The Chick Embryo Chorioallantoic Membrane In The Study Of Angiogenesis And Metastasis

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The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis

Author : Domenico Ribatti
Publisher : Springer Science & Business Media
ISBN 13 : 9048138450
Total Pages : 130 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis by : Domenico Ribatti

Download or read book The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis written by Domenico Ribatti and published by Springer Science & Business Media. This book was released on 2010-01-28 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chick embryo chorioallantoic membrane (CAM) is an extraembryonic membrane which serves as a gas exchange surface and its function is supported by a dense capillary network. Because of its extensive vascularization and easy accessibility, the CAM has been broadly used to study the morpho-functional aspects of the angiogenesis process in vivo and to investigate the efficacy and mechanisms of action of pro-angiogenic and anti-angiogenic natural and synthetic molecules. The CAM is a suitable site for transplanting tissues, which can survive and develop in the CAM by peripheral anastomoses between graft and original CAM vasculature or by new angiogenic vessels grown from the CAM that invade the graft. While the formation of peripheral anastomoses between host and pre-existing donor vessels is the main, and the most common, mechanism involved in the revascularization of embryonic grafts, the growth of CAM-derived vessels into the graft is only stimulated in tumor grafts. The CAM has long been a favored system for the study of tumor angiogenesis and metastasis, because at this stage the chick immunocompetence system is not fully developed and the conditions for rejection have not been established. Tumors remain avascular for 72 h, after which they are penetrated by new blood vessels and begin a phase of rapid growth. Also, delivery of tumor cells onto the CAM allows the fine study of the effects of tumor derived angiogenic growth factors on blood vessel structure and functionality. The CAM may also used to verify the ability to inhibit the growth of capillaries by implanting tumors onto the CAM and by comparing tumor growth and vascularization with or without the administration of an anti-angiogenic molecule. Other studies using the tumor cells/CAM model have focused on the invasion of the chorionic epithelium and the blood vessels by tumor cells. The cells invade the epithelium and the mesenchymal connective tissue below, where they are found in the form of a dense bed of blood vessels, which is a target for intravasation.

The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis

Author : Domenico Ribatti
Publisher :
ISBN 13 : 9789048138739
Total Pages : 136 pages
Book Rating : 4.1/5 (387 download)

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Book Synopsis The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis by : Domenico Ribatti

Download or read book The Chick Embryo Chorioallantoic Membrane in the Study of Angiogenesis and Metastasis written by Domenico Ribatti and published by . This book was released on 2010-09-08 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Chick Chorioallantoic Membrane Model and Precision Cancer Therapy

Author : Fuyuhiko Tamanoi
Publisher : Academic Press
ISBN 13 : 0128173998
Total Pages : 178 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Chick Chorioallantoic Membrane Model and Precision Cancer Therapy by : Fuyuhiko Tamanoi

Download or read book Chick Chorioallantoic Membrane Model and Precision Cancer Therapy written by Fuyuhiko Tamanoi and published by Academic Press. This book was released on 2019-11-12 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chick Chorioallantoic Membrane Model and Precision Cancer Therapy, Volume 46 in The Enzymes series, highlights new advances in the field, with this new volume presenting interesting chapters on the history of CAM model development, an overview of various CAM-based cancer models, the chick embryo chorioallantoic membrane as an in vivo experimental model to study multiple myelomak, bioluminescent CAM models for screening drugs against pancreatic cancer, X-ray sensitizer screen, patient derived tumor model for esophageal cancer, renal cancer and metastasis, nanoparticle characterization and tumor targeting, and patient derived tumor model for human nasopharyngeal carcinoma. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in The Enzymes series

In Vivo Models to Study Angiogenesis

Author : Domenico Ribatti
Publisher : Academic Press
ISBN 13 : 0128140216
Total Pages : 130 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis In Vivo Models to Study Angiogenesis by : Domenico Ribatti

Download or read book In Vivo Models to Study Angiogenesis written by Domenico Ribatti and published by Academic Press. This book was released on 2017-08-18 with total page 130 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Vivo Models to Study Angiogenesis provides the latest information and an overview of the most common assays for studying angiogenesis in vivo. Under physiological conditions, angiogenesis is tightly controlled, whereas increased production of angiogenic stimuli and/or reduced production of angiogenic inhibitors leads to abnormal neovascularization, such as occurs in cancer, chronic inflammatory disease, diabetic retinopathy, macular degeneration and cardiovascular disorders. Several genetic and epigenetic mechanisms are involved in the early development of the vascular system. This book presents the latest information from the extensive literature and research available. Evidence is now emerging that blood vessels themselves have the ability to provide instructive regulatory signals to surrounding non-vascular target cells during organ development. Thus, endothelial cell signaling is currently believed to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation and postnatal tissue remodeling. Provides information on the most common assays to study angiogenesis in vivo Presents an ideal reference for those interested in angiogenesis as a normal and vital process in growth and development Covers wound healing, the formation of granulation tissue, and the transition of tumors from benign to malignant

Angiogenesis Assays

Author : Carolyn A. Staton
Publisher : John Wiley & Sons
ISBN 13 : 047002934X
Total Pages : 410 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Angiogenesis Assays by : Carolyn A. Staton

Download or read book Angiogenesis Assays written by Carolyn A. Staton and published by John Wiley & Sons. This book was released on 2007-01-11 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis, the development of new blood vessels from the existing vasculature, is essential for physiological growth and over 18,000 research articles have been published describing the role of angiogenesis in over 70 different diseases, including cancer, diabetic retinopathy, rheumatoid arthritis and psoriasis. One of the most important technical challenges in such studies has been finding suitable methods for assessing the effects of regulators of eh angiogenic response. While increasing numbers of angiogenesis assays are being described both in vitro and in vivo, it is often still necessary to use a combination of assays to identify the cellular and molecular events in angiogenesis and the full range of effects of a given test protein. Although the endothelial cell - its migration, proliferation, differentiation and structural rearrangement - is central to the angiogenic process, it is not the only cell type involved. the supporting cells, the extracellular matrix and the circulating blood with its cellular and humoral components also contribute. In this book, experts in the use of a diverse range of assays outline key components of these and give a critical appraisal of their strengths and weaknesses. Examples include assays for the proliferation, migration and differentiation of endothelial cells in vitro, vessel outgrowth from organ cultures, assessment of endothelial and mural cell interactions, and such in vivo assays as the chick chorioallantoic membrane, zebrafish, corneal, chamber and tumour angiogenesis models. These are followed by a critical analysis of the biological end-points currently being used in clinical trials to assess the clinical efficacy of anti-angiogenic drugs, which leads into a discussion of the direction future studies should take. This valuable book is of interest to research scientists currently working on angiogenesis in both the academic community and in the biotechnology and pharmaceutical industries. Relevant disciplines include cell and molecular biology, oncology, cardiovascular research, biotechnology, pharmacology, pathology and physiology.

Handbook of Vascular Biology Techniques

Author : Mark Slevin
Publisher : Springer
ISBN 13 : 9401797161
Total Pages : 466 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Handbook of Vascular Biology Techniques by : Mark Slevin

Download or read book Handbook of Vascular Biology Techniques written by Mark Slevin and published by Springer. This book was released on 2015-03-27 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: A wide range of research methods for the study of vascular development, from basic laboratory protocols to advanced technologies used in clinical practice, are covered in this work. A range of methodologies such as molecular imaging platforms and signalling analysis, along with tumour models are collated here. Four sections explore in vitro techniques, in vivo and ex vivo manipulations, imaging and histological analysis and other novel techniques in vascular biology. Readers will discover basic methodologies used for analysis of endothelial cell growth in vitro, including co-culture models of vessel formation. Authors also explore isolation and purification of cells and methods for analysis of data and visualization of localized vasculature with modern imaging platforms. Both animal models and human disease are covered in this work. Each chapter contains helpful sections on trouble shooting, additional notes and links, supporting the reader to carry out protocols. This book will appeal to students, researchers and medical professionals working in all vascular-linked fields such as cardio- and cerebrovascular, cancer and dementia.

Tumor Vascularization

Author : Domenico Ribatti
Publisher : Academic Press
ISBN 13 : 0128194944
Total Pages : 198 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Tumor Vascularization by : Domenico Ribatti

Download or read book Tumor Vascularization written by Domenico Ribatti and published by Academic Press. This book was released on 2020-01-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment

Metastasis Research Protocols

Author : Susan A. Brooks
Publisher : Springer Science & Business Media
ISBN 13 : 159259137X
Total Pages : 310 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Metastasis Research Protocols by : Susan A. Brooks

Download or read book Metastasis Research Protocols written by Susan A. Brooks and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Volume I, Analysis of Cells and Tissues, we presented a range of protocols aimed at mapping and analyzing the expression of various molecules of pot- tial interest in metastasis research and for examining their production at the genetic level. In this second volume of metastasis research protocols, we move to the level of living cells and tissues and present methodologies applicable to examining metastatic behavior in vitro and in whole animal models. The methods described in the first section of this volume concentrate on the separation of cell lines with high and low metastatic potential, including the genetic modification of cell lines. The assay systems to test defined aspects of the metastatic cascade are then described in Part II and include cell migration assays, assays for matrix degrading enzymes, basement membrane degrading assays, adhesion assays, and assays of angiogenesis. The role of the specific elements of the metastatic cascade assayed in each of these systems in turn must of course be put into perspective relative to their roles in entire living organisms.

Mammary Stem Cells

Author : Maria del Mar Vivanco
Publisher : Humana
ISBN 13 : 9781493925186
Total Pages : 0 pages
Book Rating : 4.9/5 (251 download)

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Book Synopsis Mammary Stem Cells by : Maria del Mar Vivanco

Download or read book Mammary Stem Cells written by Maria del Mar Vivanco and published by Humana. This book was released on 2015-06-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The identification of normal and breast cancer stem cells has offered a new vision of this heterogeneous disease and new hopes for its prognosis and treatment. This volume provides an overview of recent developments in mammary stem cell research and discusses the many varieties of approaches used by researchers to investigate the properties and functions of mammary stem cells. The beginning chapters provide readers with an introduction to mammary stem cells, and the processes used to characterize stem cells and isolate them via fluorescent activated cell sorting. The next few chapters discuss DNA and mRNA sequencing, proteomic techniques to help profile cells, lentiviral cell transduction for gene expression, and in vivo lineage tracing. The final few chapters are dedicated to following stem cells from their initial niche to the new microenvironment at their metastasis site, and to studying these cells using physical and mathematical approaches. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results in the laboratory. Authoritative and cutting-edge, Mammary Stem Cells: Methods and Protocols aims to help members of the scientific community explore the behavior of stem cells and how to work with them in order to guide the design of new and complimentary strategies to be applied in the clinic with the ultimate end goal of fighting breast cancer.

Breast Cancer

Author : Jian Cao
Publisher : Humana
ISBN 13 : 9781493934423
Total Pages : 0 pages
Book Rating : 4.9/5 (344 download)

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Book Synopsis Breast Cancer by : Jian Cao

Download or read book Breast Cancer written by Jian Cao and published by Humana. This book was released on 2016-01-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides resources, ideas, and bench manuals for the study of breast cancer. This book is divided into five sections: methods used in clinical laboratory for diagnosis (Detection of Molecular Markers of Breast Cancer); methods used in both clinical and research laboratories for testing genetic alterations (Genetic Detection of Breast Cancer) and (Isolation of Breast Cancer Cells); methods used to study the behavior of breast cancer cells (In Vitro Experimental Assays for Breast Cancer); and methods used for mimicking human breast cancer in a living organism (In Vivo Experimental Models for Breast Cancer). Breast Cancer: Methods and Protocols also explores several recently developed techniques for the study of breast cancer progression. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and thorough, Breast Cancer: Methods and Protocols, is a valuable handbook for both graduate and advanced undergraduate students of biological sciences, as well as scientists, technicians, and physicians working in the academic, hospital, or pharmaceutical industry aimed at studying or diagnosing breast cancer.

Inflammation and Angiogenesis

Author : Domenico Ribatti
Publisher : Springer
ISBN 13 : 3319684485
Total Pages : 116 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Inflammation and Angiogenesis by : Domenico Ribatti

Download or read book Inflammation and Angiogenesis written by Domenico Ribatti and published by Springer. This book was released on 2017-11-08 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is focused on the analysis of the role played by immune cell components in the angiogenic process associated with inflammation and tumor growth. Both innate and adaptive immune cells are involved in the mechanisms of endothelial cell proliferation, migration and activation, through the production and release of a large spectrum of pro-angiogenic mediators. These may create the specific microenvironment that favors an increased rate of tissue vascularization. The link between chronic inflammation and tumorigenesis was first proposed by Rudolf Virchow in 1863 after the observation that infiltrating leukocytes are a hallmark of tumors and first established a causative connection between the lymph reticular infiltrate at sites of chronic inflammation and the development of cancer. Tumors were described as wounds that never heal and surgeons have long described the tendency of tumors to recur in healing resection margin and it has been reported that wound healing environment provides an opportunistic matrix for tumor growth. As angiogenesis is the result of a net balance between the activities exerted by positive and negative regulators, this book will also provide information on some anti-angiogenic properties of immune cells that may be utilized for a potential pharmacological use as anti-angiogenic agents in inflammation as well as in cancer. The work is written for researchers in the field and also for graduate students which approach this matter.

Advances in Metallodrugs

Author : Shahid Ul-Islam
Publisher : John Wiley & Sons
ISBN 13 : 1119640423
Total Pages : 432 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Advances in Metallodrugs by : Shahid Ul-Islam

Download or read book Advances in Metallodrugs written by Shahid Ul-Islam and published by John Wiley & Sons. This book was released on 2020-07-08 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is organized into 12 important chapters that focus on the progress made by metal-based drugs as anticancer, antibacterial, antiviral, anti-inflammatory, and anti-neurodegenerative agents, as well as highlights the application areas of newly discovered metallodrugs. It can prove beneficial for researchers, investigators and scientists whose work involves inorganic and coordination chemistry, medical science, pharmacy, biotechnology and biomedical engineering.

Avian Immunology

Author : Bernd Kaspers
Publisher : Academic Press
ISBN 13 : 0123972728
Total Pages : 456 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Avian Immunology by : Bernd Kaspers

Download or read book Avian Immunology written by Bernd Kaspers and published by Academic Press. This book was released on 2012-12-02 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research

Nutraceuticals and Natural Product Derivatives

Author : Mohammad Fahad Ullah
Publisher : John Wiley & Sons
ISBN 13 : 1119436672
Total Pages : 450 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Nutraceuticals and Natural Product Derivatives by : Mohammad Fahad Ullah

Download or read book Nutraceuticals and Natural Product Derivatives written by Mohammad Fahad Ullah and published by John Wiley & Sons. This book was released on 2019-03-06 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces readers to the growing applications of nutraceuticals and other natural product derivatives This comprehensive book presents a prophylactic and therapeutic approach to chronic disease prevention strategy by highlighting the translational potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies. It also shares the experiences of highly reputed experts working in the area of phytomedicine and nutraceutical agents in chemoprevention, to promote the significance of natural products and dietary factors as an elite priority for containing chronic diseases in the human population. Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery starts by examining natural food sources for the control of glycemia and the prevention of diabetic complications. It then looks at the anti-aging effects of sulfur-containing amino acids and nutraceuticals, and the potential of garcinia fruits to combat metabolic syndrome. Other topics covered include honey- and propolis-mediated regulation of protein networks in cancer cells; recent trends in drug discovery against Alzheimer’s disease; the therapeutic potential of metalloherbal nanoceuticals; and much more. Offers an alternative, natural approach to the prevention of chronic diseases Emphasizes the potential of plant-derived dietary and non-dietary factors from epidemiological, laboratory, and clinical studies Features contributions from world-renowned experts in the field of phytomedicine and nutraceutical agents in chemoprevention Includes prevention strategies in normal/risk populations through routine inclusion of specific dietary regimens and as therapeutic strategy for better management through adjuvant interventions with conventional treatment protocols Nutraceuticals and Natural Product Derivatives: Disease Prevention & Drug Discovery will appeal to graduate students and professionals in cell and molecular biology, translational research, pharmacology/drug discovery, medicinal chemistry, and clinical nutrition.

Physiologic and Pathologic Angiogenesis

Author : Dan Simionescu
Publisher : BoD – Books on Demand
ISBN 13 : 9535130234
Total Pages : 466 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Physiologic and Pathologic Angiogenesis by : Dan Simionescu

Download or read book Physiologic and Pathologic Angiogenesis written by Dan Simionescu and published by BoD – Books on Demand. This book was released on 2017-04-05 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.

Chemoprevention of Cancer

Author : Daniel W. Nixon
Publisher : CRC Press
ISBN 13 : 9780849368509
Total Pages : 160 pages
Book Rating : 4.3/5 (685 download)

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Book Synopsis Chemoprevention of Cancer by : Daniel W. Nixon

Download or read book Chemoprevention of Cancer written by Daniel W. Nixon and published by CRC Press. This book was released on 1994-11-08 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemoprevention of Cancer guides you through the exciting new field of cancer chemoprevention. It covers epidemiology, known chemopreventive compounds, development of new chemopreventive agents, specific examples of preventive agents and their mechanisms of action, and current prevention clinical trials.

The Triumph of the Embryo

Author : Lewis Wolpert
Publisher : Courier Corporation
ISBN 13 : 0486469298
Total Pages : 226 pages
Book Rating : 4.4/5 (864 download)

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Book Synopsis The Triumph of the Embryo by : Lewis Wolpert

Download or read book The Triumph of the Embryo written by Lewis Wolpert and published by Courier Corporation. This book was released on 2008-01-01 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This is a clear and engagingly written book," declared Nature, "recommended certainly to nonspecialists, but also to developmental biologists." Its exploration of how single cells multiply and develop offers an accessible look at a difficult subject. Easy-to-understand descriptions of experimental studies offer fascinating insights into aging, cancer, regeneration, and evolution. 1993 edition.