Author : Hailiang Zhang
Publisher : Frontiers Media SA
ISBN 13 : 2832551793
Total Pages : 104 pages
Book Rating : 4.8/5 (325 download)
Book Synopsis The Mechanism of Tumor Evolution and Microenvironmental Changes of Genitourinary Oncology in Clinical Diagnosis and Treatment,volume II by : Hailiang Zhang
Download or read book The Mechanism of Tumor Evolution and Microenvironmental Changes of Genitourinary Oncology in Clinical Diagnosis and Treatment,volume II written by Hailiang Zhang and published by Frontiers Media SA. This book was released on 2024-07-16 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor microenvironment (TME) is a bidirectional, dynamic and intricate network of interactions between tumor cells and mesenchymal tissue cells. Therefore, an in-depth study in TME is of great significance for clarifying tumor biology and molecular mechanisms during tumorigenesis and progression. The genitourinary tumors mainly include relatively high-incidence malignant prostate cancer, kidney cancer and bladder cancer, and relatively rare adrenocortical cancer, penile cancer, and so on. There are various complex intercellular communications in genitourinary tumor microenvironment. Many cells reprogram their metabolic pathways to adapt to an acidic hypoxic environment, providing energy support for growth and metastasis of genitourinary tumors. The heterogeneity of genitourinary TME makes tumor progression quite different between individuals. Therefore, it is necessary to analyze the interaction between tumor cells and stromal components, the key components that exert anti-tumor immunity (such as cytotoxic T lymphocytes, TAM, MDSC, etc.) and other genitourinary tumor microenvironment characterizations