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Author : Vladimír Betina
Publisher : Elsevier Science & Technology
ISBN 13 :
Total Pages : 600 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Chemistry and Biology of Antibiotics written by Vladimír Betina and published by Elsevier Science & Technology. This book was released on 1983 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Dev P. Arya
Publisher : John Wiley & Sons
ISBN 13 : 047174302X
Total Pages : 338 pages
Book Rating : 4.4/5 (717 download)
Download or read book Aminoglycoside Antibiotics written by Dev P. Arya and published by John Wiley & Sons. This book was released on 2007-06-29 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances that open new avenues in developing aminoglycoside antibiotics During the last twenty years, there have been numerous advances in the understanding of the chemistry, biochemistry, and recognition of aminoglycosides. This has led to the development of novel antibiotics and opened up new therapeutic targets for intervention. This is the first book to provide a complete overview of recent advances in the field and explore their tremendous potential for drug discovery and rational drug design. With chapters written by one or more leading experts in their specialty areas, the book addresses the chemistry, biology, and toxicology of aminoglycosides. Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery is a great resource for academic and industrial researchers in drug design and mechanism studies and for researchers studying antibiotic resistance, antibiotic design and synthesis, and the discovery of novel pharmaceuticals. It is also a valuable reference for graduate students in pharmacy, pharmaceutical science, biophysics, medicinal chemistry, and chemical biology.
Author : Mrinal K. Bhattacharjee
Publisher : Springer Nature
ISBN 13 : 303107582X
Total Pages : 276 pages
Book Rating : 4.0/5 (31 download)
Download or read book Chemistry of Antibiotics and Related Drugs written by Mrinal K. Bhattacharjee and published by Springer Nature. This book was released on 2022-08-23 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook builds on the success of the earlier edition, offering alternative strategies for discovering new antibiotics. It discusses how the various types of antibiotics and related drugs work to cure infections. Then it delves into the very serious matter of how bacteria are becoming resistant to these antibiotics. It also covers the global action plan on antimicrobial resistance from the World Health Organization and discusses several Antibiotic Stewardship Programs adopted by agencies at local levels. Appropriate for a one-semester course at either the graduate or advanced undergraduate level, the book is self-contained and written in accessible language. It includes all necessary background biochemistry material and a discussion of the latest developments in the field of antibiotics. Original research works are frequently cited and experimental procedures and interpretation of results are emphasized.
Author : Satoshi Omura
Publisher : Academic Press
ISBN 13 : 9780125264518
Total Pages : 668 pages
Book Rating : 4.2/5 (645 download)
Download or read book Macrolide Antibiotics written by Satoshi Omura and published by Academic Press. This book was released on 2002-06-10 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treament.
![Download Chemistry and Biology of [beta]-lactam Antibiotics PDF Online Free](https://books.google.com/books/content/images/frontcover/o_TvAAAAMAAJ?fife=w200-h370)
Author : Robert B. Morin
Publisher :
ISBN 13 :
Total Pages : 432 pages
Book Rating : 4.3/5 (91 download)
Download or read book Chemistry and Biology of [beta]-lactam Antibiotics written by Robert B. Morin and published by . This book was released on 1982 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christopher Walsh
Publisher : John Wiley & Sons
ISBN 13 : 1555819311
Total Pages : 477 pages
Book Rating : 4.5/5 (558 download)
Download or read book Antibiotics written by Christopher Walsh and published by John Wiley & Sons. This book was released on 2020-08-06 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: A chemocentric view of the molecular structures of antibiotics, their origins, actions, and major categories of resistance Antibiotics: Challenges, Mechanisms, Opportunities focuses on antibiotics as small organic molecules, from both natural and synthetic sources. Understanding the chemical scaffold and functional group structures of the major classes of clinically useful antibiotics is critical to understanding how antibiotics interact selectively with bacterial targets. This textbook details how classes of antibiotics interact with five known robust bacterial targets: cell wall assembly and maintenance, membrane integrity, protein synthesis, DNA and RNA information transfer, and the folate pathway to deoxythymidylate. It also addresses the universe of bacterial resistance, from the concept of the resistome to the three major mechanisms of resistance: antibiotic destruction, antibiotic active efflux, and alteration of antibiotic targets. Antibiotics also covers the biosynthetic machinery for the major classes of natural product antibiotics. Authors Christopher Walsh and Timothy Wencewicz provide compelling answers to these questions: What are antibiotics? Where do antibiotics come from? How do antibiotics work? Why do antibiotics stop working? How should our limited inventory of effective antibiotics be addressed? Antibiotics is a textbook for graduate courses in chemical biology, pharmacology, medicinal chemistry, and microbiology and biochemistry courses. It is also a valuable reference for microbiologists, biological and natural product chemists, pharmacologists, and research and development scientists.
Author : Trevor J. Franklin
Publisher : Springer Science & Business Media
ISBN 13 : 0387225544
Total Pages : 188 pages
Book Rating : 4.3/5 (872 download)
Download or read book Biochemistry and Molecular Biology of Antimicrobial Drug Action written by Trevor J. Franklin and published by Springer Science & Business Media. This book was released on 2005-03-03 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subject is one of major interest in basic microbiology and infectious diseases and the book is a known classic.
Author : Antony D. Buss
Publisher : Royal Society of Chemistry
ISBN 13 : 0854041931
Total Pages : 459 pages
Book Rating : 4.8/5 (54 download)
Download or read book Natural Product Chemistry for Drug Discovery written by Antony D. Buss and published by Royal Society of Chemistry. This book was released on 2010 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a comprehensive summary of where natural product chemistry is today in drug discovery. It covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products.
Author : Edwin H. Flynn
Publisher : Elsevier
ISBN 13 : 1483270173
Total Pages : 769 pages
Book Rating : 4.4/5 (832 download)
Download or read book Cephalosporins and Penicillins written by Edwin H. Flynn and published by Elsevier. This book was released on 2013-10-22 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cephalosporins and Penicillins: Chemistry and Biology describes the studies made on cephalosporin in relation to the scientific and medicinal benefits that can be derived from cephalosporin C. This collection discusses how cephalosporin C is produced through modern isolation methods. One paper discusses its structure through chemical means, its degradation products, its derivative and other metabolic products such as penicillin N and cephalosporin P. Another paper explains the preparation method for 7-aminocephalosporanic acid and 6-aminopenicillanic acid through biological or chemical means. Another paper explains the alteration of the dihydrothiazine ring of the cephalosporins as the functionalities of these rings are chemically difficult to obtain. One paper also explains the rearrangements of cephalosporins and penicillins; cephalosporin can be synthesized from penicillin through an intermediacy of penicillin sulfoxide. Other papers discuss the pharmacology and toxicology of cephalosporins, as well as the practical tests and methods of assay that can be used in most cephalosporins, and in some cases, in penicillins. This book can prove useful for pharmacologists, microchemists, research workers, and technologists dealing with toxicology.
Author : Alle Bruggink
Publisher : Springer Science & Business Media
ISBN 13 : 9401008507
Total Pages : 328 pages
Book Rating : 4.4/5 (1 download)
Download or read book Synthesis of β-Lactam Antibiotics written by Alle Bruggink and published by Springer Science & Business Media. This book was released on 2011-06-27 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Penicillins and cephalosporins have a long history in combating bacterial infections. Despite new infectious diseases and occurring resistance, beta-lactam antibiotics will for many years to come continue to play a prominent role in our therapeutic arsenal. This book covers the industrial development of the chemical and biochemical processes used to manufacture these products, as well as looking ahead to possible future processes. The interplay between synthetic organic chemistry with the understanding and application of enzymes, modeling of fermentation processes and integration through (bio-) chemical process engineering is illustrated. In-depth scientific approaches to biocatalysis and biocatalyst development including enzyme kinetics, enzyme crystal studies and semi-rational enzyme mutations are also presented. Metabolic pathway analysis and modeling of fermentation process are treated as well as molecular precision in synthetic approaches to beta-lactams, their precursors and derivatives. Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities. This book represents an excellent case study on the transformation of traditional, stoïchiometric, organic synthesis and classical fermentations into modern (bio-) catalysis and biosynthesis based on insights in metabolic pathways and enzyme actions.
Author : G.G. Gallo
Publisher : Springer Science & Business Media
ISBN 13 : 147579200X
Total Pages : 283 pages
Book Rating : 4.4/5 (757 download)
Download or read book Antibiotics written by G.G. Gallo and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this translation of the Italian second edition, the authors provide a comprehensive account of the current knowledge on antibiotics. They concisely describe how various scientific disciplines are involved in antibiotics research, development, and use. Their work also discusses the industrial and clinical development of new antibiotics, as well as the questions and controversies related to the function of antibiotics in nature. Antibiotics is richly illustrated with clear chemical structures, drawings, diagrams, and synoptical tables.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309168392
Total Pages : 238 pages
Book Rating : 4.3/5 (91 download)
Download or read book Beyond the Molecular Frontier written by National Research Council and published by National Academies Press. This book was released on 2003-03-19 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and chemical engineering have changed significantly in the last decade. They have broadened their scopeâ€"into biology, nanotechnology, materials science, computation, and advanced methods of process systems engineering and controlâ€"so much that the programs in most chemistry and chemical engineering departments now barely resemble the classical notion of chemistry. Beyond the Molecular Frontier brings together research, discovery, and invention across the entire spectrum of the chemical sciencesâ€"from fundamental, molecular-level chemistry to large-scale chemical processing technology. This reflects the way the field has evolved, the synergy at universities between research and education in chemistry and chemical engineering, and the way chemists and chemical engineers work together in industry. The astonishing developments in science and engineering during the 20th century have made it possible to dream of new goals that might previously have been considered unthinkable. This book identifies the key opportunities and challenges for the chemical sciences, from basic research to societal needs and from terrorism defense to environmental protection, and it looks at the ways in which chemists and chemical engineers can work together to contribute to an improved future.
Author : T. J. Franklin
Publisher : Springer Science & Business Media
ISBN 13 : 1475745990
Total Pages : 173 pages
Book Rating : 4.4/5 (757 download)
Download or read book Biochemistry and Molecular Biology of Antimicrobial Drug Action written by T. J. Franklin and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: The subject is one of major interest in basic microbiology and infectious diseases and the book is a known classic.
Author : Robert B. Morin
Publisher : Academic Press
ISBN 13 : 1483277194
Total Pages : 594 pages
Book Rating : 4.4/5 (832 download)
Download or read book Penicillins and Cephalosporins written by Robert B. Morin and published by Academic Press. This book was released on 2014-05-10 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemistry and Biology of ?-Lactam Antibiotics, Volume 1: Penicillins and Cephalosporins provides information pertinent to the study of antibiotics containing the ?-lactam moiety. This book discusses the occurrence of a group of ?-lactam antibiotics structurally related to cephalosporin C. Organized into five chapters, this volume begins with an overview of the mechanism of action of ?-lactam antibiotics that caused many microbiologists to develop screening tools for the detection of the ?-lactam moiety. This text then discusses the discovery of the nocardicins, the thienamycins, and olivanic acids. Other chapters provide a summary of the essential penicillin sulfoxide chemistry that gave rise to many compounds. This book discusses as well the ability of chemists to predict the level of biological activity of a compound from knowledge of its structure through theoretical and physicochemical studies. The final chapter deals with quantitative structure–activity relationships. This book is a valuable resource for microbiologists, chemists, and scientists.
Author : E. J. Corey
Publisher : John Wiley & Sons
ISBN 13 : 1118361733
Total Pages : 272 pages
Book Rating : 4.1/5 (183 download)
Download or read book Molecules and Medicine written by E. J. Corey and published by John Wiley & Sons. This book was released on 2012-02-28 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecules and Medicine provides, for the first time ever, a completely integrated look at chemistry, biology, drug discovery, and medicine. It delves into the discovery, application, and mode of action of more than one hundred of the most significant molecules in use in modern medicine. Opening sections of the book provide a unique, clear, and concise introduction, which enables readers to understand chemical formulas.
Author : R. M. Evans
Publisher :
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4./5 ( download)
Download or read book The Chemistry of the Antibiotics used in medicine written by R. M. Evans and published by . This book was released on 1969 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John Mann
Publisher : Oxford University Press
ISBN 13 : 9780716745082
Total Pages : 74 pages
Book Rating : 4.7/5 (45 download)
Download or read book Bacteria and Antibacterial Agents written by John Mann and published by Oxford University Press. This book was released on 1996 with total page 74 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text is part of the Biochemical and Medicinal Chemistry Series Series Editor: John Mann, Professor of Organic Chemistry, University of Reading The aim of this series of short textbooks is to present full accounts of topics which are at the interface of chemistry and biology, from medicinal chemistry to molecular biology. The topics chosen for inclusion are popular subjects for upper-level undergraduate and postgraduate modular courses, and yet they receive inadequate coverage in traditional textbooks of organic chemistry and of biochemistry. Each text in the series provides a concise and up to date introduction to its subject in an attractive format. Antibiotics are among the most prescribed drugs in the world today, and since their development and commercialization in the early part of this century, they have saved countless millions of lives. Combating bacterial infection has resulted in the development of compounds which include the penecillins, cephalosporins,aminoglycosides and tetracyclins. This concise and up to date textbook uses a wide range of examples to describes the structure, mechanisms of action, synthesis and biosynthetic pathways of the major classes of antibiotics. A serious problem today is the development of microorganisms that are resistant to these 'traditional' antibiotics. This important area is described, with an account of bacterial resistance mechanisms, and the latest advances aimed at overcoming these problems. This textbook is suitable for upper-level undergraduate courses given to chemists, biochemists, microbiologists, pharmacologists and medical students. Postgradates and entrants to the pharmaceutical industry will find it an invaluable introduction to the subject.
