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Author : Andreas Passos
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (125 download)
Download or read book The Effect of Red Blood Cell Deformability on Microscale Blood Flows written by Andreas Passos and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Oguz Baskurt
Publisher : CRC Press
ISBN 13 : 1439841810
Total Pages : 310 pages
Book Rating : 4.4/5 (398 download)
Download or read book Red Blood Cell Aggregation written by Oguz Baskurt and published by CRC Press. This book was released on 2011-09-28 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Red blood cells in humans-and most other mammals-have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this real
Author : Douglas MacN. Surgenor
Publisher : Academic Press
ISBN 13 : 1483257509
Total Pages : 783 pages
Book Rating : 4.4/5 (832 download)
Download or read book The Red Blood Cell written by Douglas MacN. Surgenor and published by Academic Press. This book was released on 2013-10-22 with total page 783 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Red Blood Cell, Second Edition, Volume II provides a comprehensive treatment and review of basic biomedical knowledge about the circulating, adult red blood cell. This book discusses the transport through red cell membranes; carrier-mediated glucose transport across human red cell membranes; and metabolism of methemoglobin in human erythrocytes. The interaction of oxygen and carbon dioxide with hemoglobin at the molecular level; physiological role of the oxyhemoglobin dissociation curve; hemoglobinopathies; and thalassemia syndromes are also deliberated. This publication likewise covers the red cell genetic polymorphisms; biological life of the red cell; clinical indications for red cells and blood; and biophysical behavior of red cells in suspensions. Other topics include the electrokinetic behavior of red cells; erythrocyte as a biopsy tissue in the evaluation of nutritional status; and knowledge of red cell purine and pyrimidine metabolism coming from the study of human disease. This volume is recommended for students, researchers, teachers, and physicians aiming to acquire knowledge of the red blood cell.
Author : Sha Huang (Ph. D.)
Publisher :
ISBN 13 :
Total Pages : 144 pages
Book Rating : 4.:/5 (899 download)
Download or read book The Relevance of Red Blood Cell Deformability in the Pathophysiology of Blood Disorders written by Sha Huang (Ph. D.) and published by . This book was released on 2014 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Red blood cells (RBCs) play a crucial role in delivering oxygen to the body tissues. During the 120 days of their lifespan, average RBCs would circulate for approximately 500,000 times and undergo repeated deformations in small blood capillaries and splenic cords. Increased RBC clearance in the spleen is considered as one of the direct consequences of reduced RBC deformability. On the other hand, deformability is also indirectly impacting on RBC functionality through its complex connections with underlying molecular mechanisms. With the aid of microfabrication and microfluidic, we are able to perform high-throughput single cell deformability measurement. Overall, we established RBC deformability as an important biomarker for several blood related real world problems such as malaria and blood storage lesion. The ultimate goal is through our quantitative assessment of population-wide single cell deformability, we could aid in the decision-making of various clinical scenarios including drug screening and blood transfusion. Malaria is the most deadly parasitic disease affecting hundred millions of people worldwide. Infected RBCs are found to be less deformable and therefore more susceptible to splenic RBC clearance. In this thesis, we identified several clinically used anti-malarial drugs that are capable of altering RBC deformability and ultimately modifying RBC retention in spleen. We also employed a rodent malarial model, confirming the important connection of RBC deformability with splenic RBC retention and consequently malarial anemia in vivo. Blood storage lesion is another important application of our work. Taking the advantage of device high-throughput, we profiled hundreds of single RBC deformability from a large population and identified subpopulations that are less deformable. These subpopulations also exhibited higher osmotic fragility and were therefore predicted to pose higher transfusion risk according clinical standard. Furthermore, a deformability based sorting device was also developed to filter the less deformable blood subpopulations, improving overall blood quality.
Author : Kathryn Diane Fink
Publisher :
ISBN 13 :
Total Pages : 107 pages
Book Rating : 4.:/5 (994 download)
Download or read book Microfluidic Analysis of Vertebrate Red Blood Cell Characteristics written by Kathryn Diane Fink and published by . This book was released on 2016 with total page 107 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuous multidisciplinary advancements in medicine, science and engineering have led to the rise of biomedical microfluidic devices for clinical diagnoses, laboratory research for modeling and screening of drugs or disease states, and implantable organs such as artificial kidneys. Blood is often the biological fluid of choice for these purposes. However, unique hemodynamic properties observed only in microscale channels complicate experimental repeatability and reliability. For vessels with 10-300μm diameters, red blood cell properties such as deformability have a significant impact on hemorheology, and the blood can no longer be considered as a homogeneous fluid. The flowing blood segregates into a red blood cell rich core bounded by a cell-free layer composed almost entirely of plasma. Viscous forces dominate flow behavior, and shear rates at the wall are much higher than in arteries and veins. The overall viscosity becomes dependent on vessel diameter. These unique characteristics are interesting from a biophysics perspective, but the value of biomedical microfluidic technologies makes research in this regime even more critical. Accordingly, this work focuses on experimental comparison of the microfluidic flow properties of red blood cells with varying physical characteristics. Blood viscosity in microscale tubes was investigated experimentally for 6 blood types (goat, sheep, pig, llama, chicken and turkey) at a range of hematocrits (0-50%). The selected blood types represented a small sample of the wide-ranging red blood cell characteristics found in mammals, birds, reptiles, amphibians and fish. These red blood cells vary in size over an order of magnitude, represent shapes ranging from biconcave to ellipsoidal, and include both nucleated cell types found in birds, amphibians and reptiles and denucleated mammalian cells. Pressure drop experiments at physiologically relevant flow rates were carried out for rigid tubing diameters ranging from 73μm - 161μm. The resulting viscosities were normalized relative to the measurements made of the homologous plasma for each species. The viscosity of blood in this regime is much different than in larger vessels (>500μm) or in small capillaries (
Author : Rym Mehri
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (129 download)
Download or read book Red Blood Cell Aggregation Characterization written by Rym Mehri and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Red blood cells (RBCs) are the most abundant cells in human blood, representing 40 to 45% of the blood volume (hematocrit). These cells have the particular ability to deform and bridge together to form aggregates under very low shear rates. The theory and mechanics behind aggregation are, however, not yet completely understood. The purpose of this work is to provide a novel method to analyze, understand and mimic blood behaviour in microcirculation. The main objective is to develop a methodology to quantify and characterize RBC aggregates and hence enhance the current understanding of the non-Newtonian behaviour of blood at the microscale. For this purpose, suspensions of porcine blood and human blood are tested in vitro in a Poly-di-methylsiloxane (PDMS) microchannel to characterize RBC aggregates within these two types of blood. These microchannels are fabricated using standard photolithography methods. Experiments are performed using a micro Particle Image Velocimetry ( PIV) system for shear rate measurements coupled with a high speed camera for the flow visualization. Corresponding numerical simulations are conducted using a research Computational Fluid Dynamic (CFD) solver, Nek5000, based on the spectral element method solution to the incompressible non-Newtonian Navier-Stokes equations. RBC aggregate sizes are quantified in controlled and measurable shear rate environments for 5, 10 and 15% hematocrit. Aggregate sizes are determined using image processing techniques. Velocity fields of the blood flow are measured experimentally and compared to numerical simulations using simple non-Newtonian models (Power law and Carreau models). This work establishes for the first time a relationship between RBC aggregate sizes and corresponding shear rates in a microfluidic environment as well as one between RBC aggregate sizes and apparent blood viscosity at body temperature in a microfluidic controlled environment. The results of the investigation can be used to help develop new numerical models for non-Newtonian blood flow, provide a better understanding of the mechanics of RBC aggregation and help determine aggregate behaviour in clinical settings such as for degenerative diseases like diabetes and heart disease.
Author : Edward Adam Moffatt
Publisher :
ISBN 13 :
Total Pages : 172 pages
Book Rating : 4.:/5 (157 download)
Download or read book The Effect of the Contents of the Human Red Blood Cell on Its Deformability ... written by Edward Adam Moffatt and published by . This book was released on 1971 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Göteborgs universitet
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (497 download)
Download or read book Filterability and Red Blood Cell Deformability written by Göteborgs universitet and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ryan C. Murdock
Publisher :
ISBN 13 :
Total Pages : 194 pages
Book Rating : 4.:/5 (448 download)
Download or read book An Experimental and Mathematical Analysis of the Relationship Between Red Blood Cell Deformability and Survival in the Circulation written by Ryan C. Murdock and published by . This book was released on 1999 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ir Mazkamal Mohd Zain
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (141 download)
Download or read book A Novel Method of Investigating Red Blood Cell Deformability written by Ir Mazkamal Mohd Zain and published by . This book was released on 1990 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sitong Zhou
Publisher :
ISBN 13 :
Total Pages : 112 pages
Book Rating : 4.:/5 (115 download)
Download or read book The Dynamic Roles of Red Blood Cell in Microcirculation written by Sitong Zhou and published by . This book was released on 2019 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Erythrocytes (otherwise known as red blood cells (RBCs)), are the most common cell type in the body. They are responsible for oxygen (O2) transportation as well as carbon dioxide (CO2) exchange. Different from most cells, red cells have no nuclei in mammals due to the enucleation during the maturation. The structure of erythrocytes was shown to have a phospholipid bilayer membrane, membrane proteins and cell skeleton. It provides the stability that RBCs need for the circulation in the body systems. Also, this well-established structure makes it possible for them to accomplish ion and gas exchange, which therefore keeps the osmolality and pressure stable for extracellular and intracellular environment. Although a great variety of red cell characteristics have been investigated, the mechanism and kinetics of RBCs under certain environmental stimulation have not been well studied. In this work, we studied the development of cell membrane by testing the deformability change of erythrocytes during maturation. With the design of our microfluidic channels in ex vivo experiments, we then learned that RBC can work not only as O2 transporter but also as oxygen sensor itself. When oxygen level decrease, TBC membrane becomes softer and leads to blood flow increase eventually. We then investigated the mechanism of RBC membrane change on a molecular level to study the mechanism of RBC deformability change under hypoxia. We matched our findings in both in vivo and ex vivo experiments. Via in vivo experiments, we could even connect cerebral circulation to neuroactivity. Furthermore, the behavior of RBCs under hypoxia and in shear flow, such as the ATP release, was studied as well via ex vivo experiments. In the study, we focused on the mechanosensitive channel Piezo1 on RBC membrane and found the connection between this ion channel and RBC ATP release."--Abstract.
Author : Islam Khalil
Publisher : BoD – Books on Demand
ISBN 13 : 1789858690
Total Pages : 144 pages
Book Rating : 4.7/5 (898 download)
Download or read book Current and Future Aspects of Nanomedicine written by Islam Khalil and published by BoD – Books on Demand. This book was released on 2020-05-06 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomedicine refers to the use of nanotechnological applications in biomedical fields such as therapeutics, diagnostics, monitoring, visualization, tissue engineering and even surgery. This book presents recent updates in the nanomedicine market and discusses several aspects of drug delivery and tissue regeneration using different platforms and devices.
Author : João Manuel R.S. Tavares
Publisher : Springer
ISBN 13 : 3319681958
Total Pages : 1164 pages
Book Rating : 4.3/5 (196 download)
Download or read book VipIMAGE 2017 written by João Manuel R.S. Tavares and published by Springer. This book was released on 2017-10-12 with total page 1164 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gathers papers presented at the VipIMAGE 2017-VI ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing. It highlights invited lecturers and full papers presented at the conference, which was held in Porto, Portugal, on October 18–20, 2017. These international contributions provide comprehensive coverage on the state-of-the-art in the following fields: 3D Vision, Computational Bio-Imaging and Visualization, Computational Vision, Computer Aided Diagnosis, Surgery, Therapy and Treatment, Data Interpolation, Registration, Acquisition and Compression, Industrial Inspection, Image Enhancement, Image Processing and Analysis, Image Segmentation, Medical Imaging, Medical Rehabilitation, Physics of Medical Imaging, Shape Reconstruction, Signal Processing, Simulation and Modelling, Software Development for Image Processing and Analysis, Telemedicine Systems and their Applications, Tracking and Analysis of Movement, and Deformation and Virtual Reality. In addition, it explores a broad range of related techniques, methods and applications, including: trainable filters, bilateral filtering, statistical, geometrical and physical modelling, fuzzy morphology, region growing, grabcut, variational methods, snakes, the level set method, finite element method, wavelet transform, multi-objective optimization, scale invariant feature transform, Laws’ texture-energy measures, expectation maximization, the Markov random fields bootstrap, feature extraction and classification, support vector machines, random forests, decision trees, deep learning, and stereo vision. Given its breadth of coverage, the book offers a valuable resource for academics, researchers and professionals in Biomechanics, Biomedical Engineering, Computational Vision (image processing and analysis), Computer Sciences, Computational Mechanics, Signal Processing, Medicine and Rehabilitation.
Author : Ronald F. Tuma
Publisher : Academic Press
ISBN 13 : 0080569935
Total Pages : 999 pages
Book Rating : 4.0/5 (85 download)
Download or read book Microcirculation written by Ronald F. Tuma and published by Academic Press. This book was released on 2011-04-28 with total page 999 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference is a volume in the Handbook of Physiology, co-published with The American Physiological Society. Growth in knowledge about the microcirculation has been explosive with the field becoming fragmented into numerous subdisciplines and subspecialties. This volume pulls all of the critical information into one volume. Meticulously edited and reviewed. Benefit: Provides investigators a unique tool to explore the significance of their findings in the context of other aspects of the microcirculation. In this way, the updated edition has a direct role in helping to develop new pathways of research and scholarship Highlights the explosive growth in knowledge about the microcirculation including the biology of nitric oxide synthase (NOS), endothelial cell signaling, angiogenesis, cell adhesion molecules, lymphocyte trafficking, ion channels and receptors, and propagated vasomotor responses. Benefit: Microcirculatory biology has become fragmented into numerous sub-disciplines and subspecialties, and these reference reintegrates the information in one volume
Author : Rui A. Lima
Publisher : MDPI
ISBN 13 : 3039218247
Total Pages : 174 pages
Book Rating : 4.0/5 (392 download)
Download or read book Micro/Nano Devices for Blood Analysis written by Rui A. Lima and published by MDPI. This book was released on 2019-12-03 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of micro- and nanodevices for blood analysis is an interdisciplinary subject that demands the integration of several research fields, such as biotechnology, medicine, chemistry, informatics, optics, electronics, mechanics, and micro/nanotechnologies. Over the last few decades, there has been a notably fast development in the miniaturization of mechanical microdevices, later known as microelectromechanical systems (MEMS), which combine electrical and mechanical components at a microscale level. The integration of microflow and optical components in MEMS microdevices, as well as the development of micropumps and microvalves, have promoted the interest of several research fields dealing with fluid flow and transport phenomena happening in microscale devices. Microfluidic systems have many advantages over their macroscale counterparts, offering the ability to work with small sample volumes, providing good manipulation and control of samples, decreasing reaction times, and allowing parallel operations in one single step. As a consequence, microdevices offer great potential for the development of portable and point-of-care diagnostic devices, particularly for blood analysis. Moreover, the recent progress in nanotechnology has contributed to its increasing popularity, and has expanded the areas of application of microfluidic devices, including in the manipulation and analysis of flows on the scale of DNA, proteins, and nanoparticles (nanoflows). In this Special Issue, we invited contributions (original research papers, review articles, and brief communications) that focus on the latest advances and challenges in micro- and nanodevices for diagnostics and blood analysis, micro- and nanofluidics, technologies for flow visualization, MEMS, biochips, and lab-on-a-chip devices and their application to research and industry. We hope to provide an opportunity to the engineering and biomedical community to exchange knowledge and information and to bring together researchers who are interested in the general field of MEMS and micro/nanofluidics and, especially, in its applications to biomedical areas.
Author : G. Ali Qureshi
Publisher : Elsevier
ISBN 13 : 0080489494
Total Pages : 795 pages
Book Rating : 4.0/5 (84 download)
Download or read book Oxidative Stress and Neurodegenerative Disorders written by G. Ali Qureshi and published by Elsevier. This book was released on 2007-03-22 with total page 795 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oxidative stress is the result of an imbalance in pro-oxidant/antioxidant homeostasis that leads to the generation of toxic reactive oxygen species. Brain cells are continuously exposed to reactive oxygen species generated by oxidative metabolism, and in certain pathological conditions defense mechanisms against oxygen radicals may be weakened and/or overwhelmed. DNA is a potential target for oxidative damage, and genomic damage can contribute to neuropathogenesis. It is important therefore to identify tools for the quantitative analysis of DNA damage in models on neurological disorders. This book presents detailed information on various neurodegenerative disorders and their connection with oxidative stress. This information will provide clinicians with directions to treat these disorders with appropriate therapy and is also of vital importance for the drug industries for the design of new drugs for treatment of degenerative disorders. * Contains the latest information on the subject of neurodegenerative disorders* Reflects on various factors involved in degeneration and gives suggestions for how to tackle these problems
Author : Thomas Laurell
Publisher : Royal Society of Chemistry
ISBN 13 : 1849737061
Total Pages : 593 pages
Book Rating : 4.8/5 (497 download)
Download or read book Microscale Acoustofluidics written by Thomas Laurell and published by Royal Society of Chemistry. This book was released on 2014-12-08 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: The manipulation of cells and microparticles within microfluidic systems using external forces is valuable for many microscale analytical and bioanalytical applications. Acoustofluidics is the ultrasound-based external forcing of microparticles with microfluidic systems. It has gained much interest because it allows for the simple label-free separation of microparticles based on their mechanical properties without affecting the microparticles themselves. Microscale Acoustofluidics provides an introduction to the field providing the background to the fundamental physics including chapters on governing equations in microfluidics and perturbation theory and ultrasound resonances, acoustic radiation force on small particles, continuum mechanics for ultrasonic particle manipulation, and piezoelectricity and application to the excitation of acoustic fields for ultrasonic particle manipulation. The book also provides information on the design and characterization of ultrasonic particle manipulation devices as well as applications in acoustic trapping and immunoassays. Written by leading experts in the field, the book will appeal to postgraduate students and researchers interested in microfluidics and lab-on-a-chip applications.
