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The Macrophage As Therapeutic Target
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Book Synopsis The Macrophage as Therapeutic Target by : Siamon Gordon
Download or read book The Macrophage as Therapeutic Target written by Siamon Gordon and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: During the past decade, the rapid growth of molecular and cellular knowledge of macrophages, as a specialized host defense and homeostatic system, has begun to offer attractive targets for therapeutic intervention. Macrophages play a central role in a wide range of disease processes, from genetically determined lysosomal storage diseases, to acute sepsis, chronic inflammation and repair, tissue injury and cell death. Under- or overactivity of macrophage clearance, immune effector functions and responses to metabolic abnormalities contribute to common disorders such as autoimmunity, atherosclerosis, Alzheimer’s disease and major infections including AIDS and Tuberculosis. Whilst the goals of therapeutic intervention based on improved understanding of macrophage functions and their contribution to pathogenesis may seem self evident, there are considerable difficulties in producing useful new agents. The present volume covers a range of subjects and provides opportunities for a more focused macrophage-targeted approach. The individual chapters review selected topics briefly, to place cellular processes and molecular targets in perspective. Overall, the volume should provide a broad sample of the state of the art. Useful reviews and references in the literature are cited within individual chapters.
Book Synopsis Macrophage Targeted Delivery Systems by : Swati Gupta
Download or read book Macrophage Targeted Delivery Systems written by Swati Gupta and published by Springer Nature. This book was released on 2022-02-22 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proposed book is envisioned for the nascent and entry-level researchers who are interested to work in the field of drug delivery and its applications specifically for macrophage targeting. Macrophages have gained substantial attention as therapeutic targets for drug delivery considering their major role in health and regulation of diseases. Macrophage-targeted therapeutics have now added significant value to the lives and quality of life of patients, without undue adverse effects in multiple disease settings. We anticipate examining and integrating the role of macrophages in the instigation and advancement of various diseases. The major focus of the book is on recent advancements in various targeting strategies using delivery systems or nanocarriers followed by application of these nanocarriers for the treatment of macrophage associated disorders. Macrophage Targeted Delivery Systems is primarily targeted to Pharmaceutical Industry & Academia, Medical & Pharmaceutical Professionals, Undergraduate & Post graduate students and Research Scholars, Ph.D, post docs working in the field of medical and pharmaceutical sciences.
Book Synopsis Macrophages as Therapeutic Target in Colon Carcinoma by : Marijn Bögels
Download or read book Macrophages as Therapeutic Target in Colon Carcinoma written by Marijn Bögels and published by . This book was released on 2012 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Lupus and Innate Immunity by : Samantha A. Chalmers
Download or read book Lupus and Innate Immunity written by Samantha A. Chalmers and published by . This book was released on 2016 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Therapeutic Targeting of Tumor Associated Macrophages by : Stephanie Kaye Watkins
Download or read book Therapeutic Targeting of Tumor Associated Macrophages written by Stephanie Kaye Watkins and published by . This book was released on 2007 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Previous studies on the mechanistic induction of anti-tumor responses by IL-12 cytokine therapy have focused on the adaptive immune response, specifically the activation NK cells and T cells as the primary targets of IL-12 treatment. In contrast, little attention has been given to the potential role of macrophages in the initiation of anti-tumor responses by IL-12 therapy despite reports that macrophages play a major role in promoting tumor growth and metastasis and in suppressing anti-tumor immune responses. Based on the functional adaptivity hypothesis, which is the concept that macrophages functionally adapt, rather than differentiate into specific mature subsets, in response to environmental stimuli, we hypothesized that tumor infiltrating (TIMs) as well as tumor-associated macrophages (TAMs) could be converted from tumor supportive activities to pro-immunogenic activities by IL-12 therapy. We examined the functional activities displayed by TIMs and TAMs after treatment with IL-12. Our data demonstrate (1) that tumor cells and tumor exosomes activate TIMs and TAMs by cell-contact dependent mechanisms involving ligation of CD40 and/or NKG2D, (2) that IL-12 treatment both in vivo and in vitro induces a rapid reduction of tumor supportive activities and a concomitant increase in pro-inflammatory activities in TIMs as well as TAMs, (3) that IL-12 induces a rapid release of cytoplasmic IL-I5 from the in situ activated tumor associated macrophages and (4) the release of IL-15 in essential to the recruitment of lymphocytes to the tumor and the metastatic lung, and to the destruction of the tumor and clearance of metastasis. It is concluded that macrophages in the tumor environment are activated and functionally modulated by the tumor. TIMs and TAMs respond to IL-12 treatment by rapidly converting from suppressive, tumor supportive activities to inflammatory, pro-immunogenic activities. Tumor associated macrophages thus are a critical target of IL-12 therapy and may orchestrate the subsequent NK and T cell cytotoxic response against the tumor.
Book Synopsis Macrophages as a Therapeutic Target in Inflammatory Bowel Disease by : Felicia Bloemendaal
Download or read book Macrophages as a Therapeutic Target in Inflammatory Bowel Disease written by Felicia Bloemendaal and published by . This book was released on 2020 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Macrophage as a Drug Delivery Vehicle for Cancer Treatment by : Weizhong Zhang
Download or read book Macrophage as a Drug Delivery Vehicle for Cancer Treatment written by Weizhong Zhang and published by . This book was released on 2019 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrophage has been recognized as an important therapeutic target owing to its multiple supportive roles in cancer development. Meantime, it has also been exploited as a potential tool for cancer treatment by taking advantage of its intrinsic properties. In the first chapter of my dissertation, I have reviewed the multiple roles of macrophage in cancer development as well as different strategies exploiting macrophages for cancer treatment. The second chapter is about using macrophage as a cellular drug delivery vehicle by making use of its tumor-tropic migration property. A drug-encapsulated silica nanocapsule is loaded into macrophages via internalization. A layer of silica shell is coated on top of the nanocapsule to prevent early leakage of drug payload during the migration towards tumor tissue. The nanocapsule-laden macrophages can efficiently home to tumor site, offering high drug delivery efficiency and enhanced therapeutic efficacy. The third chapter is about increasing the intratumoral macrophage content for enhanced tumor uptake of nanomedicine. As reviewed in the first chapter, macrophages in the tumor microenvironment can not only accumulate nanoparticles by phagocytosis, but also remodel the tumor microvironment to render a higher leakiness for the deposition of nanoparticles into tumor tissue. In this study, increasing the intratumoral macrophage number via intratumoral injection of macrophages shows promise in increasing the tumor deposition of iron oxide nanoparticles and doxove (liposomal doxorubicin, a type of therapeutic nanomedicines) in U-87MG human glioblastoma model, therefore benefiting the tumor imaging in T2 magnetic resonance imaging (MRI) and contributing to an improved therapeutic result. In the fourth chapter, nanoparticle-laden macrophage is exploited to enhance intratumoral immunogenic cell death (ICD) process. By taking advantage of the functional plasticity of macrophage, metal oxide nanoparticles with low cytotoxicity serve as a stimulus to promote the production of damage associated molecular pattern (DAMP) molecules of macrophage. This converts macrophage into a cellular reactor for DAMP generation, which activates the ICD process in tumor site for anti-tumor immunogenicity.
Book Synopsis Regional Chemotherapy by : Maurie Markman
Download or read book Regional Chemotherapy written by Maurie Markman and published by Springer Science & Business Media. This book was released on 2000-01-02 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maurie Markman and a panel of distinguished clinicians and leading clinical investigators comprehensively review the current status of regional antineoplastic drug delivery in the management of malignant disease. These authorities present a critical analysis of both the rationale and limitations of regional therapy and discuss potential clinical trials designed to explain the effectiveness of this method of therapy in special settings. Their presentations describe many exciting and innovative strategies for using regional drug delivery in anticancer therapy, including coverage of such areas of special interest as colorectal, skin, lung, pancreatic, ovarian, and gastrointestinal cancers. Comprehensive and authoritative, Regional Chemotherapy: Clinical Research and Practice offers surgical and medical oncologists and clinical cancer investigators a gold-standard review of the current role and future development of this increasingly powerful weapon in the battle against cancer.
Download or read book Cancer Nanotechnology written by and published by Academic Press. This book was released on 2018-06-23 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Cancer Research, Volume 139, provides invaluable information on the exciting and fast-moving field of cancer research. Original reviews are presented on a variety of topics relating to the rapidly developing intersection between nanotechnology and cancer research, with unique sections in the new release focusing on Exosomes as a theranostic for lung cancer, Nanotechnology and cancer immunotherapy, Ultrasound imaging agents and delivery systems, Dendronized systems for the delivery of chemotherapeutics, Thermosensitive liposomes for image-guided drug delivery, Supramolecular Chemistry in Tumor Analysis and Drug Delivery, Gold nanoparticles for delivery of cancer therapeutics, and Single cell barcode microchip for cancer research and therapy. Provides the latest information on cancer research Offers outstanding and original reviews on a range of cancer research topics Serves as an indispensable reference for researchers and students alike
Book Synopsis Targeting Monocytes/Macrophages to Treat Atherosclerotic Inflammation by : Alessandro Corti
Download or read book Targeting Monocytes/Macrophages to Treat Atherosclerotic Inflammation written by Alessandro Corti and published by Frontiers Media SA. This book was released on 2020-03-23 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Macrophages & Cancer by : Gloria H. Heppner
Download or read book Macrophages & Cancer written by Gloria H. Heppner and published by CRC Press. This book was released on 2019-06-04 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: First Published in 1988, this book offers a full, comprehensive guide into the relationship between macrophages and Cancer. Carefully compiled and filled with a vast repertoire of notes and references this book serves as a useful reference for Students of Medicine, Oncology and other practitioners in their respective fields.
Download or read book The Macrophage written by Bernard Burke and published by Oxford University Press, USA. This book was released on 2002 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Macrophage, second edition provides a unique, comprehensive review of the current scientific knowledge of the multifaceted role of this important and intriguing cell in health and disease. In 16 chapters, written by experts in the field, it covers the basic biology and diverse functions of macrophages in specific diseases and the complex interactions between macrophages and other cells. Ranging from their role in the defence against pathogens, their role as hosts for pathogens (including HIV), their complex roles in diseases such as arthritis and cancer, and their potential for use in novel gene therapy approaches to disease treatment, the book gives an up to the minute account of active macrophage research.
Book Synopsis Peripheral Arterial Disease by : Nishtha Sareen
Download or read book Peripheral Arterial Disease written by Nishtha Sareen and published by BoD – Books on Demand. This book was released on 2018-10-17 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Peripheral Arterial Disease - A Practical Approach" is an honest effort to provide a clinically relevant approach to the management plan in patients presenting with peripheral vascular symptoms. We have summarized the most pertinent practical aspects of peripheral vascular disease, their clinical implications, diagnostic testing, therapeutic interventions and innovations. We hope this book serves as a reference for basic and advanced peripheral vascular care.
Book Synopsis Stellate Cells in Health and Disease by : Chandrashekhar Gandhi
Download or read book Stellate Cells in Health and Disease written by Chandrashekhar Gandhi and published by Academic Press. This book was released on 2015-04-10 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stellate Cells in Health and Disease is a comprehensive reference providing the most up-to-date knowledge and perspectives on the function of stellate cells affecting the liver and other organs. The text presents comprehensive coverage of their already established role in hepatic fibrosis along with the newer emerging evidence for stellate cell participation in the liver cell (hepatocyte) survival and regeneration, hepatic immunobiology, transplant tolerance, and liver cancer. Chapters describe both animal and human research and the relevance of findings from animal research to human pathophysiology, and also contain sections on future directions which will be of special interest to basic and clinical researchers working on liver fibrosis, hepatic biology, and pathobiology. Presents coverage of the mechanisms of liver fibrosis with stellate cells as a target for therapy. Shows stellate cells as a major participant in hepatic immunobiology, including transplantation immunology. Key illustrations show the phenotypical changes in stellate cells in situ and tissue culture, their interactions with other cell types, signaling pathways and demonstrate the functions and roles of stellate cell in pathological processes.
Book Synopsis Polymyositis and Dermatomyositis by : Marinos C. Dalakas
Download or read book Polymyositis and Dermatomyositis written by Marinos C. Dalakas and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymyositis and Dermatomyositis provides extensive information regarding Polymyositis and Dermatomyositis (PM/DM), which is described as a heterogeneous disease complex. This book is divided into four sections: Part I (Clinical Features) covers the classification of PM/DM, details of the clinical presentation, and the disease's association with the other connective tissue disorders and malignancies. Part II (Etiology and Mechanisms) covers advances in the immunopathology and viral etiology of PM/DM along with a frequently recognized entity: inclusion body myositis. Part III (Diagnosis and Treatment) covers the histologic, muscle enzyme histochemical, electron microscopic, and resin histology features of PM/DM along with those electromyographic features that could help make a more accurate diagnosis. Part IV (Overview) summarizes the issues that may not have been clear and highlights differing and unsettled views or present available data. This text is directed to clinicians in private practice or in academic institutions concerned with PM/DM patients, including neurologists, rheumatologists, pediatricians, dermatologists, physiatrists, and neuromuscular investigators. This book is intended as well for neuromuscular pathologists who interpret muscle biopsy specimens and electromyographers who perform EMG studies to help determine the clinical diagnosis. Researchers in immunology and immunopathology of neuromuscular diseases will find discussions in this book invaluable.
Book Synopsis Translocator Protein (TSPO) by : Giovanni Natile
Download or read book Translocator Protein (TSPO) written by Giovanni Natile and published by MDPI. This book was released on 2018-03-05 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Translocator Protein (TSPO)" that was published in IJMS
Book Synopsis Chemokines and Cancer by : Barrett Rollins
Download or read book Chemokines and Cancer written by Barrett Rollins and published by Springer Science & Business Media. This book was released on 1999 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the introduction of microscopy, pathologists have noted tumor infiltration by inflammatory cells and presumed that this represents the host's attempt to reject its tumor. Recent advances in the molecular biology of inflammation have revealed the signals involved in attracting inflammatory cells to tumors and, for the most part, these signals are mediated by chemokines and their receptors. Chemokines are low molecular weight proteins that attract and activate specific subsets of leukocytes to the exclusion of others.
