The Haemodynamic Effects Of Nitric Oxide

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The Haemodynamic Effects of Nitric Oxide

Author : Robert T Mathie
Publisher : World Scientific
ISBN 13 : 1783262478
Total Pages : 540 pages
Book Rating : 4.7/5 (832 download)

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Book Synopsis The Haemodynamic Effects of Nitric Oxide by : Robert T Mathie

Download or read book The Haemodynamic Effects of Nitric Oxide written by Robert T Mathie and published by World Scientific. This book was released on 1999-08-30 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of nitric oxide as an endothelium-derived relaxing factor in 1987, investigations on its precise modes of action have been carried out at an extraordinary rate. Nitric oxide is now implicated in many physiological and pathological processes — not just in the control of vascular resistance, but in nerve transmission, cell proliferation, inflammatory responses and so on. Despite such rapid progress, no attempt has been made to combine the current knowledge of this subject matter in a single textbook. This volume has been written with the above in mind and presents a topical, comprehensive overview of the biochemistry and the physiological and pathophysiological effects of nitric oxide as they relate to the cardiovascular system. The therapeutic implications of nitric oxide are also considered. The text comprises contributions from many of the leading international authorities on the topic including Professor L J Ignarro, winner of the 1998 Nobel Prize in Physiology or Medicine. Contents:Physiology and Biochemistry of Nitric Oxide:Chemistry and Molecular Biology of Nitric Oxide Synthesis (A J Hobbs & L J Ignarro)Nitric Oxide Synthases Biology: Insights Gained from ‘Knockout’ Mice (A Papapetropoulos et al.)Inhibitors of Nitric Oxide Biosynthesis (G J Southan et al.)Peripheral Vascular Effects of Nitric Oxide:The Role of Nitric Oxide in Cerebrovascular Regulation and Stroke (C Iadecola)The Physiological and Pathophysiological Effects of Nitric Oxide in the Coronary Circulation (P Groves)The Effect of Nitric Oxide on Myocardial Function and Dysfunction (B D Prendergast & A M Shah)Clinical Implications of Nitric Oxide:Oxidative Tissue Injury, Nitric Oxide and Atherosclerosis (R P Patel et al.)Endothelial Dysfunction Associated with Cardiovascular Disease and Transplantation (G J Dusting & A M Dart)The Role and Therapeutic Implications of Nitric Oxide in Systemic Hypertension (P Forte & N Benjamin)and other papers Readership: Students and researchers in physiology, biochemistry and clinical methods/ laboratory medicine. Keywords:Endothelium;Vascular Smooth Muscle;Nitric Oxide Synthase;Nitrovasodilator;Shear Stress;Atherosclerosis;Hypertension;Septic Shock;Microcirculation;Coronary Circulation;Cerebal Circulation;Renal Circulation;Hepatic Circulation;Intestinal Circulation

The Cerebral Circulation

Author : Marilyn J. Cipolla
Publisher : Biota Publishing
ISBN 13 : 1615047239
Total Pages : 82 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis The Cerebral Circulation by : Marilyn J. Cipolla

Download or read book The Cerebral Circulation written by Marilyn J. Cipolla and published by Biota Publishing. This book was released on 2016-07-28 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: This e-book will review special features of the cerebral circulation and how they contribute to the physiology of the brain. It describes structural and functional properties of the cerebral circulation that are unique to the brain, an organ with high metabolic demands and the need for tight water and ion homeostasis. Autoregulation is pronounced in the brain, with myogenic, metabolic and neurogenic mechanisms contributing to maintain relatively constant blood flow during both increases and decreases in pressure. In addition, unlike peripheral organs where the majority of vascular resistance resides in small arteries and arterioles, large extracranial and intracranial arteries contribute significantly to vascular resistance in the brain. The prominent role of large arteries in cerebrovascular resistance helps maintain blood flow and protect downstream vessels during changes in perfusion pressure. The cerebral endothelium is also unique in that its barrier properties are in some way more like epithelium than endothelium in the periphery. The cerebral endothelium, known as the blood-brain barrier, has specialized tight junctions that do not allow ions to pass freely and has very low hydraulic conductivity and transcellular transport. This special configuration modifies Starling's forces in the brain microcirculation such that ions retained in the vascular lumen oppose water movement due to hydrostatic pressure. Tight water regulation is necessary in the brain because it has limited capacity for expansion within the skull. Increased intracranial pressure due to vasogenic edema can cause severe neurologic complications and death.

Organic Nitrates

Author : P. Needleman
Publisher : Springer Science & Business Media
ISBN 13 : 364266024X
Total Pages : 206 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Organic Nitrates by : P. Needleman

Download or read book Organic Nitrates written by P. Needleman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief from the chest pain that frequently occurs as a manifestation of disease of the coronary arteries. The empirical observation of the safe use of nitrates for tile alleviation of the symptoms of angina have led to their widespread medical acceptance. The use of organic nitrates preceded any knowledge of their mechanism of action or their ultimate metabolic fate. Thus, more simply stated, although sub lingual nitrates helped the patients, little was known concerning what these drugs do to the body or what the body does to the drugs. A substantial number of investigators have focused on these questions especially during the last two decades. We now have considerably more insight into the pathways of degradation of organic nitrates and the relationship of the metabolic processes to the biological action of these agents. Similarly, considerable effort has been expended in understanding the mechanism of action of these agents directly on vascular smooth muscle and on cardiac work and performance. Finally, there is a more substantive understanding of the physiology of the coronary circulation as well as the" pathophysiologic manifestations of myocardial disease.

The Role of Nitric Oxide in Heart Failure

Author : Bodh I. Jugdutt
Publisher : Springer Science & Business Media
ISBN 13 : 1402079605
Total Pages : 248 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis The Role of Nitric Oxide in Heart Failure by : Bodh I. Jugdutt

Download or read book The Role of Nitric Oxide in Heart Failure written by Bodh I. Jugdutt and published by Springer Science & Business Media. This book was released on 2007-05-08 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on nitric oxide (NO) is a very hot topic since 1998, when three prominent researchers were recognized by Nobel prize awards. Addresses clinically pertinent issues related to nitric oxide in the pathophysiology and therapeutics of heart failure. Chapters written by basic scientists and clinicians to emphasize translation character of research in nitric oxide. An excellent reference source for researchers, practitioners and students.

Signal Transduction and the Gasotransmitters

Author : Rui Wang
Publisher : Springer Science & Business Media
ISBN 13 : 1592598064
Total Pages : 372 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Signal Transduction and the Gasotransmitters by : Rui Wang

Download or read book Signal Transduction and the Gasotransmitters written by Rui Wang and published by Springer Science & Business Media. This book was released on 2004-06-11 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gasotransmitters-principally nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)-are endogenous signaling molecules that play a significant role in the biomedical, clinical, and health sciences, as well as in population health studies. In Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine, a panel of distinguished researchers and clinicians review the biological and biomedical aspects of gasotransmitters, emphasizing their signaling transduction mechanisms in general, and ion channel regulation in particular. The authors discuss the endogeneous metabolism and regulation of gasotransmitters, their toxicological profiles and biological actions, and their interactions in terms of their production and effects. The physiological roles of NO, CO, and H2S in the regulation of the cardiovascular, neuronal, and gastrointestinal systems, as well as of cell metabolism, are also reviewed, along with the interaction of the gastrotransmitters with KATP,KCa voltage-gated Ca2+, voltage-gated Na+, and cyclic nucleotide-gated ion channels. Included in the array of different mechanisms for the interaction of NO, CO, and H2S are channel phosphorylation, S-nitrosylation, carboxylation, sulfuration, and altered cellular redox status. The authors also offer guidance and suggestions for exploring and further characterizing other still unknown gasotransmitters. Authoritative and comprehensive, Signal Transduction and the Gasotransmitters: NO, CO, and H2S in Biology and Medicine offers clinical scientists and physicians not only a deeper understanding, but also a cutting-edge review, of the critically important field of gasotransmitter biology and medicine.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1796 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1796 pages. Available in PDF, EPUB and Kindle. Book excerpt:

The Effects of Nitric Oxide Inhibition on Anesthetic Requirements and Hemodynamics in Swine

Author : Patricia Ellen Balding
Publisher :
ISBN 13 :
Total Pages : 228 pages
Book Rating : 4.:/5 ( download)

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Book Synopsis The Effects of Nitric Oxide Inhibition on Anesthetic Requirements and Hemodynamics in Swine by : Patricia Ellen Balding

Download or read book The Effects of Nitric Oxide Inhibition on Anesthetic Requirements and Hemodynamics in Swine written by Patricia Ellen Balding and published by . This book was released on 1994 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Diabetes and Cardiovascular Disease

Author : Michael T. Johnstone
Publisher : Springer Science & Business Media
ISBN 13 : 1592599087
Total Pages : 645 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Diabetes and Cardiovascular Disease by : Michael T. Johnstone

Download or read book Diabetes and Cardiovascular Disease written by Michael T. Johnstone and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cause of diabetes mellitus is metabolic in origin. However, its major clinical manifestations, which result in most of the morbidity and mortality, are a result of its vascular pathology. In fact, the American Heart Association has recently stated that, “from the point of view of cardiovascular medicine, it may be appropriate to say, diabetes is a cardiovascular disease” (1). But diabetic vascular disease is not limited to just the macrovasculature. Diabetes mellitus also affects the microcirculation with devastating results, including nephropathy, neuropathy, and retinopathy. Diabetic nephropathy is the leading cause of end-stage renal disease in the United States, while diabetic retinopathy is the leading cause of new-onset blindness in working-age Americans. The importance of this text on Diabetes and Cardiovascular Disease is evident by the magnitude of the population affected by diabetes mellitus. Over 10 million Americans have been diagnosed with diabetes mellitus, while another 5 million remain undiagnosed. The impact from a public health perspective is huge and increasing. As the population of the United States grows older, more sedentary, and obese, the risk of developing diabetes and its complications will increase. Epidemiological studies have identified diabetes mellitus as a major independent risk factor for cardiovascular disease. Over 65% of patients with diabetes mellitus die from a cardiovascular cause. The prognosis of patients with diabetes mellitus who develop overt clinical cardiovascular disease is much worse than those cardiovascular patients free of diabetes mellitus.

Textbook of Clinical Hemodynamics

Author : Michael Ragosta
Publisher : Elsevier Health Sciences
ISBN 13 : 1416040005
Total Pages : 264 pages
Book Rating : 4.4/5 (16 download)

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Book Synopsis Textbook of Clinical Hemodynamics by : Michael Ragosta

Download or read book Textbook of Clinical Hemodynamics written by Michael Ragosta and published by Elsevier Health Sciences. This book was released on 2008-01-01 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Here's a source of guidance on the analysis of the hemodynamic waveforms generated in the cardiac catheterization lab. It progresses from a review of basic monitoring principles and normal waveforms through an assessment of the waveform data associated with the full range of individual coronary diseases, providing the assistance needed to accurately interpret any findings encountered in practice. Its extremely clinically oriented approach makes it an ideal hands-on tool for any clinician involved in diagnosing cardiac problems using interventional cardiology.

Blumgart's Surgery of the Liver, Biliary Tract and Pancreas, 2-Volume Set - E-Book

Author : William R. Jarnagin
Publisher : Elsevier Health Sciences
ISBN 13 : 0323697852
Total Pages : 2486 pages
Book Rating : 4.3/5 (236 download)

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Book Synopsis Blumgart's Surgery of the Liver, Biliary Tract and Pancreas, 2-Volume Set - E-Book by : William R. Jarnagin

Download or read book Blumgart's Surgery of the Liver, Biliary Tract and Pancreas, 2-Volume Set - E-Book written by William R. Jarnagin and published by Elsevier Health Sciences. This book was released on 2022-09-13 with total page 2486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Balancing basic science with information on everyday clinical practice, Blumgart's Surgery of the Liver, Biliary Tract and Pancreas, 7th Edition, provides you with expert guidance and advances in the field so you can offer patients the most optimal diagnostic and surgical care. In two convenient volumes, Dr. William Jarnagin and his team of internationally recognized surgeons cover exactly what you need to know, including advances in diagnostic and surgical techniques, minimally invasive surgeries, new interventional diagnostic techniques, and all relevant diseases. This comprehensive, practical reference is designed to help you choose and perform the most appropriate procedures that will minimize inpatient hospital time, curtail costs, and reduce overall recovery time for your patients. Presents cutting-edge guidance on pathology, diagnostics, surgery and non-operative intervention of the liver, biliary tract, and pancreas in one highly regarded, authoritative reference. Covers all surgical approaches, both open and minimally invasive. Considers all worldwide opinions and approaches to management, and includes key data on surgical outcomes to better inform clinical decision-making. Contains 161 chapters with updated references and additional figures—more than 1,500 illustrations in all. The imaging section has been reorganized to reflect a disease-based approach. Includes new and expanded sections on advances in molecular characterization of benign and malignant HPB diseases, perioperative management, interventional techniques, minimally invasive surgery and robotics, and therapeutic advances for malignant disease. Features a section dedicated entirely to operative technique, plus a new historical chapter authored by Professor Jacques Belghitti: “Hepatobiliary and Pancreatic Surgery: Historical Perspective.

Vascular Innervation and Receptor Mechanisms

Author : Rolf Uddman
Publisher : Academic Press
ISBN 13 : 0323148077
Total Pages : 498 pages
Book Rating : 4.3/5 (231 download)

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Book Synopsis Vascular Innervation and Receptor Mechanisms by : Rolf Uddman

Download or read book Vascular Innervation and Receptor Mechanisms written by Rolf Uddman and published by Academic Press. This book was released on 2012-12-02 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular Innervation and Receptor Mechanisms: New Perspectives reviews the areas of structure, function, and pathophysiology of the circulatory system. The text focuses on the role of neuropeptides and structural function of endothelium. The book begins with a brief discussion on the background of autonomic and sensory nerves in the circulatory system, which is provided in Chapter 1. Having established the basic studies in the circulatory system, the book moves to the discussion on the analysis of peptidergic innervations and peptides in vascular control in various disorders. The last part of the book features the clinical applications of neuropeptides, perivascular peptides, and vasoactive peptides in different diseases and regulation, such as cardiovascular regulation, hypertension, congestive heart failure, and migraine and cluster headache. The text will be a good reference to both students and professionals in the fields of biology, chemistry, and medicine.

Yearbook of Intensive Care and Emergency Medicine 2001

Author : Prof. Jean-Louis Vincent
Publisher : Springer Science & Business Media
ISBN 13 : 3642594670
Total Pages : 721 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Yearbook of Intensive Care and Emergency Medicine 2001 by : Prof. Jean-Louis Vincent

Download or read book Yearbook of Intensive Care and Emergency Medicine 2001 written by Prof. Jean-Louis Vincent and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: The yearbook compiles the most recent, widespread developments of experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

How Tobacco Smoke Causes Disease

Author :
Publisher :
ISBN 13 :
Total Pages : 728 pages
Book Rating : 4.:/5 (318 download)

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Book Synopsis How Tobacco Smoke Causes Disease by :

Download or read book How Tobacco Smoke Causes Disease written by and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.

Nunn's Applied Respiratory Physiology

Author : John F. Nunn
Publisher : Butterworth-Heinemann
ISBN 13 : 1483292053
Total Pages : 681 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Nunn's Applied Respiratory Physiology by : John F. Nunn

Download or read book Nunn's Applied Respiratory Physiology written by John F. Nunn and published by Butterworth-Heinemann. This book was released on 1993-10-04 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nunn's Applied Respiratory Physiology.

The ESC Textbook of Cardiovascular Medicine

Author : A. John Camm
Publisher :
ISBN 13 : 9780198824879
Total Pages : 3198 pages
Book Rating : 4.8/5 (248 download)

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Book Synopsis The ESC Textbook of Cardiovascular Medicine by : A. John Camm

Download or read book The ESC Textbook of Cardiovascular Medicine written by A. John Camm and published by . This book was released on 2019 with total page 3198 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Maternal Hemodynamics

Author : Christoph Lees
Publisher : Cambridge University Press
ISBN 13 : 1107157374
Total Pages : 281 pages
Book Rating : 4.1/5 (71 download)

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Book Synopsis Maternal Hemodynamics by : Christoph Lees

Download or read book Maternal Hemodynamics written by Christoph Lees and published by Cambridge University Press. This book was released on 2018-05-03 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover new concepts in cardiovascular and hemodynamic functionality in feto-maternal medicine, from leading experts in the field.

Pediatric Cardiac Anesthesia

Author : Carol L. Lake
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 9780781751759
Total Pages : 820 pages
Book Rating : 4.7/5 (517 download)

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Book Synopsis Pediatric Cardiac Anesthesia by : Carol L. Lake

Download or read book Pediatric Cardiac Anesthesia written by Carol L. Lake and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long established as the #1 reference on pediatric cardiac anesthesia, this definitive text is now in its thoroughly revised Fourth Edition. The book provides comprehensive guidelines on preoperative evaluation, perioperative management, and postoperative care for all pediatric cardiac surgical procedures and includes quick-reference summaries of perioperative management for each procedure. For this edition, Dr. Lake is joined by an eminent British co-editor, Peter D. Booker, and an international group of distinguished contributors. Coverage includes cutting-edge information on echocardiography, fast tracking, and the newest surgical techniques. New chapters cover teaching, practice management, anesthesia for cardiac MIS, and hemostasis, coagulation, and transfusion.