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The Location Of The Activation Gate In Small Conductance Calcium Activated Potassium Channels
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Book Synopsis The Location of the Activation Gate in Small Conductance Calcium-activated Potassium Channels by : Andrew H. Bruening-Wright
Download or read book The Location of the Activation Gate in Small Conductance Calcium-activated Potassium Channels written by Andrew H. Bruening-Wright and published by . This book was released on 2003 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Structure-function Analyses of Small-conductance, Calcium-activated Potassium Channels by : Dieter D'hoedt
Download or read book Structure-function Analyses of Small-conductance, Calcium-activated Potassium Channels written by Dieter D'hoedt and published by . This book was released on 2005 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Regulation of Small-conductance, Calcium-activated Potassium Channels (SK) in Mouse Brain in Response to Aging and Stress by : Min-Jeong Kye
Download or read book Regulation of Small-conductance, Calcium-activated Potassium Channels (SK) in Mouse Brain in Response to Aging and Stress written by Min-Jeong Kye and published by . This book was released on 2004 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Role of Small-conductance Calcium-activated Potassium Channels in the Mammalian Nervous System and Neurological Disease by : Vikram Govindaraju Shakkottai
Download or read book The Role of Small-conductance Calcium-activated Potassium Channels in the Mammalian Nervous System and Neurological Disease written by Vikram Govindaraju Shakkottai and published by . This book was released on 2004 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Modulators of Small and Intermediate Conductance Calcium-activated Potassium Channel by : David Paul Jenkins
Download or read book Modulators of Small and Intermediate Conductance Calcium-activated Potassium Channel written by David Paul Jenkins and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels generate the electrical signaling activity essential for complex life forms. Of prime importance, potassium channels establish and maintain the resting membrane potentials upon which cellular signaling dynamics are based. Potassium channels are the most diverse group of ion channels, offering great potential for selective interventions. Understanding the molecular, cellular and integrative physiology of potassium channels is critical for developing novel therapeutics. This dissertation examines the physiological roles of small- and intermediate-conductance calcium-activated potassium channels (K[subscript Ca]2/3) and the effects of their pharmacological modulation. Using a progressive chimeric approach and point-mutations, we delineated the site-of-action of NS8593, a selective negative gating modulator of K[subscript Ca]2 channels. Two residues, Ser-507 and Ala-532, adjacent to the cytoplasmic side of the selectivity filter mediate the action of NS8593. This demonstrates a site-of-action distinct from the positive gating modulators and suggests that negative gating modulation may result from a direct interaction with the physical gate of K[subscript Ca]2 channels. It further suggests that this type of gating modulation should be possible in other potassium and possibly in the related sodium and calcium channels. We identified and characterized a novel and structurally unique K[subscript Ca]3.1 blocker, NS6180, which compares favorably with the widely used TRAM-34. In heterologous expression systems and in native tissues, NS6180 inhibits K[subscript Ca]3.1 as potently (10-20 nM) as standard K[subscript Ca]3.1 blocker TRAM-34, and shares the same site-of-action, Thr-250 and Val-275. Despite these similarities, NS6180 has a distinct selectivity profile from TRAM-34, particularly showing significantly less inhibition of K[subscript V]7.2+7.3 channels. Finally, NS6180 produces immunosuppressive and anti-inflammatory effects in isolated splenocytes and DNBS induced rat colitis, demonstrating its promise for future development as a treatment of intestinal inflammation. Using optical mapping, we investigated the effects of NS8593 on action potential duration (APD) and effective refractory period (ERP) in isolated right atria from rabbits with chronic heart failure (CHF). APD was significantly decreased in CHF atria, while ERP was increased. NS8593 did not significantly affect ERP; however, it completely reversed the effects of CHF, restoring APD to control values. We have demonstrated that shortening of atrial action potentials secondary to chronic heart failure can be reversed by inhibition of K[subscript Ca]2 channels with the negative gating modulator, NS8593.
Book Synopsis A Study of Small and Intermediate Conductance Calcium-activated Potassium Channels in Sensory Neurones by :
Download or read book A Study of Small and Intermediate Conductance Calcium-activated Potassium Channels in Sensory Neurones written by and published by . This book was released on 2005 with total page 574 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Biology of The Cell by : Bruce Alberts
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ion Channels in Health and Sickness by : Fatima Shad Kaneez
Download or read book Ion Channels in Health and Sickness written by Fatima Shad Kaneez and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
Book Synopsis Clinical Arrhythmology and Electrophysiology E-Book by : Ziad Issa
Download or read book Clinical Arrhythmology and Electrophysiology E-Book written by Ziad Issa and published by Elsevier Health Sciences. This book was released on 2018-08-07 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the highly regarded Braunwald’s family of cardiology references, Clinical Arrhythmology and Electrophysiology, 3rd Edition, offers complete coverage of the latest diagnosis and management options for patients with arrhythmias. Expanded clinical content and clear illustrations keep you fully abreast of current technologies, new syndromes and diagnostic procedures, new information on molecular genetics, advances in ablation, and much more.
Book Synopsis Store-Operated Calcium Channels by :
Download or read book Store-Operated Calcium Channels written by and published by Academic Press. This book was released on 2013-07-24 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Store-operated calcium channels are found in most animal cells and regulate many cellular functions including cell division, growth, differentiation, and cell death. This volume provides a concise and informative overview of the principles of store-operated calcium entry and the key developments in the field from researchers who have led these advances. The overall goal of the volume is to provide interested students and investigators with sufficient information to enable a broad understanding of the progress and current excitement in the field. The volume contains a wealth of information that even experienced investigators in the field will find useful. The volume provides a comprehensive overview of the mechanisms and functions of store-operated calcium channels Contributors are authoritative researchers who have produced important advances in the field The volume is well-illustrated with cartoons and data to facilitate easy comprehension of the subject
Book Synopsis Neuronal Dynamics by : Wulfram Gerstner
Download or read book Neuronal Dynamics written by Wulfram Gerstner and published by Cambridge University Press. This book was released on 2014-07-24 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: This solid introduction uses the principles of physics and the tools of mathematics to approach fundamental questions of neuroscience.
Book Synopsis Handbook of Nutrition, Diet, and the Eye by : Victor R. Preedy
Download or read book Handbook of Nutrition, Diet, and the Eye written by Victor R. Preedy and published by Academic Press. This book was released on 2019-06-11 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Nutrition, Diet, and the Eye, Second Edition, thoroughly addresses common features and etiological factors on how dietary and nutritional factors affect the eye. The ocular system is perhaps one of the least studied organs in diet and nutrition, yet the consequences of vision loss are devastating. There are a range of ocular defects that have either their origin in nutritional deficiencies/excess or have been shown to respond favorably to nutritional components. Featuring a new section on animal model studies where both the ocular problem and dietary remedies can be varied, there are also new chapters on dietary supplements. Serves as a foundational collection for neuroscience, neurology and nutrition researchers, illustrating the importance of nutrition and diet in eye health and function Provides a common language for readers to discuss how nutritional factors and related diseases and syndromes affect the eye Features new chapters on infectious diseases of the eye where nutrition is a factor Discusses animal model studies, dietary supplements, natural dietary extracts from around the world, and age-related changes in ocular health
Book Synopsis Voltage Gated Sodium Channels by : Peter C. Ruben
Download or read book Voltage Gated Sodium Channels written by Peter C. Ruben and published by Springer Science & Business Media. This book was released on 2014-04-15 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: A number of techniques to study ion channels have been developed since the electrical basis of excitability was first discovered. Ion channel biophysicists have at their disposal a rich and ever-growing array of instruments and reagents to explore the biophysical and structural basis of sodium channel behavior. Armed with these tools, researchers have made increasingly dramatic discoveries about sodium channels, culminating most recently in crystal structures of voltage-gated sodium channels from bacteria. These structures, along with those from other channels, give unprecedented insight into the structural basis of sodium channel function. This volume of the Handbook of Experimental Pharmacology will explore sodium channels from the perspectives of their biophysical behavior, their structure, the drugs and toxins with which they are known to interact, acquired and inherited diseases that affect sodium channels and the techniques with which their biophysical and structural properties are studied.
Book Synopsis Heart Physiology and Pathophysiology by : Yoshihisa Kurachi
Download or read book Heart Physiology and Pathophysiology written by Yoshihisa Kurachi and published by Elsevier. This book was released on 2000-10-09 with total page 1286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students. Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology
Book Synopsis BK Channels: Integrators of Cellular Signals in Health and Disease by : Thomas M. Weiger
Download or read book BK Channels: Integrators of Cellular Signals in Health and Disease written by Thomas M. Weiger and published by Frontiers Media SA. This book was released on 2017-11-10 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Maxi calcium-activated potassium channels (BK) are an amazing category of ion channels which are found in cellular plasma membranes as well as in membranes of intracellular organelles. The function of these channels is to repolarize any excited membrane by passing a potassium outward current, in response to depolarization and/or increase in local calcium levels. Thus, voltage and calcium ions are involved in gating the channel under physiological conditions. This dual activation makes them perfect sensors for many cellular events that require integration between intracellular calcium levels and electrical signals. A plethora of physiological and pathophysiological functions, such as membrane hyperpolarization, modulation of synaptic transmission, hormone secretion or mental deficiencies, vaso-regulation, epilepsies, heart diseases, myotonic dystrophies, hypertension etc, in almost all cells and tissues were reported for these channels. BK channels are main targets for important ligands like alcohol and gaseous neurotransmitters, such as NO, CO or H2S, to name a few. In the last years, the molecular entities and mechanisms involved in modulation of BK channels have gained tremendous attention, as the key role of these channels in cellular processes became increasingly recognized. Indeed, accessory proteins such as slob, beta and gamma subunits, all serve to modulate the channel gating characteristics. Moreover, channel subunit expression and function is further tuned by phosphorylation/ dephosphorylation processes, redox mechanisms and the lipid microenvironment of the BK channel protein complex. This e-book contains structural and functional aspects of BK channels, channel modulation by a variety of agents and cellular components, as well as the channel’s relevance in health and disease.
Book Synopsis Low-voltage-activated T-type Calcium Channels by : Richard W. Tsien
Download or read book Low-voltage-activated T-type Calcium Channels written by Richard W. Tsien and published by . This book was released on 1998 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Biological Membrane Ion Channels by : Shin-Ho Chung
Download or read book Biological Membrane Ion Channels written by Shin-Ho Chung and published by Springer Science & Business Media. This book was released on 2007-11-13 with total page 657 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences.
