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Author : Alvin M. Mauer
Publisher :
ISBN 13 :
Total Pages : 266 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Biology of Human Leukemia written by Alvin M. Mauer and published by . This book was released on 1990 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : AM. Mauer
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (985 download)
Download or read book The Biology of Human Leukemia written by AM. Mauer and published by . This book was released on 1990 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinical Features of Human Leukemia; The Diagnosis of the Acute and Chronic Leukemias, Morphologic Considerations; Immunologic Advances in the Classification of Leukemia; Evidence of the Clonal Proliferation of Hematopoietic Stem Cells in Leukemia; The Clonal Culture of Leukemic Cells; In Vivo and In Vitro Differentiation of Myeloid Leukemic Cells; Cytogenetic Changes in Leukemia and Their Biologic Significance; Genetic Abnormalities in Human Leukemia.
Author : L.O. Baker
Publisher : Springer Science & Business Media
ISBN 13 : 1461326095
Total Pages : 271 pages
Book Rating : 4.4/5 (613 download)
Download or read book Biology and Therapy of Acute Leukemia written by L.O. Baker and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: This year notes two major changes in the annual Detroit Cancer Symposium. The first is our intention of selecting top ics of broad interest to the cancer community and examining the subject from both a basic laboratory and clinical viewpoint. In this way, the importance of both elements of cancer research are noted and the interplay between them emphasized. Further, we believe that Symposia such as this act to stimulate the basic scientist and clinician to continue their studies with the know ledge of the impact that each has upon the other and the nec essary cooperation required to solve the cancer problem. The second change is the publication of this Symposium. The pre vious sixteen were not committed to manuscript form. Given the change in format and intent of the series, we believe that this and subsequent volumes will make important contributions to the cancer literature. The topic of "Biology and Therapy of Acute Leukemia" was chosen for the first Symposium because of its historical signif icance in cancer chemotherapy. The therapeutic rationale for human leukemia is the result of understanding the basic tumor biology largely derived from transplantable leukemias in exper imental animals. It is through these models, as discussed by Dr. Fred Valeriote, that we learned the cellular kinetics of leukemia, the antileukemic effects of new agents and the ef fect of growth perturbation by various chemotherapeutic agents and their combinations.
Author : Rolf Neth
Publisher : Springer Science & Business Media
ISBN 13 : 3642768296
Total Pages : 518 pages
Book Rating : 4.6/5 (427 download)
Download or read book Modern Trends in Human Leukemia IX written by Rolf Neth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive account of the most recent trends in human leukemia, as presented at the Ninth Wilsede Meeting. The internationally renowned contributors deal with all different aspects of these diseases: As well as discussing important clinical aspects of leukemia, new information on the biological basis of leukemia gained using the methods of molecular genetics, cell and molecular biology, virology, and immunology is covered. The book shows both the complexity of leukemia research, as well as the value of basic scientific research in furthering clinical medicine and therapy.
Author : Rolf Neth
Publisher :
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.3/5 (91 download)
Download or read book Modern Trends in Human Leukemia written by Rolf Neth and published by . This book was released on 1974 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael G. Kharas
Publisher :
ISBN 13 : 9781621821427
Total Pages : 300 pages
Book Rating : 4.8/5 (214 download)
Download or read book Leukemia and Lymphoma: Molecular and Therapeutic Insights written by Michael G. Kharas and published by . This book was released on 2020 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Leukemia and lymphoma are cancers that affect cells of the blood. This book examines the genetic and epigenetic changes in blood cells that lead to these conditions and current treatment strategies. Topics covered in this essential volume include: - Cancer Stem Cells - Pediatric Leukemias and Lymphomas - Mouse Models of Myeloid Malignancies - Non-Hodgkin Lymphomas - Immunotherapy - The Future of New Treatment Paradigms
Author : Rolf Neth
Publisher : Springer Science & Business Media
ISBN 13 : 3642746217
Total Pages : 580 pages
Book Rating : 4.6/5 (427 download)
Download or read book Modern Trends in Human Leukemia VIII written by Rolf Neth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: You see things, and sa)' why? But I dream 1hings that never were, and I say, 11'hy 110t? George Bernhard Shaw Far ahead of his time, June 1st, 1909, Alexander Maximov communicated in a lecture, given in the Charite in Berlin, the fundamental knowledge, that there exists a lymphoid hemopoetic stem cell. Alexander Friedenstein explained that during the following years, Maximov also showed that the idea of interaction between hemopoetic cells and their stroma to be one of the most significant experiences. Monoclonal antibodies, recombinant DNA technics and the improvement of tissue culture models are the major developments to improve our possibilities to clarify growth and differentiation functions of hemopoetic cells. During the last two decades it was shown that soluble products, released from T cells, were not only involved in inducing B cells to produce specific immunoglobulin secretion after antigen stimulation. Furthermore, lymphokines together with other cytokines regulate the growth and differentiation of hemopoetic cells. As I have learned from Dick Gershon, our knowledge of the cellular basis for immunoregulation has come a long way since 450 B.C. Thucydides comments on the possible role of immune response in controlling the Black Death. Dick Gershon speculated that no scientific interest for these interesting observations was put forth at that time. Perhaps the problems, the Athenians were having with the Spartans, converted money from basis research into the military budget.
Author : César Cobaleda
Publisher : Humana
ISBN 13 : 9781071608098
Total Pages : 479 pages
Book Rating : 4.6/5 (8 download)
Download or read book Leukemia Stem Cells written by César Cobaleda and published by Humana. This book was released on 2020-12-11 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: The detailed volume aims to provide a comprehensive hands-on manual covering all the techniques involved in the cellular and molecular identification and characterization of both normal hematopoietic and leukemic stem cells, both from human patients and from mouse models of human leukemia. The book also covers the most frequently used experimental approaches for the generation of such stem cell-based models of human leukemia. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and comprehensive, Leukemia Stem Cells: Methods and Protocols serves as an ideal guide for researchers, both expert and novice, seeking to further our knowledge of this vital avenue of cancer research.
Author : Kristin Jill Hope
Publisher :
ISBN 13 : 9780494280218
Total Pages : 328 pages
Book Rating : 4.2/5 (82 download)
Download or read book Characterization of the Biology of Human Acute Myeloid Leukemia Stem Cells written by Kristin Jill Hope and published by . This book was released on 2007 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite a rapidly evolving understanding of the murine HSC niche, its signalling components, and the mechanisms utilized for trafficking to these sites, less is known of the microenvironmental requirements for human HSCs, while the gap in understanding for LSCs is even more pronounced. We demonstrate that administration of an activating anti-CD44 antibody impaired in vivo AML cell homing and facilitated eradication of these cells, including serially transplantable SL-IC in pre-engrafted NOD/SCID mice. Our results highlight CD44 as a key regulator of AML-LSC function, essential for their trafficking to microenvironmental niches and for maintaining their primitive state. The potential importance of microRNAs (miRNA) in the pathogenesis of cancer and in stem cell regulation prompted our investigation into the involvement of miRNAs in the initiation and/or maintenance of AML-LSC. Here we use global miRNA profiling of purified stem, progenitor and mature cell subfractions from primary AML samples to demonstrate the existence of a unique LSC-specific miRNA signature. We also show that mir-155, a miRNA highly expressed at elevated levels in human lymphomas, is also dysregulated in human AML and may play a functional role in maintaining the developmental status and abnormal growth properties of these leukemias. Transplantation models have provided valuable tools with which to investigate hematopoiesis and have been essential in elucidating the hierarchical nature of the murine blood system. In particular, these assays permit the study of hematopoietic stem cells (HSCs), unique in their capacity to re-establish enduring donor hematopoiesis. Similarly, the use of immunodeficient SCID and NOD/SCID mouse strains as recipients for human hematopoietic cells has facilitated the study of human SCID-repopulating cells and SCID-leukemia initiating cells (SL-ICs), responsible for initiating and perpetuating normal and malignant hematopoiesis respectively. Here we use lentiviruses to transduce acute myeloid leukemia (AML) SL-ICs with high efficiency, enabling in vivo tracking of individual SL-ICs. We show that the leukemia stem cell (LSC) compartment is heterogeneous with the existence of distinct classes that differ in proliferation and self-renewal capacity. The finding of a similar functional hierarchy within the normal HSC and LSC compartments represents compelling evidence of a stem cell origin for AML.
Author : R. Neth
Publisher : Springer Science & Business Media
ISBN 13 : 3642875246
Total Pages : 563 pages
Book Rating : 4.6/5 (428 download)
Download or read book Modern Trends in Human Leukemia II written by R. Neth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mene Stil in jeglicher Kunst, daft er die spezijischen Schranken derselben zu entfernen weip, ohne doch ihre spezijischen Vorzuge mit aufzuhe ben, und durch eine weise Benut zung ihrer Eigentumlichkeit ihr einen mehr allgemeinen Charakter erteilt. Friedrich Schiller - Ober die as the tische Erziehung des Menschen. In den Horen, 22. Brief (1795) We are glad that you have all come to this small village and I hope that you will feel at home here for the next few days. The special atmosphere of the surround ings will probably have a good influence on our discussions, and you will perhaps remember this when you are back home again. It takes hard work to save this little piece of nature for man in our highly industrialized world, and we should all be grateful to the Verein Naturschutzpark e. V. (founded in 1909), Alfred Toepfer and his associates for their efforts. We intend to discuss modern trends in human leukemia in this workshop, but we should also take the opportunity to reflect on the trends of the past, which might still be modern.
Author : Harry T. Poteat
Publisher :
ISBN 13 :
Total Pages : 262 pages
Book Rating : 4.:/5 (23 download)
Download or read book The Biology of the Human T Cell Leukemia Virus Type I: Interactions with Cellular Second Messengers written by Harry T. Poteat and published by . This book was released on 1990 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Vinod Pullarkat
Publisher : Springer Nature
ISBN 13 : 3030783111
Total Pages : 200 pages
Book Rating : 4.0/5 (37 download)
Download or read book Biology and Treatment of Leukemia and Bone Marrow Neoplasms written by Vinod Pullarkat and published by Springer Nature. This book was released on 2021-10-09 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a concise update on current understanding of the biology of acute and chronic leukemias and other bone marrow neoplasms, including myelodysplastic and myeloproliferative disorders, and explores new and emerging treatments. There is a particular focus on the molecular abnormalities that are drivers of leukemia and on their detection by modern molecular techniques. Knowledge of the ways in which genomic and metabolic abnormalities in the hematologic neoplasms affect prognosis and treatment decision making is reviewed. Detailed attention is devoted to targeted therapies, including novel drugs, and to potential targets for future drug development. In addition, readers find in-depth discussion of cellular and antibody-based immunotherapies as well as the role of hematopoietic stem cell transplantation in the treatment of leukemias and bone marrow malignancies. The book is of special interest for hematologists, oncologists, and cancer researchers; it is also of value for hematology trainees and medical students.
Author : Gesellschaft Deutscher Naturforscher und Ärzte
Publisher : Springer
ISBN 13 :
Total Pages : 628 pages
Book Rating : 4.3/5 (91 download)
Download or read book Modern Trends in Human Leukemia III written by Gesellschaft Deutscher Naturforscher und Ärzte and published by Springer. This book was released on 1979 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Noel Lawrence Warner
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.:/5 (31 download)
Download or read book Leukaemia written by Noel Lawrence Warner and published by . This book was released on 1981 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Carolien Marthe Wolthuis
Publisher :
ISBN 13 : 9789036762151
Total Pages : pages
Book Rating : 4.7/5 (621 download)
Download or read book The Biology of Human Hematopoietic Stem and Progenitor Cells in Acute Myeloid Leukemia, Aging and Autologous Transplantation written by Carolien Marthe Wolthuis and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bernhard Ø Palsson
Publisher : Springer Science & Business Media
ISBN 13 : 0306468778
Total Pages : 399 pages
Book Rating : 4.3/5 (64 download)
Download or read book Cancer Cell Lines written by Bernhard Ø Palsson and published by Springer Science & Business Media. This book was released on 2006-04-11 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes all human leukemia-lymphoma cell lines that have been established and that grow continuously under standardised in vitro conditions. These lines are derived from cells belonging to all the major hematopoietic cell lineages, i.e. B- and T-lymphocytes, natural killer cells, granulocytic cells and megakaryocytic cells. The clinical data, the culture conditions and the major phenotypic features of the cell lines are described with citations. This book is the first book describing human leukemia-lymphoma cell lines and will be of interest to scientists involved in the areas of hematology, oncology, immunology, molecular biology and cytogenetics. Cancer Cell Lines, Volumes 1-3: These 3 volumes provide a comprehensive text on the culture of established cell lines from every type of human cancer. The volumes provide a basic manual and reference resource for every cancer research scientist using human cancer cells.
Author : Rolf Neth
Publisher : Springer
ISBN 13 :
Total Pages : 484 pages
Book Rating : 4.3/5 (91 download)
Download or read book Modern Trends in Human Leukemia IX written by Rolf Neth and published by Springer. This book was released on 1992 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides a comprehensive account of the most recent trends in human leukemia, as presented at the Ninth Wilsede Meeting. The internationally renowned contributors deal with all different aspects of these diseases: As well as discussing important clinical aspects of leukemia, new information on the biological basis of leukemia gained using the methods of molecular genetics, cell and molecular biology, virology, and immunology is covered. The book shows both the complexity of leukemia research, as well as the value of basic scientific research in furthering clinical medicine and therapy.
