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The Iuphar Compendium Of Receptor Characterization And Classification
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Book Synopsis The IUPHAR compendium of receptor characterization and classification by : International Union of Pharmacology
Download or read book The IUPHAR compendium of receptor characterization and classification written by International Union of Pharmacology and published by . This book was released on 2000 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Melatonin written by S. R. Pandi-Perumal and published by Nova Publishers. This book was released on 2007 with total page 932 pages. Available in PDF, EPUB and Kindle. Book excerpt: Melatonin is a neurohormone produced in the brain by the pineal gland, from the amino acid tryptophan. Melatonin possesses antioxidant activity, and many of its proposed therapeutic or preventive uses are based on this property. This book presents a wide spectrum of research on melatonin.
Book Synopsis Phytohormones in Plant Biotechnology and Agriculture by : Ivana Machácková
Download or read book Phytohormones in Plant Biotechnology and Agriculture written by Ivana Machácková and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phytohormone research is a crucially important area of plant sciences. Phytohormones are one of the key systems integrating metabolic and developmental events in the whole plant and the response of plants to external factors. Thus, they influence the yield and quality of crops. During the last decade we have slowly begun to understand the molecular mechanisms underlying phytohormone action, largely as a result of the rapid developments that have been made internationally in the field of plant molecular genetics. Putative receptor proteins for ethylene (1993- 95), brassinosteroids (1997) and cytokinins (2001) have been identified and the genes that encode them cloned. Primary response genes and elements of hormonal signal transduction have also been identified for most known phytohormones. There is now little doubt that phytohormones, like their animal counterparts, function as signal molecules and create a signalling network in the whole plant organism. The in vivo activity of hormones depends, among other things, on their rate of biosynthesis and metabolism, and on their transport into and out of target cells. Consequently, genes and enzymes involved in these processes are of particular interest. In recent years a number of genes encoding enzymes for the synthesis, modification and degradation of different phytohormones have been cloned and identified, as have genes encoding proteins involved in phytohormone transport and its regulation. Some classes of phytohormone have been shown to participate in stress reactions and can increase the resistance of plants to unfavorable environmental factors.
Book Synopsis Aspirin and Related Drugs by : Kim D. Rainsford
Download or read book Aspirin and Related Drugs written by Kim D. Rainsford and published by CRC Press. This book was released on 2004-10-28 with total page 1355 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviewing over a century of aspirin research and use, Aspirin and Related Drugs provides a comprehensive source of information on the history, chemistry, absorption in the body, therapeutic effects, toxicology, elimination, and future uses of aspirin. Highlighting the historical evolution of the salicylates and the commercial development of
Book Synopsis The Adrenergic Receptors by : Dianne M. Perez
Download or read book The Adrenergic Receptors written by Dianne M. Perez and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative review of the current state-of-the-art understanding of the structure and function of the adrenergic receptor subtypes, as well as of the role played by these receptors in physiological and pathophysiological settings. Topics range from structure-function studies and the imaging of adrenergic receptors to the use of genetically altered mouse models and pharmacogenomics. Highlights include a survey of the knockout and overexpressed mouse models, a review of the new ways that adrenergic receptors can signal, and the effects of polymorphisms on clinical outcomes and on potential gene therapy applications. The side-by-side comparison of all the adrenergic receptors (a1, a2, and b) provides the reader with an excellent survey of the field, including the rationale for designing better drugs to control blood pressure and heart function.
Book Synopsis International Review of Cytology by : Kwang W. Jeon
Download or read book International Review of Cytology written by Kwang W. Jeon and published by Elsevier. This book was released on 2004-12-18 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cytology presents current advances and comprehensive reviews in cell biology – both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address therapeutic strategies for duchenne and becker dystrophies, cellular distribution and functions of P2 receptor subtypes in different systems, neuropeptides in hypothalamic neuronal disorders, and multiple parallelisms in animal cytokinesis.
Book Synopsis Encyclopedia of Molecular Pharmacology by : Stefan Offermanns
Download or read book Encyclopedia of Molecular Pharmacology written by Stefan Offermanns and published by Springer Science & Business Media. This book was released on 2008-08-14 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.
Book Synopsis Annual Reports in Medicinal Chemistry by :
Download or read book Annual Reports in Medicinal Chemistry written by and published by Academic Press. This book was released on 1999-09-08 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports in Medicinal Chemistry continues to strive to provide timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences which are expected to provide the basis for entirely new future therapies. Volume 34 retains the familiar format of previous volumes, this year with 33 chapters. Sections I-IV are disease-oriented and generally report on specific medicinal agents with updates from Volume 33 on antithrombotics, neurokinin receptor antagonists, anticoagualants, and new antibacterials. As in past volumes, annual updates have been limited to only the most active areas of research in favor of specifically focused and mechanistically oriented chapters, where the objective is to provide the reader with the most important new results in a particular field. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design as well as the critical interfaces among these disciplines. This volume concludes with To Market, To Market--a chapter on NCE and NBE introductions worldwide in 1998, a chapter on pharmagenomics, and finally one on malaria as a third world disease in need of a first world drug development.
Book Synopsis The Chemical Languages of the Nervous System by : Josef Donnerer
Download or read book The Chemical Languages of the Nervous System written by Josef Donnerer and published by Karger Medical and Scientific Publishers. This book was released on 2006-01-01 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurochemical transmission accounts for the majority of information transfer both in the central and peripheral nervous system. The initial findings centred around the experimental work of the two Nobel Prize winners Sir Henry H. Dale and Otto Loewi as well as Wilhelm Feldberg. Their historical findings opened the door to further investigations and extended the list of neurotransmitters to many others such as amino acids, peptides, purines and nitric oxide. In the first part, the publication provides fascinating insights into the life of the three scientists. Their personality and scientific approach are presented through autobiographical sketches and personal memories by authors. Various comments and details of the atmosphere in the laboratory complete the picture of the conditions at the time. The second part is dedicated to the history of the substances, such as neurotransmitters, their antagonists and analogues. The stories of these substances are presented to the reader in a succinct way, including many anecdotes and unusual events on the way to their therapeutic application. Contents Preface Introduction Otto Loewi Otto Loewi Introductory Remarks Autobiographic Sketch. By O. Loewi Otto Loewi 1873-1961. By H.H. Dale Otto Loewi. By F. Brucke Loewi's Time in Graz Comment on Loewi's Dream An Overlooked Parallel to Kekule's Dream: The Discovery of the Chemical Transmission of Nerve Impulses by Otto Loewi. By U. Weiss and R.A. Brown The Loewi Family's Way to the New World Comment on the Film Nobelpreistrager Otto Loewi Henry Hallett Dale Henry Hallett Dale Introductory Remarks Henry Hallett Dale 1875-1968. By W. Feldberg Fifty Years after the Nobel Prize Award to H.H. Dale and Otto Loewi. By G.B. Koelle Religious Reflections of Dale and Loewi Wilhelm Feldberg Wilhelm Feldberg Introductory Remarks The Early History of Synaptic and Neuromuscular Transmission by Acetylcholine: Reminiscences of an Eye Witness. By W. Feldberg From the History of Scientists to that of Neurotransmitters A Substance Isolated from Brain, Synthesized and Called Neurin: Acetylcholine Adrenaline, Noradrenaline and Dopamine: The Catecholamines Enteramine and Serotonin: Two Names and Three Functions of 5-Hydroxytryptamine Histamine: One Substance and Three Functions The Amino Acid Transmitter Family A Cloud of Peptides Substance P Calcitonin Gene-Related Peptide Neuropeptide, Galanine and Vasoactive Intephinal Polypeptide Opioid Peptides Nitric Oxide ATP and Adenosine Peripheral Neurogenic Stimulators Neurotransmission in the Central Nervous System From Transmitter to Receptor: Progress within 50 Years.
Book Synopsis Purinergic and Pyrimidinergic Signalling by : Maria P. Abracchio
Download or read book Purinergic and Pyrimidinergic Signalling written by Maria P. Abracchio and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physiological, pharmacological and molecular biological data generated over the past three decades have demonstrated the existence of two major families of extracellular receptors, the P1, a family of four G-protein coupled receptors and the P2, a family of at least 12 receptors responsive to purine (ATP, ADP) and pyrimidine (UTP) nucleotides through which adenosine and ATP can function as extracellular messengers. The present two-part volume represents an integrated compendium of invited chapters by leading researchers in the area focusing on advances in the understanding of purinergic and pyrimidinergic signaling systems, their role(s) in tissue function and pathophysiology and advances in developing potential new medications based on the modulation of P1 and P2 receptor signaling processes. The volumes will thus provide the reader with a topical, comprehensive and integrated overview of this important area.
Book Synopsis Annual Reports in Medicinal Chemistry by : Annette M. Doherty
Download or read book Annual Reports in Medicinal Chemistry written by Annette M. Doherty and published by Academic Press. This book was released on 2003-09-10 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease-orientated and generally report on specific medicinal agents. Sections V-VI continue to emphasize important topics in medicinal chemistry, biology and drug design. In addition to the chapter reviews, a comprehensive set of indices has been included to enable the reader to easily locate topics in Volumes 1-38 of this series.
Book Synopsis Drug Discovery and Evaluation: Pharmacological Assays by : Hans Vogel
Download or read book Drug Discovery and Evaluation: Pharmacological Assays written by Hans Vogel and published by Springer Science & Business Media. This book was released on 2007-10-30 with total page 2118 pages. Available in PDF, EPUB and Kindle. Book excerpt: The new edition of this successful reference offers both cutting-edge and classic pharmacological methods. Thoroughly revised and expanded to two volumes, it offers an updated selection of the most frequently used assays for reliably detecting the pharmacological effects of potential drugs. Every chapter has been updated, and numerous assays have been added. Each of the more than 1,000 assays comprises a detailed protocol outlining purpose and rationale, and a critical assessment of the results and their pharmacological and clinical relevance.
Book Synopsis Extracellular Nucleotides and Nucleosides: Release, Receptors, and Physiological & Pathophysiological Effects by :
Download or read book Extracellular Nucleotides and Nucleosides: Release, Receptors, and Physiological & Pathophysiological Effects written by and published by Elsevier. This book was released on 2003-09-10 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Purinergic receptors are proteins that bind ATP as their extracellular ligand. Once thought only as an intracellular molecule that provides energy, ATP is also now considered an essential autocrine/paracrine agonist that acts extracellularly within tissues and tissue microenvironments. Receptors for ATP and its metabolites, so-called "purinergic receptors," are essential membrane receptors that transduce the extracellular signal carried by ATP. Many cell types or tissues express multiple types of these receptors, often on the same cell. This volume will cover the history and overall impact of extracellular ATP signaling, methods to detect ATP release and signaling, the molecular and cell biology of purinergic receptors, the pharmacology of purinergic receptors, the ion channel biophysics and biochemistry of P2X purinergic receptor channels, and the physiology and pathophysiology of purinergic receptors. Key Features* Organized and written by world-renowned experts* Covers state-of-the-art experimental methods* Has broad appeal to basic and clinical scientists, the biotch industry and pharmaceutical research companies
Book Synopsis Pharmacology for Health Professionals ebook by : Kathleen Knights
Download or read book Pharmacology for Health Professionals ebook written by Kathleen Knights and published by Elsevier Health Sciences. This book was released on 2014-10-31 with total page 1169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Perfect for: Undergraduate Health science, Paramedic science, Nursing, Midwifery, Podiatry and Optometry students. Pharmacology for Health Professionals 4th Edition provides a comprehensive introduction to fundamental pharmacology principles and concepts. The fourth edition has been fully updated and revised to reflect the most up-to-date information on the clinical use of drugs, Australian and New Zealand scheduling, drug legislation and ethics. • Anatomy and physiology integrated throughout • Discipline-specific information integrated throughout and additional resources provided via Evolve • Key drug information at your fingertips: Drug Monographs, Drug Interactions Tables, Clinical Interest Boxes and key terms and abbreviations • End-of-chapter review exercises to test your understanding. • Evolve resources for both lecturer and student. • New and updated Drug Monographs describing important aspects of drugs and drug groups • Updated tables outlining detailed drug interactions occurring with major drug groups • Recent changes in the pharmacological management of major conditions • New Clinical Interest Boxes, including current New Zealand specific and pharmacological treatment of common diseases and conditions • Referencing most up-to-date reviews of drugs and major disease management • Guidelines for clinical choice and use of drugs • Enhanced information on the use of complementary and alternative medicine (CAM) modalities, with a focus on interactions between drugs and CAM therapies • Improved internal design for ease of navigation.
Book Synopsis Chemogenomics and Chemical Genetics by : ERIC MARECHAL
Download or read book Chemogenomics and Chemical Genetics written by ERIC MARECHAL and published by Springer Science & Business Media. This book was released on 2011-06-21 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological and chemical sciences have undergone an unprecedented transformation, reflected by the huge use of parallel and automated technologies in key fields such as genome sequencing, DNA chips, nanoscale functional biology or combinatorial chemistry. It is now possible to generate and store from tens of thousands to millions of new small molecules, based on enhanced chemical synthesis strategies. Automated screening of small molecules is one of the technologies that has revolutionized biology, first developed for the pharmaceutical industry and recently introduced in academic laboratories. High-throughput and high-content screening allow the identification of bioactive compounds in collections of molecules (chemical libraries), being effective on biological targets defined at various organisational scales, from proteins to cells to complete organisms. These bioactive molecules can be therapeutic drug candidates, molecules for biotech, diagnostic or agronomic applications, or tools for basic research. Handling a large number of biological (genomic and post-genomic), chemical and experimental information, screening approaches cannot be envisaged without any electronic storage and mathematical treatment of the data. “Chemogenomics and Chemical Genetics” is an introductory manual presenting methods and concepts making up the basis for this recent discipline. This book is dedicated to biologists, chemists and computer scientist beginners. It is organized in brief, illustrated chapters with practical examples. Clear definitions of biological, chemical and IT concepts are given in a glossary section to help readers who are not familiar with one of these disciplines. "Chemogenomics and Chemical Genetics" should therefore be helpful for students (from Bachelor's degree level), technological platform engineers, and researchers in biology, chemistry, bioinformatics, cheminformatics, both in biotech and academic laboratories.
Download or read book Nociceptin Opioid written by and published by Academic Press. This book was released on 2015-02-06 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on nociceptin opioid. Expertise of the contributors Coverage of a vast array of subjects In depth current information at the molecular to the clinical levels Three-dimensional structures in color Elaborate signaling pathways
Book Synopsis The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems by : T. Kenakin
Download or read book The Pharmacology of Functional, Biochemical, and Recombinant Receptor Systems written by T. Kenakin and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This, the 148th volume of the Handbook of Experimental Pharmacology series, focuses on the very core of pharmacology, namely receptor theory. It is fitting that the originator of receptor pharmacology, A. J. CLARK, authored the fourth volume of this series 63 years ago. In that volume CLARK further developed his version of receptor theory first described four years earlier in his classic book The Mode of Action of Drugs. An examination of the topics covered in volume 4 reveals a striking similarity to the topics covered in this present volume; pharmacologists today are still as interested in unlocking the secrets of dose-response relationships to reveal the biological and che mical basis of drug action as they were over half a century ago. Sections in that 1937 volume such as "Curves relating exposure to drugs with biological effects" and "Implications of monomolecular theory" show Clark's keen insight into the essential questions that required answers to move pharma cology forward. With the advent of molecular biological cloning of human receptors has come a transformation of receptor pharmacology. Thus the expression of human receptors into surrogate host cells helped unlock secrets of receptor mechanisms and stimulus-transduction pathways. To a large extent, this elim inates the leap of faith required to apply receptor activity of drugs tested on animal receptor systems to the human therapeutic arena. However, a new leap of faith concerning the veracity of the effects found in recombinant systems with respect to natural ones is now required.
