Molecular Pathology of Lung Cancer written by Philip T. Cagle and published by Springer Science & Business Media. This book was released on 2012-06-14 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: As with other books in the Molecular Pathology Library Series, Molecular Pathology of Lung Cancer bridges the gap between the molecular specialist and the clinical practitioner, including the surgical pathologist who now has a key role in decisions regarding molecular targeted therapy for lung cancer. Molecular Pathology of Lung Cancer provides the latest information and current insights into the molecular basis for lung cancer, including precursor and preinvasive lesions, molecular diagnosis, molecular targeted therapy, molecular prognosis, molecular radiology and related fields for lung cancer generally and for the specific cell types. As many fundamental concepts about lung cancer have undergone revision in only the past few years, this book will likely be the first to comprehensively cover the new molecular pathology of lung cancer. It provides a foundation in this field for pathologists, medical oncologists, radiation oncologists, thoracic surgeons, thoracic radiologists and their trainees, physician assistants, and nursing staff.
Author : Alan Weitberg
Publisher : Springer Science & Business Media
ISBN 13 : 1592590934
Total Pages : 352 pages
Book Rating : 4.5/5 (925 download)
Download or read book Cancer of the Lung written by Alan Weitberg and published by Springer Science & Business Media. This book was released on 2001-10-04 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alan B. Weitberg, MD, and a panel of internationally recognized basic scientists and clinicians present a comprehensive discussion of lung cancer, including a practice-oriented review of its diagnosis, evaluation, and treatment. The contributors offer not only an understandable description of its molecular origins-an essential key to developing future therapies and preventive measures-but also rigorously discuss well-tested approaches, as well as those that are currently being evaluated for future use in both the laboratory and clinic. The book also elucidates the creation and effective deployment of treatment guidelines introduced by third party payers to improve clinical outcomes, even while lowering healthcare costs.
Author : John K. Cowell
Publisher : Gulf Professional Publishing
ISBN 13 : 9780121501006
Total Pages : 544 pages
Book Rating : 4.5/5 (1 download)
Download or read book Molecular Genetics of Cancer written by John K. Cowell and published by Gulf Professional Publishing. This book was released on 2001 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first volume was published, there has been significant success in isolating genes responsible for particular cancers as well as a major improvement in our understanding of the molecular events leading to tumors. This book explores possible genetic treatments that can suppress cancer cells that have formed tumors and it presents the details of the isolation and characterization of new human cancer genes that have recently been identified. Molecular Genetics of Cancer, 2E is an essential book for anyone involved in cancer research and the search for a cure.
Author : John Cowell
Publisher : Garland Science
ISBN 13 : 1135323836
Total Pages : 407 pages
Book Rating : 4.1/5 (353 download)
Download or read book Molecular Genetics of Cancer written by John Cowell and published by Garland Science. This book was released on 2003-12-16 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Genetics of Cancer, Second Edition provides an authoritative and up to date review of the key genes known to be critical in the development or progression of cancer. Throughout the book, scientific advances and their clinical relevance are covered in detail, particularly in the light of findings concerning the inheritance of genes predisposing to tumorigenesis. The book is therefore a valuable source of reference for clinicians and genetic counsellors as well as researchers.
Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lai-Shan Tai
Publisher :
ISBN 13 : 9781361205044
Total Pages : pages
Book Rating : 4.2/5 (5 download)
Download or read book Molecular Genetic Characterizations of Human Non-Small Cell Lung Cancer written by Lai-Shan Tai and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Molecular Genetic Characterizations of Human Non-small Cell Lung Cancer" by Lai-shan, Tai, 戴麗珊, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Molecular genetic characterizations of human Non-Small Cell Lung Cancer Submitted by TAI Lai-Shan For the degree of Doctor of Philosophy at the University of Hong Kong in April 2005 Lung cancer is one of the most common malignances worldwide. It is the first leading cause of cancer death in both men and women in Hong Kong and in the United States. The prognosis of this prevalent disease is poor with a 5-year survival rate at about 15%. A better understanding of the underlying genetic molecular mechanism is crucial and essential for better diagnosis and therapeutic design purposes for cancer treatment. However, a clear molecular machinery for the carcinogenesis remains far to be discovered. In this study, genetic alterations of non-small cell lung cancer, the major subtype of human lung cancer were extensively studied. By using comparative genomic hybridization, the most frequent chromosomal regions showing DNA copy number gains and losses were investigated. Besides, patterns of chromosomal aberrations between adenocarcinoma and squamous cell carcinoma of NSCLC were compared and found to be greatly different. Results indicated that chromosome 3q gain is the most prominent difference between the two sub-groups (pAssociation between genetic alterations and clinical significance was also investigated. Interestingly, we found that gains of chromosomes 5p and 20q and loss of 5q were significantly correlated to the advanced stage of NSCLC (pWe have established three human primary NSCLC cell lines and performed cytogenetic and molecular characterization of each. All of the three cells exhibited complex numerical and structural chromosomal changes. EGFR and FGF3 were found to be highly amplified and expressed in one of the NSCLC cell line. By studying protein expression in large sample population profile, we were the first to report the expression of FGF3 in NSCLC. Here we demonstrated the use of in vitro cell model for cancer-related genes identification and provide tools for further mechanistic and functional study. Apart from chromosomal gains, regions with DNA loss are also the study targets in tumorgenesis investigation. According to our CGH results, chromosome 3p is the region found with the most frequent copy number loss. Here we reported the use of SNP markers for high resolution 3p allelic loss study using Sequenom platform. Our data serve the basis for putative tumor suppressor genes identification in the future. An abstract of 412 words DOI: 10.5353/th_b3137531 Subjects: Lungs - Cancer - Genetic aspects Molecular genetics
Author : B.A. Ponder
Publisher : Springer Science & Business Media
ISBN 13 : 9401106770
Total Pages : 222 pages
Book Rating : 4.4/5 (11 download)
Download or read book The Genetics of Cancer written by B.A. Ponder and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.
Author : Robert Stockley
Publisher : Birkhäuser
ISBN 13 : 3034887841
Total Pages : 209 pages
Book Rating : 4.0/5 (348 download)
Download or read book Molecular Biology of the Lung written by Robert Stockley and published by Birkhäuser. This book was released on 2013-12-01 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : United States. Public Health Service. Office of the Surgeon General
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author : Fiona Macdonald
Publisher : Garland Science
ISBN 13 : 0203503449
Total Pages : 269 pages
Book Rating : 4.2/5 (35 download)
Download or read book Molecular Biology of Cancer written by Fiona Macdonald and published by Garland Science. This book was released on 2004-01-15 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular Biology of Cancer has been extensively revised and covers heredity cancer, microarray technology and increased study of childhood cancers. It continues to provide a detailed overview of the process which lead to the development and proliferation of cancer cells, including the techniques available for their study. It also describes the means by which tumor suppressor genes and oncogenes may be used in the diagnosis and in determining the prognosis of a wide variety of cancers, including breast, genitourinary, lung and gastrointestinal cancer.
