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The Design Synthesis And Biological Evaluation Of Novel Multiple Targeting Anti Cancer Agents
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Book Synopsis The Design, Synthesis and Biological Evaluation of Novel Multiple Targeting Anti-cancer Agents by :
Download or read book The Design, Synthesis and Biological Evaluation of Novel Multiple Targeting Anti-cancer Agents written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis and Biological Evaluation of Novel Tumor-targeting Taxane-based Anticancer Agents by : Jin Chen
Download or read book Design, Synthesis and Biological Evaluation of Novel Tumor-targeting Taxane-based Anticancer Agents written by Jin Chen and published by . This book was released on 2006 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: A novel series of the second-generation taxoid conjugates with o-3 polyunsaturated fatty acids (PUFA) such as docosahexanoic acid (DHA), linolenic acid (LNA) and linoleic acid (LA) has been successfully developed. The new conjugates, tested in vivo, exhibited strong activity against both resistant and sensitive colon and ovarian cancer xenografts. Two of the new conjugates (DHA-SB-T-1214 and DHA-SB-T-1213) caused the total regression of resistant and sensitive type cancers, respectively, with reduced side toxicity.
Book Synopsis Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Applications to Tumor-targeting Drug Delivery Systems by : Xianrui Zhao
Download or read book Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Applications to Tumor-targeting Drug Delivery Systems written by Xianrui Zhao and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Tumor Targeting Delivery by : Larisa Kuznetsova
Download or read book Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Tumor Targeting Delivery written by Larisa Kuznetsova and published by . This book was released on 2005 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Anticancer Agents by : Qiao-Hong Chen
Download or read book Anticancer Agents written by Qiao-Hong Chen and published by MDPI. This book was released on 2021-03-02 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Book Synopsis Synthesis and Biological Evaluation of Novel Anti-cancer Agents by : Nicola Dione Henderson
Download or read book Synthesis and Biological Evaluation of Novel Anti-cancer Agents written by Nicola Dione Henderson and published by . This book was released on 1994 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis and Biological Evaluation of Tumor-targeting Taxane-based Anticancer Agents and MDR Modulators by : Xinyuan Wu
Download or read book Design, Synthesis and Biological Evaluation of Tumor-targeting Taxane-based Anticancer Agents and MDR Modulators written by Xinyuan Wu and published by . This book was released on 2003 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis and Biological Evaluation of Novel Cyclin-dependent Kinase 9 Inhibitors as Anticancer Agents by : Hamad Musfer Alkhtani
Download or read book Design, Synthesis and Biological Evaluation of Novel Cyclin-dependent Kinase 9 Inhibitors as Anticancer Agents written by Hamad Musfer Alkhtani and published by . This book was released on 2015 with total page 470 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis and Biological Evaluation of Some Novel Anti-cancer and Anti-HIV Chemotherapeutic Agents by : Brian Colin Nicholas Morgan Jones
Download or read book Design, Synthesis and Biological Evaluation of Some Novel Anti-cancer and Anti-HIV Chemotherapeutic Agents written by Brian Colin Nicholas Morgan Jones and published by . This book was released on 1991 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design, Synthesis, and Biological Evaluation of Novel Antitumor Agents by : Jude E. Mathews
Download or read book The Design, Synthesis, and Biological Evaluation of Novel Antitumor Agents written by Jude E. Mathews and published by . This book was released on 1996 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis, Photophysical and Biological Evaluation of Novel 1,8-naphthalimide Derivatives as DNA Binders and Potential Anti-cancer Agents by : Emma B. Veale
Download or read book Design, Synthesis, Photophysical and Biological Evaluation of Novel 1,8-naphthalimide Derivatives as DNA Binders and Potential Anti-cancer Agents written by Emma B. Veale and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design, Synthesis and Biological Evaluation of Novel Antitumour Compounds by : Hachemi Kadri
Download or read book The Design, Synthesis and Biological Evaluation of Novel Antitumour Compounds written by Hachemi Kadri and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis, and Biological Evaluations of Novel Taxane-based and Taxane-free Anticancer Agents by : Xudong Geng
Download or read book Design, Synthesis, and Biological Evaluations of Novel Taxane-based and Taxane-free Anticancer Agents written by Xudong Geng and published by . This book was released on 2002 with total page 1608 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis and Evaluation of Novel and Clinically Used Anti-cancer Agents Targeted Intracellularly by : Omar Mohammed
Download or read book Design, Synthesis and Evaluation of Novel and Clinically Used Anti-cancer Agents Targeted Intracellularly written by Omar Mohammed and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis, and Biological Evaluation of Novel Histone Deacetylase Inhibitors as Anti-cancer Agents by : Ayad Abed Ali Chiad Al-Hamashi
Download or read book Design, Synthesis, and Biological Evaluation of Novel Histone Deacetylase Inhibitors as Anti-cancer Agents written by Ayad Abed Ali Chiad Al-Hamashi and published by . This book was released on 2018 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite major advances in cancer treatment strategies in recent years, significant limitations still remain. Selectively targeting cancer cells without affecting normal cells is a challenging task. Epigenetic modifications such as histone acetylation and methylation seem to play a crucial role in cancer pathophysiology. Histone acetylation is the most extensively studied epigenetic modification. Two groups of enzymes, histone deacetylases (HDACs) and histone acetyltransferases (HATs) control the acetylation status of histones. HDAC enzymes, which are overexpressed in many cancer tissues, provide a potential target for cancer chemotherapy. Therefore, HDAC inhibitors are currently being widely investigated as anticancer agents. Most of the current HDAC inhibitors are not selective and have toxic side effects. Selective inhibition of specific HDAC isoforms to preferentially suppress the proliferation of cancer cells is a goal yet to be achieved. Largazole is a macrocyclic, depsipeptide anticancer agent isolated from a marine cyanobacterium. It is a class I selective HDAC inhibitor. The depsipeptide cap group (CG) of largazole interacts with a less conserved area of the HDACs surface and can be targeted to develop isoform-selective HDAC inhibitors. We have used molecular modeling approaches to design several new largazole analogs with modified CGs to modulate the binding interaction with the enzyme surface. We used a novel protection/deprotection protocol to synthesize these analogs. The antiproliferative activity and HDAC isoform selectivity of the synthesized analogs were evaluated. The majority of the clinically used HDAC inhibitors are hydroxamates. Poor selectivity, poor pharmacokinetics, and severe toxic side effects are major limitations in their clinical use. There is a high need to develop new HDAC inhibitors with non-hydroxamate zinc binding groups (ZBG) with superior activity and selectivity profiles. We used molecular modeling studies to design a new class of HDAC inhibitors containing a 1-(1H-imidazol-2-yl)ethan-1-one (HIE) moiety as the ZBG. A structure-activity relationship (SAR) study was conducted by synthesizing a series of HIEs with different structural properties. Some of these compounds showed promising cell growth inhibition with GI50s in the upper nanomolar to lower micromolar range. A representative HIE compound inhibited purified HDAC enzymes with single digit micromolar IC50, with no selectivity preference among different HDAC isoforms. Replacing the ZBG with other groups such as 1-(thiazol-2-yl)ethan-1-one (TE), 1-(pyrimidin-2-yl)ethan-1-one (PE), and 1-(2-hydroxyphenyl)ethan-1-one (HPE) did not result in active compounds.
Book Synopsis Design, Synthesis, and Biological Evaluation of Compounds of Interest in the Chemotherapy of Cancer by : Cong Jiang
Download or read book Design, Synthesis, and Biological Evaluation of Compounds of Interest in the Chemotherapy of Cancer written by Cong Jiang and published by . This book was released on 1987 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design, Synthesis, and Biological Evaluation of Novel Dual-target Inhibitors of Aminoacyl-tRNA Synthetases as Potential Antibacterial Agents by : Nicola Jane Potter
Download or read book Design, Synthesis, and Biological Evaluation of Novel Dual-target Inhibitors of Aminoacyl-tRNA Synthetases as Potential Antibacterial Agents written by Nicola Jane Potter and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: