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Author : Mary Martin Sherman
Publisher :
ISBN 13 :
Total Pages : 366 pages
Book Rating : 4.:/5 (89 download)
Download or read book The Biosynthesis and Production of the Polyether Antibiotic Lasalocid A written by Mary Martin Sherman and published by . This book was released on 1985 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mary Martin Sherman
Publisher :
ISBN 13 :
Total Pages : 512 pages
Book Rating : 4.:/5 (891 download)
Download or read book The Biosynthesis and Production of the Polyether Antibiotic Lasalocid A written by Mary Martin Sherman and published by . This book was released on 1985 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John W. Corcoran
Publisher : Springer Science & Business Media
ISBN 13 : 364267724X
Total Pages : 393 pages
Book Rating : 4.6/5 (426 download)
Download or read book Biosynthesis written by John W. Corcoran and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Series on Antibiotics produced by Springer-Verlag began more than a decade ago with the nearly simultaneous appearance of two volumes, one dealing with the mode of action of antibiotics and the other concerning the biosynthesis of them. The standards set by the original Editors were high, and these books have proved useful to many. The rapid advances in our knowl edge of the mode of action of antibiotics and other antitumor agents has stimu lated two further works in the same series (Volume III, 1975; and Volumes Vj1 and Vj2, 1979). For some time it had appeared to Dr. Konrad Springer that the time might' be ripe' for bringing the subject of the biosynthesis of antibiotics up-to-date. This Editor agreed to survey the literature and discuss this possibility with his colleagues who are active in research on antibiotics. In spite of the appearance of numerous review articles, both of a highly special ized and general nature, on the biosynthesis of antibiotics, it was agreed generally that it would be extremely useful to add a new volume on biosynthesis to the Series. Such a work should focus on collecting a group of contributions dealing with those antibiotics whose biosynthesis is understood in much greater detail now than it was in the middle 1960's. Since Volume II on biosynthesis continues to be available, this addition to the series has not dealt with each and every antibiotic whose biosynthesis was studied long ago.
Author : J. W. Westley
Publisher : CRC Press
ISBN 13 : 9780367451929
Total Pages : 432 pages
Book Rating : 4.4/5 (519 download)
Download or read book Polyether Antibiotics written by J. W. Westley and published by CRC Press. This book was released on 2019-12-02 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of essays will stimulate the use of ionophores in different research areas. It includes information on potential breakthroughs in the halogenated derivatives of lasalocid and ethers of antibiotic A204A, polyethers and analytical techniques used to unravel their complex structures.
Author :
Publisher : Academic Press
ISBN 13 : 0080923364
Total Pages : 644 pages
Book Rating : 4.0/5 (89 download)
Download or read book Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates written by and published by Academic Press. This book was released on 2009-04-11 with total page 644 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. Gathers tried and tested methods and techniques from top players in the field Provides an extremely useful reference for the experienced research scientist Covers biosynthesis of Polyketides, Tarpenoids, Aminocoumarins and Crabohydrates
Author : Richard J. Petroski
Publisher : Springer Science & Business Media
ISBN 13 : 1461530121
Total Pages : 373 pages
Book Rating : 4.4/5 (615 download)
Download or read book Secondary-Metabolite Biosynthesis and Metabolism written by Richard J. Petroski and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book was developed from the proceedings of the American Chemical Society, Division of Agricultural & Food Chemistry, subdivision of Natural Products Symposium "Biosynthesis and Metabolism of Secondary Natural Products" held in Atlanta, Georgia, April 1991. The objective of the conference was to bring together people from apparently diverse fields, ranging from biotechnology, metabolism, mechanistic organic chemistry, enzymology, fermentation, and biosynthesis, but who share a common interest in either the biosynthesis or the metabolism of natural products. It is our intention to help bridge the gap between the fields of mechanistic bio-organic chemistry and biotechnology. Our thanks go to Dr. Henry Yokoyama, co-organizer of the symposium, the authors who so kindly contributed chapters, the conference participants, and to those who assisted in the peer review process. We also thank the financial supporters of the symposium: ACS/AGFD, NIH General Medical Sciences, and the agricultural, pharmaceutical, biotechnology, and chromatography companies. A full list of the supporting corporations and institutions is given on the following page. Pharma-Tech and P.C., Inc. are manufacturers of instrumentation for high-speed countercurrent chromatography. We thank the Agricultural Research Service and the U. S. Department of Agriculture for granting me permission to co-organize the conference and for us to complete the book. Richard J. Petroski Susan P. McCormick USDA, ARS, National Center for Agricultural Utilization Research Peoria, IL 61604 June 10, 1992 vii CONTENTS ANTIBIOTICS Polyketide Synthetases: Enzyme Complexes and Multifunctional Proteins Directing the Biosynthesis of Bacterial Metabolites from Fatty Acids. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 . . . . . . . . . . .
Author : Christopher T Walsh
Publisher : Royal Society of Chemistry
ISBN 13 : 1839168013
Total Pages : 1133 pages
Book Rating : 4.8/5 (391 download)
Download or read book Natural Product Biosynthesis written by Christopher T Walsh and published by Royal Society of Chemistry. This book was released on 2022-12-14 with total page 1133 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by leading experts in the enzymology of natural product biosynthesis, this completely revised and updated edition provides a description of the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era. Although some 500 000 – 600 000 natural products have been isolated and characterized over the past two centuries, there may be a 10-fold greater inventory awaiting immediate exploration based on biosynthetic gene cluster predictions. The approach of this book is to codify the chemical logic that underlies each natural product structural class as they are assembled from building blocks of primary metabolism. This second edition integrates many new findings into the sets of principles of the first edition that parsed categories of natural product chemistries into the underlying enzymatic mechanisms and the catalytic machinery for building the varied and complex end product metabolites. New chapters include evaluation of a core set of thermodynamically activated but kinetically stable metabolites that power both primary and secondary metabolic pathways. Also, after decades of uncertainty about the existence of various pericyclase classes, a series of genome mining, heterologous expression, and enzymatic activity characterization have validated a plethora of pericyclases over the past decade. The several types of pericyclases are involved in biosynthetic complexity generation of almost every major category of natural products. This text will serve as a reference point for chemists of every subdiscipline, including synthetic organic chemists and medicinal chemists. It will also be valuable to bioinformatic and computational biologists, pharmacognocists and chemical ecologists, and bioengineers and synthetic biologists.
Author : Colin Stuttard
Publisher : Butterworth-Heinemann
ISBN 13 : 1483295079
Total Pages : 704 pages
Book Rating : 4.4/5 (832 download)
Download or read book Genetics and Biochemistry of Antibiotic Production written by Colin Stuttard and published by Butterworth-Heinemann. This book was released on 2014-06-28 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: * Emphasizes the molecular genetics of antibiotic production * Provides the latest information on the organization of genes encoding the biosynthetic pathway * Explores the mechanisms governing their expression and regulation * Examines the role of resistance genes in protecting organisms from their own lethal products Genetics and Biochemistry of Antibiotic Production brings together the most up-to-date information on the genetic and biochemical mechanisms involved in antibiotic production. A collection of internationally recognized authors provide the latest information on the organization, function and regulation of genes responsible for antibiotic synthesis in a range of bacteria. This unique book groups antibiotics according to their biosynthetic affiliation, providing a background into evolutionary relationships while raising intriguing questions about the raison d'etre of antibiotics in nature.
Author : Kirk-Othmer
Publisher : John Wiley & Sons
ISBN 13 : 0471485039
Total Pages : 885 pages
Book Rating : 4.4/5 (714 download)
Download or read book Kirk-Othmer Encyclopedia of Chemical Technology, Volume 20 written by Kirk-Othmer and published by John Wiley & Sons. This book was released on 2006-04-07 with total page 885 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fifth edition of the Kirk-Othmer Encyclopedia of Chemical Technology builds upon the solid foundation of the previous editions, which have proven to be a mainstay for chemists, biochemists, and engineers at academic, industrial, and government institutions since publication of the first edition in 1949. The new edition includes necessary adjustments and modernisation of the content to reflect changes and developments in chemical technology. Presenting a wide scope of articles on chemical substances, properties, manufacturing, and uses; on industrial processes, unit operations in chemical engineering; and on fundamentals and scientific subjects related to the field. The Encyclopedia describes established technology along with cutting edge topics of interest in the wide field of chemical technology, whilst uniquely providing the necessary perspective and insight into pertinent aspects, rather than merely presenting information. * Set began publication in January 2004 * Over 1,000 articles * More than 600 new or updated articles 27 volumes
Author : Christopher T. Walsh
Publisher : Royal Society of Chemistry
ISBN 13 : 1788010760
Total Pages : 787 pages
Book Rating : 4.7/5 (88 download)
Download or read book Natural Product Biosynthesis written by Christopher T. Walsh and published by Royal Society of Chemistry. This book was released on 2017-04-28 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.
Author : J. W. Westley
Publisher : CRC Press
ISBN 13 : 1000944522
Total Pages : 433 pages
Book Rating : 4.0/5 (9 download)
Download or read book Polyether Antibiotics written by J. W. Westley and published by CRC Press. This book was released on 2023-06-14 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection of essays will stimulate the use of ionophores in different research areas. It includes information on potential breakthroughs in the halogenated derivatives of lasalocid and ethers of antibiotic A204A, polyethers and analytical techniques used to unravel their complex structures.
Author :
Publisher : Academic Press
ISBN 13 : 0080564364
Total Pages : 331 pages
Book Rating : 4.0/5 (85 download)
Download or read book Advances in Applied Microbiology written by and published by Academic Press. This book was released on 1978-01-10 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Applied Microbiology
Author : John W. Westley
Publisher :
ISBN 13 :
Total Pages : 492 pages
Book Rating : 4.:/5 (319 download)
Download or read book Polyether Antibiotics: Biology written by John W. Westley and published by . This book was released on 1982 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 916 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1977 with total page 916 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ari M. P. Koskinen
Publisher : John Wiley & Sons
ISBN 13 : 111970703X
Total Pages : 388 pages
Book Rating : 4.1/5 (197 download)
Download or read book Asymmetric Synthesis of Natural Products written by Ari M. P. Koskinen and published by John Wiley & Sons. This book was released on 2022-09-09 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asymmetric Synthesis of Natural Products Fully updated learning resource covering the concept of using natural product chemistry for strategies in asymmetric synthesis The third edition of Asymmetric Synthesis of Natural Products introduces students to the rapidly growing field of natural products in organic chemistry, discussing the practical, mainly pharmacological, importance of selected compounds and emphasizing the target-oriented approach of organic synthesis which is key in industrial strategies. To aid in reader comprehension, the text includes key references and an Index of Compounds. The textbook is based on two lecture courses (Asymmetric Synthesis & Asymmetric Synthesis of Natural Products), which the author has delivered more than 50 times over the past 20 years in Finland, the UK, Italy, and Greece. This third edition is fully updated from the earlier versions (published by Wiley in 1993 and 2012). The importance of natural products as truly renewable raw materials in sustainable chemistry and circular economy is illustrated through applications of e.g. organocatalysis, organometallic catalysis, and biocatalysis. The contents consist of traditional text supplemented with illustrations (such as chemical drawings and structural formulae). Three dimensional aspects are also discussed with the use of 3D renderings of structures for both reaction mechanisms (molecular modeling) and crystallographic data. Sample topics covered in the textbook include: The foundations of asymmetric synthesis, including the theory and applications of individual asymmetric reactions Sustainable development, the circular economy, and use of renewable raw materials that have become prominent in many fields of science and technology Various natural product classes, including carbohydrates, amino acids, peptides, proteins, nucleosides, nucleotides, nucleic acids, and polyketides The properties of these natural product classes, including their structures, biosynthesis, and interrelationships, as well as examples of asymmetric syntheses and the practical value of these compounds Asymmetric Synthesis of Natural Products is a comprehensive, authoritative, and up-to-date learning resource on the subject for advanced level undergraduate or early-stage graduate students. It is also useful for specialists already working in synthesis who wish to learn about asymmetric synthesis.
Author :
Publisher : Academic Press
ISBN 13 : 0080923356
Total Pages : 703 pages
Book Rating : 4.0/5 (89 download)
Download or read book Complex Enzymes in Microbial Natural Product Biosynthesis, Part A: Overview Articles and Peptides written by and published by Academic Press. This book was released on 2009-04-10 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microbial natural products have been an important traditional source of valuable antibiotics and other drugs but interest in them waned in the 1990s when big pharma decided that their discovery was no longer cost-effective and concentrated instead on synthetic chemistry as a source of novel compounds, often with disappointing results. Moreover understanding the biosynthesis of complex natural products was frustratingly difficult. With the development of molecular genetic methods to isolate and manipulate the complex microbial enzymes that make natural products, unexpected chemistry has been revealed and interest in the compounds has again flowered. This two-volume treatment of the subject will showcase the most important chemical classes of complex natural products: the peptides, made by the assembly of short chains of amino acid subunits, and the polyketides, assembled from the joining of small carboxylic acids such as acetate and malonate. In both classes, variation in sub-unit structure, number and chemical modification leads to an almost infinite variety of final structures, accounting for the huge importance of the compounds in nature and medicine. - Gathers tried and tested methods and techniques from top players in the field - In depth coverage of ribosomally-synthesised and Non-ribosomally-synthesised peptides - Provides an extremely useful reference for the experienced research scientist
Author : James Morrison
Publisher : Elsevier
ISBN 13 : 0323152546
Total Pages : 393 pages
Book Rating : 4.3/5 (231 download)
Download or read book Asymmetric Synthesis V4 written by James Morrison and published by Elsevier. This book was released on 2012-12-02 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asymmetric Synthesis, Volume 4: The Chiral Carbon Pool and Chiral Sulfur, Nitrogen, Phosphorus, and Silicon Centers describes the practical methods of obtaining chiral fragments. Divided into five chapters, this book specifically examines initial chiral transmission and extension. The opening chapter describes the so-called chiral carbon pool, the readily available chiral carbon fragments used as building blocks in synthesis. This chapter also provides a list of 375 chiral building blocks, along with their commercial sources, approximate prices, and methods of synthesis. Schemes involving almost 1,300 structures and the use of chiral building blocks to prepare alkaloids, arachidonic acid metabolites, compounds with chemotherapeutic and pharmacological activity, insect pheromones, sugars, vitamins, terpenoids, and miscellaneous compounds are also included in this text. The remaining chapters provide a similar overview of the chemistry of compounds chiral at sulfur, phosphorus, nitrogen, and silicon. Synthetic chemists and researchers, especially those engaged in pharmaceutical research and specialty chemicals production, will find this book invaluable.
