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The Aza Annulation Reaction As A Synthetic Tool For Asymmetric Synthesis And The Construction Of Potentially Biologically Active Compounds
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Book Synopsis The Aza-annulation Reaction as a Synthetic Tool for Asymmetric Synthesis and the Construction of Potentially Biologically Active Compounds by : Petr Beňovský
Download or read book The Aza-annulation Reaction as a Synthetic Tool for Asymmetric Synthesis and the Construction of Potentially Biologically Active Compounds written by Petr Beňovský and published by . This book was released on 1997 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Dissertation Abstracts International by :
Download or read book Dissertation Abstracts International written by and published by . This book was released on 1998 with total page 950 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Aromatic 3-Aza-Cope Rearrangement and Aza-annulation Reaction as Synthetic Tools for the Construction of Nitrogen Heterocycles by : Lars Guenter Beholz
Download or read book The Aromatic 3-Aza-Cope Rearrangement and Aza-annulation Reaction as Synthetic Tools for the Construction of Nitrogen Heterocycles written by Lars Guenter Beholz and published by . This book was released on 1994 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Asymmetric Synthesis by :
Download or read book Advances in Asymmetric Synthesis written by and published by Elsevier. This book was released on 1995-03-01 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Asymmetric Synthesis
Book Synopsis American Doctoral Dissertations by :
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1997 with total page 806 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Asymmetric Synthesis by : Bozzano G Luisa
Download or read book Advances in Asymmetric Synthesis written by Bozzano G Luisa and published by Elsevier. This book was released on 1997-05-16 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Asymmetric Synthesis
Book Synopsis Asymmetric Synthesis of Non-Proteinogenic Amino Acids by : Ashot S. Saghyan
Download or read book Asymmetric Synthesis of Non-Proteinogenic Amino Acids written by Ashot S. Saghyan and published by John Wiley & Sons. This book was released on 2016-11-14 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Authored by two internationally recognized experts with an excellent track record, this much-needed reference summarizes latest research in the rapidly developing field of stereoselective synthesis of enantiomerically enriched amino acids, particularly of non-proteinogenic origin. It highlights several different catalytic and stoichiometric asymmetric methods for their synthesis and also provides information on origin, biological properties, different synthetic strategies and important applications in medicine and pharmacology. Essential reading for synthetic chemists working in the field of asymmetric synthesis, natural products and peptide synthesis, stereochemistry, medicinal chemistry, biochemistry, pharmacology, and biotechnology.
Book Synopsis Asymmetric Synthesis by : James D. Morrison
Download or read book Asymmetric Synthesis written by James D. Morrison and published by Elsevier. This book was released on 2012-12-02 with total page 409 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chapters in this volume have been written by some of the foremost practictioners in the field and should be of interest to both mechanistic and synthetic chemists.
Book Synopsis Principles and Applications of Asymmetric Synthesis by : Guo-Qiang Lin
Download or read book Principles and Applications of Asymmetric Synthesis written by Guo-Qiang Lin and published by Wiley-Interscience. This book was released on 2003-05-29 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asymmetric synthesis remains a challenge to practicing scientists as the need for enantiomerically pure or enriched compounds continues to increase. Over the last decade, a large amount of literature has been published in this field. Principles and Applications of Asymmetric Synthesis consolidates and evaluates the most useful methodologies into a one-volume resource for the convenience of practicing scientists and students. Authored by internationally renowned scientists in the field, this reliable reference covers more than 450 reactions and includes important stoichiometric as well as catalytic asymmetric reactions. The first chapter reviews the basic principles, common nomenclature, and analytical methods, and the remainder of the book is organized according to reaction type. The text examines such topics as: Carbon-carbon bond formations involving carbonyls, enamines, imines, and enolates Asymmetric C-O bond formations including epoxidation, dihydroxylation, and aminohydroxylation Asymmetric synthesis using the Diels-Alder reaction and other cyclizations Applications to the total synthesis of natural products Use of enzymes in asymmetric synthesis Practicing chemists in the pharmaceutical, fine chemical, and agricultural professions as well as graduate students will find that Principles and Applications of Asymmetric Synthesis affords comprehensive and current coverage.
Book Synopsis Atropisomerism And Axial Chirality by : Lassaletta Jose M
Download or read book Atropisomerism And Axial Chirality written by Lassaletta Jose M and published by World Scientific. This book was released on 2019-05-23 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atropisomerism and Axial Chirality provides a global survey of the chemistry of axially chiral compounds including biaryls, heterobiaryls, non-biaryl atropisomers, allenes and spyrocyclic derivatives. From the perspective of a synthetic organic chemist, this book provides a unique compilation of the available methodologies for their synthesis, with emphasis on the most efficient and modern strategies, a review of the huge amount of practical applications in the field of asymmetric catalysis, either as transition metal ligands or as organocatalysts, and an overview of their occurrence as bioactive compounds and natural products.The first of its kind, this book serves as a general introduction and a practical reference to advanced chemistry students and researchers, while also offering creative ideas for further developments in the field.
Book Synopsis Asymmetric Synthesis and Application of Alpha-Amino Acids by : Vadim A Soloshonok
Download or read book Asymmetric Synthesis and Application of Alpha-Amino Acids written by Vadim A Soloshonok and published by American Chemical Society. This book was released on 2009-07-09 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents the most recent and comprehensive collection of reviews on methodological developments in the field of alpha-amino acids.
Book Synopsis Catalytic Asymmetric Synthesis by : Takahiko Akiyama
Download or read book Catalytic Asymmetric Synthesis written by Takahiko Akiyama and published by John Wiley & Sons. This book was released on 2022-05-27 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.
Book Synopsis Progress Toward a Scalable Synthesis of Azaspirene, an Angiogenesis Inhibitor and Synthesis of 2-Amino-benzimidazole Compounds Targeting Subdomain IIa of the Internal Ribosome Entry Site Inhibiting Translation of the Hepatitis C Virus by :
Download or read book Progress Toward a Scalable Synthesis of Azaspirene, an Angiogenesis Inhibitor and Synthesis of 2-Amino-benzimidazole Compounds Targeting Subdomain IIa of the Internal Ribosome Entry Site Inhibiting Translation of the Hepatitis C Virus written by and published by . This book was released on 2014 with total page 193 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical studies toward the synthesis of an angiogenesis inhibitor azaspirene is described. There is a need for a concise and scalable asymmetric synthesis of azaspirene. The current strategy employed can lead to the production of small libraries of azaspirene derivatives and other members of the pseurotin family, where structure activity relationship (SAR) studies can be conducted in anticipation of creating innovative and more effective anti-cancer drugs. Amino acids as well as other optically active compounds make great raw materials for the synthesis of asymmetric products with deliberate stereocontrol. Numerous synthetic routes for the synthesis of azaspirene are presented with the latest strategy starting from optically active malic acid showing the most viability. Azaspirene has a highly oxygenated complex spirocyclic structure that poses abundant synthetic challenges which are addressed herein. D-Malic acid is made by the double inversion of D-aspartic acid and the stereocenter is preserved throughout the synthesis. Cyclization to the succinimide derivative forms the lactam present in azaspirene. An aldol reaction and subsequent DMP oxidation form the 1,3-diketone necessary for an asymmetric palladium-mediated [alpha]-hydroxylation reaction. The chiral alcohol will be used as the oxygen in the [Beta]-oxygenated enone ring after Margaretha cyclization using a highly functionalized ester to add the diene tail of azaspirene. The benzyl group found in azaspirene will be added via a Grignard reaction at a late stage in the synthesis allowing for diversity. The synthesis of a small set of 2-amino-benzimidazole compounds that bind a RNA construct of the hepatitis C virus (HCV) internal ribosome entry site (IRES) with ligand affinity in the submicro-molar range is described. The binding interaction is demonstrated by a 2.2Å resolution crystal structure of a 2-amino-benzimidazole compound bound to the RNA construct published by the Bergdahl group with collaborators. The total synthesis and crystal structure were used to guide the production of novel compounds, and the results presented herein will influence the design and construction of novel inhibitors expected to increase potency against HCV.
Book Synopsis Asymmetric Synthesis by : Robert Alan Aitken
Download or read book Asymmetric Synthesis written by Robert Alan Aitken and published by Blackie Academic and Professional. This book was released on 1992 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Asymmetric synthesis is now one of the most important areas of research and development in synthetic organic chemistry, and has wide-ranging industrial applications. This introduction to the subject covers chirality, nomenclature and analytical methods of resolution. The main body of the text describes the principal methods available to the organic chemist wishing to synthesize chiral compounds. Case studies are included, and reference sections allow access to the relevant review and research literature.
Book Synopsis Asymmetric Synthesis: Catalysis, Methods and Applications by : Jack Riley
Download or read book Asymmetric Synthesis: Catalysis, Methods and Applications written by Jack Riley and published by . This book was released on 2018-02-09 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a branch of chemistry, asymmetric synthesis refers to that form of chemical synthesis, which produces stereoisomeric products and chirality in large unequal amounts. This synthesis is used in pharmaceutics because it produces diastereomers and enantiomers which are very helpful in drug discovery. This book presents the complex subject of asymmetric synthesis in the most comprehensible and easy to understand language. Different approaches, evaluations and methodologies have been included in it. This textbook will serve as a reference to a broad spectrum of readers.
Book Synopsis Asymmetric Synthesis by : Tamio Hayashi
Download or read book Asymmetric Synthesis written by Tamio Hayashi and published by . This book was released on 1998 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advanced Asymmetric Synthesis by : G.R.Stephenson
Download or read book Advanced Asymmetric Synthesis written by G.R.Stephenson and published by . This book was released on 2009-12-01 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt:
