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The Histone Code And Beyond
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Book Synopsis The Histone Code and Beyond by : Shelley L. Berger
Download or read book The Histone Code and Beyond written by Shelley L. Berger and published by Springer Science & Business Media. This book was released on 2007-01-19 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.
Book Synopsis The Histone Code and Beyond by : Shelley L. Berger
Download or read book The Histone Code and Beyond written by Shelley L. Berger and published by Springer. This book was released on 2009-09-02 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.
Book Synopsis Beyond Mechanism by : Brian G. Henning
Download or read book Beyond Mechanism written by Brian G. Henning and published by Rowman & Littlefield. This book was released on 2013 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: It has been said that new discoveries and developments in the human, social, and natural sciences hang "in the air" (Bowler, 1983; 2008) prior to their consummation. While neo-Darwinist biology has been powerfully served by its mechanistic metaphysic and a reductionist methodology in which living organisms are considered machines, many of the chapters in this volume place this paradigm into question. Pairing scientists and philosophers together, this volume explores what might be termed "the New Frontiers" of biology, namely contemporary areas of research that appear to call an updating, a supplementation, or a relaxation of some of the main tenets of the Modern Synthesis. Such areas of investigation include: Emergence Theory, Systems Biology, Biosemiotics, Homeostasis, Symbiogenesis, Niche Construction, the Theory of Organic Selection (also known as "the Baldwin Effect"), Self-Organization and Teleodynamics, as well as Epigenetics. Most of the chapters in this book offer critical reflections on the neo-Darwinist outlook and work to promote a novel synthesis that is open to a greater degree of inclusivity as well as to a more holistic orientation in the biological sciences.
Book Synopsis Beyond Sex Differences by : Barry Keverne
Download or read book Beyond Sex Differences written by Barry Keverne and published by Cambridge University Press. This book was released on 2017-09-07 with total page 233 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the evolutionary lead taken by the matriline in providing the intergenerational co-adaptations required for successful pregnancy.
Book Synopsis Looking Beyond Pattern Recognition: Perturbations in Cellular Homeostasis and Metabolism as Emerging Regulators of Dendritic Cell Function by : Fabiola Osorio
Download or read book Looking Beyond Pattern Recognition: Perturbations in Cellular Homeostasis and Metabolism as Emerging Regulators of Dendritic Cell Function written by Fabiola Osorio and published by Frontiers Media SA. This book was released on 2019-12-09 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Metaphors and Analogies in Sciences and Humanities by : Shyam Wuppuluri
Download or read book Metaphors and Analogies in Sciences and Humanities written by Shyam Wuppuluri and published by Springer Nature. This book was released on 2022-05-30 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this highly-interdisciplinary volume, we systematically study the role of metaphors and analogies in (mis)shaping our understanding of the world. Metaphors and Analogies occupy a prominent place in scientific discourses, as they do in literature, humanities and at the very level of our thinking itself. But when misused they can lead us astray, blinding our understanding inexorably. How can metaphors aid us in our understanding of the world? What role do they play in our scientific discourses and in humanities? How do they help us understand and skillfully deal with our complex socio-political scenarios? Where is the dividing line between their use and abuse? Join us as we explore some of these questions in this volume.
Book Synopsis Cognition Beyond the Brain by : Stephen J. Cowley
Download or read book Cognition Beyond the Brain written by Stephen J. Cowley and published by Springer. This book was released on 2017-03-28 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book challenges neurocentrism by advocating a systemic view of cognition based on investigating how action shapes the experience of thinking, placing interactivity at its heart. This systemic viewpoint makes three main claims. First, that many elaborate cognitive skills like language, problem solving and human-computer interaction (HCI) are based in sense-saturated coordination or interactivity. Second, interactivity produces a tightly woven scaffold of resources, some internal to the agent and others external, that elevates and transforms thinking. Third, human agents entwine brains, bodies and their surroundings as they manage multi-scalar dynamics. This new edition continues to demonstrate how a systemic perspective casts a productive light on thinking in applied domains such as crime scene analysis, the use of information technology in construction, and computer-meditated trusts and presents new studies on the cognitive ecology of the web, multi-scalar temporal and organisational cognition and the importance of interactive material engagement in digital architecture. Authors use various scales of the systemic viewpoint to illustrate how bodies and artefacts shape thinking, but in all cases the experience of materiality is meshed with activity that involves the world beyond the body. Cognition Beyond the Brain is a valuable reference for researchers, practitioners and graduate students within the fields of Computer Science, Psychology, Linguistics and Cognitive Sciences.
Book Synopsis Codes and Evolution by : Marcello Barbieri
Download or read book Codes and Evolution written by Marcello Barbieri and published by Springer Nature. This book was released on with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Proteins in Eukaryotic Transcription by :
Download or read book Proteins in Eukaryotic Transcription written by and published by Elsevier. This book was released on 2004-03-19 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Transcription is a key element of cellular and organ regulation. Proteins in Eukaryotic Transcription covers structure and function of all major elements associated with transcription. Mechanism of RNA polymerase I Transcription Structure and function of RNA Polymerase II Structure and function of the TFIID complex Functional properties of Chromatin Remodeling Enzymes Posttranslational modification
Book Synopsis The DNA, RNA, and Histone Methylomes by : Stefan Jurga
Download or read book The DNA, RNA, and Histone Methylomes written by Stefan Jurga and published by Springer Nature. This book was released on 2019-08-28 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the chemical, regulatory, and physiological mechanisms of protein arginine and lysine methyltransferases, as well as nucleic acid methylations and methylating enzymes. Protein and nucleic acid methylation play key and diverse roles in cellular signalling and regulating macromolecular cell functions. Protein arginine and lysine methyltransferases are the predominant enzymes that catalyse S-adenosylmethionine (SAM)-dependent methylation of protein substrates. These enzymes catalyse a nucleophilic substitution of a methyl group to an arginine or lysine side chain nitrogen (N) atom. Cells also have additional protein methyltransferases, which target other amino acids in peptidyl side chains or N-termini and C-termini, such as glutamate, glutamine, and histidine. All these protein methyltransferases use a similar mechanism. In contrast, nucleic acids (DNA and RNA) are substrates for methylating enzymes, which employ various chemical mechanisms to methylate nucleosides at nitrogen (N), oxygen (O), and carbon (C) atoms. This book illustrates how, thanks to there ability to expand their repertoire of functions to the modified substrates, protein and nucleic acid methylation processes play a key role in cells.
Book Synopsis Ontogenesis Beyond Complexity by : Cary Wolfe
Download or read book Ontogenesis Beyond Complexity written by Cary Wolfe and published by Routledge. This book was released on 2021-12-27 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based upon the collaborative efforts of the Ontogenetics Process Group (OPG) – an interdisciplinary, multi-institutional, multi-national research group that began meeting in 2017 to explore new and innovative ways of thinking the problem of complexity in living, physical, and social systems outside the algorithmic models that have dominated paradigms of complexity to date. For all the descriptive and predictive power that the complexity sciences offer (the ability to compute feedback systems, recursive networks, emergent dynamics, etc.), they also presume that the living world in all of its modalities (biological, semiotic, economic, affective, social) can be reduced to finite schema of description that delimits in advance all possible outcomes. What is proposed in this volume are conceptual architectures for the living that are not only irreducible to physico-mathematical frames of reference, but that are also as vital as the phenomena they wish to express. In short: life is more complex than complexity. What emerges from this engagement is not the ascendance of a new transcendental principle (or, what amounts to the same thing, a foundational bedrock) derived from the physico-mathematical sciences, but just the opposite: a domain in which the ontological and the epistemological domains enter a zone of strange (and unavoidable) entanglement. The chapters in this book were originally published as a special issue of Angelaki.
Book Synopsis Beyond Histocompatibility – Understanding the Non-MHC Determinants Shaping Transplantation Outcome and Tolerance Induction by : Heth Roderick Turnquist
Download or read book Beyond Histocompatibility – Understanding the Non-MHC Determinants Shaping Transplantation Outcome and Tolerance Induction written by Heth Roderick Turnquist and published by Frontiers Media SA. This book was released on 2021-10-22 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Targeting DNA Repair and the DNA Damage Response: Beyond the Standard PI3 Kinase-like Kinases by : John J. Turchi
Download or read book Targeting DNA Repair and the DNA Damage Response: Beyond the Standard PI3 Kinase-like Kinases written by John J. Turchi and published by Frontiers Media SA. This book was released on 2022-11-09 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis AR Signaling in Human Malignancies: Prostate Cancer and Beyond by : Emmanuel S. Antonarakis
Download or read book AR Signaling in Human Malignancies: Prostate Cancer and Beyond written by Emmanuel S. Antonarakis and published by MDPI. This book was released on 2018-03-23 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "AR Signaling in Human Malignancies: Prostate Cancer and Beyond" that was published in Cancers
Book Synopsis The Mysterious Epigenome by : Thomas Woodward
Download or read book The Mysterious Epigenome written by Thomas Woodward and published by Kregel Publications. This book was released on 2011-12-01 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this creative and inventive treatment, authors Thomas E. Woodward and James P. Gills take readers on an exploration of the human epigenome. Acting as tour guides leading visitors through a 3-D model of a human cell, Woodward and Gills bring to life the human molecular makeup. Readers (as visitors) will get up close and personal with the minute details of human molecular structure, including E. coli, flagellum, a DNA helix, an RNA molecule, and more. By seeing it with their own eyes, readers will gain a better understanding of their genetic systems and a better appreciation for the Creator who put this all into place.
Book Synopsis The Codes of Life by : Marcello Barbieri
Download or read book The Codes of Life written by Marcello Barbieri and published by Springer Science & Business Media. This book was released on 2007-10-26 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building on a range of disciplines – from biology and anthropology to philosophy and linguistics – this book draws on the expertise of leading names in the study of organic, mental and cultural codes brought together by the emerging discipline of biosemiotics. The volume represents the first multi-authored attempt to deal with the range of codes relevant to life, and to reveal the ubiquitous role of coding mechanisms in both organic and mental evolution.
Download or read book Information written by Werner Gitt and published by New Leaf Publishing Group. This book was released on 2023-09-06 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Go Beyond the Boundary of Science and Discover the Divine Source of Universal Information Consider the complexity of information within our bodies and all other life on this planet, deliberately programmed into us by a powerful, all-knowing God. Engineer and author Dr. Werner Gitt has created a compelling argument in the evolution vs. creation debate with a groundbreaking technical exploration of the Theory of Universal Information. He refutes the worldview in which matter or energy is the sole entity and cause for everything. Lays out the scientific logic for an alternate worldview in which a purposeful Creator God is the best and only rational alternative. Understand the true definition and source of information found within life Discover what can be learned just from the magnificent coding system found in the DNA/RNA system containing the richest source of information known to mankind as well as an incredibly complex, perfectly integrated molecular infrastructure to implement this information
