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Author :
Publisher :
ISBN 13 : 9780948926129
Total Pages : 54 pages
Book Rating : 4.9/5 (261 download)
Download or read book The Fitness for Purpose of Analytical Methods written by and published by . This book was released on 1998-01-01 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Chris Burgess
Publisher : Royal Society of Chemistry
ISBN 13 : 1847552285
Total Pages : 98 pages
Book Rating : 4.8/5 (475 download)
Download or read book Valid Analytical Methods and Procedures written by Chris Burgess and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Analytical Methods Committee of the Royal Society of Chemistry has for many years been involved in national and international efforts to establish a comprehensive framework for achieving appropriate quality in chemical measurement. This handbook attempts to select or define robust procedures that ensure the best use of resources and enable laboratories to generate consistent, reliable data. Written in concise, easy-to-read language and illustrated with worked examples, it is a guide to current best practice and establishes a control framework for the development and validation of laboratory-based analytical methods. Topics include samples and sampling, method selection, equipment calibration and qualification, method development and validation, evaluation of data and statistical approaches for method performance and comparison. Valid Analytical Methods and Procedures will be welcomed by many organisations throughout the world who are required to prove that the validity of their analytical results can be established beyond reasonable doubt.
Author : Bernd W. Wenclawiak
Publisher : Springer Science & Business Media
ISBN 13 : 3642136095
Total Pages : 343 pages
Book Rating : 4.6/5 (421 download)
Download or read book Quality Assurance in Analytical Chemistry written by Bernd W. Wenclawiak and published by Springer Science & Business Media. This book was released on 2010-08-05 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: knowledge. This material provided has been collected from different sources. One important source is the material available from EURACHEM. Eurachem is a network of organisations in Europe having the objective of establishing a system for the international tra- ability of chemical measurements and the promotion of good quality practices. It provides a forum for the discussion of common problems and for developing an informed and considered approach to both technical and policy issues. It provides a focus for analytical chemistry and quality related issues in Europe. You can find more information about EURACHEM on the internet via “Eurachem –A Focus for Analytical Chemistry in Europe” (http://www.eurachem.org). In particular the site Guides and Documents contains a number of different guides, which might help you to set up a quality system in your laboratory. The importance of quality assurance in analytical chemistry can best be described by the triangles depicted in Figs. 1 and 2. Quality is checked by testing and testing guaranties good quality. Both contribute to progress in QA (product control and quality) and thus to establishing a market share. Market success depends on quality, price, and flexibility. All three of them are interconnected. Before you can analyse anything the sample must be taken by someone. This must be of major concern to any analytical chemist. There is no accurate analysis wi- out proper sampling. For correct sampling you need a clear problem definition. There is no correct sampling without a clear problem definition
Author : Eurachem/CITAC Working Group
Publisher :
ISBN 13 : 9780948926150
Total Pages : 120 pages
Book Rating : 4.9/5 (261 download)
Download or read book Quantifying Uncertainty in Analytical Measurement written by Eurachem/CITAC Working Group and published by . This book was released on 2000-01-01 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : D. Brynn Hibbert
Publisher : Oxford University Press
ISBN 13 : 9780195162134
Total Pages : 306 pages
Book Rating : 4.1/5 (621 download)
Download or read book Quality Assurance in the Analytical Chemistry Laboratory written by D. Brynn Hibbert and published by Oxford University Press. This book was released on 2007-03-29 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical chemical results touch everyone's lives: Can we eat the food? Do I have a disease? Did the defendant leave his DNA at the crime scene? Should I invest in that gold mine? When a chemist measures something, how do we know that the result is appropriate? What is "fit for purpose" in the context of analytical chemistry? Quality Assurance for the Analytical Chemistry Laboratory explains the practices that chemistry laboratories adopt so that we all can have confidence in the answers to these questions.
Author : Paul De Bièvre
Publisher : Springer Science & Business Media
ISBN 13 : 9783540207887
Total Pages : 190 pages
Book Rating : 4.2/5 (78 download)
Download or read book Validation in Chemical Measurement written by Paul De Bièvre and published by Springer Science & Business Media. This book was released on 2005-01-12 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: The validation of analytical methods is based on the characterisation of a measurement procedure (selectivity, sensitivity, repeatability, reproducibility). This volume collects 31 outstanding papers on the topic, mostly published in the period 2000-2003 in the journal "Accreditation and Quality Assurance". They provide the latest understanding, and possibly the rationale why it is important to integrate the concept of validation into the standard procedures of every analytical laboratory. In addition, this anthology considers the benefits to both: the analytical laboratory and the user of the measurement results.
Author : Joachim Ermer
Publisher : John Wiley & Sons
ISBN 13 : 3527604472
Total Pages : 418 pages
Book Rating : 4.5/5 (276 download)
Download or read book Method Validation in Pharmaceutical Analysis written by Joachim Ermer and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 418 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adopting a practical approach, the authors provide a detailed interpretation of the existing regulations (GMP, ICH), while also discussing the appropriate calculations, parameters and tests. The book thus allows readers to validate the analysis of pharmaceutical compounds while complying with both the regulations as well as the industry demands for robustness and cost effectiveness. Following an introduction to the basic parameters and tests in pharmaceutical validation, including specificity, linearity, range, precision, accuracy, detection and quantitation limits, the text focuses on a life-cycle approach to validation and the integration of validation into the whole analytical quality assurance system. The whole is rounded off with a look at future trends. With its first-hand knowledge of the industry as well as regulating bodies, this is an invaluable reference for analytical chemists, the pharmaceutical industry, pharmaceutists, QA officers, and public authorities.
Author : A Fajgelj
Publisher : Royal Society of Chemistry
ISBN 13 : 1847551750
Total Pages : 317 pages
Book Rating : 4.8/5 (475 download)
Download or read book Principles and Practices of Method Validation written by A Fajgelj and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Practices of Method Validation is an overview of the most recent approaches used for method validation in cases when a large number of analytes are determined from a single aliquot and where a large number of samples are to be analysed. Much of the content relates to the validation of new methods for pesticide residue analysis in foodstuffs and water but the principles can be applied to other similar fields of analysis. Different chromatographic methods are discussed, including estimation of various effects, eg. matrix-induced effects and the influence of the equipment set-up. The methods used for routine purposes and the validation of analytical data in the research and development environment are documented. The legislation covering the EU-Guidance on residue analytical methods, an extensive review of the existing in-house method validation documentation and guidelines for single-laboratory validation of analytical methods for trace-level concentrations of organic chemicals are also included. With contributions from experts in the field, any practising analyst dealing with method validation will find the examples presented in this book a useful source of technical information.
Author : Uwe Zerbst
Publisher : Academic Press
ISBN 13 : 0080552838
Total Pages : 313 pages
Book Rating : 4.0/5 (85 download)
Download or read book Fitness-for-Service Fracture Assessment of Structures Containing Cracks written by Uwe Zerbst and published by Academic Press. This book was released on 2013-10-22 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of Fitness-for-Service Fracture Assessment of Structures Containing Cracks is to facilitate the use of fracture mechanics based failure assessment procedures for the evaluation and design of structures and components. All practical structures contain flaws and the optimum combination of cost efficiency and safety whilst achieving the required capability, can only be realised by using state of the art methods such as that represented by the European flaw assessment method SINTAP/FITNET to analyse the safety risk. This book is written by practitioners with extensive experience in both the development and use of integrity assessment methods and provides comprehensive information on the basic principles and use of analytical flaw assessment. It provides an introduction to the method, its background, how it can be applied, its potential and, importantly, its limitations. The explanations are complimented by using a large number of worked examples and validation exercises which illustrate all aspects of the procedure. In addition, for students and engineers who are new to the subject, a comprehensive glossary of basic terms used in fracture mechanics based integrity evaluations is included. The topics addressed include: - Crack driving force (CDF) and failure assessment diagram (FAD) type analyses - Preparation of the input parameters (crack dimensions, stress-strain properties, fracture toughness, statistical aspects) - Determination of the model parameters, (stress intensity factor and yield load solutions) - Treatment of combined primary and secondary loading, together with residual stress effects - Analysis of the effect of constraint effects (treatment of small defects and section size effects) - Treatment of mixed mode loading - Consideration of the influences of strength mismatch - Reliability aspects - Comprehensive description of the use of structural integrity methods to optimise cost effectiveness and safety - Detailed description of how to evaluate the integrity of structures containing cracks - Valuable background information for understanding the methods, their potential and limitations - Large number of worked examples, which demonstrate all aspects of the methods - Descriptive, readable writing style - Applicable to a wide range of interests, from the student (university or self study) to the expert who requires a 'state of the art' document
Author : Chung Chow Chan
Publisher : John Wiley & Sons
ISBN 13 : 047146371X
Total Pages : 320 pages
Book Rating : 4.4/5 (714 download)
Download or read book Analytical Method Validation and Instrument Performance Verification written by Chung Chow Chan and published by John Wiley & Sons. This book was released on 2004-04-23 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Validation describes the procedures used to analyze pharmaceutical products so that the data generated will comply with the requirements of regulatory bodies of the US, Canada, Europe and Japan. Calibration of Instruments describes the process of fixing, checking or correcting the graduations of instruments so that they comply with those regulatory bodies. This book provides a thorough explanation of both the fundamental and practical aspects of biopharmaceutical and bioanalytical methods validation. It teaches the proper procedures for using the tools and analysis methods in a regulated lab setting. Readers will learn the appropriate procedures for calibration of laboratory instrumentation and validation of analytical methods of analysis. These procedures must be executed properly in all regulated laboratories, including pharmaceutical and biopharmaceutical laboratories, clinical testing laboratories (hospitals, medical offices) and in food and cosmetic testing laboratories.
Author : Paul De Bièvre
Publisher : Springer Science & Business Media
ISBN 13 : 3662051737
Total Pages : 294 pages
Book Rating : 4.6/5 (62 download)
Download or read book Measurement Uncertainty in Chemical Analysis written by Paul De Bièvre and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is now becoming recognized in the measurement community that it is as important to communicate the uncertainty related to a specific measurement as it is to report the measurement itself. Without knowing the uncertainty, it is impossible for the users of the result to know what confidence can be placed in it; it is also impossible to assess the comparability of different measurements of the same parameter. This volume collects 20 outstanding papers on the topic, mostly published from 1999-2002 in the journal "Accreditation and Quality Assurance." They provide the rationale for why it is important to evaluate and report the uncertainty of a result in a consistent manner. They also describe the concept of uncertainty, the methodology for evaluating uncertainty, and the advantages of using suitable reference materials. Finally, the benefits to both the analytical laboratory and the user of the results are considered.
Author : Mark Stauffer
Publisher : BoD – Books on Demand
ISBN 13 : 1789230845
Total Pages : 176 pages
Book Rating : 4.7/5 (892 download)
Download or read book Calibration and Validation of Analytical Methods written by Mark Stauffer and published by BoD – Books on Demand. This book was released on 2018-04-25 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book seeks to introduce the reader to current methodologies in analytical calibration and validation. This collection of contributed research articles and reviews addresses current developments in the calibration of analytical methods and techniques and their subsequent validation. Section 1, "Introduction," contains the Introductory Chapter, a broad overview of analytical calibration and validation, and a brief synopsis of the following chapters. Section 2 "Calibration Approaches" presents five chapters covering calibration schemes for some modern analytical methods and techniques. The last chapter in this section provides a segue into Section 3, "Validation Approaches," which contains two chapters on validation procedures and parameters. This book is a valuable source of scientific information for anyone interested in analytical calibration and validation.
Author : Aldo Polettini
Publisher : Pharmaceutical Press
ISBN 13 : 9780853696292
Total Pages : 310 pages
Book Rating : 4.6/5 (962 download)
Download or read book Applications of LC-MS in Toxicology written by Aldo Polettini and published by Pharmaceutical Press. This book was released on 2006 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Analytical toxicologists are involved in the analysis of drugs and poisons in biological samples in different environments. Many scientists in the field of analytical toxicology have adopted LC-MS in their daily work, and this is illustrated by the increasing numbers of research papers published and presented at relevant conferences.
Author : Frank N. Crespilho
Publisher : Springer Nature
ISBN 13 : 303115889X
Total Pages : 194 pages
Book Rating : 4.0/5 (311 download)
Download or read book COVID-19 Metabolomics and Diagnosis written by Frank N. Crespilho and published by Springer Nature. This book was released on 2023-02-20 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focus on COVID-19 topics, with emphasis on metabolomics and diagnosis. The chapters cover the chemical science for prevention and understanding outbreaks of infectious diseases. This book compiles the most widespread methodologies of application of quality statistical tools added to the evaluation of diagnostic tests for detection of SARS-CoV-2, metabolic behavior of COVID infection severity, and trends in rapid test for COVID-19.
Author : Bernd W. Wenclawiak
Publisher : Springer
ISBN 13 : 3662096218
Total Pages : 306 pages
Book Rating : 4.6/5 (62 download)
Download or read book Quality Assurance in Analytical Chemistry written by Bernd W. Wenclawiak and published by Springer. This book was released on 2013-12-20 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quality Assurance in Chemical Measurement, an advanced EURACHEM textbook, provides in-depth but easy-to-understand coverage for training, teaching and continuing studies. The CD-ROM accompanying the book contains course materials produced by ten experienced specialists, including more than 750 overheads (graphics and text) in ready-to-use PowerPoint® documents in English and German language. The book will serve as an advanced textbook for analytical chemistry students and professionals in industry and service labs and as a reference text and source of course materials for lecturers. The second edition has been completely revised according to the newest legislation.
Author : Richard O'Kennedy
Publisher : CRC Press
ISBN 13 : 1351797352
Total Pages : 438 pages
Book Rating : 4.3/5 (517 download)
Download or read book Immunoassays written by Richard O'Kennedy and published by CRC Press. This book was released on 2017-06-26 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept behind this book is to provide a detailed and practical overview of the development and use of immunoassays in many different areas. Immunoassays are analytical tests that utilise antibodies to measure the amount, activity or identity of an analyte. This book is designed to provide a critical and helpful insight into the subject and to give the user practical information that may be of assistance in assay format selection, antibody generation/selection and choice of appropriate detection strategies. It is comprised of 13 chapters written by highly experienced researchers in the fields of antibody-based research, immunoassay development, assay validation, diagnostics and microfluidics. Beginning with a comprehensive survey of antibodies, immunoassay formats and signalling systems, the book elucidates key topics related to the development of an ideal antibody-based sensor, focuses on the important topic of surface modification, explores key parameters in the immobilisation of antibodies onto solid surfaces, discusses the move to ‘lab-on-a-chip’-based devices and investigates the key parameters necessary for their development. Three of the chapters are dedicated to the areas of clinical diagnostics, infectious disease monitoring and food security, where immunoassay-based applications have become highly valuable tools. The future of immunoassays, including next-generation immunoassays, electrochemical-immunoassays and ‘lab-on-a-chip’-based systems, is also discussed. The book also covers the use of optical detection systems (with a focus on surface plasmon resonance) in immunoassays, provides a compilation of important, routinely used immunoassay protocols and addresses problems that may be encountered during assay development.
Author : Boris L. Milman
Publisher : Springer Science & Business Media
ISBN 13 : 3642153615
Total Pages : 295 pages
Book Rating : 4.6/5 (421 download)
Download or read book Chemical Identification and its Quality Assurance written by Boris L. Milman and published by Springer Science & Business Media. This book was released on 2013-06-17 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to show how to apply the principles of quality assurance to the identification of analytes (qualitative chemical analysis). After presenting the principles of identification and metrological basics, the author focuses on the reliability and the errors of chemical identification. This is then applied to practical examples such as EPA methods, EU, FDA, or WADA regulations. Two whole chapters are devoted to the analysis of unknowns and identification of samples such as foodstuffs or oil pollutions. Essential reading for researchers and professionals dealing with the identification of chemical compounds and the reliability of chemical analysis.
