The Extension Of 4 C Storage Time Of Frozen Thawed Red Blood Cells

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The Extension of 4 C Storage Time of Frozen-Thawed Red Blood Cells

Author : Byron A. Myhre
Publisher :
ISBN 13 :
Total Pages : 28 pages
Book Rating : 4.:/5 (227 download)

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Book Synopsis The Extension of 4 C Storage Time of Frozen-Thawed Red Blood Cells by : Byron A. Myhre

Download or read book The Extension of 4 C Storage Time of Frozen-Thawed Red Blood Cells written by Byron A. Myhre and published by . This book was released on 1990 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: The process of freezing and storing red blood cells has been developed into a relatively simple and practical technic. The storage of frozen red blood cells has been approved by the FDA for up to 10 years of storage time. However once the blood is thawed and reconstituted, the red cells can be stored in a normal blood bank refrigerator for a period of only 72 hrs after which they must be discarded. This short storage period creates great problems in the military environment as well as in civilian life. The reasons for this short period of storage are usually stated as follows: A. The thawed red cells have been suspended in a saline preservative medium with a small amount of added glucose which has limited nutritive value. Over a period of time the red cells deplete the nutrients and begin to autolyze; B. Some of the storage media used for longer term preservation are not isoosmotic with red cells and thus produce some destruction of these cells due to hypotonic shock when they are placed in this medium during the storage period; C. As the red cells metabolize the glucose, the pH slowly drops. This decrease in pH causes a decreased viability of the red cells and decrease in the intermediary metabolites necessary for Rbc function; D. Mos of the methods of washing cells employ equipment that is not completely sealed and therefore there is a possibility that bacteria could be introduced into the blood and grow during the storage period. The purpose of this study was to determine if adding one of several currently acceptable anticoagulants to the blood after washing would increase their survival during storage. (ttl).

Extension of Post-Than-Wash Storage of Glycerol-Frozen Red Blood Cells at 4 C In 0.9% Sodium Chloride-0.1% Glucose Solution

Author : C. Valeri
Publisher :
ISBN 13 :
Total Pages : 39 pages
Book Rating : 4.:/5 (455 download)

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Book Synopsis Extension of Post-Than-Wash Storage of Glycerol-Frozen Red Blood Cells at 4 C In 0.9% Sodium Chloride-0.1% Glucose Solution by : C. Valeri

Download or read book Extension of Post-Than-Wash Storage of Glycerol-Frozen Red Blood Cells at 4 C In 0.9% Sodium Chloride-0.1% Glucose Solution written by C. Valeri and published by . This book was released on 1994 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: The FDA has approved the protocol by which red blood cells can be frozen with 40% W/V glycerol, stored at -80 deg C, deglycerolized using the Naval Blood Research Laboratory (NBRL) Standard Operating Procedure for non-rejuvenated red blood cells, and stored in a 0.9% sodium chloride-0.2% glucose solution for 24 hours at 4 deg C. The Department of Defense (DoD) has approved this method for the deployment of frozen blood banks where glycerol-frozen red blood cells are stored at -8 deg C for 10 years. The NBRL has collected the enclosed data to support the extension of the postthaw storage period from 24 hours to 5 days. We are requesting the extension of the post-thaw-wash storage period for red blood cells from 24 hours to 5 days in view of the fact that the FDA has approved the storage of platelets at 22 deg C for 5 days, and the potential for contamination is similar for both.

Frozen Red Cell Outdating

Author : Peter B. Sherer
Publisher :
ISBN 13 :
Total Pages : 120 pages
Book Rating : 4.:/5 (327 download)

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Book Synopsis Frozen Red Cell Outdating by : Peter B. Sherer

Download or read book Frozen Red Cell Outdating written by Peter B. Sherer and published by . This book was released on 1975 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Blood Donors and the Supply of Blood and Blood Products

Author : Forum on Blood Safety and Blood Availability
Publisher : National Academies Press
ISBN 13 : 0309589622
Total Pages : 132 pages
Book Rating : 4.3/5 (95 download)

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Book Synopsis Blood Donors and the Supply of Blood and Blood Products by : Forum on Blood Safety and Blood Availability

Download or read book Blood Donors and the Supply of Blood and Blood Products written by Forum on Blood Safety and Blood Availability and published by National Academies Press. This book was released on 1996-08-09 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses the current state of the nation's blood supply--including studies of blood availability, ways of enhancing blood collection and distribution, frozen red cell technology, logistical concerns in prepositioning frozen blood, extended liquid storage of red cells, and blood substitutes.

Frozen Red Cell Outdating--March 14, 1975, Bethesda, Maryland

Author : Peter B. Sherer
Publisher :
ISBN 13 :
Total Pages : 120 pages
Book Rating : 4.:/5 (2 download)

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Book Synopsis Frozen Red Cell Outdating--March 14, 1975, Bethesda, Maryland by : Peter B. Sherer

Download or read book Frozen Red Cell Outdating--March 14, 1975, Bethesda, Maryland written by Peter B. Sherer and published by . This book was released on 1975 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Blood Donors and the Supply of Blood and Blood Products

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309175283
Total Pages : 131 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Blood Donors and the Supply of Blood and Blood Products by : Institute of Medicine

Download or read book Blood Donors and the Supply of Blood and Blood Products written by Institute of Medicine and published by National Academies Press. This book was released on 1996-07-26 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume discusses the current state of the nation's blood supplyâ€"including studies of blood availability, ways of enhancing blood collection and distribution, frozen red cell technology, logistical concerns in prepositioning frozen blood, extended liquid storage of red cells, and blood substitutes.

Safe Extension of Red Blood Cell Storage Life at 4°C.

Author :
Publisher :
ISBN 13 :
Total Pages : 10 pages
Book Rating : 4.:/5 (683 download)

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Book Synopsis Safe Extension of Red Blood Cell Storage Life at 4°C. by :

Download or read book Safe Extension of Red Blood Cell Storage Life at 4°C. written by and published by . This book was released on 1996 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: The project sought to develop methods to extend the storage life of red blood cells. Extended storage would allow donor to self or autologous transfusion, expand and stabilize the blood supply, reduce the cost of medical care and eliminate the risk of transfusion related infections, including a spectrum of hepatitides (A, B and C) and HIV. The putative cause of red blood cell spoilage at 4 C has been identified as oxidative membrane damage resulting from deoxyhemoglobin and its denaturation products including hemichrome, hemin and Fe{sup 3+}. Trials with carbon monoxide, which is a stabilizer of hemoglobin, have produced striking improvement of red blood cell diagnostics for cells stored at 4 C. Carbonmonoxy hemoglobin is readily converted to oxyhemoglobin by light in the presence of oxygen. These findings have generated a working model and an approach to identify the best protocols for optimal red cell storage and hemoglobin regeneration.

Clinical Uses of Frozen-thawed Red Blood Cells

Author : John A. Griep
Publisher : Alan R. Liss
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Clinical Uses of Frozen-thawed Red Blood Cells by : John A. Griep

Download or read book Clinical Uses of Frozen-thawed Red Blood Cells written by John A. Griep and published by Alan R. Liss. This book was released on 1976 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1840 pages
Book Rating : 4.3/5 (243 download)

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Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1840 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Manual of Veterinary Transfusion Medicine and Blood Banking

Author : Kenichiro Yagi
Publisher : John Wiley & Sons
ISBN 13 : 1118933036
Total Pages : 405 pages
Book Rating : 4.1/5 (189 download)

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Book Synopsis Manual of Veterinary Transfusion Medicine and Blood Banking by : Kenichiro Yagi

Download or read book Manual of Veterinary Transfusion Medicine and Blood Banking written by Kenichiro Yagi and published by John Wiley & Sons. This book was released on 2016-08-03 with total page 405 pages. Available in PDF, EPUB and Kindle. Book excerpt: Das Manual of Veterinary Transfusion Medicine and Blood Banking bietet mit seinem praxisorientierten Ansatz jedem Veterinärmediziner evidenzbasierte Leitlinien für die klinische Praxis. - Liefert evidenzbasierte Informationen zu Verfahren in der Transfusionsmedizin und bei Blutbanken. - Umfasst Kapitel zum Screening von Transfusionsempfängern, zur Auswahl von Spendern, zur Blutentnahme und Lagerung sowie darüber, wie die Nachfrage nach Blut erfüllt wird. - Beinhaltet nützliche Transfusions- und Blutbankprotokolle, die für die klinische Praxis relevant sind. - Ausgewogene Inhalte, aus Sicht von Veterinärmedizinern und Veterinärtechnikern. - Mit Informationen zu Groß- und Kleintieren sowie Exoten.

Method for Extending the Useful Shelf-life of Refrigerated Red Blood Cells by Flushing with Inert Gas

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (873 download)

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Book Synopsis Method for Extending the Useful Shelf-life of Refrigerated Red Blood Cells by Flushing with Inert Gas by :

Download or read book Method for Extending the Useful Shelf-life of Refrigerated Red Blood Cells by Flushing with Inert Gas written by and published by . This book was released on 1997 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Method using oxygen removal for extending the useful shelf-life of refrigerated red blood cells. A cost-effective, 4.degree. C. storage procedure that preserves red cell quality and prolongs post-transfusion in vivo survival is described. Preservation of adenosine triphosphate levels and reduction in hemolysis and in membrane vesicle production of red blood cells stored at 4.degree. C. for prolonged periods of time is achieved by removing oxygen therefrom at the time of storage; in particular, by flushing with an inert gas. Adenosine triphosphate levels of the stored red blood cells are boosted in some samples by addition of ammonium phosphate.

Advances in Cryogenic Engineering

Author : K. Timmerhaus
Publisher : Springer Science & Business Media
ISBN 13 : 1475702086
Total Pages : 563 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Advances in Cryogenic Engineering by : K. Timmerhaus

Download or read book Advances in Cryogenic Engineering written by K. Timmerhaus and published by Springer Science & Business Media. This book was released on 2013-03-13 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the 1975 Cryogenic Engineering Conference this se ries enters the third decade of presenting the latest advances in the field of cryogenic engineering. The 1975 Cryogenic Engineering Conference also marked the first time the meeting had been held outside the territorial limits of the United States. Based on the enthusiastic response of the attendees and the exemplary hospitality of the Canadian hosts, it certainly will not be the last meeting to convene beyond the confines of the fifty states. The Cryogenic Engineering Conference Board is extremely grateful to The Royal Military College of Canada and Queen's University for the invitation to hold this meeting in Kingston, Ontario, Canada. The assistance of A. C. Leonard and his staff added immeasurably in making this visit to Canada both a pie asant and a memorable one. The 1975 Cryogenic Engineering Conference was the first meeting of this group on the new biennial conference schedule. Since the last conference in 1973, the Western Hemisphere has experienced the impact of various energy shortages. Thus, it was appropriate that the theme "Cryogenics Applied to Natural Resource Management" for this Conference was not only timely but also an opportunity for the scientific community engaged in cryogenic activities to review the role of cryogenics in meeting these new challenges and problems facing the energy-deficient nations of the world. The Cryogenic Engineering Conference was also pleased to have the Interna tional Cryogenic Materials Conference join them in this meeting.

Liquid Storage at 4C of Previously Frozen Red Cells

Author : G. L. Moore
Publisher :
ISBN 13 :
Total Pages : 3 pages
Book Rating : 4.:/5 (227 download)

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Book Synopsis Liquid Storage at 4C of Previously Frozen Red Cells by : G. L. Moore

Download or read book Liquid Storage at 4C of Previously Frozen Red Cells written by G. L. Moore and published by . This book was released on 1987 with total page 3 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fresh human blood was collected in citrate-phosphate-dextrose, frozen by a high-glycerol technique, and stored at -80C. The red cells ere thawed, deglycerolized, and resuspended in a final was solution, ADSOL (Fenwal Laboratories), or an additive solution (AS) containing glucose, adenine, mannitol, and phosphate. The cells were then stored at 4 to 6C for 21 days and assayed weekly for adenosine triphosphate and 2,3 diphosphoglycerate, pH, glucose use, and lysis. AS and, to a lesser extent, ADSOL produced metabolic profiles similar to or better than profiles of cells not frozen and stored in commercially available additive solutions. AS offers a potential post-thaw preservative solution for red cells that would greatly increase the flexibility and reduce the expense of using frozen blood. A sterile post-thaw storage capability will make the stockpiling of frozen red cells a practical concept for both military and civilian blood banks.

Wintrobe's Clinical Hematology

Author : John P. Greer
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1469846225
Total Pages : 3094 pages
Book Rating : 4.4/5 (698 download)

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Book Synopsis Wintrobe's Clinical Hematology by : John P. Greer

Download or read book Wintrobe's Clinical Hematology written by John P. Greer and published by Lippincott Williams & Wilkins. This book was released on 2013-08-29 with total page 3094 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the 13th edition, Wintrobe’s Clinical Hematology once again bridges the gap between the clinical practice of hematology and the basic foundations of science. Broken down into eight parts, this book provides readers with a comprehensive overview of: Laboratory Hematology, The Normal Hematologic System, Transfusion Medicine, Disorders of Red Cells, Hemostasis and Coagulation; Benign Disorders of Leukocytes, The Spleen and/or Immunoglobulins; Hematologic Malignancies, and Transplantation. Within these sections, there is a heavy focus on the morphological exam of the peripheral blood smear, bone marrow, lymph nodes, and other tissues. With the knowledge about gene therapy and immunotherapy expanding, new, up-to-date information about the process and application of these therapies is included. Likewise, the editors have completely revised material on stem cell transplantation in regards to both malignant and benign disorders, graft versus host disease, and the importance of long-term follow-up of transplantation survivors.

Joint Trauma System (JTS) Clinical Practice Guidelines

Author :
Publisher : Jeffrey Frank Jones
ISBN 13 :
Total Pages : 731 pages
Book Rating : 4./5 ( download)

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Book Synopsis Joint Trauma System (JTS) Clinical Practice Guidelines by :

Download or read book Joint Trauma System (JTS) Clinical Practice Guidelines written by and published by Jeffrey Frank Jones. This book was released on with total page 731 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over 700 total pages ... The JTS Clinical Practice Guidelines (CPGs) are to the greatest extent possible evidence-based. The guidelines are developed using a rigorous process that involves subject matter experts in each field evaluating the best available data. If you are interested in learning more about the process of developing CPGs, please click this link: CPG Development Process. This guide for CPG development will help lead you through the methods used to develop and monitor CPGs. The JTS remains committed to using the highest levels of analytical and statistical analysis in its CPG development process. COMPLETE LIST OF CURRENT JTS CPGs JTS CPG Documentation Process - 01 December 2017 Acute Extremity Compartment Syndrome - Fasciotomy - 25 July 2016 Acute Respiratory Failure - 23 January 2017 Airway Management of Traumatic Injuries - 17 July 2017 Amputation - 1 July 2016 Anesthesia - 23 Jun 2016.pdf Aural Blast Injury/Acoustic Trauma and Hearing Loss - 12 Aug 2016 Battle/Non-Battle Injury Documentation Resuscitation Record - 5 Dec 13 Blunt Abdominal Trauma, Splenectomy, and Post-Splenectomy Vaccination - 12 August 2016 Burn Care - 11 May 2016 Catastrophic Non-Survivable Brain Injury 27 Jan 2017 Cervical & Thoracolumbar Spine Injury Evaluation, Transport, and Surgery in Deployed Setting - 05 August 2016 Clinical Mgmt of Military Working Dogs Combined - 19 Mar 2012 Clinical Mgmt of Military Working Dogs Zip - 19 Mar 2012.zip Damage Control Resuscitation - 03 Feb 2017 DCoE Concussion Management Algorithm Cards.pdf DoD Policy Guidance for Management of Mild Traumatic Brain Injury/Concussion in the Deployed Setting Drowning Management - 27 October 2017 Emergent Resuscitative Thoracotomy - 11 June 2012 Fresh Whole Blood Transfusion - 24 Oct 12 Frostbite and Immersion Foot Care - 26 Jan 2017 Frozen Blood - 11 July 2016 High Bilateral Amputations and Dismounted Complex Blast Injury - 01 August 2016 Hyperkalemia and Dialysis in the Deployed Setting - 24 January 2017 Hypothermia Prevention - 20 Sept 2012 Infection Prevention in Combat-Related Injuries - 08 August 2016 Inhalation Injury and Toxic Industrial Chemical Exposure - 25 July 2016 Initial Care of Ocular and Adnexal Injuries - 24 Nov 2014 Intratheater Transfer and Transport - 19 Nov 2008 Invasive Fungal Infection in War Wounds - 04 August 2016 Management of Pain Anxiety and Delirium 13 March 2017 Management of War Wounds - 25 April 2012 Neurosurgery and Severe Head Injury - 02 March 2017 Nutritional Support Using Enteral and Parenteral Methods - 04 August 2016 Orthopaedic Trauma: Extremity Fractures - 15 July 2016 Pelvic Fracture Care - 15 March 2017 Prehospital Care - 24 Nov 2014 Prevention of Deep Venous Thrombosis - Inferior Vena Cava Filter - 02 August 2016 Radiology - 13 March 2017 REBOA for Hemorrhagic Shock - 06 July 2017 Unexploded Ordnance Management - 14 Mar 2017 Urologic Trauma Management - 1 Nov 2017 Use of Electronic Documentation - 5 Jun 2012 Use of MRI in Mgmt of mTBI in the Deployed Setting - 11 June 2012 Vascular Injury - 12 August 2016 Ventilator Associated Pneumonia - 17 Jul 2012

Effects of Storage of CPD-ADSOL Red Cells at 4C for as Long as 49 Days, Biochemical Modification, Freeze-Preservation, and Post-Wash Storage at 4C for 24 Hours

Download Effects of Storage of CPD-ADSOL Red Cells at 4C for as Long as 49 Days, Biochemical Modification, Freeze-Preservation, and Post-Wash Storage at 4C for 24 Hours PDF Online Free

Author :
Publisher :
ISBN 13 :
Total Pages : 35 pages
Book Rating : 4.:/5 (946 download)

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Book Synopsis Effects of Storage of CPD-ADSOL Red Cells at 4C for as Long as 49 Days, Biochemical Modification, Freeze-Preservation, and Post-Wash Storage at 4C for 24 Hours by :

Download or read book Effects of Storage of CPD-ADSOL Red Cells at 4C for as Long as 49 Days, Biochemical Modification, Freeze-Preservation, and Post-Wash Storage at 4C for 24 Hours written by and published by . This book was released on 1992 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human CPD-collected red blood cells from 7 healthy male volunteers were stored in ADSOL (adenine, glucose, mannitol, and sodium chloride solution) at 4C for various periods: the red blood cells from one volunteer were stored for 35 days; red blood cells from 3 volunteers were stored for 42 days; and red blood cells from 3 other volunteers were stored for 49 days. A 100 ml aliquot was removed from each unit for in vitro and in vivo survival measurements. The remainder of the unit was biochemically modified with pyruvate, inosine, phosphate, and adenine (PIPA) solution, frozen with 40% W/V glycerol using a double centrifugation procedure and stored at -80C for 84 to 309 days. After thawing and washing, the previously frozen red blood cells were stored at 4C for 24 hours prior to in vitro and in vivo testing. CPD-ADSOL red blood cells stored at 4C for up to 42 days, biochemically treated with PIPA solution, frozen, thawed, washed and stored at 4C for 24-hours exhibited a mean in vitro recovery value of 83%, a mean 24-hour posttransfusion survival value of 72%, improved oxygen transport function, and only minimal residual hemolysis. CPD-ADSOL red blood cells treated in an identical manner except for a 49-day liquid storage period had a mean in vitro recovery value of only 73% and a mean 24-hour posttransfusion survival value of only 61%, but ATP, DPG, P50 levels, and the level of residual hemolysis were satisfactory. Our data show that 42-days is the maximum period that red blood cells can be stored in CPD-ADSOL solution at 4C and have satisfactory in vitro recovery and in vivo survival results following biochemical treatment with PIPA solution, freezing, thawing, washing, and post-wash storage at 4C for 24-hours.

Status Report on Red Blood Cell Freezing: Biochemical Modification and Freeze-Preservation in the Original Polyvinyl Chloride Plastic Collection Bag

Download Status Report on Red Blood Cell Freezing: Biochemical Modification and Freeze-Preservation in the Original Polyvinyl Chloride Plastic Collection Bag PDF Online Free

Author : C. Robert Valeri
Publisher :
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4.:/5 (227 download)

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Book Synopsis Status Report on Red Blood Cell Freezing: Biochemical Modification and Freeze-Preservation in the Original Polyvinyl Chloride Plastic Collection Bag by : C. Robert Valeri

Download or read book Status Report on Red Blood Cell Freezing: Biochemical Modification and Freeze-Preservation in the Original Polyvinyl Chloride Plastic Collection Bag written by C. Robert Valeri and published by . This book was released on 1977 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently the Naval Blood Research Laboratory has been freezing red blood cells in a collection system which uses either a triple or a quadruple bag setup. Blood collection and red blood cell biochemical modification and freeze-preservation can be accomplished with this system. For the past 6 years the laboratory has been biochemically modifying liquid-stored red blood cells to increase their 2,3 DPG and ATP levels and thus improve the oxygen transport function of the preserved red blood cells upon infusion. Biochemically modified red blood cells, or 'rejuvenated' red blood cells as they are sometimes referred to, can be freeze-preserved or not as the situation demands. Red blood cells that have exceeded their mandatory shelf-life have been biochemically modified with a solution of pyruvate, inosine, glucose, phosphate, and adenine. The stored red blood cells are incubated with the 'rejuvenation' solution for 1 hour at 37 C. Biochemically modified red blood cells must be washed before transfusion whether or not they have been frozen to remove the additives used in the solution. This report describes a new blood collection system. The cost of processing can be reduced at least 50% the storage capacity in the -80 C mechanical refrigerator can be doubled, and the potential for contamination of the blood product is reduced. Biochemically modified freeze-preserved red blood cells have been used successfully in a number of important clinical situations.