The Clinical Neurobiology Of Fibromyalgia And Myofascial Pain

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The Clinical Neurobiology of Fibromyalgia and Myofascial Pain

Author : Robert M. Bennett
Publisher : CRC Press
ISBN 13 : 1000156788
Total Pages : 306 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis The Clinical Neurobiology of Fibromyalgia and Myofascial Pain by : Robert M. Bennett

Download or read book The Clinical Neurobiology of Fibromyalgia and Myofascial Pain written by Robert M. Bennett and published by CRC Press. This book was released on 2020-08-11 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Is chronic fatigue syndrome an early process of muscle aging? Is fibromyalgia a central pain state? This book covers the latest developments in pain research as presented at the Fifth World Congress on Myofascial Pain (MYOPAIN 2001). It examines the results of a wide scope of basic and applied research on soft-tissue pain, with a strong focus on therapeutic approaches. Its three main sections explore the neurobiology of central sensitization, regional pain syndromes, and chronic widespread pain. In addition, this well-referenced book presents a fascinating chapter on the complex relationship between muscle pain and aging. Handy graphs, charts, and illustrations make the information easy to assimilate. The Clinical Neurobiology of Fibromyalgia and Myofascial Pain: Therapeutic Implications contains up-to-date information on: the brain?s reactions to states of persistent pain the physical aftermath of torture ways to define and address the emotional distress that commonly observed in chronic pain patients the mechanisms and manifestations of muscle hyperalgesia the pathophysiology of inflammatory muscle pain regional muscle pain syndromes state-of-the-art information on the pathophysiology of visceral pain and visceral-somatic pain representations a case study of a physical therapy approach to fibromyalgia using Myofascial trigger points the epidemiology of widespread pain and its development after injuries syndromes that share overlapping clinical features with fibromyalgia the connection between HPA dysfunction, ANS dysfunction, and fibromyalgia the plasticity of excitatory synaptic transmission in the spinal dorsal horn and its role in the pathogenesis of pain hypersensitivity how the central mechanisms of pain transmission relate to pharmacological systems that are responsible for generating central sensitization states what PET and MRI show us about the role that the cerebral cortex plays in the perception and modulation of pain

Clinical Overview and Pathogenesis of the Fibromyalgia Syndrome, Myofascial Pain Syndrome, and Other

Author : Irwin Jon Russell
Publisher : CRC Press
ISBN 13 : 9781560248330
Total Pages : 262 pages
Book Rating : 4.2/5 (483 download)

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Book Synopsis Clinical Overview and Pathogenesis of the Fibromyalgia Syndrome, Myofascial Pain Syndrome, and Other by : Irwin Jon Russell

Download or read book Clinical Overview and Pathogenesis of the Fibromyalgia Syndrome, Myofascial Pain Syndrome, and Other written by Irwin Jon Russell and published by CRC Press. This book was released on 1996-09-27 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Overview and Pathogenesis of the Fibromyalgia Syndrome, Myofascial Pain Syndrome, and Other Pain Syndromes highlights the work of featured speakers from the MYOPAIN ?95 Third World Congress, an international meeting of the minds regarding the two soft tissue pain conditions of myofascial pain syndrome and fibromyalgia syndrome. The work compiled in this anthology advances reader understanding of these two disorders by sharing the most advanced research in this field. The authors in Clinical Overview and Pathogenesis of the Fibromyalgia Syndrome, Myofascial Pain Syndrome, and Other Pain Syndromes range from clinician investigators to basic scientists, from around the world, whose work has been an important overlap with the directions being taken by clinician investigators in each field. These authors review what has been learned about the clinical features of patient presentation and the contemporary treatments for each disorder. Authors also trace past progress of these disorders as a means for understanding their pathogenesis and to point toward future research directions. This unrivaled source allows physicians, dentists, researchers, and others working in this field to build on proven progress and prepare for the MYOPAIN ?98 meeting in Italy.

The Concise Encyclopedia of Fibromyalgia and Myofascial Pain

Author : Roberto Patarca Montero
Publisher : CRC Press
ISBN 13 : 9780789015273
Total Pages : 0 pages
Book Rating : 4.0/5 (152 download)

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Book Synopsis The Concise Encyclopedia of Fibromyalgia and Myofascial Pain by : Roberto Patarca Montero

Download or read book The Concise Encyclopedia of Fibromyalgia and Myofascial Pain written by Roberto Patarca Montero and published by CRC Press. This book was released on 2002-08-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: An A-to-Z look at these crippling disorders! Compiled by one of the foremost researchers in the field of immunology, The Concise Encyclopedia of Fibromyalgia and Myofascial Pain is an A-to-Z summary of current knowledge that updates patients and health care professionals on these disabling clinical disorders. This vital information has been organized in an easy-to-use format that lets you become familiar with highlights of the most relevant topics. The Concise Encyclopedia of Fibromyalgia and Myofascial Pain gives you immediate access to the latest advances in rheumatology, cardiovascular medicine, endocrinology, epidemiology, immunology, infectious diseases, neurology, psychiatry, and psychology that form the basis for new lines of research and therapeutic intervention. This comprehensive reference summarizes information published mainly in the last decade, providing a thoughtful and balanced resource that will educate and increase awareness of these often-misdiagnosed disorders. The Concise Encyclopedia of Fibromyalgia and Myofascial Pain allows easy access to: relevant case study findings, summarized to provide the answers you need evidence-based alternative medicine approaches pertinent findings on related disorders an extensive bibliography Comprehensive and thorough, The Concise Encyclopedia of Fibromyalgia and Myofascial Pain gives you the information you’ve been looking for on these painful disorders that affect more than six million Americans. This important book gives health care professionals a greater understanding and awareness of fibromyalgia and myofascial pain and gives patients help at their fingertips.

The Fibromyalgia Syndrome

Author : Irwin Jon Russell
Publisher : CRC Press
ISBN 13 : 1000156745
Total Pages : 144 pages
Book Rating : 4.0/5 (1 download)

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Book Synopsis The Fibromyalgia Syndrome by : Irwin Jon Russell

Download or read book The Fibromyalgia Syndrome written by Irwin Jon Russell and published by CRC Press. This book was released on 2020-07-24 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover the latest information for correctly diagnosing FMS at your practice The National Fibromyalgia Association estimates that about 10 million Americans and approximately 3% of the population worldwide suffer with fibromyalgia syndrome, yet the criteria used by doctors to diagnose fibromyalgia is 14 years out of date. The Fibromyalgia Syndrome examines the expert consensus developed by the Health Canada Fibromyalgia Syndrome Committee with the goal of helping practitioners distinguish FMS from other syndromes/illnesses that exhibit chronic body pain. The text encompasses a very broad scope of FMS, including its clinical manifestations, diagnosis, and treatment. This resource provides you with: a new approach to case definition proposed research to validate the new case definition a practical approach to assessment of severity empathetic management what is known about pathogenesis This book meets the growing need for up-to-date information about objective abnormalities in people with FMS and for an integrated approach to its diagnosis and management by primary care physicians. The Fibromyalgia Syndrome will also encourage the scientific and academic communities to actively research the clinical care of people with FMS, ensuring that more effective therapies and medications will be available in the future. These guidelines present a flexible framework that includes the 1990 American College of Rheumatology (ACR) criteria and encompasses more of the potential symptomatic expression of patients. The Fibromyalgia Syndrome provides several appendices to help you find crucial information at a moment’s notice, including: a glossary of acronyms a list of both commonly and rarely seen signs and symptoms of FMS a fibromyalgia syndrome clinical worksheet differential diagnoses of the symptoms of FMS a Symptom Severity and Hierarchy Profile (SSHP) worksheet the Pain Visual Analog Scale (PAIN VAS) and Body Pain Diagram and more The Fibromyalgia Syndrome offers proposed methods and studies to develop and validate the clinical case definition to ascertain its applicability to the clinical practice setting. With better education and increased awareness of FMS, physicians can make a diagnosis earlier in the patient’s course and initiate valuable outpatient care, lessening expensive hospitalization and associated costs.

Soft Tissue Pain Syndromes

Author : Irwin Jon Russell
Publisher : CRC Press
ISBN 13 : 9780789031389
Total Pages : 158 pages
Book Rating : 4.0/5 (313 download)

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Book Synopsis Soft Tissue Pain Syndromes by : Irwin Jon Russell

Download or read book Soft Tissue Pain Syndromes written by Irwin Jon Russell and published by CRC Press. This book was released on 2006-03-03 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: International experts present the latest advances in soft tissue pain diagnosis and treatment Soft Tissue Pain Syndromes: Clinical Diagnosis and Pathogenesis is a collection of the finest presentations from the 2004 International MYOPAIN Society’s Sixth World Congress held in Munich, Germany. Internationally respected experts present the state-of-the-art in pain mechanisms, myofascial pain syndrome, fibromyalgia syndrome, and inflammatory myopathies. Up-to-date innovative studies illustrate appropriate diagnosis approaches and latest practical treatments for soft tissue pain syndromes of all types. To remain effective, physicians and other health care professionals treating soft tissue pain must strive to stay current on the latest research and cutting-edge therapies. Soft Tissue Pain Syndromes explores the latest advances in clinical evaluation, investigation, and principles of management of soft tissue pain in tendons, ligaments, bursa, fascia, muscles and nerves. The book is extensively referenced and contains several figures, tables, and graphs to enhance understanding. Topics in Soft Tissue Pain Syndromes include: new developments in the understanding of myofascial trigger points (TrPs) medical and structural conditions associated with TrPs the causes of orofacial pain treatment to inactivate TrPs effective therapies for myofascial pain the latest developments in the understanding of fibromyalgia syndrome diagnostic criteria and differential diagnosis of fibromyalgia innovative nonpharmacologic therapies for fibromyalgia the metabolism of muscle cells and metabolic myopathies studies on therapies for idiopathic inflammatory myopathies (IIM) low back pain—with the latest therapies reactions in the spinal cord to a painful lesion of a muscle the latest findings in the morphopathogenetic background of muscle pain Soft Tissue Pain Syndromes is crucial reading for physicians and other health care professionals interested in the latest innovations in treating soft tissue pain.

Myopain '04

Author : Irwin Jon Russell
Publisher : CRC Press
ISBN 13 : 9780789027269
Total Pages : 154 pages
Book Rating : 4.0/5 (272 download)

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Book Synopsis Myopain '04 by : Irwin Jon Russell

Download or read book Myopain '04 written by Irwin Jon Russell and published by CRC Press. This book was released on 2004-06-07 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Myofascial Pain and Dysfunction

Author : Janet G. Travell
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 0683083678
Total Pages : 660 pages
Book Rating : 4.6/5 (83 download)

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Book Synopsis Myofascial Pain and Dysfunction by : Janet G. Travell

Download or read book Myofascial Pain and Dysfunction written by Janet G. Travell and published by Lippincott Williams & Wilkins. This book was released on 1992 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt: ...gives a thorough understanding of what myofascial pain actually is, and provides a unique and effective approach to the diagnosis and treatment of this syndrome for the lower body muscles.

Symptom Oriented Pain Management

Author : D K Baheti
Publisher : JP Medical Ltd
ISBN 13 : 9350257971
Total Pages : 626 pages
Book Rating : 4.3/5 (52 download)

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Book Synopsis Symptom Oriented Pain Management by : D K Baheti

Download or read book Symptom Oriented Pain Management written by D K Baheti and published by JP Medical Ltd. This book was released on 2012-07-31 with total page 626 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to help practitioners diagnose the cause of pain based on symptoms presented, and facilitate its management with appropriate treatment. Beginning with an introduction to clinical examination and radiology, the following sections each examine pain in a different part of the body and possible causes and treatment. The final sections discuss alternative pain management with physiotherapy, psychotherapy and allied therapy.

Neuroimaging of Pain

Author : Luca Saba
Publisher : Springer
ISBN 13 : 3319480464
Total Pages : 508 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Neuroimaging of Pain by : Luca Saba

Download or read book Neuroimaging of Pain written by Luca Saba and published by Springer. This book was released on 2017-06-08 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by world renowned scientists, this book expertly reviews all the imaging techniques and exciting new methods for the analysis of the pain, including novel tracers, biomarker, metabolomic and gene-array profiling, together with cellular, genetic, and molecular approaches. Recent advances in human brain imaging techniques have allowed a better understand of the functional connectivity in pain pathways, as well as the functional and anatomical alterations that occur in chronic pain patients. Modern imaging techniques have permitted rapid progress in the understanding of networks in the brain related to pain processing and those related to different types of pain modulation. Neuroimaging of Pain is designed to be a valuable resource for radiologists, neuroradiologists, neurologists and neuroscientists, working in hospitals and universities from junior trainees to consultants.

Mayo Clinic Guide to Fibromyalgia

Author : Andy Abril
Publisher : Mayo Clinic Press
ISBN 13 : 1893005496
Total Pages : 274 pages
Book Rating : 4.8/5 (93 download)

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Book Synopsis Mayo Clinic Guide to Fibromyalgia by : Andy Abril

Download or read book Mayo Clinic Guide to Fibromyalgia written by Andy Abril and published by Mayo Clinic Press. This book was released on 2019-09-24 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fibromyalgia is a condition that’s often misunderstood by the general public and doctors alike. This book aims to dispel myths about fibromyalgia and offers practical strategies that can help anyone living with this condition manage it successfully and return to a fulfilling and enjoyable life. Drawing on decades of experience in treating fibromyalgia, Mayo Clinic Guide to Fibromyalgia offers research-supported, practical strategies that can help anyone with fibromyalgia live their best life now. From personal stories of people living with fibromyalgia to the compassionate expertise of its medical editors, this book seeks to first connect with people who have fibromyalgia in a way that they may not have experienced from loved ones and even doctors. From there, readers will learn about what fibromyalgia is – and isn’t – and find solace in knowing that they’re not alone in the challenges that they face. The half of the book sets the foundation for the second half, which outlines practical strategies shown to be effective in managing fibromyalgia. Along the way, worksheets will help guide readers toward finding the best mix of strategies for managing their symptoms. The entire book comes together in the last part, where readers will put everything they’ve learned into an actionable daily plan that they can start using right away. This book is divided into 4 parts: Part 1 defines fibromyalgia, describes what causes it, and lists the challenges it can pose Part 2 outlines treatment options Part 3 describes strategies for managing fibromyalgia Part 4 outlines steps toward working with your health care team and family and creating a daily action plan for managing symptoms From Publishers Weekly: Coming from one of the most reliable, respected health resources that Americans have, this book is the first one a newly diagnosed patient should consult. (Sept.)

Novel Insights Into the Pathophysiology and Treatment of Fibromyalgia

Author : Bente Danneskiold-Samsøe
Publisher :
ISBN 13 : 9781780844374
Total Pages : pages
Book Rating : 4.8/5 (443 download)

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Book Synopsis Novel Insights Into the Pathophysiology and Treatment of Fibromyalgia by : Bente Danneskiold-Samsøe

Download or read book Novel Insights Into the Pathophysiology and Treatment of Fibromyalgia written by Bente Danneskiold-Samsøe and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, authored by members of the MDS working groups of the Department of Hematology, Oncology and Clinical Immunology of the Heinrich-Heine University of Düsseldorf (Germany) and the Georg-August University Göttingen (Germany), provides an overview and discussion of the pathophysiological concepts, diagnostic procedures and therapeutic approaches in MDS

Pain Management and the Opioid Epidemic

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309459575
Total Pages : 483 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Pain Management and the Opioid Epidemic by : National Academies of Sciences, Engineering, and Medicine

Download or read book Pain Management and the Opioid Epidemic written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-09-28 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug overdose, driven largely by overdose related to the use of opioids, is now the leading cause of unintentional injury death in the United States. The ongoing opioid crisis lies at the intersection of two public health challenges: reducing the burden of suffering from pain and containing the rising toll of the harms that can arise from the use of opioid medications. Chronic pain and opioid use disorder both represent complex human conditions affecting millions of Americans and causing untold disability and loss of function. In the context of the growing opioid problem, the U.S. Food and Drug Administration (FDA) launched an Opioids Action Plan in early 2016. As part of this plan, the FDA asked the National Academies of Sciences, Engineering, and Medicine to convene a committee to update the state of the science on pain research, care, and education and to identify actions the FDA and others can take to respond to the opioid epidemic, with a particular focus on informing FDA's development of a formal method for incorporating individual and societal considerations into its risk-benefit framework for opioid approval and monitoring.

Integrative Pain Medicine

Author : Joseph F. Audette
Publisher : Springer Science & Business Media
ISBN 13 : 1597453447
Total Pages : 580 pages
Book Rating : 4.5/5 (974 download)

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Book Synopsis Integrative Pain Medicine by : Joseph F. Audette

Download or read book Integrative Pain Medicine written by Joseph F. Audette and published by Springer Science & Business Media. This book was released on 2008-02-26 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: This important book fills a need in the developing area of Pain Medicine. It provides physicians with an up-to-date resource that details the current understanding about the basic science underlying the mechanism of action of the various CAM therapies used for pain. It summarizes the clinical evidence both for efficacy and safety, and finishes with practical guidelines about how such treatments could be successfully and safely integrated into a Pain practice.

Pain Medicine

Author : Salim M. Hayek
Publisher : Oxford University Press, USA
ISBN 13 : 0199931488
Total Pages : 457 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Pain Medicine by : Salim M. Hayek

Download or read book Pain Medicine written by Salim M. Hayek and published by Oxford University Press, USA. This book was released on 2015 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain Medicine approaches the management of common chronic pain conditions using a unique interdisciplinary approach focusing on multiple facets of patients' clinical presentations. The comprehensive discussions in each chapter are centered on a vignette that mimics a fairly typical case presentation. In addition to detailed classical descriptions of the epidemiology, pathophysiology, prognosis, and confounding psychosocial factors of each disease entity, the text provides various interdisciplinary management approaches. The case-based approach illustrates key clinical points and demonstrates how practitioners from a variety of disciplines can work together to deliver optimal patient care. The ACGME criteria for fellowship training in Pain Medicine calls for an interdisciplinary approach, with required training and exposure to the fields of Anesthesiology, Neurology, Psychiatry, and Physical Medicine & Rehabilitation. As this trend is occurring in private pain clinics and practices as well as in academic institutions, there is a need for a volume which integrates the approaches of the various disciplines into a coherent whole to guide clinicians and trainees in the interdisciplinary management of pain. With each chapter authored by respected experts in the key specialties involved with pain management, Pain Medicine is a highly applicable clinical reference for practitioners, an excellent anchor text for fellows and residents in training, and a thorough review for initial board certification as well as maintenance of certification exams.

Temporomandibular Disorders

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309670489
Total Pages : 427 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Temporomandibular Disorders by : National Academies of Sciences, Engineering, and Medicine

Download or read book Temporomandibular Disorders written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-01 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: Temporomandibular disorders (TMDs), are a set of more than 30 health disorders associated with both the temporomandibular joints and the muscles and tissues of the jaw. TMDs have a range of causes and often co-occur with a number of overlapping medical conditions, including headaches, fibromyalgia, back pain and irritable bowel syndrome. TMDs can be transient or long-lasting and may be associated with problems that range from an occasional click of the jaw to severe chronic pain involving the entire orofacial region. Everyday activities, including eating and talking, are often difficult for people with TMDs, and many of them suffer with severe chronic pain due to this condition. Common social activities that most people take for granted, such as smiling, laughing, and kissing, can become unbearable. This dysfunction and pain, and its associated suffering, take a terrible toll on affected individuals, their families, and their friends. Individuals with TMDs often feel stigmatized and invalidated in their experiences by their family, friends, and, often, the health care community. Misjudgments and a failure to understand the nature and depths of TMDs can have severe consequences - more pain and more suffering - for individuals, their families and our society. Temporomandibular Disorders: Priorities for Research and Care calls on a number of stakeholders - across medicine, dentistry, and other fields - to improve the health and well-being of individuals with a TMD. This report addresses the current state of knowledge regarding TMD research, education and training, safety and efficacy of clinical treatments of TMDs, and burden and costs associated with TMDs. The recommendations of Temporomandibular Disorders focus on the actions that many organizations and agencies should take to improve TMD research and care and improve the overall health and well-being of individuals with a TMD.

Problem-Based Pain Management

Author : Eric S. Hsu
Publisher : Cambridge University Press
ISBN 13 : 1107513448
Total Pages : 398 pages
Book Rating : 4.1/5 (75 download)

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Book Synopsis Problem-Based Pain Management by : Eric S. Hsu

Download or read book Problem-Based Pain Management written by Eric S. Hsu and published by Cambridge University Press. This book was released on 2013-10-24 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pain management is an essential part of clinical practice for all healthcare providers from trainees, physician assistants and nurse practitioners through to practising physicians. Problem-Based Pain Management is a collaboration between experts in anesthesiology, geriatric medicine, neurology, psychiatry and rehabilitation which presents a multidisciplinary management strategy. Over 60 chapters follow a standard, easy-to-read, quick access format on: clinical presentation, signs and symptoms, lab tests, imaging studies, differential diagnosis, pharmacotherapy, non-pharmacologic approach, interventional procedure, follow-up and prognosis. The broad spectrum of topics include headache, neck and back pain, bursitis, phantom limb pain, sickle cell disease and palliative care. Unlike other large, cumbersome texts currently available, this book serves as a quick, concise and pertinent reference in the diagnosis and management of common pain syndromes.

Neuropathic Pain

Author : Jianguo Cheng
Publisher : Oxford University Press
ISBN 13 : 0190298359
Total Pages : 337 pages
Book Rating : 4.1/5 (92 download)

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Book Synopsis Neuropathic Pain by : Jianguo Cheng

Download or read book Neuropathic Pain written by Jianguo Cheng and published by Oxford University Press. This book was released on 2019-01-21 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuropathic pain is one of the most common, most debilitating, most costly, and most difficult to treat categories of chronic pain conditions that are characterized by a lesion or disease of the somatosensory nervous system. Managing neuropathic pain is challenging and requires skillful assessment and comprehensive and integrated treatment strategies that are mechanism-guided, evidence-based, and individualized. However, these critical and integral elements are very fragmented in the current literature. The mechanistic understanding of neuropathic pain is typically found in basic research articles. Clinical research evidence is presented in forms of clinical trials with emphasis on minimizing biases such as those from patient selection and assessment. Individualized considerations for each patient are usually presented in case reports and problem-based learning discussions. This book overcomes these barriers and integrates all the critical elements around individual patient care into a coherent management strategy that is practical and applicable to daily clinical practice. Rather than compiling what have been published in the literature, this work emphasizes on identifying and highlighting the key points or findings that guide decision-making in clinical practice. It integrates the key points around a typical case scenario that not only represents the core of the diagnostic and therapeutic processes but also allows introduction and differentiation of painful conditions that bare similarities with the case in hand. The overarching goal is to improve clinical outcomes through better understanding of the mechanisms, more accurate diagnosis, and wiser and more comprehensive treatment strategies.