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The Design Synthesis And Characterization Of Novel Triple Helical Collagen Mimetic Structures
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Book Synopsis The Design, Synthesis and Characterization of Novel Triple Helical Collagen Mimetic Structures by : Juliann Mijong Kwak
Download or read book The Design, Synthesis and Characterization of Novel Triple Helical Collagen Mimetic Structures written by Juliann Mijong Kwak and published by . This book was released on 2002 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design, Synthesis and Characterization of Scaffold-assembled and Dendritic Collagen Mimetics by : Garth Alden Kinberger
Download or read book The Design, Synthesis and Characterization of Scaffold-assembled and Dendritic Collagen Mimetics written by Garth Alden Kinberger and published by . This book was released on 2002 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design, Synthesis and Characterization of Scaffold-assembled Collagen Mimetics and Peptide Dendrimers by : Weibo Cai
Download or read book The Design, Synthesis and Characterization of Scaffold-assembled Collagen Mimetics and Peptide Dendrimers written by Weibo Cai and published by . This book was released on 2004 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Peptides: The Wave of the Future by : Richard A. Houghten
Download or read book Peptides: The Wave of the Future written by Richard A. Houghten and published by Springer. This book was released on 2014-11-14 with total page 1171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the Second International Peptide Symposium and the Seventeenth American Peptide Symposium, held on 9-14 June, 2001, at the Town and Country Resort in San Diego, California. The biennial meeting was held under the auspices of the American Peptide Society. In addition to the main Symposium, we were honored to have the Merrifield Satellite Symposium, honoring Bruce Merrifield's accomplishments on his 80th birthday. Over 1250 participants from around the world attended the lectures, posters, and exhibits. Reflecting the international nature of the Symposium, there were participants from 37 countries in attendance. In addition to the 75 plenary lectures, there were over 575 poster presentations, and 70 commercial exhibits as well as booths from the American, Australian, Chinese, European, and Japanese Peptide Societies. These proceedings include plenary lectures and oral and poster presentations collected from a wide diversity of topics providing a truly comprehensive and up-to-date overview of the field of peptide science. This publication contains essential reference information for researchers active in peptide science.
Book Synopsis Conformational Assembly and Biological Properties of Collagen Mimetic Peptides and Their Thermally Responsive Polymer Conjugates by : Ohm Divyam Krishna
Download or read book Conformational Assembly and Biological Properties of Collagen Mimetic Peptides and Their Thermally Responsive Polymer Conjugates written by Ohm Divyam Krishna and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Collagens are one of the most abundant proteins found in body tissues and organs, endowing structural integrity, mechanical strength, and multiple biological functions. Destabilized collagen inside human body leads to various degenerative diseases (ex. osteoarthritis) and ageing. This has continued to motivate the design of synthetic peptides and bio-synthetic polypeptides to closely mimic the native collagens in terms of triple helix structure and stability, potential for higher order assembly, and biological properties. However, the widespread application of de novo collagens has been limited in part by the need for hydroxylated proline in the formation of stable triple helical structures. To address this continued need, a hydroxyproline-free, thermally stable collagen-mimetic peptide (CLP-Cys) was rationally designed via the incorporation of electrostatically stabilized amino acid triplets. CLP-Cys was synthesized via solid phase peptide synthesis. The formation and stability of the triple helical structure were indicated via circular dichroism (CD) experiments and confirmed via differential scanning calorimetry (DSC) results. CLP-Cys also self-assembled into nano-rods and micro-fibrils, as evidenced via a combination of dynamic light scattering and transmission electron microscopy. Given the high thermal stability and its propensity for higher-order assembly, CLP-Cys was further functionalized at both the ends with a thermally responsive polymer, poly(diethylene glycol methyl ether methacrylate), (PDEGMEMA) to synthesize a biohybrid triblock copolymer. The CD results indicated that the triple helical form is retained, the thermal unfolding is sustained and helix to coil transition is reversible in the triblock hybrid context. The LCST of PDEGMEMA homopolymer (26 °C) is increased (to 35 °C) upon conjugation to the hydrophilic collagen peptide domain. Further, a combination of static light scattering, Cryo-SEM, TEM and confocal microscopy elucidated that the collapse of the thermo-responsive polymer upon heating (to above the LCST) leads to the assembly of these hybrid materials as micrometer sized spheres. At 75 °C a morphological transformation from spheres to fibrils were observed. These studies provided unique perspectives about the impact of stimuli-responsive polymers and the triple-helix forming peptides on each other; and how temperature as a stimulus can be employed to sequentially guide the assembly. The development of self-assembling hybrid materials with multiple sensitivities to temperature would offer useful opportunities in the design of stimuli-responsive nano-materials. The CLP-Cys peptide sequence has been designed to incorporate biologically relevant amino acid triplets (GEKGER) and its positive impact was seen via recruitment of human mesenchymal stem cells (hMSCs) for adhesion, spreading and proliferation on CLP-Cys functionalized glass and hyaluronic acid based hydrogel surfaces. Therefore, the prospects of these materials in biomedical applications including wound healing and tissue engineering are promising.
Download or read book Collagen written by Peter Fratzl and published by Springer Science & Business Media. This book was released on 2008-05-10 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: Not only does this book provide a comprehensive review of current research advances in collagen structure and mechanics, it also explores this biological macromolecule’s many applications in biomaterials and tissue engineering. Readers gain an understanding of the structure and mechanical behavior of type I collagen and collagen-based tissues in vertebrates across all length scales, from the molecular (nano) to the organ (macro) level.
Book Synopsis Design, Synthesis and Characterization of Artificial Extracellular Matrix Proteins for Tissue Engineering by : Alyssa Panitch
Download or read book Design, Synthesis and Characterization of Artificial Extracellular Matrix Proteins for Tissue Engineering written by Alyssa Panitch and published by . This book was released on 1997 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Collagen-Derived Materials by : Feng Wang
Download or read book Collagen-Derived Materials written by Feng Wang and published by John Wiley & Sons. This book was released on 2022-02-14 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: b”Collagen-Derived MaterialsComprehensive Resource for Current Ideas and Strategies for the Synthesis and Characterization of Advanced Collagen-Derived Materials This book presents and summarizes new synthetic strategies and multi-functional applications of collagen-derived materials in electrochemical energy storage and conversion. Through easily-comprehensible illustrations and images, the book presents basic knowledge for collagen-derived materials (including gelatin and collagen-derived carbons) and their typical synthesis and applications, thus enabling students and new researchers to obtain a thorough understanding of different materials and corresponding application areas. This book also serves as an important reference book for scientists and engineers in different research fields. It presents the up-to-date ideas and strategies for the synthesis and characterization of advanced collagen-derived materials, as well as multi-functional applications (especially in energy-related areas). Sample topics covered within the book include: Structural compositions, properties, and extraction of collagen and gelatin Precursors, structural compositions, and synthesis of collagen-derived carbons Applications of collagen-derived materials in electrochemical energy storage and conversion Applications of collagen-derived materials as electrode and supporting materials in the electrochemical energy storage and conversion systems, including capacitors, batteries, and electrocatalysts Challenges and opportunities for the design and synthesis of different collagen-derived materials For electrochemists, materials scientists, chemical engineers and students in related programs of study who are interested in the topic of collagen-derived materials, Collagen-Derived Materials: Synthesis and Applications in Electrochemical Energy Storage and Conversion serves as an important resource for gaining a holistic understanding of the field and learning about the state of the art based on promising energy-related applications.
Download or read book Peptides written by James P. Tam and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 913 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fifteen American Peptide Symposium (15APS) was held in Nashville, Tennessee, on June 14-19, 1997. This biennial meeting was jointly sponsored by the American Peptide Society and Vanderbilt University. The attendance of 1,081 participants from 37 countries was lower than the two previously held Symposia. However, the number of participating countries was the largest. Thus, it was gratifying to see that this meeting retained both its international flavor and participant loyalty at a time when there are many more symposia held each year on similar subjects. The scientific program, thanks to the insights and efforts of the Program Committee as well as Dr. Peter Schiller, the President of the American Peptide Society, was extraordinarily rich, diverse, and exciting. It was comprised of 124 oral and 550 poster presentations. Three prominent format changes were installed. First, the Symposium started on Saturday instead of Sunday. Second, the program opened on Saturday afternoon with a Mini-symposium by the Young Investigators to give them an early start and attention. Finally, 40 short and definitive reports were given in two parallel sessions. The expanded format permitted an unprecedented number of lectures and enabled wider participation by the attending delegates.
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2008 with total page 906 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Collagen written by Marcel E. Nimni and published by CRC Press. This book was released on 2018-01-18 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series was conceived with the idea of integrating current aspects of ongoing research in the collagen field. The book consists of a spectrum of papers which discus divers aspects such as X-ray structure, the thermodynamics and mechanism of fibrillogenesis, and the use of collagen as a biomaterial for the manufacturing of many implantable, sometimes lifesaving, devises.
Book Synopsis Design, Synthesis and Conformational Analysis of Multi-facial Helix Mimetics by : Theo Flack
Download or read book Design, Synthesis and Conformational Analysis of Multi-facial Helix Mimetics written by Theo Flack and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Directory of Graduate Research written by and published by . This book was released on 2001 with total page 1846 pages. Available in PDF, EPUB and Kindle. Book excerpt: Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Book Synopsis A Review of the Higher-Order Structures and Applications of Collagen Mimetic Peptides by : Max Goldmeier
Download or read book A Review of the Higher-Order Structures and Applications of Collagen Mimetic Peptides written by Max Goldmeier and published by . This book was released on 2016 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collagen is a protein that is a major component of the human body and makes up thirty percent of the total protein in the human body. Collagen mimetic peptides (CMPs) have been used to study the formation of the triple helix of collagen and its higher-ordered structures. This article discusses how CMPs have been used to learn about the physical properties of the triple helix and how the amino acid sequence affects the physical properties, formation, and stability of the triple helix. CMPs have also been designed to form higher-ordered structures for various applications. This work reviews the design principles and strategies employed with various interactions to form higher-ordered structures from CMPs. These strategies include the use of electrostatic interactions, the incorporation of cysteine knots, and metal-induced self-assembly, among others. Many of these higher-ordered structures have applications such as biomolecule attraction, cellular adhesion, nanowire fabrication, and hydrogel formation.
Book Synopsis Synthesis and Biophysical Characterization of Collagen-like Peptides by : James Gerald Bann
Download or read book Synthesis and Biophysical Characterization of Collagen-like Peptides written by James Gerald Bann and published by . This book was released on 2000 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Conformational Analysis of Functionalized Collagen Triple Helices by : Roman Erdmann
Download or read book Synthesis and Conformational Analysis of Functionalized Collagen Triple Helices written by Roman Erdmann and published by . This book was released on 2012 with total page 139 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
