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Author : Hoorig Nassanian
Publisher :
ISBN 13 :
Total Pages : 444 pages
Book Rating : 4.:/5 (1 download)
Download or read book The Biology of the C-Type Lectin Receptor DC-SIGN written by Hoorig Nassanian and published by . This book was released on 2008 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ajit Varki
Publisher : CSHL Press
ISBN 13 : 9780879696818
Total Pages : 694 pages
Book Rating : 4.6/5 (968 download)
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Author : Sho Yamasaki
Publisher : Springer
ISBN 13 : 4431560157
Total Pages : 213 pages
Book Rating : 4.4/5 (315 download)
Download or read book C-Type Lectin Receptors in Immunity written by Sho Yamasaki and published by Springer. This book was released on 2016-03-22 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book presents the latest findings on C-type lectin receptors, focusing on individual receptors and their signaling. In recent years there have been great advances in the understanding of the function of these receptors as a newly emerging family of pattern-recognition receptors (PRRs) for pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs). Comprising four parts: ITAM-coupled Activating Receptors; HemITAM-bearing Receptors; ITIM-bearing Receptors; and Other Receptors and Related Topics, this comprehensive review covers a broad range of C-type lectin receptors. The updated information on C-type lectin receptors and their ligands provided will appeal to a wide readership, from basic immunologists to physicians and surgeons. In addition, sections on novel drug development make this a valuable resource for pharmaceutical scientists.
Author : Jun Hirabayashi
Publisher : Humana
ISBN 13 : 9781071604298
Total Pages : 0 pages
Book Rating : 4.6/5 (42 download)
Download or read book Lectin Purification and Analysis written by Jun Hirabayashi and published by Humana. This book was released on 2020-04-18 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a series of experimental protocols for glycan analysis using lectins and the functional analysis of lectins. A key feature in this book are two comprehensive overview chapters on lectin structures and a list of the all the lectins—these chapters discuss the latest findings in the field. The remainder of the book covers topics such as lectins from mammals, non-mammalian animals; plants, algae, fungi, protists, bacteria, and viruses. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, Lectin Purification and Analysis: Methods and Protocols is a valuable tool for any scientist interested in learning more about these life systems.
Author : Bernd Lepenies
Publisher : Frontiers Media SA
ISBN 13 : 2889632555
Total Pages : 239 pages
Book Rating : 4.8/5 (896 download)
Download or read book Lectins and Their Ligands in Shaping Immune Responses written by Bernd Lepenies and published by Frontiers Media SA. This book was released on 2019-12-23 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Anthony P Moran
Publisher : Elsevier
ISBN 13 : 0080923240
Total Pages : 1037 pages
Book Rating : 4.0/5 (89 download)
Download or read book Microbial Glycobiology written by Anthony P Moran and published by Elsevier. This book was released on 2009-10-01 with total page 1037 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents in an easy-to-read format a summary of the important central aspects of microbial glycobiology, i.e. the study of carbohydrates as related to the biology of microorganisms. Microbial glycobiology represents a multidisciplinary and emerging area with implications for a range of basic and applied research fields, as well as having industrial, medical and biotechnological implications. - Individual chapters provided by leading international scientists in the field yield insightful, concise and stimulating reviews - Provides researchers with an overview and synthesis of the latest research - Each chapter begins with a brief 200 word Summary/Abstract detailing the topic and focus of the chapter, as well as the concepts to be addressed - Allows researchers to see at a glance what each chapter will cover - Each chapter includes a Research Focus Box - Identifies important problems that still need to be solved and areas that require further investigation
Author : Karlijn Gijzen
Publisher :
ISBN 13 : 9789090220970
Total Pages : 157 pages
Book Rating : 4.2/5 (29 download)
Download or read book Modulation of the Immune System by Ligands of the C-type Lectin DC-SIGN written by Karlijn Gijzen and published by . This book was released on 2007 with total page 157 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sho Yamasaki
Publisher : Springer Nature
ISBN 13 : 3030622371
Total Pages : 203 pages
Book Rating : 4.0/5 (36 download)
Download or read book C-Type Lectins in Immune Homeostasis written by Sho Yamasaki and published by Springer Nature. This book was released on 2020-10-31 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on C-type lectin receptors, a newly emerging family of pattern-recognition receptors (PRRs) and a crucial part of the human innate immune system. Above all, the authors highlight these receptors’ role in the recognition of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) – one of the first steps in responding to foreign and potentially dangerous structures in the human body. The respective chapters chiefly examine various C-type lectin receptors, their corresponding ligands, and signalling. In addition to offering immunologists and clinicians important insights from the latest research, they may also provide novel points of departure for future drug development.
Author :
Publisher :
ISBN 13 :
Total Pages : 248 pages
Book Rating : 4.:/5 (913 download)
Download or read book Chemical Probes of Dendritic Cell C-type Lectin Receptors written by and published by . This book was released on 2014 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dendritic cells (DCs) are professional antigen-presenting cells that possess the unique ability to induce primary immune responses. They directly capture invading pathogens and transmit danger signals to the adaptive immune system, which ultimately initiates a robust immune response. DCs sense invading pathogens through an arsenal of receptors that recognize highly conserved, pathogenic epitopes. These receptors include C-type lectin receptors (CLRs) that bind to pathogenic glycans to facilitate pathogen uptake and degradation. In addition, CLRs also complex host glycans to mediate DC locomotion and cell-cell communication. Despite a clear importance in immunity, many CLRs are exploited by pathogens for nefarious purposes. For example, DC-SIGN is co-opted by pathogens, including HIV-1 and Mycobacterium tuberculosis, to facilitate infection and dissemination. However, the mechanisms that pathogens use to exploit DC-SIGN remain poorly understood. This thesis describes strategies for ligand synthesis that can afford probes of DC-SIGN function. These strategies can be generalized and applied to any CLR of interest. In light of emerging evidence that glycan structure may affect CLR function, I designed polymers bearing pendant carbohydrates (glycopolymers) to function as glycan surrogates. By employing glycopolymers of defined composition, we observed that glycopolymer valency affects both DC-SIGN-mediated internalization and trafficking within the cell. Studying CLRs is challenging due to their overlapping ligand specificities. To target DC-SIGN, we previously generated non-carbohydrate glycomimetics from (--)-shikimic acid that mimic the DC-SIGN ligand, D-mannose. By expanding this approach, I have demonstrated that these compounds can be converted into probes that elicit DC-SIGN function (e.g. internalization, signaling). Moreover, I have developed a divergent synthetic route to non-natural epimers of shikimic acid, thus allowing access to glycomimetics that mimic other CLR ligands. This strategy will therefore allow access to glycomimetic agonists to target any CLR of interest. Finally, I have outlined a methodology to probe antigen presentation in DCs. Using glycopolymers bearing peptide cargo, we are poised to explore two distinct mechanisms of antigen presentation in DCs. We envision this strategy will elucidate the putative roles CLRs may play in antigen presentation. Moreover, this approach may validate CLRs as potential therapeutic targets for vaccine design.
Author : Dieter Klemm
Publisher : Springer
ISBN 13 : 3540371036
Total Pages : 308 pages
Book Rating : 4.5/5 (43 download)
Download or read book Polysaccharides II written by Dieter Klemm and published by Springer. This book was released on 2006-10-06 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book has the Highest Impact Factor of all publications ranked by ISI within Polymer Science. It contains short and concise reports on physics and chemistry of polymers, each written by the world renowned experts. The book is still valid and useful after 5 or 10 years. The electronic version is available free of charge for standing order customers at: springer.com/series/12/
Author : Bernd Kaspers
Publisher : Academic Press
ISBN 13 : 0123972728
Total Pages : 456 pages
Book Rating : 4.1/5 (239 download)
Download or read book Avian Immunology written by Bernd Kaspers and published by Academic Press. This book was released on 2012-12-02 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. - With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far - Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors - Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research
Author : Preetham Elumalai
Publisher : Springer Nature
ISBN 13 : 9811674620
Total Pages : 306 pages
Book Rating : 4.8/5 (116 download)
Download or read book Lectins written by Preetham Elumalai and published by Springer Nature. This book was released on 2022-03-09 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the relationship between receptors, carbohydrate moieties, and pathogenic surfaces and lectins’ pathophysiology of immune responses and examines the mechanisms of action of the molecules for the treatment potentials. Increasing evidence has suggested that lectin-carbohydrate interactions perform important roles in various regulations of immune responses, but much remains to be learned about these crucial properties and their interplay with other molecules. In addition, a better understanding of the structural and functional properties of lectin and the activated immune response will be of critical importance for the development of new diagnostic tools and therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the various lectin types from animal and plant as well as microbial or marine lectins, and this wide range of molecular knowledge directs us to various diseases, including infectious diseases and cancer. In presenting state-of-the-art knowledge on the interactions between lectin and its interactions,the book will help to pave the way for the development of novel targets for the prevention and treatment of many disorders.
Author : Shie-Liang Hsieh
Publisher : Springer Nature
ISBN 13 : 9811515808
Total Pages : 240 pages
Book Rating : 4.8/5 (115 download)
Download or read book Lectin in Host Defense Against Microbial Infections written by Shie-Liang Hsieh and published by Springer Nature. This book was released on 2020-03-09 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systemically presents the latest research on lectins, covering all the major topics in the field, including the heterocomplex of lectins and Toll-like receptors, protective versus pathogenic functions in connection with microbial infections, and novel strategies for enhancing host immunity against infectious diseases caused by viruses, bacteria, and fungi. Lectins are a large group of glycan-binding proteins that recognize diverse glycan and non-glycan structures expressed on prokaryotic and eukaryotic cells, and are vital to cell-cell interactions, the attachment of microbes to host cells, and the recognition and activation of immune responses to exogenous and endogenous danger signals. The composition and structure of microbes are complex and include numerous ‘pathogen-associated molecular patterns’ or ‘damage-associated molecular patterns’. As such, microbes’ interactions with immune cells activate multiple innate immunity receptors and produce distinct inflammatory reactions, which can be protective to contain microbial invasion, or pathogenic to cause tissue damage and shock syndrome in the host. The book shares lessons learned from state-of-the art research in this field, highlights the latest discoveries, and provides insightful discussions on lectin-mediated inflammatory reactions, while also outlining future research directions.
Author : Gerold Schuler
Publisher : CRC Press
ISBN 13 : 9780849356469
Total Pages : 336 pages
Book Rating : 4.3/5 (564 download)
Download or read book Epidermal Langerhans Cells written by Gerold Schuler and published by CRC Press. This book was released on 1990-12-26 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Epidermal Langerhans Cells focuses on epidermal Langerhans cells (LCs) and the important role they play in the induction of contact hypersensitivity and graft rejection. This in-depth work discusses how these antigen-presenting cells are modulated by various physicochemical agents (such as UV light) and how they can be infected by the AIDS virus. It also reveals that cytokines mediate their development into potent T cell-stimulatory dendritic cells. This comprehensive review covers important experimental details and methods, and fascinating information on LCs. It also provides an overview of the immune system as it relates to the skin in health and disease. This up-to-date publication is an indispensable resource for all investigative and clinical dermatologists, as well as immunologists interested in antigen-presenting cells.
Author : Marija Pezer
Publisher : Springer Nature
ISBN 13 : 3030769127
Total Pages : 588 pages
Book Rating : 4.0/5 (37 download)
Download or read book Antibody Glycosylation written by Marija Pezer and published by Springer Nature. This book was released on 2021-10-22 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book summarizes recent advances in antibody glycosylation research. Covering major topics relevant for immunoglobulin glycosylation - analytical methods, biosynthesis and regulation, modulation of effector functions - it provides new perspectives for research and development in the field of therapeutic antibodies, biomarkers, vaccinations, and immunotherapy. Glycans attached to both variable and constant regions of antibodies are known to affect the antibody conformation, stability, and effector functions. Although it focuses on immunoglobulin G (IgG), the most explored antibody in this context, and unravels the natural phenomena resulting from the mixture of IgG glycovariants present in the human body, the book also discusses other classes of human immunoglobulins, as well as immunoglobulins produced in other species and production systems. Further, it reviews the glycoanalytical methods applied to antibodies and addresses a range of less commonly explored topics, such as automatization and bioinformatics aspects of high-throughput antibody glycosylation analysis. Lastly, the book highlights application areas ranging from the ones already benefitting from antibody glycoengineering (such as monoclonal antibody production), to those still in the research stages (such as exploration of antibody glycosylation as a clinical or biological age biomarker), and the potential use of antibody glycosylation in the optimization of vaccine production and immunization protocols. Summarizing the current knowledge on the broad topic of antibody glycosylation and its therapeutic and biomarker potential, this book will appeal to a wide biomedical readership in academia and industry alike. Chapter 4 is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author : Binghe Wang
Publisher : John Wiley & Sons
ISBN 13 : 0470592079
Total Pages : 448 pages
Book Rating : 4.4/5 (75 download)
Download or read book Carbohydrate Recognition written by Binghe Wang and published by John Wiley & Sons. This book was released on 2011-09-06 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains contributions from interdisciplinary scientists to collectively address the issue of targeting carbohydrate recognition for the development of novel therapeutic and diagnostic agents. The book covers (1) biological problems involving carbohydrate recognition, (2) structural factors mediating carbohydrate recognition, (3) design and synthesis of lectin mimics that recognize carbohydrate ligands with high specificity and affinity, and (4) modulation of biological and pathological processes through carbohydrate recognition.
Author : Adeel Malik
Publisher : CRC Press
ISBN 13 : 1000344320
Total Pages : 305 pages
Book Rating : 4.0/5 (3 download)
Download or read book The Glycome written by Adeel Malik and published by CRC Press. This book was released on 2021-07-07 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive understanding of the enigmatic identity of the glycome, a complex but important area of research that has been largely ignored due to its complexity. The authors thoroughly deal with almost all aspects of the glycome, i.e., elucidation of the glycan identity enigma and its role in regulation of the cellular process, and in disease etiology. The book bridges the knowledge gap in understanding the glycome, from being a cell signature to its applications in disease etiology. In addition, it details many of the major insights regarding the possible role of the glycome in various diseases as a therapeutic marker. The book systematically covers the major aspects of the glycome, including the significance of substituting the diverse monosaccharide units to glycoproteins, the role of glycans in disease pathologies, and the challenges and advances in glycobiology. The authors stress the significance and huge encoding power of carbohydrates as well as provide helpful insights in framing the bigger picture. The Glycome: Understanding the Diversity and Complexity of Glycobiology details state-of-the-art developments and emerging challenges of glycome biology, which are going to be key areas of future research, not only in the glycobiology field but also in pharmaceutics.
