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Author : Lynn Marie Richard
Publisher :
ISBN 13 :
Total Pages : 250 pages
Book Rating : 4.:/5 (289 download)
Download or read book The Energetics and Dynamics of Motion in Heme Proteins written by Lynn Marie Richard and published by . This book was released on 1993 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : David M. Leitner
Publisher : CRC Press
ISBN 13 : 1420087045
Total Pages : 450 pages
Book Rating : 4.4/5 (2 download)
Download or read book Proteins written by David M. Leitner and published by CRC Press. This book was released on 2009-09-28 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational modeling can provide a wealth of insight into how energy flow in proteins mediates protein function. Computational methods can also address fundamental questions related to molecular signaling and energy flow in proteins. Proteins: Energy, Heat and Signal Flow presents state-of-the-art computational strategies for studying energy redi
Author : Amit Kessel
Publisher : CRC Press
ISBN 13 : 1498747213
Total Pages : 1423 pages
Book Rating : 4.4/5 (987 download)
Download or read book Introduction to Proteins written by Amit Kessel and published by CRC Press. This book was released on 2018-03-22 with total page 1423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Proteins provides a comprehensive and state-of-the-art introduction to the structure, function, and motion of proteins for students, faculty, and researchers at all levels. The book covers proteins and enzymes across a wide range of contexts and applications, including medical disorders, drugs, toxins, chemical warfare, and animal behavior. Each chapter includes a Summary, Exercies, and References. New features in the thoroughly-updated second edition include: A brand-new chapter on enzymatic catalysis, describing enzyme biochemistry, classification, kinetics, thermodynamics, mechanisms, and applications in medicine and other industries. These are accompanied by multiple animations of biochemical reactions and mechanisms, accessible via embedded QR codes (which can be viewed by smartphones) An in-depth discussion of G-protein-coupled receptors (GPCRs) A wider-scale description of biochemical and biophysical methods for studying proteins, including fully accessible internet-based resources, such as databases and algorithms Animations of protein dynamics and conformational changes, accessible via embedded QR codes Additional features Extensive discussion of the energetics of protein folding, stability and interactions A comprehensive view of membrane proteins, with emphasis on structure-function relationship Coverage of intrinsically unstructured proteins, providing a complete, realistic view of the proteome and its underlying functions Exploration of industrial applications of protein engineering and rational drug design Each chapter includes a Summary, Exercies, and References Approximately 300 color images Downloadable solutions manual available at www.crcpress.com For more information, including all presentations, tables, animations, and exercises, as well as a complete teaching course on proteins' structure and function, please visit the author's website: http://ibis.tau.ac.il/wiki/nir_bental/index.php/Introduction_to_Proteins_Book. Praise for the first edition "This book captures, in a very accessible way, a growing body of literature on the structure, function and motion of proteins. This is a superb publication that would be very useful to undergraduates, graduate students, postdoctoral researchers, and instructors involved in structural biology or biophysics courses or in research on protein structure-function relationships." --David Sheehan, ChemBioChem, 2011 "Introduction to Proteins is an excellent, state-of-the-art choice for students, faculty, or researchers needing a monograph on protein structure. This is an immensely informative, thoroughly researched, up-to-date text, with broad coverage and remarkable depth. Introduction to Proteins would provide an excellent basis for an upper-level or graduate course on protein structure, and a valuable addition to the libraries of professionals interested in this centrally important field." --Eric Martz, Biochemistry and Molecular Biology Education, 2012
Author : Michael Abiodun Ibrahim
Publisher :
ISBN 13 :
Total Pages : 386 pages
Book Rating : 4.:/5 (15 download)
Download or read book Conformational Flexibility in Heme Proteins written by Michael Abiodun Ibrahim and published by . This book was released on 1982 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Amit Kessel
Publisher : CRC Press
ISBN 13 : 1439810729
Total Pages : 623 pages
Book Rating : 4.4/5 (398 download)
Download or read book Introduction to Proteins written by Amit Kessel and published by CRC Press. This book was released on 2010-12-17 with total page 623 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the tools and techniques of structural biophysics assume greater roles in biological research and a range of application areas, learning how proteins behave becomes crucial to understanding their connection to the most basic and important aspects of life. With more than 350 color images throughout, Introduction to Proteins: Structure, Function, and Motion presents a unified, in-depth treatment of the relationship between the structure, dynamics, and function of proteins. Taking a structural–biophysical approach, the authors discuss the molecular interactions and thermodynamic changes that transpire in these highly complex molecules. The text incorporates various biochemical, physical, functional, and medical aspects. It covers different levels of protein structure, current methods for structure determination, energetics of protein structure, protein folding and folded state dynamics, and the functions of intrinsically unstructured proteins. The authors also clarify the structure–function relationship of proteins by presenting the principles of protein action in the form of guidelines. This comprehensive, color book uses numerous proteins as examples to illustrate the topics and principles and to show how proteins can be analyzed in multiple ways. It refers to many everyday applications of proteins and enzymes in medical disorders, drugs, toxins, chemical warfare, and animal behavior. Downloadable questions for each chapter are available at CRC Press Online.
Author : Hans Frauenfelder
Publisher :
ISBN 13 :
Total Pages : 28 pages
Book Rating : 4.:/5 (227 download)
Download or read book Pressure Studies of Protein Dynamics written by Hans Frauenfelder and published by . This book was released on 1990 with total page 28 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our work during the past decade has shown conclusively that the energy landscape of proteins is complex: The ground state of proteins is highly degenerate and consists of a very large number of energy valleys separated by energy mountains and ridges. Moreover, the energy landscape may be hierarchical and contain valleys within valleys. Evidence is mounting that many, maybe all, complex systems are characterized by a highly degenerate and hierarchicaly arranged ground state. Among such systems and problems are glasses, spin glasses, evolution, learning, neural networks, computer and chip design, and the traveling salesman problem. Proteins consequently may be models for many other systems and progress in protein dynamics may have impact on these other fields. We investigate three aspects of protein dynamics: (1) the structure and organization of the energy landscape, (2) conformational motions (dynamics), and (3) the laws governing the motions (reaction theory). In all three aspects, we intend to study the phenomena in one protein (myoglobin) in detail and then explore how the phenomena depend on changes in protein structure. Keywords: Pressure, Protein dynamics, Myoglobin, Heme proteins, Conformational substates, Photolysis, Fourier spectroscopy. (JG).
Author : A. A. Rashin
Publisher :
ISBN 13 :
Total Pages : 128 pages
Book Rating : 4.:/5 (355 download)
Download or read book Aspects of Protein Energetics and Dynamics written by A. A. Rashin and published by . This book was released on 1993 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Reinhard Schweitzer-Stenner
Publisher : Elsevier
ISBN 13 : 0443159645
Total Pages : 326 pages
Book Rating : 4.4/5 (431 download)
Download or read book The Physics of Protein Structure and Dynamics written by Reinhard Schweitzer-Stenner and published by Elsevier. This book was released on 2024-10-17 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Physics of Protein Structure and Dynamics looks at various aspects of protein structure and dynamics from a physico-chemical point of view. It goes into some depth regarding the description of non-covalent forces that determine the relative stability of folded and unfolded proteins. Anharmonic protein dynamics involving motions between different minima of a rugged Gibbs energy landscape is described in great detail. The book combines various aspects of the protein folding/unfolding processes with an overview of intrinsically disordered proteins, which have attracted considerable interest of the protein community over the last 25 years but are thus far underrepresented in classroom-oriented textbooks. The book looks at protein folding and intrinsically disordered proteins as heavily interrelated topics that need to be viewed together. Furthermore, it presents some basic physico-chemical aspects of protein/peptide self-assembly into nanoscale fibrils. Intrinsically disordered peptides and proteins play a major role particularly in aggregation and self-assembly processes that lead to various diseases (Alzheimer, Parkinson, Huntington, Mad-Cow). Therefore, the relevance of protein disorder for protein self-assembly deserves a closer look. Protein self-assembly cannot be separated from protein folding since it is frequently the product of misfolding. With regard to modern theories, the folding processes are linked to insights on protein dynamics and the discovered relationship between proteins and spin glasses.
Author : Jeffrey Alan Stevens
Publisher :
ISBN 13 :
Total Pages : 147 pages
Book Rating : 4.:/5 (719 download)
Download or read book Time Resolved Femtosecond Optical Studies of Heme Proteins Myoglobin and Cytochrome C written by Jeffrey Alan Stevens and published by . This book was released on 2011 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract: Our goal was to develop methods to study protein dynamics on the picosecond to nanosecond time scale. We used wavelength and femtosecond resolved fluorescence and absorbance spectroscopy coupled with site-directed mutagenesis to study the heme proteins myoglobin and cytochrome c and determine protein dynamics occurring on the picosecond to nanosecond time scale. The intrinsic amino acid tryptophan was used as a local optical probe and placed one at a time with site-directed mutagenesis that allowed us to achieve a spatial resolution down to a single amino acid. We systematically characterized resonance energy transfer (RET) between a single tryptophan and the prosthetic heme group in myoglobin to develop a novel energy-transfer pair as a molecular ruler in heme proteins to study local conformation fluctuations. Using site-directed mutagenesis, we placed a single tryptophan throughout myoglobin. We observed picosecond RET in tens to hundreds of picoseconds. We also characterized steady state parameters associated with RET allowing us to determine the orientation factor between tryptophan and heme and thus examine changes at different mutation sites revealing relative local structure flexibility and conformation fluctuations. Additionally, local environment relaxation occurs on similar time scales as the RET dynamics, resulting in a nonequilibrium dynamic process. We were able to determine the time scales of such nonequilibrium energy-transfer dynamics and elucidate the mechanism of the nonexponential RET dynamics caused by local dynamic heterogeneity and/or local environment relaxation. In cytochrome c, RET between the lone intrinsic tryptophan and heme was used to study protein folding/unfolding for various states (ferric, ferrous and CO-bound ferrous) of cytochrome c. We systematic studied heme dynamics and induced protein conformational relaxations in cytochrome c and myoglobin with femtosecond transient absorption (TA). A wide range of probing wavelengths from the visible to the UV was probed to unambiguously determine the protein dynamics of the ferric and ferrous state of cytochrome c. For cytochrome c in the ferrous state, the heme undergoes ligand bond breaking and rebinding process generating proteinquakes that perturb the local heme site and shake global protein conformation which was detected by the nearby lone intrinsic tryptophan. Cytochrome c in the ferric state has dynamics that mainly occur at the local site, including ultrafast internal conversion, vibrational cooling, and complete ground-state recovery with no global conformation relaxation observed. We expanded our studies by coupling site-directed mutagenesis of tryptophan at various locations throughout cytochrome c utilizing TA studies. Ligand photolysis from heme was used to generate proteinquakes perturbing the local heme site and shakes global protein conformation and was observed by several of the tryptophan mutations. Additionally, we observed the protein dynamics as a function of denaturing agent. The region that we studied was the pre-unfolding transition region; hence the protein was "softened." In myoglobin, we similarly characterized the heme dynamics of the ferric, ferrous and CO-bound ferrous states. We attempted to use tryptophan as a local probe of protein dynamics for CO-bound myoglobin, but concluded that the perturbation created by CO photolysis was much smaller compared to the proteinquake generated in cytochrome c.
Author : Charles B. Harris
Publisher : Springer Science & Business Media
ISBN 13 : 3642842690
Total Pages : 567 pages
Book Rating : 4.6/5 (428 download)
Download or read book Ultrafast Phenomena VII written by Charles B. Harris and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 567 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent improvements in the performance of light sources, i.e. reduction in pulse length and increases in wavelength range and power levels, have led to ultrafast technology becoming a basic tool in a wide variety of scientific fields. This book describes the remarkable technological improvements and results of new applications in the natural sciences and various engineering fields.
Author :
Publisher :
ISBN 13 :
Total Pages : 980 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 980 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : C. Helene
Publisher : Springer Science & Business Media
ISBN 13 : 9400970528
Total Pages : 413 pages
Book Rating : 4.4/5 (9 download)
Download or read book Structure, Dynamics, Interactions and Evolution of Biological Macromolecules written by C. Helene and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of a Colloquium held at Orléans, France, July 5-9, 1982
Author : P.L. Christiansen
Publisher : Springer Science & Business Media
ISBN 13 : 1489916091
Total Pages : 549 pages
Book Rating : 4.4/5 (899 download)
Download or read book Future Directions of Nonlinear Dynamics in Physical and Biological Systems written by P.L. Christiansen and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Early in 1990 a scientific committee was formed for the purpose of organizing a high-level scientific meeting on Future Directions of Nonlinear Dynamics in Physical and Biological Systems, in honor of Alwyn Scott's 60th birthday (December 25, 1991). As preparations for the meeting proceeded, they were met with an unusually broad-scale and high level of enthusiasm on the part of the international nonlinear science community, resulting in a participation by 168 scientists from 23 different countries in the conference, which was held July 23 to August 11992 at the Laboratory of Applied Mathematical Physics and the Center for Modelling, Nonlinear Dynamics and Irreversible Thermodynamics (MIDIT) of the Technical University of Denmark. During the meeting about 50 lectures and 100 posters were presented in 9 working days. The contributions to this present volume have been grouped into the following chapters: 1. Integrability, Solitons, and Coherent Structures 2. Nonlinear Evolution Equations and Diffusive Systems 3. Chaotic and Stochastic Dynamics 4. Classical and Quantum Lattices and Fields 5. Superconductivity and Superconducting Devices 6. Nonlinear Optics 7. Davydov Solitons and Biomolecular Dynamics 8. Biological Systems and Neurophysics. AI Scott has made early and fundamental contributions to many of these different areas of nonlinear science. They form an important subset of the total number of the papers and posters presented at the meeting. Other papers from the meeting are being published in a special issue of Physica D Nonlinear Phenomena.
Author : Hans Frauenfelder
Publisher : Springer Science & Business Media
ISBN 13 : 1441910441
Total Pages : 423 pages
Book Rating : 4.4/5 (419 download)
Download or read book The Physics of Proteins written by Hans Frauenfelder and published by Springer Science & Business Media. This book was released on 2010-05-30 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides an introduction to the structure and function of biomolecules --- especially proteins --- and the physical tools used to investigate them The discussion concentrates on physical tools and properties, emphasizing techniques that are contributing to new developments and avoiding those that are already well established and whose results have already been exploited fully New tools appear regularly - synchrotron radiation, proton radiology, holography, optical tweezers, and muon radiography, for example, have all been used to open new areas of understanding
Author :
Publisher :
ISBN 13 :
Total Pages : 1336 pages
Book Rating : 4.:/5 (31 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1991 with total page 1336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. Andrew McCammon
Publisher : Cambridge University Press
ISBN 13 : 9780521356527
Total Pages : 256 pages
Book Rating : 4.3/5 (565 download)
Download or read book Dynamics of Proteins and Nucleic Acids written by J. Andrew McCammon and published by Cambridge University Press. This book was released on 1988-04-29 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.
Author : Jean-Louis Martin
Publisher : Springer
ISBN 13 :
Total Pages : 712 pages
Book Rating : 4.:/5 (321 download)
Download or read book Ultrafast Phenomena VIII written by Jean-Louis Martin and published by Springer. This book was released on 1993-04-29 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Papers presented at the Eighth International Conference on Ultrafast Phenomena"--Pref.
