The Effects Of Lymph Node Status On Predicting Outcome In Er Her2 Tamoxifen Treated Breast Cancer Patients Using Gene Signatures

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The Effects of Lymph Node Status on Predicting Outcome in ER+ /HER2- Tamoxifen Treated Breast Cancer Patients Using Gene Signatures

Author : Cali Cali Press
Publisher :
ISBN 13 : 9781542335829
Total Pages : 40 pages
Book Rating : 4.3/5 (358 download)

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Book Synopsis The Effects of Lymph Node Status on Predicting Outcome in ER+ /HER2- Tamoxifen Treated Breast Cancer Patients Using Gene Signatures by : Cali Cali Press

Download or read book The Effects of Lymph Node Status on Predicting Outcome in ER+ /HER2- Tamoxifen Treated Breast Cancer Patients Using Gene Signatures written by Cali Cali Press and published by . This book was released on 2017-01-03 with total page 40 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lymph node (LN) status is the most important prognostic variable used to guide ER positive (+) breast cancer treatment. While a positive nodal status is traditionally associated with a poor prognosis, a subset of these patients respond well to treatment and achieve long-term survival. Several gene signatures have been established as a means of predicting outcome of breast cancer patients, but the development and indication for use of these assays varies. Here we compare the capacity of two approved gene signatures and a third novel signature to predict outcome in distinct LN negative (-) and LN+ populations. We also examine biological differences between tumours associated with LN- and LN+ disease. Proceeds from the sale of this book go to support an elderly disabled person.

Adjuvant Therapy for Breast Cancer

Author : Monica Castiglione
Publisher : Springer Science & Business Media
ISBN 13 : 0387751157
Total Pages : 483 pages
Book Rating : 4.3/5 (877 download)

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Book Synopsis Adjuvant Therapy for Breast Cancer by : Monica Castiglione

Download or read book Adjuvant Therapy for Breast Cancer written by Monica Castiglione and published by Springer Science & Business Media. This book was released on 2009-07-11 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.

Biomarkers in Breast Cancer

Author : Giampietro Gasparini
Publisher : Springer Science & Business Media
ISBN 13 : 159259915X
Total Pages : 335 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Biomarkers in Breast Cancer by : Giampietro Gasparini

Download or read book Biomarkers in Breast Cancer written by Giampietro Gasparini and published by Springer Science & Business Media. This book was released on 2008-01-17 with total page 335 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

Handbook of Cardiac Electrophysiology, Second Edition

Author : Andrea Natale
Publisher : CRC Press
ISBN 13 : 1482214946
Total Pages : 892 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Handbook of Cardiac Electrophysiology, Second Edition by : Andrea Natale

Download or read book Handbook of Cardiac Electrophysiology, Second Edition written by Andrea Natale and published by CRC Press. This book was released on 2016-01-15 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second edition of a bestseller provides a practical, user-friendly manual guiding the theory and practice of cardiac electrophysiolology. The handbook provides the specialist in training with a thorough grounding procedures, and clinical findings for clinicians. It provides a review of the main kinds of arrhythmia with illustrations of typical ECG findings supported where appropriate by correlative imaging. It also details the principal diagnostic and therapeutic procedures include implantation of pacemakers, resynchronization therapy, and ablation techniques.

Breast Disease

Author : Adnan Aydiner
Publisher : Springer
ISBN 13 : 3030167925
Total Pages : 824 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Breast Disease by : Adnan Aydiner

Download or read book Breast Disease written by Adnan Aydiner and published by Springer. This book was released on 2019-07-01 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: This second updated volume on breast cancer provides a comprehensive overview of its clinical management and current therapies. Updated to reflect the changes in breast cancer staging, the progress in immunotherapy approaches, as well as the latest guidelines for therapies, this book brings readers up to speed with the latest therapeutic regimens in breast cancer and provides an in-depth account of current and new therapeutic approaches. The most important phase III trials, high quality meta-analysis, consensus reports and guidelines are extensively discussed in this new edition and provide the reader with the most up-to-date information. Divided in themed parts, the book examines invasive breast cancer, pre-operative systemic therapy surgical management and recurrence among others, thus providing an in-depth account of breast cancer at the clinical stage. Among the themed parts are a section dedicated to special therapeutic problems, such as breast cancer in older women, Paget’s disease and phyllodes tumors and a section on supportive and follow-up care. By adopting a multidisciplinary approach to breast cancer, this book is a must-have for breast cancer practitioners. With a high number of colored illustrations and edited by highly experienced clinicians, this work enables readers to gain an interdisciplinary perspective on breast diseases. Contributions from an international team of experts present invaluable insight into clinical practice across different settings. Covering both theoretical and practical aspects of breast cancer, this is a highly informative and carefully presented book which will appeal to an international audience of medical, radiation and surgical oncologists.

The Breast - E-Book

Author : Kirby I. Bland
Publisher : Elsevier Health Sciences
ISBN 13 : 0323833667
Total Pages : 1196 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis The Breast - E-Book by : Kirby I. Bland

Download or read book The Breast - E-Book written by Kirby I. Bland and published by Elsevier Health Sciences. This book was released on 2023-03-18 with total page 1196 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multidisciplinary in scope and fully up to date with the latest advances in medical oncology and more, Bland and Copeland's The Breast, 6th Edition, covers every clinically relevant aspect of the field: cancer, congenital abnormalities, hormones, reconstruction, anatomy and physiology, benign breast disease, and more. In a practical, easy-to-use format ideal for today’s busy practitioners, this truly comprehensive resource is ideal for surgical oncologists, breast surgeons, general surgeons, medical oncologists, and others who need to stay informed of the latest innovations in this complex and fast-moving area. Offers the most comprehensive, up-to-date information on the diagnosis and management of, and rehabilitation following, treatment for benign and malignant diseases of the breast. Updates include an extensively updated oncoplastic section and extended medical and radiation oncology sections. Delivers step-by-step clinical guidance highlighted by hundreds of superb illustrations that depict relevant anatomy and pathology, as well as medical and surgical procedures. Reflects the collaborative nature of diagnosis and treatment among radiologists, pathologists, breast and plastic surgeons, radiation and medical oncologists, geneticists and other health care professionals who contribute to the management of patients with breast disease. Includes access to procedural videos that provide expert visual guidance on how to execute key steps and techniques.

Molecular Pathology in Clinical Practice

Author : Debra G.B. Leonard
Publisher : Springer
ISBN 13 : 331919674X
Total Pages : 1001 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Molecular Pathology in Clinical Practice by : Debra G.B. Leonard

Download or read book Molecular Pathology in Clinical Practice written by Debra G.B. Leonard and published by Springer. This book was released on 2016-02-02 with total page 1001 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative textbook offers in-depth coverage of all aspects of molecular pathology practice and embodies the current standard in molecular testing. Since the successful first edition, new sections have been added on pharmacogenetics and genomics, while other sections have been revised and updated to reflect the rapid advances in the field. The result is a superb reference that encompasses molecular biology basics, genetics, inherited cancers, solid tumors, neoplastic hematopathology, infectious diseases, identity testing, HLA typing, laboratory management, genomics and proteomics. Throughout the text, emphasis is placed on the molecular variations being detected, the clinical usefulness of the tests and important clinical and laboratory issues. The second edition of Molecular Pathology in Clinical Practice will be an invaluable source of information for all practicing molecular pathologists and will also be of utility for other pathologists, clinical colleagues and trainees.

Prognostic and Predictive Factors in Breast Cancer

Author : Rosemary A Walker
Publisher : CRC Press
ISBN 13 : 9780367386931
Total Pages : 198 pages
Book Rating : 4.3/5 (869 download)

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Book Synopsis Prognostic and Predictive Factors in Breast Cancer by : Rosemary A Walker

Download or read book Prognostic and Predictive Factors in Breast Cancer written by Rosemary A Walker and published by CRC Press. This book was released on 2019-08-30 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This title reviews the key prognostic factors in breast cancer, discussing the methodologies involved in measuring and reporting. It also examines the roles of major predictive markers such as the steroid receptors, p53 and HER-2. Given the wealth of information in the medical literature on breast cancer, this volume is useful in that it focuses strictly on these factors. That focus makes this text extremely useful for oncologists and researchers who want to learn more about best practices in prognoses.

Handbook of Metastatic Breast Cancer

Author : Charles Swanton
Publisher : CRC Press
ISBN 13 : 1841848123
Total Pages : 314 pages
Book Rating : 4.8/5 (418 download)

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Book Synopsis Handbook of Metastatic Breast Cancer by : Charles Swanton

Download or read book Handbook of Metastatic Breast Cancer written by Charles Swanton and published by CRC Press. This book was released on 2011-11-14 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent developments with novel systemic drugs, palliative surgical techniques and diagnostic imaging have given hope for the treatment of patients whose breast cancer has spread beyond its primary tumour. Written by a team from leading cancer centers in Europe, including the UK's Royal Marsden Hospital, the Handbook of Metastatic Breast Cancer, Sec

Endocrine Therapy in Breast Cancer

Author : William R. Miller
Publisher : CRC Press
ISBN 13 : 0203909836
Total Pages : 395 pages
Book Rating : 4.2/5 (39 download)

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Book Synopsis Endocrine Therapy in Breast Cancer by : William R. Miller

Download or read book Endocrine Therapy in Breast Cancer written by William R. Miller and published by CRC Press. This book was released on 2002-03-08 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference evaluates and describes the latest strategies for hormone suppression and blockade in the management of early and advanced stage breast cancer and explores the effects of tamoxifen, selective estrogen receptor modulators (SERMs), aromatase inhibitors, and their combination on both breast cancers and normal tissues. Endocrine T

The Breast E-Book

Author : Kirby I. Bland
Publisher : Elsevier Health Sciences
ISBN 13 : 1437711219
Total Pages : 1605 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis The Breast E-Book by : Kirby I. Bland

Download or read book The Breast E-Book written by Kirby I. Bland and published by Elsevier Health Sciences. This book was released on 2009-09-09 with total page 1605 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Breast: Comprehensive Management of Benign and Malignant Diseases, 4th Edition, by Kirby I. Bland, MD, and Edward M. Copeland, III, MD, is a surgical reference that offers the most comprehensive, up-to-date resource on the diagnosis and management of, and rehabilitation following, surgery for benign and malignant diseases of the breast. With its multidisciplinary approach, sweeping updates, new contributors, and authoritative guidance, you’ll have exactly what you need to inspire patient confidence and provide the best possible outcomes. Features multidisciplinary advice from experts in surgery, radiation and medical oncology, pathology, molecular biology, pharmacokinetics, and genetics for a well-rounded perspective to enhance patient outcomes. Includes more than 1,500 figures and tables that offer high quality depictions of surgery and treatment procedures. Offers step-by-step guidance through both text and clinical boxes that makes the material relevant to everyday practice. Provides cross-referencing between chapters, as well as references to carefully selected journal articles, that makes further research easier. Uses a new full-color design to highlight key areas of the text and help you focus on important concepts. Presents updated coverage including an expanded section on pathology...and new chapters on granular cell tumors, targeted therapies, integration of radiotherapy and chemotherapy to keep you current. Includes revised chapters on the psychosocial consequences of breast cancer, lifestyle interventions for breast cancer patients, and patient and family resources that equip you to offer complete and compassionate care. Provides additional information on genetics to keep you up to date with the latest genetic discoveries linked to breast cancer and breast diseases. Features the work of many new contributors who provide the latest and freshest perspectives.

Abeloff's Clinical Oncology E-Book

Author : Martin D. Abeloff
Publisher : Elsevier Health Sciences
ISBN 13 : 1437720560
Total Pages : 2586 pages
Book Rating : 4.4/5 (377 download)

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Book Synopsis Abeloff's Clinical Oncology E-Book by : Martin D. Abeloff

Download or read book Abeloff's Clinical Oncology E-Book written by Martin D. Abeloff and published by Elsevier Health Sciences. This book was released on 2008-06-30 with total page 2586 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.

Breast Cancer Biology for the Radiation Oncologist

Author : Jonathan Strauss
Publisher : Springer
ISBN 13 : 3642312209
Total Pages : 94 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Breast Cancer Biology for the Radiation Oncologist by : Jonathan Strauss

Download or read book Breast Cancer Biology for the Radiation Oncologist written by Jonathan Strauss and published by Springer. This book was released on 2015-05-04 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first textbook of its kind devoted to describing the biological complexities of breast cancer in a way that is relevant to the radiation oncologist. Radiation Oncology has long treated breast cancer as a single biological entity, with all treatment decisions being based on clinical and pathologic risk factors. We are now beginning to understand that biological subtypes of breast cancer may have different risks of recurrence as well as different intrinsic sensitivity to radiotherapy. Multi-gene arrays that have for years been used to predict the risk of distant recurrence and the value of systemic chemotherapy may also have utility in predicting the risk of local recurrence. Additionally, the targeted agents used to treat breast cancer may interact with radiotherapy in ways that can be beneficial or undesirable. All of these emerging issues are extensively discussed in this book, and practical evidence-based treatment recommendations are presented whenever possible.

Pathobiology of Human Disease

Author :
Publisher : Elsevier
ISBN 13 : 0123864577
Total Pages : 5000 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Pathobiology of Human Disease by :

Download or read book Pathobiology of Human Disease written by and published by Elsevier. This book was released on 2014-08-01 with total page 5000 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathobiology of Human Disease bridges traditional morphologic and clinical pathology, molecular pathology, and the underlying basic science fields of cell biology, genetics, and molecular biology, which have opened up a new era of research in pathology and underlie the molecular basis of human disease. The work spans more than 48 different biological and medical fields, in five basic sections: Human Organ Systems Molecular Pathology/Basic Mechanisms of Diseases Animal Models/Other Model Systems Experimental Pathology Clinical Pathology Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from research professionals to advanced undergraduate students. Reviews quantitative advances in the imaging and molecular analysis of human tissue, new microarray technologies for analysis of genetic and chromosomal alterations in normal and diseased cells and tissues, and new transgenic models of human disease using conditional, tissue-specific gene targeting Articles link through to relevant virtual microscopy slides, illustrating side-by-side presentation of "Normal" and "Disease" anatomy and histology images Fully-annotated with many supplementary full color images, graphs, tables, and video files linked to data sets and to live references, enabling researchers to delve deeper and visualize solutions

Breast Disease

Author : Adam I. Riker
Publisher : Springer
ISBN 13 : 1493911457
Total Pages : 580 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis Breast Disease by : Adam I. Riker

Download or read book Breast Disease written by Adam I. Riker and published by Springer. This book was released on 2014-11-07 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast Disease: Comprehensive Management provides a clear, concise source of information in order to make real-life, evidence-based decisions for all aspects of breast disease, both benign and malignant. The volume provides the latest breakthroughs in breast cancer research, ranging from paradigm shifts in the surgical management of the axilla, the changing role of adjuvant and neoadjuvant chemotherapy, the impact of molecular medicine in decision-making and the controversial role of prophylactic mastectomy in our era. Within select chapters, “How I do it” clinical scenarios are supplied and described in very practical terms. Also included at the end of each chapter are synoptic questions with detailed answers, akin to the self-assessment (SESAP) format questions and answers. These questions provide a basis for continuous medical education (CME) for the practicing physician and surgeon, further in surgical oncology and breast surgery, medical oncologists, radiation oncologists, and breast radiologists enhancing a focused approach to the management of breast disease in preparation for the American Board of Surgery certification and re-certification for the general surgeon. Breast Disease: Comprehensive Management is of great value to general surgeons, breast surgeons, surgical oncologists, general surgery residents, and fellows.

Breast Cytohistology

Author : Joan Cangiarella
Publisher : Cambridge University Press
ISBN 13 : 052151553X
Total Pages : 223 pages
Book Rating : 4.5/5 (215 download)

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Book Synopsis Breast Cytohistology by : Joan Cangiarella

Download or read book Breast Cytohistology written by Joan Cangiarella and published by Cambridge University Press. This book was released on 2013-09-12 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Each volume in this richly illustrated series, published in association with the Papanicolaou Society of Cytopathology, provides an organ-based approach to the cytological and histological diagnosis of small tissue samples. Benign, pre-malignant and malignant entities are presented in a well-organized and standardized format, with high-resolution color photomicrographs, tables, and lists of key specific morphologic criteria. Example vignettes allow the reader to assimilate the diagnostic principles in a case-based format. This volume provides comprehensive coverage of both surgical pathology and cytopathology of breast lesions. With a focus on malignant tumors, the full spectrum of inflammatory disorders, benign lesions, and hyperplasias are also covered in detail. Advantages and disadvantages of aspiration and core biopsy are discussed, as well as ancillary testing such as hormonal and molecular markers. With over 500 printed photomicrographs and a CD-ROM offering all images in a downloadable format, this is an important resource for all anatomic pathologists.

Breast Pathology, E-Book

Author : David J Dabbs
Publisher : Elsevier Health Sciences
ISBN 13 : 0323795234
Total Pages : 1008 pages
Book Rating : 4.3/5 (237 download)

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Book Synopsis Breast Pathology, E-Book by : David J Dabbs

Download or read book Breast Pathology, E-Book written by David J Dabbs and published by Elsevier Health Sciences. This book was released on 2023-05-19 with total page 1008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written with useful practicality in mind, Breast Pathology, 3rd Edition, provides surgical pathologists with authoritative guidance on the selection and best use of proper diagnostic techniques when reporting on breast specimens. Dr. David J. Dabbs and a team of internationally acclaimed pathologists incorporate genomic and molecular information, gross and microscopic findings, radiologic and laboratory diagnosis, theranostics, and immunohistochemistry to cover every aspect of benign and malignant lesions of the breast, helping you minimize diagnostic variation and error in the sign-out room. Brings you fully up to date with recent advances, including new molecular information for breast entities, new surgical techniques, more widely used multigene prognostic tests, and assays used to determine treatment, such as PD-L1 as a new immunotherapy biomarker for triple-negative breast cancer. Incorporates the latest classifications of breast pathology and molecular diagnosis. Organizes each topical chapter around relevant genomic and molecular information, clinical presentation, gross and microscopic pathologic findings and diagnostic and molecular immunohistochemistry. Maps immunohistochemistry for each entity according to diagnostic, theranostic, and genomic applications, with specific regard to disease entities in each chapter. Discusses breast specimen handling in detail to assure proper sampling and processing for optimal molecular and immunohistochemistry resulting. Supplies a convenient quick reference at the beginning of each chapter that includes all relevant diagnostic, theranostic, and genomic data for fast retrieval. Features approximately 2,000 full-color pathological images that clearly depict clinical, radiological, molecular, immunohistochemical, and theranostic aspects of disease. Includes biomarker guideline updates throughout. Reflects updates to new tumor staging data in the American Joint Committee on Cancer (AJCC) 8th Edition and updated ASCO/CAP guidelines for interpreting HER2 assays.