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The Immunology Of The Cat
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Book Synopsis The Immunology of the Cat by : Ian R Tizard
Download or read book The Immunology of the Cat written by Ian R Tizard and published by Elsevier. This book was released on 2024-09-01 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Immunology of the Cat makes available the first single-source, comprehensive review of the feline immune system, reporting on all immunologic aspects of diseases of the cat and its relatives and relating recent basic science to important clinical issues. The book opens with the evolution, domestication, and development of the cat then provides detailed information on immunity to infectious diseases, feline allergic diseases, the top feline autoimmune diseases, and feline immunodeficiencies. Content examines feline vaccines, hypersensitivity, cancer, nutrition, and the aged cat. Professionals in veterinary research and practice will appreciate complete information on all aspects of feline immunology in one essential resource. Introduces the first comprehensive review of feline immunology Links recent basic science to important clinical issues Provides detailed and current information in one resource
Book Synopsis Clinical Immunology of the Dog and Cat by : Michael Day
Download or read book Clinical Immunology of the Dog and Cat written by Michael Day and published by CRC Press. This book was released on 2011-11-28 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of a bestseller details the manifestations, diagnosis and treatment of immune-related disease in the dog and cat. It is illustrated throughout in full color, to show and explain to the reader as clearly as possible the complicated principles of disease and immunodiagnostic tests, supported by clinical cases, gross and histopatho
Book Synopsis Clinical Immunology of the Dog and Cat by : Michael Day
Download or read book Clinical Immunology of the Dog and Cat written by Michael Day and published by CRC Press. This book was released on 2011-11-28 with total page 935 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of a bestseller details the manifestations, diagnosis and treatment of immune-related disease in the dog and cat. It is illustrated throughout in full color, to show and explain to the reader as clearly as possible the complicated principles of disease and immunodiagnostic tests, supported by clinical cases, gross and histopatho
Book Synopsis Handbook of Vertebrate Immunology by : Paul-Pierre Pastoret
Download or read book Handbook of Vertebrate Immunology written by Paul-Pierre Pastoret and published by Academic Press. This book was released on 1998-05-21 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book provides a comprehensive and comparative guide to the immune systems of major vertebrate species, including domestic and wild animals of veterinary or medical interest, fish and amphibia. Data in this essential reference work has been compiled by world-renowned editors and an international group of authors. For each species, the information is presented in a structured 'user-friendly' format allowing easy cross reference and comparison between the various species. This book will be considered the definitive reference work on vertebrate immunology and will be essential for scientists and professionals working in Immunology, Vaccinology or with Animal Models, for students of Veterinary or Human Medicine, Biology and researchers in Comparative Medicine and Physiology. Each section, devoted to a major animal group covers: Lymphoid organs and their anatomical disposition Leukocytes and their markers Leukocyte traffic and associated molecules Cytokines T cell receptors Immunoglobulins MHC antigens Ontogeny of the immune system Passive transfer of immunity Neonatal immune responses Non-specific immunity Complement system Mucosal immunity Immunodeficiencies Tumours of the immune system Autoimmunity
Book Synopsis Feline Immunology and Immunodeficiency by : B. J. Willett
Download or read book Feline Immunology and Immunodeficiency written by B. J. Willett and published by . This book was released on 1995 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery of feline immunodeficiency virus (FIV) has heightened interest in feline immunology, with FIV emerging as an animal model for HIV infection in humans. Researchers in the AIDS field and veterinary researchers alike will find this compilation of state-of-the-art studies on the principal small animal model for AIDS essential reading. Willett and Jarrett provide a much needed overview of feline immunology and immunodeficiency. Subjects covered include basic immunology of the cat, including surface marker expression, the T-cell receptor, MHC, cytokines, and immunoglobulins. Many aspects of FIV pathogenesis are also covered including viral tropism, the effects of infection on the immune system, genomic structure and variation, epitope mapping of viral proteins, FIV-induced CTL, and vaccination against FIV infection. Researchers in the AIDS field and veterinary researchers alike will find this essential reading: it is a compilation of state-of-the-art studies on the principal small animal model for AIDS.
Book Synopsis Infectious Disease Management in Animal Shelters by : Lila Miller
Download or read book Infectious Disease Management in Animal Shelters written by Lila Miller and published by John Wiley & Sons. This book was released on 2011-11-16 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious Disease Management in Animal Shelters is a comprehensive guide to preventing, managing, and treating disease outbreaks in shelters. Emphasizing strategies for the prevention of illness and mitigation of disease, this book provides detailed, practical information regarding fundamental principles of disease control and specific management of important diseases affecting dogs and cats in group living environments. Taking an in-depth, population health approach, the text presents information to aid in the fight against the most significant and costly health issues in shelter care facilities.
Book Synopsis Veterinary Immunology by : Michael J. Day
Download or read book Veterinary Immunology written by Michael J. Day and published by CRC Press. This book was released on 2014-06-23 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Veterinary Immunology: Principles and Practice has become the adopted text in numerous veterinary schools throughout the world. Widely updated with advances in knowledge since 2011, this second edition reflects the rapid development in the field. The new edition presents expanded information on commonly used diagnostic test procedures and discusses
Book Synopsis Veterinary Immunology by : Michael J. Day
Download or read book Veterinary Immunology written by Michael J. Day and published by CRC Press. This book was released on 2010-08-15 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book accompanies and complements the teaching of immunology within the veterinary curriculum. It covers large and small animals, and provides clear learning objectives focusing on immunological principles while applying them to the disease process and to clinical practice. The book is case based and illustrated throughout in color.
Book Synopsis Feline Immunology by : Niels C. Pedersen
Download or read book Feline Immunology written by Niels C. Pedersen and published by . This book was released on 1998 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chimpanzees in Biomedical and Behavioral Research by : National Research Council
Download or read book Chimpanzees in Biomedical and Behavioral Research written by National Research Council and published by National Academies Press. This book was released on 2011-12-05 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.
Book Synopsis Day Clinical Immunology of Dog and Cat by : Granada Learning Limited
Download or read book Day Clinical Immunology of Dog and Cat written by Granada Learning Limited and published by . This book was released on 1999-01-01 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Clinical Medicine of the Dog and Cat by : Michael Schaer
Download or read book Clinical Medicine of the Dog and Cat written by Michael Schaer and published by CRC Press. This book was released on 2016-09-14 with total page 2216 pages. Available in PDF, EPUB and Kindle. Book excerpt: No other comprehensive small animal veterinary medicine book exists with a comparable amount of relevant illustrated material. This new third edition continues and expands on the revolutionary approach of the previous two editions, now including more than 1,850 highly valuable clinical colour photographs, diagrams, and tables. The book is now divided into five color-coded sections – General Approach, Disease of Specific Organ Systems, Multisystemic Disorders, Elements of Therapy and Case Studies. As with the first and second editions of this book the overriding principle of succinct, yet comprehensive text presented in a clear format with an abundance of good quality images remains. Section I: General Approach is completely new and covers medical history and client communication, and common clinical problems. Section II: Specific Organ Systems is organized by body system with chapters structured in a systematic manner that include the definition for each disorder, its causes, clinical features, differential diagnoses, diagnostic methodology, treatment and prognosis, providing readers with easy access to important clinical information. New to this section are chapters covering diseases of the oral cavity and teeth, approach to thoracic radiographs, approach to abdominal radiographs, and disorders of hemostasis. Section III: Multisystemic Disorders covers revised and updated chapters including clinical toxicology, infectious diseases, and immunologic disorders. Section IV: Elements of Therapy covers therapies such as fluid therapy, pain management, nutrition of the critically ill dog and cat and a new chapter on management of the obese dog or cat. Section V: Case Studies includes over 25 case studies that enable the reader to relate the knowledge gained in the book to clinical cases seen in practice. Written by board-certified experts with several case contributions by clinicians in advanced phases of resident training, topics were carefully selected to make this a valuable resource to the general practitioner and also to small animal interns and veterinary students.
Book Synopsis Peripheral and Placental Immunology in the Feline Immunodeficiency Virus (FIV)-infected Cat Model by : Crystal Elizabeth Boudreaux
Download or read book Peripheral and Placental Immunology in the Feline Immunodeficiency Virus (FIV)-infected Cat Model written by Crystal Elizabeth Boudreaux and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: We are using the feline immunodeficiency virus (FIV)-infected cat to model HIV mother-to-child-transmission (MTCT). Vertical transmission of either virus may result not only in infected offspring, but also failed pregnancy. In HIV infections, maternal hematological and virological parameters predict MTCT. We hypothesized that such parameters would likewise be predictors of FIV vertical transfer. We inoculated ten cats with FIV-B-2542; 10 cats were uninoculated. Cats were allowed to breed naturally. Fetuses were delivered at approximately week 3 (early) gestation by cesarean section. Fetal and placental tissues were collected. Blood samples were collected from the day of inoculation through delivery. We quantified CD4:CD8 T cell ratios, proviral load, and plasma viremia, and monitored seroreactivity to FIV proteins in longitudinal sera from both groups of cats. We documented clinical and reproductive outcome. The infected group produced reduced litter size and more failed pregnancies; CD4:CD8 ratios were depressed by 3.5 months p.i. Proviral DNA was detected in 14 of 14 (100%) placentas tested and 12 of 14 (86%) fetuses. However, the parameters assessed were not predictive of reproductive outcome and suggested a role for placental immunopathology in compromised pregnancy. Regulatory T cells (Treg) are anti-inflammatory and essential in maintaining pregnancy. Th17 cells are pro-inflammatory and associated with pregnancy failure. The activation of these cell populations is regulated by the cytokines TGF-[Beta] and IL-6. We hypothesized that placental immunology may result from altered dynamics of these cell populations. Using immunofluorescence confocal microscopy to measure Treg and Th17 markers FoxP3 and ROR[subscript Gamma], respectively, we quantified these cells in placental specimens from FIV-infected and control cats at early and late (week 8) gestation. Significantly higher levels of ROR[subscript Gamma] were measured in FIV-infected placentas at early pregnancy; these cells co-localized at the maternal-fetal interface. We quantified the expression of Treg immunomodulators by quantitative PCR, noting higher expression of TGF-[Beta] in infected queens. A positive correlation of ROR[subscript Gamma] with IL-6 occurred in control placentas, as predicted, but not in infected placentas. Collectively, the data suggest that an inflammatory placental microenvironment at early pregnancy in infected queens may result, in part, from dysregulation of the Treg/Th17 balance.
Book Synopsis Feline Mucosal Immunity by : Araya Radtanakatikanon
Download or read book Feline Mucosal Immunity written by Araya Radtanakatikanon and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cat is of importance to humans as a pet as well as a large animal model for the study of host-pathogen interactions as well as immunopathology disorders. Similar to the human, lymphoma is the most common hematopoietic tumor in cat and epitheliotropic intestinal T cell lymphoma has been found to resemble the WHO type II enteropathy-associated T-cell lymphoma in humans. Although, the cat holds potential as an immunological animal model, integrative study of feline T cell was limited, and identification of T cell lineage/subpopulation was restricted due to the lack of specific antibodies. The recent release of a high-quality feline genome assembly coupled with a more approachable high-throughput sequencing technique provide a basis for the studying of antigen receptor gene loci in cats. The research outcome would benefit the use of cats as a model for spontaneous diseases and contribute to feline health. The primary scope of this dissertation research was to broaden the knowledge of feline mucosal immunity by investigating T cell receptor locus structure and expressed repertoire, developing T cell clonalities and analysis of novel lymphocyte populations. The following three objectives were discussed: 1) characterization of the genomic organization and expressed repertoire of the feline T cell receptor alpha/delta (TRA/TRD), beta (TRB) and gamma (TRG) loci; 2) development of clonality assays for feline T cell lymphoma; 3) identification of Fe7.3D12 antibody binding protein expressed on feline intestinal intraepithelial lymphocytes. To study the structure of feline TR genes, we employed a Hidden Markov Model and blastn-based approaches to comprehensively identify TRA/TRD, TRB and TRG germline genes on the Felis_catus_9.0 assembly. High-throughput sequencing was used to access the expressed repertoire in normal lymphoid organs. Gene nomenclature and functionality in this study was approved by the international immunogenetics information system (IMGT). The feline TRG locus contains 7 TRGV, 12 TRGJ and 6 TRGC, the TRB locus contains 32 TRBV, 2 TRBD, 10 TRBJ and 2 TRBC genes and the TRA/TRD locus contains 60 TRAV, 63 TRAJ, 1 TRAC, 11 TRDV, 2 TRDD, 4 TRDJ and 1 TRDC genes. The genomic organization of the feline TR loci was similar to the previously described gnathostomata with the exception of the feline TRG locus which was organized in 5 complete and 1 incomplete V-J-(J)-C cassettes. Functional feline T cell receptor V genes formed monophyletic clades with their orthologs and were subjected to the birth-and-death model of evolution. Expressed repertoire analyses showed a biased V/J usage mainly in the TRG and TRD loci. In addition to the understanding of feline TR gene topology and expressed repertoire benefit to future research on feline medicine and translational studies on immunopathology diseases in human, this data will also facilitate the development and improvement of molecular diagnostic tests for lymphoproliferative disorders, a common diseases in domestic cats. Molecular clonality assays have been used as an adjunctive test for the diagnosis of lymphoma when histopathological assessment is inconclusive. However, the assays occasionally yield false negative results and the target TR gene assessment is restricted only to the TRG locus. To improve the sensitivity of feline T cell clonality assays, we employed knowledge of topology and expressed repertoire of feline T cell receptor loci obtained from previous studies to develop new clonality assays targeting multiple TR loci. Three novel multiplex clonality assays targeting TRG, TRD and TRB loci were successfully optimized and 6 TRG primers, 5 TRD primers and 27 TRB primers were multiplexed in one reaction tube per locus. New multiplex clonality assays and the original singleplex TRG assay were validated on series of neoplastic and non-neoplastic lymphoid tissues. In testing phase, the TRG and TRD primer sets were able to detect rare rearrangement utilized by invariant T lymphocyte population in both normal and diseased livers. The primers which recognized the canonical rearrangement were omitted to avoid false positivity. The invariant T lymphocyte population residing in liver will be further investigated. The multiplex TRG assay yielded the highest sensitivity (95.5%) and the multiplex TRD assay yielded the lowest sensitivity (62.9%). All assays yielded 100% specificity except for the multiplex TRG assay (97.3%). The combination of the multiplex TRG and TRB assays yielded the highest sensitivity (98.9%) and specificity (97.0%). We recommend performing this combination of multiple gene target clonality assays to increase the overall sensitivity and specificity for the diagnosis of feline T-cell lymphomas. Intraepithelial lymphocytes (IELs) are exclusively comprised of T lymphocyte populations that function in both mucosal immunity and inflammation-induced pathology. In the development of antibodies to feline (GlcNAc)6 integrin (CD103), an antibody (Ab) clone designated Fe7.3D12 (3D12) was generated. The IELs expressing the 3D12-binding molecule exhibited potential regulatory function and a high incidence of 3D12 positivity in feline epitheliotropic T cell lymphoma was also observed. This dissertation chapter objective was to identify this molecule for further characterization of IEL subpopulations and potentially elucidate intestinal mucosal immunopathology. In this effort, Protein lysates from feline IELs were immunoprecipitated (IP) using 3D12 conjugated magnetic beads. Mass spectrometry revealed that the best match for the 3D12 binding protein was a previously uncharacterized 30.8 KDa protein (Uniprot: M3X555) containing a predicted transmembrane domain at amino acid residues 56-78 and a predicted C-type lectin domain at amino acid residues 133-274. The M3X555 protein is encoded by an uncharacterized gene (Ensembl: ENSFCAG00000025057) that has 63.0% homology with the killer cell lectin-like receptor family J member 1 (KLRJ, Ly49) gene of Bos Taurus. The M3X555 protein was successfully expressed on HEK293 cells and confirmed by immunofluorescence and WB using 3D12 Ab. The relationship to the Natural Killer (NK) cell gene complex and homology with C-type lectin-like receptors expressed by NK cells and cytotoxic T-cells are indicative of a probable biological significance. Thus, the membrane protein recognized by 3D12 Ab is likely associated with IEL biology and possibly in the pathogenesis of feline intestinal T cell lymphoma. Conclusion of this dissertation research has extended the knowledge of feline mucosal immunology by providing a large-scale dataset of T cell receptor genes and expressed repertoire. This comprehensive data has facilitated the development of clonality assays with high sensitivity that can be used for both the diagnosis of feline T cell lymphomas and the investigation of feline T cell population and neoplasms.
Book Synopsis Arthropod-borne Infectious Diseases of the Dog and Cat by : Michael J. Day
Download or read book Arthropod-borne Infectious Diseases of the Dog and Cat written by Michael J. Day and published by CRC Press. This book was released on 2016-04-21 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is an invaluable resource for information on the clinical presentation, pathogenesis, diagnosis and treatment of major arthropod-transmitted diseases of dogs and cats. Illustrated in colour throughout, the book incorporates photographs of clinical cases, haematology, cytology and gross and microscopic pathology, which help understand the diagnosis and treatment of these diseases. The book goes beyond just covering the diseases themselves and also provides information on the arthropods that transmit them. With the effects of climate change and increasing international pet travel, this book will be a valuable addition to every small animal practitioner's library.
Book Synopsis The Neurobiological Basis of Suicide by : Yogesh Dwivedi
Download or read book The Neurobiological Basis of Suicide written by Yogesh Dwivedi and published by CRC Press. This book was released on 2012-06-25 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.
Book Synopsis Primer to the Immune Response by : Tak W. Mak
Download or read book Primer to the Immune Response written by Tak W. Mak and published by Newnes. This book was released on 2013-12-23 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written in the same engaging conversational style as the acclaimed first edition, Primer to The Immune Response, 2nd Edition is a fully updated and invaluable resource for college and university students in life sciences, medicine and other health professions who need a concise but comprehensive introduction to immunology. The authors bring clarity and readability to their audience, offering a complete survey of the most fundamental concepts in basic and clinical immunology while conveying the subject’s fascinating appeal. The content of this new edition has been completely updated to include current information on all aspects of basic and clinical immunology. The superbly drawn figures are now in full color, complemented by full color plates throughout the book. The text is further enhanced by the inclusion of numerous tables, special topic boxes and brief notes that provide interesting insights. At the end of each chapter, a self-test quiz allows students to monitor their mastery of major concepts, while a set of conceptual questions prompts them to extrapolate further and extend their critical thinking. Moreover, as part of the Academic Cell line of textbooks, Primer to The Immune Response, 2nd Edition contains research passages that shine a spotlight on current experimental work reported in Cell Press articles. These articles also form the basis of case studies that are found in the associated online study guide and are designed to reinforce clinical connections. Complete yet concise coverage of the basic and clinical principles of immunology Engaging conversational writing style that is to the point and very readable Over 200 clear, elegant color illustrations Comprehensive glossary and list of abbreviations
